Clinical and Experimental Dermatology最新文献

Delusional infestation syndrome (DI) is a rare psychiatric disorder characterized by a persistent, false belief of being infested by parasites. In this study, we evaluated the epidemiological and clinical characteristics of the individuals suffering from DI, referred to a hospital in the north of Paris from 2009 to 2024. Women and the patients over 41 years old were the most affected individuals. The presence of matchbox sign along with symptoms such as distress, anxiety, and insomnia were frequently recorded. In addition, the occurrence of this syndrome was not influenced by the patient's occupation. The healthcare workers should be aware of this disorder, its diagnosis and appropriate treatment.

Background: Basal cell carcinoma (BCC) is the most common skin cancer. Recently, aminolaevulinic acid-photodynamic therapy (ALA-PDT) has emerged as a non-invasive treatment for facial lesions.

Objectives: This research aimed to evaluate the efficacy and safety of second-intention healing after tumor excision with ALA-PDT in periocular BCC.

Methods: A total of 16 patients with periocular BCC from an academic, large metropolitan-based hospital were included in this study. All the patients received marginal resection combined with topical ALA-PDT. No suture was performed, and ALA-PDT treatments (3-6 times) were applied to each patient with 633 nm red light directly after surgical resection. Patient demographics, images, medication, and prognosis were evaluated and recorded. Patient Satisfaction Questionnaire (PSQ) that consists of the overall satisfaction with medical experience (0-10 scores) and cosmetic outcome (0-10 scores) were recorded.

Results: 10 women and 6 men aged between 33 to 84 years old periocular BCC (8/16 were nodular type, 2/16 were infiltrative type, 2/16 were nodular cystic type, 1/16 were ulcerative type and 3/16 were unknown type) completed the treatment with good overall satisfaction with medical experience (mean score: 9.5) and cosmetic outcome (mean score: 8.625). No serious complications and scar formation were reported in all the patients. No recurrence of tumor was observed in the long-term follow-up of 1 -3.5 years.

Conclusions: Our results indicate that second-intention healing after marginal resection combined with ALA-PDT can reduce the tissue defect and maintain excellent cure rate, offers an alternative and aesthetic treatment for localized periocular BCC.

Background: Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life-threatening reactions that cause blistering of the skin and mucous membranes. Survivors can experience long term physical and psychological complications. The 'My SJS Passport' was co-produced by the Patient and Public Involvement group and research team at the Wolfson Centre for Personalised Medicine to improve the care and experiences of survivors.

Objectives: The aim of the study was to implement the 'My SJS Passport' in a real-world setting for evaluation by those with lived experience of SJS/TEN. The objectives were to assess participant's perceptions of its acceptability and utility when used during appointments with healthcare professionals and to explore participants' perceptions of its value and potential barriers to implementation.

Methods: A proof-of-concept study to evaluate the acceptability and usability of the passport using a mixed methods approach.

Results: A questionnaire was completed by 19 (86.4%) females and 3 (13.6%) males, while 11/22 participated focus groups. Findings suggest the passport a valuable communication tool, as it acted as the 'patient's voice' and helped in validating diagnosis with healthcare professionals, family and friends.

Conclusion: The study provides the first formal evaluation of the passport and showed that the tool is acceptable, functional and of benefit to the user. Minor barriers to implementation were identified, largely due to the COVID-19 pandemic and, to a lesser extent, the passport design. There is no comparable tool in use; thus, based on these preliminary findings, it is thought that the passport has a valuable role in supporting this underserved population.