Pub Date : 2018-02-10DOI: 10.25040/ECPB2018.04.031
O. S. Payenok, I. Pankiv, A. Payenok
Background. Vitamin D deficiency is one of the risk factors for insulin resistance and there is a relationship between hypovitaminosis of vitamin D with the prevalence of primary hypo Experimental thyroidism. The effect of cholecalciferol supplementation on insulin resistance in women with primary hypothyroidism has not been investigated before. The aim of the study is to evaluate the role of cholecalciferol supplementation on insulin resistance in primary hypothyroidism. Materials and methods. 72 women, aged 31-75 took part in the study. Serum thyroid stimulating hormone (TSH), insulin and 25(OH)D concentration were measured and HOMA-IR was calculated. All measurements were performed at the beginning and the end of the study. Women with hypothyroidism had been receiving 21.000 unit of cholecalciferol orally per week during twelve weeks. The results were analyzed by descriptive tests and the comparison between variables was made by using paired T-tests. Results. All participants had vitamin D deficiency. Mean serum 25(OH)D concentration was 21.94 ± 6.31 ng/ml. The results at the beginning and at the end were for insulin 18.37 ± 2.48 and 10.19 ± 2.13 mIU/L (p = 0.041) and for HOMA-IR, 3.97 ± 0.36 and 2.32 ± 0.18 (p = 0.039), respectively. Conclusion. Vitamin D deficiency is common in women with primary hypothyroidism. Our data have shown some significant improvement in serum insulin and in HOMA-IR after treatment with cholecalciferol.
{"title":"The Role of Cholecalciferol in the Reduction of Insulin Resistance and Rehabilitation of Women with Primary Hypothyreosis","authors":"O. S. Payenok, I. Pankiv, A. Payenok","doi":"10.25040/ECPB2018.04.031","DOIUrl":"https://doi.org/10.25040/ECPB2018.04.031","url":null,"abstract":"Background. Vitamin D deficiency is one of the risk factors for insulin resistance and there is a relationship between hypovitaminosis of vitamin D with the prevalence of primary hypo Experimental thyroidism. The effect of cholecalciferol supplementation on insulin resistance in women with primary hypothyroidism has not been investigated before. The aim of the study is to evaluate the role of cholecalciferol supplementation on insulin resistance in primary hypothyroidism. Materials and methods. 72 women, aged 31-75 took part in the study. Serum thyroid stimulating hormone (TSH), insulin and 25(OH)D concentration were measured and HOMA-IR was calculated. All measurements were performed at the beginning and the end of the study. Women with hypothyroidism had been receiving 21.000 unit of cholecalciferol orally per week during twelve weeks. The results were analyzed by descriptive tests and the comparison between variables was made by using paired T-tests. Results. All participants had vitamin D deficiency. Mean serum 25(OH)D concentration was 21.94 ± 6.31 ng/ml. The results at the beginning and at the end were for insulin 18.37 ± 2.48 and 10.19 ± 2.13 mIU/L (p = 0.041) and for HOMA-IR, 3.97 ± 0.36 and 2.32 ± 0.18 (p = 0.039), respectively. Conclusion. Vitamin D deficiency is common in women with primary hypothyroidism. Our data have shown some significant improvement in serum insulin and in HOMA-IR after treatment with cholecalciferol.","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78460926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-02-10DOI: 10.25040/ECPB2018.04.054
H. Lavryk, O. Korniychuk, J. Fedechko
{"title":"The Comparative Studies of the Immune Response to Biofilm and Planktonic Forms of Staphylococci","authors":"H. Lavryk, O. Korniychuk, J. Fedechko","doi":"10.25040/ECPB2018.04.054","DOIUrl":"https://doi.org/10.25040/ECPB2018.04.054","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80222942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.061
Z. O. Bumbar, O. Pinyazhko
{"title":"The Investigation of the Combined Application of Thiotriazolin and Urolesan in Experimental Periodontitis on the Background of Urolithiasis","authors":"Z. O. Bumbar, O. Pinyazhko","doi":"10.25040/ECPB2017.04.061","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.061","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87306918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.071
A. Petik
{"title":"The Role оf Fibrin Clot Structure to Ensure its Physiological Functions","authors":"A. Petik","doi":"10.25040/ECPB2017.04.071","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.071","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88305255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.052
V. Akimova
{"title":"The Content of Medium Mass Molecules and Circulating Immune Complexes in the Blood of Patients with Acute Appendicitis and Abdominal Tuberculosis in the Complex Assessment of Endogenous Intoxication","authors":"V. Akimova","doi":"10.25040/ECPB2017.04.052","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.052","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87835052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.046
R. Fafula, О. Meskalo, E. Lychkovskyy, Z. Vorobets
{"title":"Effect of Hydrogen Peroxide on the Main Kinetic Parameters of ATP Hydrolysis by by Ca2 + ,Mg2 + -ATP-ase in Spermatozoa of Infertile Men","authors":"R. Fafula, О. Meskalo, E. Lychkovskyy, Z. Vorobets","doi":"10.25040/ECPB2017.04.046","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.046","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77927267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.024
M. Roman'ko
{"title":"Influence of Nanoparticles of Metals on Energy Bacterium Cell Metabolism Indicators in Conditions of Their Liofilization and Rehedration","authors":"M. Roman'ko","doi":"10.25040/ECPB2017.04.024","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.024","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87273854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.031
P. Lykhatskyi, L. Fira
{"title":"Possibility of Sorbent Carboline use for Correction of Disorders in the Body of Rats Infected with Sodium Nitrite on the Background of Tobacco Intoxication","authors":"P. Lykhatskyi, L. Fira","doi":"10.25040/ECPB2017.04.031","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.031","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79217786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.040
L. Mogylnytska
{"title":"Serum Levels of Fibronectin in Type 1 Diabetes Patients with Microangiopathy and Arterial Hypertension","authors":"L. Mogylnytska","doi":"10.25040/ECPB2017.04.040","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.040","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83378814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.013
Y. Hrytsak, O. Mysakovets, O. Mel’nyk, L. G. Barylyak, Hotel Spa Complex “Karpaty”
{"title":"Features of Immunity Considered in Various Constellations of Principal Adaptation Hormones and Autonomous Regulation in Rats","authors":"Y. Hrytsak, O. Mysakovets, O. Mel’nyk, L. G. Barylyak, Hotel Spa Complex “Karpaty”","doi":"10.25040/ECPB2017.04.013","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.013","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91505297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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