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Laboratory detection of carbapenemases among Gram-negative organisms 实验室检测革兰氏阴性菌中的碳青霉烯酶
IF 36.8 1区 医学 Q1 MICROBIOLOGY Pub Date : 2024-11-15 DOI: 10.1128/cmr.00054-22
Patricia J. SimnerJohann D. D. PitoutTanis C. Dingle1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA2Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA3Cummings School of Medicine, University of Calgary, Calgary, Calgary, Alberta, Canada4Alberta Precision Laboratories, Diagnostic Laboratory, Calgary, Alberta, Canada5University of Pretoria, Pretoria, Gauteng, South Africa6Alberta Precision Laboratories, Public Health Laboratory, Calgary, Alberta, CanadaGraeme N. ForrestChristopher PfeifferKevin Alby
Clinical Microbiology Reviews, Ahead of Print.
临床微生物学评论》,提前出版。
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引用次数: 0
Animal models for exploring Chagas disease pathogenesis and supporting drug discovery 探索南美锥虫病发病机制和支持药物研发的动物模型
IF 36.8 1区 医学 Q1 MICROBIOLOGY Pub Date : 2024-11-15 DOI: 10.1128/cmr.00155-23
Archie A. KhanMartin C. TaylorAmanda Fortes FranciscoShiromani JayawardhanaRichard L. AthertonFrancisco OlmoMichael D. LewisJohn M. Kelly1Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United KingdomLouisa A. MessengerValeria Tekiel
Clinical Microbiology Reviews, Ahead of Print.
临床微生物学评论》,提前出版。
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引用次数: 0
Comprehensive analysis of the global impact and distribution of tick paralysis, a deadly neurological yet fully reversible condition. 全面分析蜱虫麻痹的全球影响和分布,这是一种致命的神经系统疾病,但完全可以逆转。
IF 36.8 1区 医学 Q1 MICROBIOLOGY Pub Date : 2024-10-23 DOI: 10.1128/cmr.00074-24
Yuan-Ping Deng,Yi-Tian Fu,Hany M Elsheikha,Mei-Ling Cao,Xing-Quan Zhu,Jin-Lei Wang,Xue-Ling Zhang,Shi-Chen Xie,Chaoqun Yao,Guo-Hua Liu
SUMMARYTick paralysis is a potentially fatal condition caused by neurotoxins secreted by the salivary glands of certain ticks. Documented cases have been reported worldwide, predominantly in the United States, Canada, and Australia, with additional reports from Europe and Africa. This condition also affects animals, leading to significant economic losses and adverse impacts on animal health and welfare. To date, 75 tick species, mostly hard ticks, have been identified as capable of causing this life-threatening condition. Due to symptom overlap with other conditions, accurate diagnosis of tick paralysis is crucial to avoid misdiagnosis, which could result in adverse patient outcomes. This review provides a comprehensive analysis of the current literature on tick paralysis, including the implicated tick species, global distribution, tick toxins, molecular pathogenesis, clinical manifestations, diagnosis, treatment, control, and prevention. Enhancing awareness among medical and veterinary professionals is critical for improving the management of tick paralysis and its health impacts on both humans and animals.
摘要蜱虫麻痹症是由某些蜱虫唾液腺分泌的神经毒素引起的一种潜在致命疾病。全世界都有记录在案的病例报告,主要发生在美国、加拿大和澳大利亚,欧洲和非洲也有报告。这种疾病也会影响动物,导致重大经济损失,并对动物健康和福利造成不利影响。迄今为止,已确认有 75 种蜱虫可导致这种危及生命的疾病,其中大多数是硬蜱。由于蜱虫麻痹症的症状与其他病症重叠,因此准确诊断蜱虫麻痹症至关重要,以避免误诊,从而对患者造成不良后果。本综述全面分析了目前有关蜱虫麻痹的文献,包括涉及的蜱虫种类、全球分布、蜱虫毒素、分子致病机理、临床表现、诊断、治疗、控制和预防。提高医疗和兽医专业人员的认识对于改善蜱虫麻痹的管理及其对人类和动物健康的影响至关重要。
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引用次数: 0
Harnessing the host response for precision infectious disease diagnosis. 利用宿主反应进行精准传染病诊断。
IF 36.8 1区 医学 Q1 MICROBIOLOGY Pub Date : 2024-10-15 DOI: 10.1128/cmr.00078-24
E Wilbur Woodhouse,Micah T McClain,Christopher W Woods
SUMMARYDetection of the presence of infection and its etiology must be accurate and timely to facilitate appropriate antimicrobial use. Diagnostic strategies that rely solely on pathogen detection often are insufficient due to poor test characteristics, inability to differentiate colonization from infection, or protracted delay to result. Understanding the human response across different pathogens on a clinical and molecular level can provide more accurate, timely, and useful answers, especially in critical illness and diagnostic uncertainty. Improvements in understanding the human immune response including genomics, protein analysis, gene expression, and cellular morphology have led to rapid innovation of new host response-based diagnostic tests. This review describes the limitations of pathogen-focused technology and the benefits of examining the breadth of immune response to diagnose infection. It then explores biomarkers that have been studied for this purpose and scrutinizes the performance of host-based multianalyte testing. Currently cleared diagnostics and those in late-stage development are described in depth, with a focus on the purpose of testing and its utility for clinicians. Finally, it concludes by examining opportunities for further host response-derived diagnostic innovation.
摘要必须准确及时地检测是否存在感染及其病因,以便适当使用抗菌药物。仅依靠病原体检测的诊断策略往往不够充分,因为检测特性差,无法区分定植和感染,或结果延迟时间长。在临床和分子水平上了解人类对不同病原体的反应,可以提供更准确、及时和有用的答案,尤其是在危重病和诊断不确定的情况下。对人体免疫反应的理解,包括基因组学、蛋白质分析、基因表达和细胞形态学等方面的改进,促使基于宿主反应的新型诊断测试迅速创新。本综述介绍了以病原体为重点的技术的局限性,以及检查免疫反应的广度对诊断感染的益处。然后探讨了为此目的而研究的生物标志物,并仔细研究了基于宿主的多分析测试的性能。报告深入介绍了目前已批准使用的诊断方法和处于后期开发阶段的诊断方法,重点是检测的目的及其对临床医生的效用。最后,报告探讨了宿主反应衍生诊断创新的机会。
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引用次数: 0
Artemisinin-resistant malaria 青蒿素抗药性疟疾
IF 36.8 1区 医学 Q1 MICROBIOLOGY Pub Date : 2024-10-15 DOI: 10.1128/cmr.00109-24
N. J. WhiteK. Chotivanich1Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand2Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom3Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, ThailandFerric C. FangSunil Parikh
Clinical Microbiology Reviews, Ahead of Print.
临床微生物学评论》,提前出版。
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引用次数: 0
Molecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections. 用于诊断中枢神经系统感染的脑脊液分子诊断法。
IF 36.8 1区 医学 Q1 MICROBIOLOGY Pub Date : 2024-10-15 DOI: 10.1128/cmr.00021-24
Sabine E Olie,Christian Ø Andersen,Diederik van de Beek,Matthijs C Brouwer
SUMMARYCentral nervous system (CNS) infections can be caused by various pathogens, including bacteria, viruses, fungi, and parasites. Molecular diagnostic methods are pivotal for identifying the different causative pathogens of these infections in clinical settings. The efficacy and specificity of these methods can vary per pathogen involved, and in a substantial part of patients, no pathogen is identified in the cerebrospinal fluid (CSF). Over recent decades, various molecular methodologies have been developed and applied to patients with CNS infections. This review provides an overview of the accuracy of nucleic acid amplification methods in CSF for a diverse range of pathogens, examines the potential value of multiplex PCR panels, and explores the broad-range bacterial and fungal PCR/sequencing panels. In addition, it evaluates innovative molecular approaches to enhance the diagnosis of CNS infections.
摘要中枢神经系统(CNS)感染可由多种病原体引起,包括细菌、病毒、真菌和寄生虫。分子诊断方法对于在临床环境中确定这些感染的不同致病病原体至关重要。这些方法的有效性和特异性因病原体而异,在相当一部分患者的脑脊液(CSF)中无法确定病原体。近几十年来,已开发出各种分子方法并应用于中枢神经系统感染患者。本综述概述了 CSF 中各种病原体的核酸扩增方法的准确性,研究了多重 PCR 检测板的潜在价值,并探讨了范围广泛的细菌和真菌 PCR/测序检测板。此外,它还评估了增强中枢神经系统感染诊断的创新分子方法。
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引用次数: 0
How long do bacteria, fungi, protozoa, and viruses retain their replication capacity on inanimate surfaces? A systematic review examining environmental resilience versus healthcare-associated infection risk by “fomite-borne risk assessment” 细菌、真菌、原生动物和病毒在无生命表面的复制能力能保持多久?通过 "飞沫传播风险评估 "对环境复原力与医疗保健相关感染风险进行系统性审查
IF 36.8 1区 医学 Q1 MICROBIOLOGY Pub Date : 2024-10-10 DOI: 10.1128/cmr.00186-23
Axel KramerFranziska LexowAnna BludauAntonia Milena KösterMartin MisailovskiUlrike SeifertMaren EggersWilliam RutalaStephanie J. DancerSimone Scheithauer1Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany2Department for Infectious Diseases, Unit 14: Hospital Hygiene, Infection Prevention and Control, Robert Koch Institute, Berlin, Germany3Department of Infection Control and Infectious Diseases, University Medical Center Göttingen (UMG), Georg-August University Göttingen, Göttingen, Germany4Department of Geriatrics, University of Göttingen Medical Center, Göttingen, Germany5Friedrich Loeffler-Institute of Medical Microbiology – Virology, University Medicine Greifswald, Greifswald, Germany6Labor Prof. Dr. G. Enders MVZ GbR, Stuttgart, Germany7Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA8Department of Microbiology, University Hospital Hairmyres, Glasgow, United..
Clinical Microbiology Reviews, Ahead of Print.
临床微生物学评论》,提前出版。
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引用次数: 0
The American Society for Microbiology collaboration with the CDC Laboratory Medicine Best Practices initiative for evidence-based laboratory medicine. 美国微生物学会与疾病预防控制中心实验室医学最佳实践倡议合作,开展循证实验室医学研究。
IF 36.8 1区 医学 Q1 MICROBIOLOGY Pub Date : 2024-09-25 DOI: 10.1128/cmr.00065-18
Alice S Weissfeld,Vickie Baselski,Nancy E Cornish,Colleen S Kraft,Mark T LaRocco,Peggy McNult,Irving Nachamkin,James Scott Parrott,Sandra S Richter,Matthew Rubinstein,Michael A Saubolle,Robert L Sautter,James W Snyder,Joanna Taliano,Donna M Wolk
SUMMARYClinical medicine has embraced the use of evidence for patient treatment decisions; however, the evaluation strategy for evidence in laboratory medicine practices has lagged. It was not until the end of the 20th century that the Institute of Medicine (IOM), now the National Academy of Medicine, and the Centers for Disease Control and Prevention, Division of Laboratory Systems (CDC DLS), focused on laboratory tests and how testing processes can be designed to benefit patient care. In collaboration with CDC DLS, the American Society for Microbiology (ASM) used an evidence review method developed by the CDC DLS to develop a program for creating laboratory testing guidelines and practices. The CDC DLS method is called the Laboratory Medicine Best Practices (LMBP) initiative and uses the A-6 cycle method. Adaptations made by ASM are called Evidence-based Laboratory Medicine Practice Guidelines (EBLMPG). This review details how the ASM Systematic Review (SR) Processes were developed and executed collaboratively with CDC's DLS. The review also describes the ASM transition from LMBP to the organization's current EBLMPG, maintaining a commitment to working with agencies in the U.S. Department of Health and Human Services and other partners to ensure that EBLMPG evidence is readily understood and consistently used.
摘要 临床医学已将证据用于患者的治疗决策;然而,实验室医学实践中的证据评估策略却一直滞后。直到 20 世纪末,美国医学研究所(IOM)(现为美国国家医学科学院)和美国疾病控制与预防中心实验室系统部(CDC DLS)才开始关注实验室检验以及如何设计检验流程以利于患者治疗。美国微生物学会(ASM)与 CDC DLS 合作,使用 CDC DLS 开发的证据审查方法来制定实验室检测指南和实践方案。CDC DLS 的方法被称为实验室医学最佳实践(LMBP)计划,采用 A-6 循环方法。ASM 所做的调整被称为循证实验室医学实践指南 (EBLMPG)。本综述详细介绍了 ASM 系统性综述 (SR) 流程是如何与 CDC 的 DLS 合作开发和执行的。本综述还介绍了 ASM 从 LMBP 向该组织当前的 EBLMPG 过渡的情况,并继续致力于与美国卫生与公众服务部的各机构及其他合作伙伴合作,以确保 EBLMPG 的证据易于理解并得到一致使用。
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引用次数: 0
Neurological complications caused by SARS-CoV-2 由 SARS-CoV-2 引起的神经系统并发症
IF 36.8 1区 医学 Q1 MICROBIOLOGY Pub Date : 2024-09-18 DOI: 10.1128/cmr.00131-24
Zehan PangAo TangYujie HeJunfen FanQingmao YangYigang TongHuahao Fan1College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China2Department of Neurology, Institute of Cerebrovascular Diseases Research, Xuanwu Hospital of Capital Medical University, Beijing, China3School of Life Sciences, Tianjin University, Tianjin, ChinaGraeme N. Forrest
Clinical Microbiology Reviews, Ahead of Print.
临床微生物学评论》,提前出版。
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引用次数: 0
Infections caused by Haemophilus ducreyi: one organism, two stories 杜克雷嗜血杆菌引起的感染:一种生物,两个故事
IF 36.8 1区 医学 Q1 MICROBIOLOGY Pub Date : 2024-09-17 DOI: 10.1128/cmr.00135-24
Jaffar A. Al-TawfiqStanley M. Spinola1Infectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia2Department of Medicine, Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA3Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA4Department of Microbiology and Immunology, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USA5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USAGraeme N. Forrest
Clinical Microbiology Reviews, Ahead of Print.
临床微生物学评论》,提前出版。
{"title":"Infections caused by Haemophilus ducreyi: one organism, two stories","authors":"Jaffar A. Al-TawfiqStanley M. Spinola1Infectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia2Department of Medicine, Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA3Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA4Department of Microbiology and Immunology, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USA5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USAGraeme N. Forrest","doi":"10.1128/cmr.00135-24","DOIUrl":"https://doi.org/10.1128/cmr.00135-24","url":null,"abstract":"Clinical Microbiology Reviews, Ahead of Print. <br/>","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"13 1","pages":""},"PeriodicalIF":36.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142236278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical Microbiology Reviews
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