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Clinical and Experimental Dermatology最新文献

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Cutaneous toxicities in patients with metastatic uveal melanoma receiving tebentafusp: a retrospective review. The experience of a single large specialist institution. 接受tebentafusp治疗的转移性葡萄膜黑色素瘤患者的皮肤毒性：一项回顾性回顾。一个大型专业机构的经验。
IF 2.8 4区 医学 Q1 DERMATOLOGY
Clinical and Experimental Dermatology
Pub Date : 2026-01-27 DOI: 10.1093/ced/llaf426
Xingyue Maria Wang, Andrew Furness, Kara Heelan

Tebentafusp is a novel T-cell receptor-based bispecific protein that targets glycoprotein 100 and CD3. It is the only approved systemic therapy for patients with unresectable or metastatic human leucocyte antigen (HLA)-A*02:01-positive uveal melanoma. Cutaneous toxicities are common, yet there are limited studies in the literature. We conducted a retrospective observational cohort study of patients with HLA-A*02:01-positive unresectable or metastatic uveal melanoma who received tebentafusp therapy from August 2021 to January 2024 at the Royal Marsden NHS Foundation Trust (London, UK), a tertiary referral centre. Cutaneous toxicity occurred in 16/18 (89%) patients, but reactions were manageable, with no patients permanently discontinuing treatment. To our knowledge, we also report the first case of bullous pemphigoid associated with tebentafusp.

Tebentafusp是一种针对糖蛋白100和CD3的新型t细胞受体双特异性蛋白。它是唯一被批准用于不可切除或转移性HLA-A*02:01阳性葡萄膜黑色素瘤患者的全身疗法。皮肤毒性是常见的，但文献研究有限。我们对三级转诊中心的HLA-A*02:01-阳性不可切除或转移性葡萄膜黑色素瘤患者进行了一项回顾性观察队列研究，这些患者于2021年8月至2024年1月接受了替本他福治疗。89%的患者发生皮肤毒性，但反应是可控的，没有患者永久停止治疗。据我们所知，我们也报告了第一例大疱性类天疱疮与tebentafusp相关。
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引用次数: 0
The joys of peer reviewing. 同行评议的乐趣。
IF 2.8 4区 医学 Q1 DERMATOLOGY
Clinical and Experimental Dermatology
Pub Date : 2026-01-27 DOI: 10.1093/ced/llaf470
Celia Moss
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引用次数: 0
Chronic recurrent dermatitis induced by Millepora dichotoma (fire coral): a case of long duration. 火珊瑚千孔虫所致慢性复发性皮炎1例。
IF 2.8 4区 医学 Q1 DERMATOLOGY
Clinical and Experimental Dermatology
Pub Date : 2026-01-27 DOI: 10.1093/ced/llaf455
Antonio Di Guardo, Umberto Gallo, Francesca Feresin, Federica Trovato, Alessandra Rallo, Steven P Nisticò, Dario Didona, Giovanni Pellacani
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引用次数: 0
Ultraviolet-induced fluorescence dermoscopy of scabies mite-gallery unit: three patients in the same family. 紫外线荧光皮肤镜检查疥疮螨库单位(MGU)-同一家庭三例。
IF 2.8 4区 医学 Q1 DERMATOLOGY
Clinical and Experimental Dermatology
Pub Date : 2026-01-27 DOI: 10.1093/ced/llaf458
Aadharsha A, Aravind Baskar Murthy, Murali Narasimhan
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引用次数: 0
Localized demodicosis of the scalp following hair transplantation. 头发移植后头皮局部蠕虫病。
IF 2.8 4区 医学 Q1 DERMATOLOGY
Clinical and Experimental Dermatology
Pub Date : 2026-01-27 DOI: 10.1093/ced/llaf421
Pelin Koҫyiğit, Feride Ongun, Gizem Nur Öztürk, Özlem Dicle, Aylin Okçu Heper
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引用次数: 0
Comment on 'Nail Matrix Melanoma in Adolescents and Young Adults': Shifting the Diagnostic Paradigm: Replacing "Adult Age" with "After Puberty" for Earlier Detection. 评论“青少年和年轻人的指甲基质黑色素瘤”：转移诊断范式：用“青春期后”代替“成年年龄”进行早期检测。
IF 2.8 4区 医学 Q1 DERMATOLOGY
Clinical and Experimental Dermatology
Pub Date : 2026-01-27 DOI: 10.1093/ced/llag039
Junhua Qi, Gang Nie
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引用次数: 0
Generalized bullous haemorrhagic pyoderma gangrenosum following tick-borne encephalitis vaccination. 蜱传脑炎疫苗接种后的广泛性大疱性出血性坏疽性脓皮病。
IF 2.8 4区 医学 Q1 DERMATOLOGY
Clinical and Experimental Dermatology
Pub Date : 2026-01-27 DOI: 10.1093/ced/llaf479
Thilo Gambichler, Ocko Kautz, Marne Handke, Stefanie Boms
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引用次数: 0
Paediatrics and genetics. 儿科和遗传学。
IF 2.8 4区 医学 Q1 DERMATOLOGY
Clinical and Experimental Dermatology
Pub Date : 2026-01-27 DOI: 10.1093/ced/llaf451
Meghana Reddy, Arun Somasundaram, Arun Philips Arulnathan, Laxmisha Chandrashekar
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引用次数: 0
Dapsone use in dermatology: indication, efficacy and tolerability experience of a UK tertiary dermatology department. 氨苯砜在皮肤科的应用——英国三级皮肤科的适应症、疗效和耐受性经验。
IF 2.8 4区 医学 Q1 DERMATOLOGY
Clinical and Experimental Dermatology
Pub Date : 2026-01-27 DOI: 10.1093/ced/llaf464
Zhao Xuan Tan, Lauren Passby, Lucy Button, Shireen Velangi

Dapsone has been a quick and affordable treatment option for a diverse range of dermatological pathologies. Although licensed for the management of leprosy and dermatitis herpetiformis, its uses expand to a range of neutrophil- and eosinophil-driven pathologies. This retrospective study examined the use of dapsone at a large tertiary dermatology department in the UK serving a diverse population. In our report, we assess indications for use and treatment efficacy, and provide 3-year follow-up data on clinical outcomes and adverse events, and their frequency. These data demonstrate the unpredictable efficacy of dapsone, and allow dermatologists to better inform their patients regarding possible treatment success with dapsone, as well as to counsel patients regarding the frequency and range of possible adverse events.

氨苯砜一直是一种快速和负担得起的治疗选择的各种皮肤病的病理。虽然获得许可用于麻风病和疱疹样皮炎的治疗，但其用途扩大到一系列中性粒细胞和嗜酸性粒细胞驱动的病理。本回顾性研究评估了在英国为不同人群服务的大型三级皮肤科使用氨苯砜的情况。我们评估了使用适应症和治疗效果，并提供了关于临床结果、不良事件及其发生频率的三年随访数据。这一数据证明了氨苯砜不可预测的疗效，并允许皮肤科医生更好地告知他们的患者氨苯砜可能的治疗成功，以及就可能的不良事件的频率和范围向患者提供咨询。
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引用次数: 0
Chronic hand eczema treated with topical delgocitinib cream. 局部delgocitinib乳膏治疗慢性手部湿疹。
IF 2.8 4区 医学 Q1 DERMATOLOGY
Clinical and Experimental Dermatology
Pub Date : 2026-01-27 DOI: 10.1093/ced/llaf454
Charmaine Wilson, Simon Tso
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引用次数: 0
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