Pub Date : 2023-01-01DOI: 10.4103/cjhr.cjhr_140_21
Ankan Bisai, D. Sengupta
Background: As of December 17, 2021, India has been reporting a daily increase of over 7447 in fresh COVID-19 cases, total over 3.4 crore cases. Lack of knowledge and perceptions among health-care workers (HCWs) can pose challenges to disease control. HCWs are high-risk group for COVID-19; Adequate knowledge and COVID appropriate behavior can help prevent and contain the disease. Only early diagnosis and quarantine with proper management help to limit the COVID-19 transmission. Methodology: A cross-sectional study was carried for 30 days, from the September 16, 2020–October 15, 2020, in a block of Paschim Medinipur, West Bengal, with varying cumulative incidence of COVID-19 cases. A 36-item survey instrument on various domains was adapted for assessment of COVID-19 awareness. Results: The survey was conducted among 115 frontline HCWs engaged in screening and treating COVID-19 patients. Survey results indicated that majority have good knowledge about the disease, its symptom, testing, management guidelines but lack of knowledge found on mode of organ damage and home isolation advices. Addressing their perceptions and placing additional focus on practices across all health facilities is recommended as a preparedness measure. Conclusions: As the global threat of COVID-19 still continues to emerge, targeted interventions are required for HCWs, and further studies are warranted on field level HCWs.
{"title":"Tackling adverse COVID-19 situation in India: A perspective on frontline health-care workers","authors":"Ankan Bisai, D. Sengupta","doi":"10.4103/cjhr.cjhr_140_21","DOIUrl":"https://doi.org/10.4103/cjhr.cjhr_140_21","url":null,"abstract":"Background: As of December 17, 2021, India has been reporting a daily increase of over 7447 in fresh COVID-19 cases, total over 3.4 crore cases. Lack of knowledge and perceptions among health-care workers (HCWs) can pose challenges to disease control. HCWs are high-risk group for COVID-19; Adequate knowledge and COVID appropriate behavior can help prevent and contain the disease. Only early diagnosis and quarantine with proper management help to limit the COVID-19 transmission. Methodology: A cross-sectional study was carried for 30 days, from the September 16, 2020–October 15, 2020, in a block of Paschim Medinipur, West Bengal, with varying cumulative incidence of COVID-19 cases. A 36-item survey instrument on various domains was adapted for assessment of COVID-19 awareness. Results: The survey was conducted among 115 frontline HCWs engaged in screening and treating COVID-19 patients. Survey results indicated that majority have good knowledge about the disease, its symptom, testing, management guidelines but lack of knowledge found on mode of organ damage and home isolation advices. Addressing their perceptions and placing additional focus on practices across all health facilities is recommended as a preparedness measure. Conclusions: As the global threat of COVID-19 still continues to emerge, targeted interventions are required for HCWs, and further studies are warranted on field level HCWs.","PeriodicalId":10321,"journal":{"name":"CHRISMED Journal of Health and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47232884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ahsan Imam, Nazish Fatima, M. Shameem, Shariq Ahmed
Purpose: Early diagnosis of extrapulmonary tuberculosis (TB) with simultaneous detection of rifampicin (RIF) resistance (RR) directly from the sample is a revolution brought by GeneXpert Mycobacterium TB (MTB/RIF) assay. Line probe assay (LPA) is not recommended for extrapulmonary/nonsputum specimens; GeneXpert MTB/RIF provides a diagnostic option for these. Hence, the following study aimed to evaluate the performance of GeneXpert MTB/RIF assay in nonsputum samples. Materials and Methods: A total number of 642 extrapulmonary and nonsputum respiratory samples were subjected to Ziehl–Neelsen (ZN) staining technique, fluorescent microscopy (FM), and GeneXpert MTB/RIF Assay. All samples were cultured on a solid Lowenstein–Jensen (LJ) medium and culture-positive samples were subjected to GenoType MTBDRplus LPA and drug susceptibility testing by 1% proportion method on a solid LJ medium. Results: GeneXpert MTB/RIF assay detected MTB in 25.9% (166/642) of the samples. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ZN staining technique and FM were 21.52%, 99.35%, 91.89%, and 78.77% and 27.22%, 99.78%, 97.73%, and 80.07%, respectively. Sensitivity, specificity, PPV, and NPV of GeneXpert MTB/RIF in the detection of MTB were 93.75%, 96.53%, 90.36%, and 97.80%, and RIF RR was 92.0%, 97.74%, 88.46%, and 98.48%, respectively. LPA performed on positive culture growth showed 100% sensitivity and specificity in the detection of RIF and isoniazid resistance. Conclusion: GeneXpert MTB/RIF showed high sensitivity and specificity in detecting MTB and simultaneous RIF RR among the nonsputum samples which had a good concordance to LPA. It provides a judicious option for early detection of multidrug-resistant TB in extrapulmonary and nonsputum respiratory samples.
{"title":"Evaluation of the genexpert Mycobacterium tuberculosis/Rifampicin assay for early detection of extrapulmonary tuberculosis and rifampicin resistance in aligarh region of Northern India","authors":"M. Ahsan Imam, Nazish Fatima, M. Shameem, Shariq Ahmed","doi":"10.4103/cjhr.cjhr_45_22","DOIUrl":"https://doi.org/10.4103/cjhr.cjhr_45_22","url":null,"abstract":"Purpose: Early diagnosis of extrapulmonary tuberculosis (TB) with simultaneous detection of rifampicin (RIF) resistance (RR) directly from the sample is a revolution brought by GeneXpert Mycobacterium TB (MTB/RIF) assay. Line probe assay (LPA) is not recommended for extrapulmonary/nonsputum specimens; GeneXpert MTB/RIF provides a diagnostic option for these. Hence, the following study aimed to evaluate the performance of GeneXpert MTB/RIF assay in nonsputum samples. Materials and Methods: A total number of 642 extrapulmonary and nonsputum respiratory samples were subjected to Ziehl–Neelsen (ZN) staining technique, fluorescent microscopy (FM), and GeneXpert MTB/RIF Assay. All samples were cultured on a solid Lowenstein–Jensen (LJ) medium and culture-positive samples were subjected to GenoType MTBDRplus LPA and drug susceptibility testing by 1% proportion method on a solid LJ medium. Results: GeneXpert MTB/RIF assay detected MTB in 25.9% (166/642) of the samples. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ZN staining technique and FM were 21.52%, 99.35%, 91.89%, and 78.77% and 27.22%, 99.78%, 97.73%, and 80.07%, respectively. Sensitivity, specificity, PPV, and NPV of GeneXpert MTB/RIF in the detection of MTB were 93.75%, 96.53%, 90.36%, and 97.80%, and RIF RR was 92.0%, 97.74%, 88.46%, and 98.48%, respectively. LPA performed on positive culture growth showed 100% sensitivity and specificity in the detection of RIF and isoniazid resistance. Conclusion: GeneXpert MTB/RIF showed high sensitivity and specificity in detecting MTB and simultaneous RIF RR among the nonsputum samples which had a good concordance to LPA. It provides a judicious option for early detection of multidrug-resistant TB in extrapulmonary and nonsputum respiratory samples.","PeriodicalId":10321,"journal":{"name":"CHRISMED Journal of Health and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44346883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Afaf Shuaib, A. Sultan, Mohd W. Azam, M. Rizvi, F. Khan, H. Khan, M. Shahid
Background: An early and effective immune response has a role in disease presentation and clearance of pathogen. Chemokine and cytokine responses in the immunopathogenesis of scrub typhus (ST) are the least explored aspect. This study aimed to analyze interleukin (IL)-2, IL-6, tumor necrosis factor-alpha (TNF-α), IL-10, transforming growth factor (TGF)-β, and human macrophage inflammatory protein-1 (HMIP-1) β cytokine levels in ST-positive patients during the acute phase of illness. Materials and Methods: A total of 112 ST-positive patients were included in the study with 30 healthy controls (HC). Diagnosis was confirmed by immunoglobulin M enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence assay. The serum levels of cytokines were measured using the ELISA. Statistical analysis was performed with the IBM SPSS Statistics 20 and MedCalc 16.1 Software. Results: The mean level of IL-6, IL-10, TNF-α, and HMIP1-β (72 pg/ml, 86.7 pg/ml, 187.05 pg/ml, and 12.23 pg/ml vs. 7.30 pg. ml, 8.73 pg/ml, 56.62 pg/ml, and 6.94 pg/ml, respectively) was significantly raised among the ST patients compared to the control group (P < 0.001) However, the mean and median levels of IL-2 and TGF-β were not differed significantly between ST patients and HC (P = 0.0207 and 0.0386, respectively). The severity of the disease involved respiratory complications. Around 90.1% (101/112) of patients showed high levels of IL-6, whereas IL-10, TNF-α, and HMIP-1 β levels were raised in 97 (86.6%), 63 (56.2%), and 69 (61.6%) cases, respectively. There was a higher TNF-α level in severe cases with a few values up to 298.77 pg/ml. Conclusion: Proinflammatory cytokines and IL-10 were found to be increased in ST patients during the acute phase of infection. A proper balance of these cytokines is required for a better outcome. These findings suggest that the status of TNF-α levels in the acute phase may predict the severity of ST disease.
{"title":"Cytokine profile of scrub typhus patients during the acute phase of illness","authors":"Afaf Shuaib, A. Sultan, Mohd W. Azam, M. Rizvi, F. Khan, H. Khan, M. Shahid","doi":"10.4103/cjhr.cjhr_38_22","DOIUrl":"https://doi.org/10.4103/cjhr.cjhr_38_22","url":null,"abstract":"Background: An early and effective immune response has a role in disease presentation and clearance of pathogen. Chemokine and cytokine responses in the immunopathogenesis of scrub typhus (ST) are the least explored aspect. This study aimed to analyze interleukin (IL)-2, IL-6, tumor necrosis factor-alpha (TNF-α), IL-10, transforming growth factor (TGF)-β, and human macrophage inflammatory protein-1 (HMIP-1) β cytokine levels in ST-positive patients during the acute phase of illness. Materials and Methods: A total of 112 ST-positive patients were included in the study with 30 healthy controls (HC). Diagnosis was confirmed by immunoglobulin M enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence assay. The serum levels of cytokines were measured using the ELISA. Statistical analysis was performed with the IBM SPSS Statistics 20 and MedCalc 16.1 Software. Results: The mean level of IL-6, IL-10, TNF-α, and HMIP1-β (72 pg/ml, 86.7 pg/ml, 187.05 pg/ml, and 12.23 pg/ml vs. 7.30 pg. ml, 8.73 pg/ml, 56.62 pg/ml, and 6.94 pg/ml, respectively) was significantly raised among the ST patients compared to the control group (P < 0.001) However, the mean and median levels of IL-2 and TGF-β were not differed significantly between ST patients and HC (P = 0.0207 and 0.0386, respectively). The severity of the disease involved respiratory complications. Around 90.1% (101/112) of patients showed high levels of IL-6, whereas IL-10, TNF-α, and HMIP-1 β levels were raised in 97 (86.6%), 63 (56.2%), and 69 (61.6%) cases, respectively. There was a higher TNF-α level in severe cases with a few values up to 298.77 pg/ml. Conclusion: Proinflammatory cytokines and IL-10 were found to be increased in ST patients during the acute phase of infection. A proper balance of these cytokines is required for a better outcome. These findings suggest that the status of TNF-α levels in the acute phase may predict the severity of ST disease.","PeriodicalId":10321,"journal":{"name":"CHRISMED Journal of Health and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48176866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pranay Jindal, Irfana Shah, Jisha Mathew, Shihab Kannappillil, Ma Igna Sibayan, Parvathy Ragesh, Sashtha Girish, I. Cabanillas, Ana Villa, Matheus Petrus Van Rens, Mohamed Alturk, M. Mahmah, Mai AlQuabaisi, Noora AlMudehka, A. Hussein
Background: Neonates admitted to the neonatal intensive care unit (NICU) are at risk of neuromotor and behavioral impairments, and therapy services can optimize their neurodevelopment. Physiotherapy (PT) and Occupational therapy (OT) services are available in the NICU of Women's Wellness and Research Center, and as per the guidelines, physicians should refer the neonates for appropriate services. Baseline analysis of 1-month data revealed that 25%, 36%, 62%, and 10% of eligible neonates were not referred to (1) inpatient OT, (2) inpatient PT, (3) baby therapy, and (4) neonatal neurodevelopmental clinic, respectively. The study's objective is to increase the number of babies being referred, by reducing the number of eligible neonates not being referred to 4 available therapy services to 50% of the baseline data after 1 month of implementation. Methods: A Plan-Do-Study-Act cycle guided the interventions. The 1st phase identified stakeholders' challenges for not referring the babies to appropriate services. Based on their feedback, the referral criteria were revised. The 2nd phase involved implementing the revised criteria. Steps included (a) stakeholders' education on the revised criteria and making it available all the time, (b) daily triage and huddle to inform stakeholders of the needed referrals, and (c) establishing communication pathways. Results: Exceeding the targets, all eligible and 75% of the eligible neonates for neonatal neurodevelopmental and baby therapy clinics, respectively, were referred. For inpatient OT and PT services, 22% (targeted 12.5%) and 20% (targeted 18%) of the eligible neonates were missed. Conclusion: Within 1 month, we decreased the number of nonreferrals to all 4 therapy services. Inpatient PT and OT referrals need more focus.
{"title":"A quality improvement study to improve the utilization of occupational therapy and physiotherapy services in a level 4 neonatal intensive care unit and neurodevelopmental follow-up clinics","authors":"Pranay Jindal, Irfana Shah, Jisha Mathew, Shihab Kannappillil, Ma Igna Sibayan, Parvathy Ragesh, Sashtha Girish, I. Cabanillas, Ana Villa, Matheus Petrus Van Rens, Mohamed Alturk, M. Mahmah, Mai AlQuabaisi, Noora AlMudehka, A. Hussein","doi":"10.4103/cjhr.cjhr_87_22","DOIUrl":"https://doi.org/10.4103/cjhr.cjhr_87_22","url":null,"abstract":"Background: Neonates admitted to the neonatal intensive care unit (NICU) are at risk of neuromotor and behavioral impairments, and therapy services can optimize their neurodevelopment. Physiotherapy (PT) and Occupational therapy (OT) services are available in the NICU of Women's Wellness and Research Center, and as per the guidelines, physicians should refer the neonates for appropriate services. Baseline analysis of 1-month data revealed that 25%, 36%, 62%, and 10% of eligible neonates were not referred to (1) inpatient OT, (2) inpatient PT, (3) baby therapy, and (4) neonatal neurodevelopmental clinic, respectively. The study's objective is to increase the number of babies being referred, by reducing the number of eligible neonates not being referred to 4 available therapy services to 50% of the baseline data after 1 month of implementation. Methods: A Plan-Do-Study-Act cycle guided the interventions. The 1st phase identified stakeholders' challenges for not referring the babies to appropriate services. Based on their feedback, the referral criteria were revised. The 2nd phase involved implementing the revised criteria. Steps included (a) stakeholders' education on the revised criteria and making it available all the time, (b) daily triage and huddle to inform stakeholders of the needed referrals, and (c) establishing communication pathways. Results: Exceeding the targets, all eligible and 75% of the eligible neonates for neonatal neurodevelopmental and baby therapy clinics, respectively, were referred. For inpatient OT and PT services, 22% (targeted 12.5%) and 20% (targeted 18%) of the eligible neonates were missed. Conclusion: Within 1 month, we decreased the number of nonreferrals to all 4 therapy services. Inpatient PT and OT referrals need more focus.","PeriodicalId":10321,"journal":{"name":"CHRISMED Journal of Health and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70707021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aishwarya Babu, S. Bhatawadekar, Mahadevan Kumar, M. Modak
Ochrobactrum anthropi is an organism which is commonly distributed in the environment and water sources including normal saline, antiseptic solutions, and dialysis fluid. However, it is an opportunistic pathogen, especially in critically ill or immunocompromised patients. The presence of central venous catheter line is a risk factor. Here, we report two cases of bacteremia caused by O. anthropi in patients undergoing chemotherapy.
{"title":"Ochrobactrum anthropi: An unusual emerging pathogen","authors":"Aishwarya Babu, S. Bhatawadekar, Mahadevan Kumar, M. Modak","doi":"10.4103/cjhr.cjhr_95_22","DOIUrl":"https://doi.org/10.4103/cjhr.cjhr_95_22","url":null,"abstract":"Ochrobactrum anthropi is an organism which is commonly distributed in the environment and water sources including normal saline, antiseptic solutions, and dialysis fluid. However, it is an opportunistic pathogen, especially in critically ill or immunocompromised patients. The presence of central venous catheter line is a risk factor. Here, we report two cases of bacteremia caused by O. anthropi in patients undergoing chemotherapy.","PeriodicalId":10321,"journal":{"name":"CHRISMED Journal of Health and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43587320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sukriti Kumar, K. Yadav, N. Kohli, M. Gutch, N. Kumar, Ankur Bajaj, A. Parihar
Background: Neoplastic and infective brain lesions may present as imaging mimickers. This study aims to help differentiate between etiology of lesions based on diffusion tensor imaging (quantitatively and qualitatively). Method: DTI was performed in 50 patients (12 - metastases,13 - high grade glioma,13 - tuberculoma, 12 - Neurocysticercosis). Lesional and perilesional Fractional anisotropy (FA) and mean diffusivity (MD) values were calculated. Lesional and perilesional mean FA and MD values were compared by using Student's 't'-test. Result: Mean FA values in the perilesional area of neoplastic lesions were found to be significantly higher (0.17±0.12 vs. 0.08±0.02), P < 0.001) in comparison to infective lesions. Mean MD values in the perilesional area of infective lesions were found to be significantly higher (1.51±0.22 vs. 1.20±0.33x10-3mm2/sec, P < 0.001) in comparison to neoplastic lesions. Perilesional FA was found to be significantly higher and perilesional ADC to be significantly lower in High Grade Gliomas (HGG) when compared with Metastasis, Tuberculomas or Neurocysticercosis. Infective group showed significantly higher prevalence of displacement of white matter tracts (60%) and the neoplastic group showed significantly higher prevalence of the disruption (40%). Conclusion: FA and MD values from the lesion and from perilesional region are helpful in differentiating among brain lesions. Fiber tracking along with quantitative parameters is helpful in determining type of involvement of tracts, thus helping in prognostication.
{"title":"Use of diffusion tensor imaging in distinguishing neoplastic and infective intra-axial brain lesions: An intergroup and etiology wise inter sub-group analysis - Experience from a tertiary health care center in Northern India","authors":"Sukriti Kumar, K. Yadav, N. Kohli, M. Gutch, N. Kumar, Ankur Bajaj, A. Parihar","doi":"10.4103/cjhr.cjhr_65_22","DOIUrl":"https://doi.org/10.4103/cjhr.cjhr_65_22","url":null,"abstract":"Background: Neoplastic and infective brain lesions may present as imaging mimickers. This study aims to help differentiate between etiology of lesions based on diffusion tensor imaging (quantitatively and qualitatively). Method: DTI was performed in 50 patients (12 - metastases,13 - high grade glioma,13 - tuberculoma, 12 - Neurocysticercosis). Lesional and perilesional Fractional anisotropy (FA) and mean diffusivity (MD) values were calculated. Lesional and perilesional mean FA and MD values were compared by using Student's 't'-test. Result: Mean FA values in the perilesional area of neoplastic lesions were found to be significantly higher (0.17±0.12 vs. 0.08±0.02), P < 0.001) in comparison to infective lesions. Mean MD values in the perilesional area of infective lesions were found to be significantly higher (1.51±0.22 vs. 1.20±0.33x10-3mm2/sec, P < 0.001) in comparison to neoplastic lesions. Perilesional FA was found to be significantly higher and perilesional ADC to be significantly lower in High Grade Gliomas (HGG) when compared with Metastasis, Tuberculomas or Neurocysticercosis. Infective group showed significantly higher prevalence of displacement of white matter tracts (60%) and the neoplastic group showed significantly higher prevalence of the disruption (40%). Conclusion: FA and MD values from the lesion and from perilesional region are helpful in differentiating among brain lesions. Fiber tracking along with quantitative parameters is helpful in determining type of involvement of tracts, thus helping in prognostication.","PeriodicalId":10321,"journal":{"name":"CHRISMED Journal of Health and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44479672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shariq Ahmed, M. Shameem, Nazish Fatima, Uzma Tayyaba
Objectives: This study was conducted to compare the disease severity of COVID-19 in pregnant and nonpregnant females of reproductive age group and to evaluate the effect of COVID-19 on neonatal outcome. Materials and Methods: The present prospective observational study was conducted at a tertiary care center in northern India over a period of 6 months. Females of reproductive age group (15–44 years) that were admitted in COVID isolation ward with reverse transcription–polymerase chain reaction-positive COVID-19 disease were included in the study and followed till discharge. Results: Among the 60 females of reproductive age group, 41.67% (25) were pregnant and 58.34% (35) were nonpregnant. The median duration of hospitalization among pregnant and nonpregnant females was 9 and 8.5 days, respectively. The severity of infection among pregnant and nonpregnant females was as follows: asymptomatic + mild disease 96% (24) and 77.14% (27) and moderate + severe disease 4% (1) and 22.86% (8), respectively. There were no maternal mortalities. Forty percent (10) of pregnant females had lower segment cesarean section (LSCS) and 32% (8) had normal vaginal delivery. There were 8 preterm, 6 full-term, 3 early-term, and 1 late-term deliveries. Twelve newborns had normal birth weight, 4 were low birth weight (LBW), 1 was very LBW, and 2 intrauterine deaths IUD were reported. No case of neonatal death or neonatal asphyxia was reported. Conclusion: In comparison to nonpregnant women with COVID-19 pneumonia, the infected pregnant females had mild or no respiratory symptoms, and none developed severe respiratory compromise or required intensive care. Preterm delivery, LSCS, and LBW were common in COVID-19-infected females.
{"title":"Severity of COVID-19 disease in pregnant and nonpregnant females of reproductive age group: A preliminary comparative study","authors":"Shariq Ahmed, M. Shameem, Nazish Fatima, Uzma Tayyaba","doi":"10.4103/cjhr.cjhr_47_22","DOIUrl":"https://doi.org/10.4103/cjhr.cjhr_47_22","url":null,"abstract":"Objectives: This study was conducted to compare the disease severity of COVID-19 in pregnant and nonpregnant females of reproductive age group and to evaluate the effect of COVID-19 on neonatal outcome. Materials and Methods: The present prospective observational study was conducted at a tertiary care center in northern India over a period of 6 months. Females of reproductive age group (15–44 years) that were admitted in COVID isolation ward with reverse transcription–polymerase chain reaction-positive COVID-19 disease were included in the study and followed till discharge. Results: Among the 60 females of reproductive age group, 41.67% (25) were pregnant and 58.34% (35) were nonpregnant. The median duration of hospitalization among pregnant and nonpregnant females was 9 and 8.5 days, respectively. The severity of infection among pregnant and nonpregnant females was as follows: asymptomatic + mild disease 96% (24) and 77.14% (27) and moderate + severe disease 4% (1) and 22.86% (8), respectively. There were no maternal mortalities. Forty percent (10) of pregnant females had lower segment cesarean section (LSCS) and 32% (8) had normal vaginal delivery. There were 8 preterm, 6 full-term, 3 early-term, and 1 late-term deliveries. Twelve newborns had normal birth weight, 4 were low birth weight (LBW), 1 was very LBW, and 2 intrauterine deaths IUD were reported. No case of neonatal death or neonatal asphyxia was reported. Conclusion: In comparison to nonpregnant women with COVID-19 pneumonia, the infected pregnant females had mild or no respiratory symptoms, and none developed severe respiratory compromise or required intensive care. Preterm delivery, LSCS, and LBW were common in COVID-19-infected females.","PeriodicalId":10321,"journal":{"name":"CHRISMED Journal of Health and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44776278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/cjhr.cjhr_124_22
B. Meena, Ashok Kumar, N. Joshi, Y. Jain, Mrinalini Mingwal, P. Bhardwaj
Background: High blood pressure (BP) in adolescents and young adults is a rising concern in today's world. Behavioral factors largely contribute toward the development of hypertension. Once these are established, they often persist throughout life, and if identified timely, might play a significant role in prevalence reduction. This study was conducted to assess the prevalence and association of hypertension and its risk factors in college students of Jodhpur district. Methodology: A cross-sectional study was conducted in ten colleges across five zones of Jodhpur district using modified WHO STEPS questionnaire and by taking physical measurements of BP, height, and weight. Descriptive analysis was done using means and percentages, and statistical significance was established using prevalence odds ratio (POR). Results: Of the 421 study participants, 251 (59.60%) were males and 170 (40.20%) were females, with a mean age of 20.12. The prevalence of risk factors and significant association were observed between gender and educational level with behavioral habits. Further, hypertension prevalence (16.15%) was found to be associated with smoking (POR = 2.72), high salt intake (POR = 3.21), physical activity (POR = 0.30), overweight (POR = 2.34), and obese body mass index (POR = 4.02). Conclusion: The study provided evidence of high prevalence of hypertension and its associated behavioral risk factors such as tobacco, salt, and physical inactivity. Such evidences may be utilized for health promotion programs for the specific age group and region.
{"title":"Hypertension and its risk factors among college students of Jodhpur, Rajasthan","authors":"B. Meena, Ashok Kumar, N. Joshi, Y. Jain, Mrinalini Mingwal, P. Bhardwaj","doi":"10.4103/cjhr.cjhr_124_22","DOIUrl":"https://doi.org/10.4103/cjhr.cjhr_124_22","url":null,"abstract":"Background: High blood pressure (BP) in adolescents and young adults is a rising concern in today's world. Behavioral factors largely contribute toward the development of hypertension. Once these are established, they often persist throughout life, and if identified timely, might play a significant role in prevalence reduction. This study was conducted to assess the prevalence and association of hypertension and its risk factors in college students of Jodhpur district. Methodology: A cross-sectional study was conducted in ten colleges across five zones of Jodhpur district using modified WHO STEPS questionnaire and by taking physical measurements of BP, height, and weight. Descriptive analysis was done using means and percentages, and statistical significance was established using prevalence odds ratio (POR). Results: Of the 421 study participants, 251 (59.60%) were males and 170 (40.20%) were females, with a mean age of 20.12. The prevalence of risk factors and significant association were observed between gender and educational level with behavioral habits. Further, hypertension prevalence (16.15%) was found to be associated with smoking (POR = 2.72), high salt intake (POR = 3.21), physical activity (POR = 0.30), overweight (POR = 2.34), and obese body mass index (POR = 4.02). Conclusion: The study provided evidence of high prevalence of hypertension and its associated behavioral risk factors such as tobacco, salt, and physical inactivity. Such evidences may be utilized for health promotion programs for the specific age group and region.","PeriodicalId":10321,"journal":{"name":"CHRISMED Journal of Health and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49455979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HIV infection has an impact on the natural course of chronic HBV infection, as it results in an increase in HBV DNA levels, accelerated progression of liver disease, and increased liver-related mortality compared with HBV mono-infection. In HIV/HBV co-infected individuals, widespread uptake and early initiation of HBV-active antiretroviral therapy have drastically improved the natural history of viral infection; however, liver disease remains common. In this paper we have reviewed the epidemiology, prevalence, treatment, pathogenesis of HIV and HBV co-infection. Co-infection of HBV-HIV is more likely to progress and complicate the disease and should be closely monitored and treated.
{"title":"A review on the epidemiology of HBV and HIV co-infection","authors":"Asaad Mohd, Hiba Sami, P. Khan, H. Khan","doi":"10.4103/cjhr.cjhr_34_22","DOIUrl":"https://doi.org/10.4103/cjhr.cjhr_34_22","url":null,"abstract":"HIV infection has an impact on the natural course of chronic HBV infection, as it results in an increase in HBV DNA levels, accelerated progression of liver disease, and increased liver-related mortality compared with HBV mono-infection. In HIV/HBV co-infected individuals, widespread uptake and early initiation of HBV-active antiretroviral therapy have drastically improved the natural history of viral infection; however, liver disease remains common. In this paper we have reviewed the epidemiology, prevalence, treatment, pathogenesis of HIV and HBV co-infection. Co-infection of HBV-HIV is more likely to progress and complicate the disease and should be closely monitored and treated.","PeriodicalId":10321,"journal":{"name":"CHRISMED Journal of Health and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43759499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Rashid, M. Husain, S. Salman, Sonali Ohri, Nikhat Sartaj
Groin hernias are most common among patients presenting with hernia. Males have more predisposition mainly due to anatomy. However, females with groin hernia present with varied abdominal contents including ovaries and fallopian tubes. The worrisome feature of inguinal hernia with ovaries/fallopian tubes as content is torsion. Uncomplicated groin hernia with ovaries as content is managed with conventional laparoscopic or open hernia repair. Young females with groin hernias need to be evaluated thoroughly for features of androgen insensitivity syndrome or any underlying genetic disorder. A 12 years young female presented to our OPD with chief complaints of swelling in the right inguinal region for 6 months. Patient had not achieved menarche yet, however development milestones were found to be normal. On general physical examinations, deformities were noted in the right ear and left upper limb. On local examination, swelling of approximately 3x3 cm was noted in the right inguinal region. An ultrasonography scan of whole abdomen and pelvis which was suggestive of right inguinal hernia containing right ovary with malposition of the right kidney in the pelvis. Consequently, MRI whole abdomen with pelvis confirmed the findings of USG. Patient was taken for laparoscopic inguinal hernia repair. There was right sided indirect inguinal hernia with right ovary as content and a solid mass was also noted in the right pelvic region suggestive of right pelvic kidney. Right ovary was reduced back to the abdomen with transection of the right round ligament and the defect was closed back with interrupted 3'0 Vicryl sutures. Postoperative course was uneventful. Patient was counselled for genetic analysis to rule out any syndrome association. Uncomplicated groin hernia in young females and paediatric age groups with ovarian content can be easily managed with laparoscopic repair. Early intervention should be advised to prevent ovarian torsion and hence long term morbidity.
{"title":"Laparoscopic inguinal hernia repair in a young female with associated multiple congenital defects: A rare case","authors":"T. Rashid, M. Husain, S. Salman, Sonali Ohri, Nikhat Sartaj","doi":"10.4103/cjhr.cjhr_71_22","DOIUrl":"https://doi.org/10.4103/cjhr.cjhr_71_22","url":null,"abstract":"Groin hernias are most common among patients presenting with hernia. Males have more predisposition mainly due to anatomy. However, females with groin hernia present with varied abdominal contents including ovaries and fallopian tubes. The worrisome feature of inguinal hernia with ovaries/fallopian tubes as content is torsion. Uncomplicated groin hernia with ovaries as content is managed with conventional laparoscopic or open hernia repair. Young females with groin hernias need to be evaluated thoroughly for features of androgen insensitivity syndrome or any underlying genetic disorder. A 12 years young female presented to our OPD with chief complaints of swelling in the right inguinal region for 6 months. Patient had not achieved menarche yet, however development milestones were found to be normal. On general physical examinations, deformities were noted in the right ear and left upper limb. On local examination, swelling of approximately 3x3 cm was noted in the right inguinal region. An ultrasonography scan of whole abdomen and pelvis which was suggestive of right inguinal hernia containing right ovary with malposition of the right kidney in the pelvis. Consequently, MRI whole abdomen with pelvis confirmed the findings of USG. Patient was taken for laparoscopic inguinal hernia repair. There was right sided indirect inguinal hernia with right ovary as content and a solid mass was also noted in the right pelvic region suggestive of right pelvic kidney. Right ovary was reduced back to the abdomen with transection of the right round ligament and the defect was closed back with interrupted 3'0 Vicryl sutures. Postoperative course was uneventful. Patient was counselled for genetic analysis to rule out any syndrome association. Uncomplicated groin hernia in young females and paediatric age groups with ovarian content can be easily managed with laparoscopic repair. Early intervention should be advised to prevent ovarian torsion and hence long term morbidity.","PeriodicalId":10321,"journal":{"name":"CHRISMED Journal of Health and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45286671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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