Circulation最新文献

{"title":"Letter by Sun Regarding Article, \"Nonculprit Vulnerable Plaques and Prognosis in Myocardial Infarction With Versus Without ST-Segment Elevation: A PROSPECT II Substudy\".","authors":"Peng Sun","doi":"10.1161/CIRCULATIONAHA.125.076450","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.125.076450","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"153 3","pages":"e16"},"PeriodicalIF":38.6,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Heart Stress and Blood Pressure Management in Older Adults: Post Hoc Analysis of the ASPREE Trial.","authors":"Anping Cai, Antoni Bayes-Genis, Joanne Ryan, Yingqing Feng, James L Januzzi, Andrew M Tonkin, Jiazhen Zheng, Mark R Nelson, Johannes T Neumann, Robyn L Woods, Cammie Tran, Aletta E Schutte, Ambarish Pandey, Lin Yee Chen, Lin Liu, Junguo Zhang, John J McNeil, Lawrence Beilin, Hung-Fat Tse, Gianfranco Parati, Zhen Zhou","doi":"10.1161/CIR.0000000000001413","DOIUrl":"https://doi.org/10.1161/CIR.0000000000001413","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"153 3","pages":"e20"},"PeriodicalIF":38.6,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple Versus Dual Lipid-Lowering Therapy in Acute Coronary Syndrome: The ES-BempedACS Randomized Clinical Trial.","authors":"Sergio Raposeiras-Roubín, Emad Abu Assi, César Jiménez Méndez, Ester Mínguez de la Guía, José Ángel Pérez Rivera, Marta Marcos Mangas, Ana Ayesta, Aitor Uribarri, Pablo Jorge Pérez, Pablo José Antúnez Muinos, Clara Bonanad Lozano, Anna Carrasquer, Ana Viana-Tejedor, Pablo Domínguez Erquicia, Alberto Villar Ruiz, Macarena López Vázquez, Lara Aguilar Iglesias, Alberto Alén Andrémar, Maria Vidal Burdeus, Marta Maria Martin Cabeza, María Cristina González Cambeiro, Daznia Bompart, Juan Carlos Gómez Polo, Marina Teresa García García, Ana Merino Merino, José Rozado, José Antonio Panera de la Mano, Francisco Salmerón Martínez, Ester Sánchez Corral, Isabel Santos Sánchez, Ángel Víctor Hernández-Martos, Andrés Antelo Abejón, Andrés Iñiguez Romo, Miguel Corbi-Pascual, Albert Ariza-Solé","doi":"10.1161/CIRCULATIONAHA.125.075388","DOIUrl":"10.1161/CIRCULATIONAHA.125.075388","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines recommend a stepwise strategy to achieve low-density lipoprotein cholesterol (LDL-C) goals after acute coronary syndrome (ACS). Earlier intensive strategies based on a combination of lipid-lowering therapies (LLTs) could be useful from the onset of ACS. However, the role of bempedoic acid in ACS, particularly when combined with high-intensity statins and ezetimibe, remains uncertain. The aim of ES-BempedACS (Efficacy and Security of Bempedoic Acid in Acute Coronary Syndrome) was to compare the efficacy and safety of triple LLT (high-dose, high-intensity statin+ezetimibe+bempedoic acid) versus standard of care (high-dose, high-intensity statin+ezetimibe) after ACS.</p><p><strong>Methods: </strong>ES-BempedACS is a multicenter, independent, pragmatic, prospective, randomized, open, blinded end point controlled trial conducted in 12 Spanish hospitals between November 2023 and October 2024. The primary end point was the proportion of patients achieving LDL-C <55 mg/dL (<1.4 mmol/L) at 8 weeks after ACS, comparing triple LLT with standard of care.</p><p><strong>Results: </strong>A total of 206 patients (59.5±10.9 years of age [mean±SD]; 21.4% women) were randomized within the first 72 hours of ACS to triple LLT or standard therapy of high-intensity statin+ezetimibe (ie, dual LLT). The baseline LDL-C level was 133.6±28.8 mg/dL. After 8 weeks, the LDL-C level was reduced to <55 mg/dL in 59.4% of patients in the triple LLT group compared with 53.1% in the control group (dual LLT; <i>P</i>=0.376). The percentage change in LDL-C level was 57.5±17.8% and 56.9±18.5% in the triple and dual LLT groups, respectively (<i>P</i>=0.823). Triple versus dual LLT showed similar results in reduction of non-high-density lipoprotein cholesterol levels (49.0±25.4 in triple LLT versus 49.1±31.2 in dual LLT; <i>P</i>=0.970) and triglyceride levels (14.9±36.9 in triple LLT versus 16.8±36.0 in dual LLT;) <i>P</i>=0.718), without differences in adverse events.</p><p><strong>Conclusions: </strong>Both dual and triple LLT after ACS allow for high rates (>50%) of adequate LDL-C control (<55 mg/dL) at 8 weeks. Adding bempedoic acid to statin-ezetimibe therapy in the setting of ACS is safe but failed to improve the percentage of patients achieving the LDL-C goal (<55 mg/dL) at 8 weeks. Larger, randomized studies are needed to confirm our findings.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrialsregister.eu; Unique identifier: 2021-006550-31.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"140-149"},"PeriodicalIF":38.6,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145457891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Novel Use of Z Codes to Identify Social Determinants of Cardiovascular Disease Outcomes.","authors":"Nancy Song, Tariku J Beyene, Daniel K Amponsah, Steven M Asch, Paul A Heidenreich, Celina M Yong","doi":"10.1161/CIR.0000000000001414","DOIUrl":"https://doi.org/10.1161/CIR.0000000000001414","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"153 3","pages":"e19"},"PeriodicalIF":38.6,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective mRNA Translation: A New Player in Ferroptosis After Myocardial Infarction.","authors":"Jinlong He,Yi Zhu","doi":"10.1161/circulationaha.125.077933","DOIUrl":"https://doi.org/10.1161/circulationaha.125.077933","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"275 1","pages":"185-188"},"PeriodicalIF":37.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Race-Based to Equity-Informed Antihypertensive Medication Selection: Rationale for the 2025 AHA/ACC Guideline Change.","authors":"Jordana B Cohen,Daniel W Jones,John M Flack","doi":"10.1161/circulationaha.125.077650","DOIUrl":"https://doi.org/10.1161/circulationaha.125.077650","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"63 1","pages":"137-139"},"PeriodicalIF":37.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Real-Time Notification of AI-Detected Incidental Coronary Artery Calcium on Statin Prescription: The NOTIFY-PICTURE Trial.","authors":"Ramzi Dudum, Sneha S Jain, Domenico Mastrodicasa, Adam Furst, Shiqin Xu, Summer Ngo, David Eng, Nishith Khandwala, Doug Sousa, Akshay Chaudhari, Curtis Langlotz, Alexander T Sandhu, David J Maron, Fatima Rodriguez","doi":"10.1161/CIRCULATIONAHA.125.078155","DOIUrl":"10.1161/CIRCULATIONAHA.125.078155","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"210-212"},"PeriodicalIF":38.6,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing the First Step: Lessons From ES-BempedACS and the Era of Multi-Mechanism LDL-C Lowering.","authors":"Jelani K Grant,Thorsten M Leucker","doi":"10.1161/circulationaha.125.077771","DOIUrl":"https://doi.org/10.1161/circulationaha.125.077771","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"87 1","pages":"150-153"},"PeriodicalIF":37.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic and Structural Barriers to Addressing Obesity in Communities: A Scientific Statement From the American Heart Association.","authors":"Stephanie T Chung,Josephine Harrington,Namratha R Kandula,Kiarri N Kershaw,Morgana Mongraw-Chaffin,Foster Osei Baah,Angela F Pfammatter,Michael V Stanton,Fatima Cody Stanford, ","doi":"10.1161/cir.0000000000001395","DOIUrl":"https://doi.org/10.1161/cir.0000000000001395","url":null,"abstract":"The obesity epidemic continues largely unabated, affecting more than one-third of the US population and disproportionately burdening individuals from socioeconomically disadvantaged populations. Numerous factors contribute to the high prevalence of obesity, including socioeconomic and structural barriers impeding primordial and primary prevention efforts. Despite broad recognition that social determinants of health are key drivers of obesity, the importance of socioeconomic and structural factors as contemporary barriers to individual-, community-, and population-level obesity prevention and intervention efforts remains underappreciated. This scientific statement highlights multilevel barriers to obesity prevention and management, with an emphasis on social determinants of health, societal culture, and shared biases that may interfere with the success of healthy weight management programs. The assessment includes a comprehensive review of policy and community-level strategies used to address the obesity epidemic and identifies key areas for future research.","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"74 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Transcatheter Closure of Patent Foramen Ovale with a Novel Biodegradable Device: A Prospective, Multicenter, Randomized Controlled Clinical Trial.","authors":"Fengwen Zhang, Jie Dong, Peijian Wei, Weiyi Fang, Hao Hu, Xiangqing Kong, Ming Bai, Jiahua Pan, Zhiling Luo, Ping Zhang, Baiming Qu, Jinpeng Hu, Yaoxing Lu, Chuangshi Wang, Shouzheng Wang, Xiangbin Pan","doi":"10.1161/CIR.0000000000001411","DOIUrl":"https://doi.org/10.1161/CIR.0000000000001411","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"153 2","pages":"e13"},"PeriodicalIF":38.6,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}