Pub Date : 2018-02-10DOI: 10.25040/ECPB2018.04.005
A. Aleksandrov, V. Konopelniuk, O. V. Skopenko, I. Kompanets, L. Ostapchenko
Background. Obesity is one of the most common complex health problems in the world. Main reasons of the development of obesity are marketing the unhealthy food, passive lifestyle, hormonal disorders. Obesity can lead to the development of diabetes mellitus, ischemic heart disease and certain cancers. Numerous neuropeptides and transmitters as well as multiple peripheral hormones take part not only in the regulation of feeding but also in the physical activity. Peptides - serotonin, insulin, glucagon, hormones of hypothalamus and hypophysis, thyroid hormones are the examples of weight regulated hormones. The use of drugs based on steroid hormones, particularly progesterone, can also be one of many factors contributing to obesity. It is known that progesterone which enters the female body artificially leads to fat accumulation. Phenolic biopolymers are the most thoroughly studied natural genesis of macromolecular structures. Melanin occupies a special place among natural polymers. Melanin is chemically relatively inert, but at the same time it is the only polymer with biological properties of a stable free radical. These characteristics determine the structure of their photo- and radioprotective, antioxidant and other properties that is why melanin is widely used in medicine, pharmacology, cosmetology, agriculture and food industry. This article is focused on the molecular and clinical associations between melanin and serum amino acids under progesterone-induced obesity. Serum amino acids are a source for synthesis of hormones that have peptide and protein nature. Revealing these interactions and mechanisms of progesterone-induced obesity may improve our understanding of the complex treatment of obesity. In the current study we used white nonlinear female rats that were divided into three groups. Rats of group 1 – control; group 2 – progesterone-induced obese; group 3 – progesterone-induced obese group under melanin treatment (10 mg/kg body weight, treated daily during 28 days). Amino acid blood serum levels were determined by ion exchange chromatography analyzer (Spekman, Stein, Moore). The statistical analysis of data was carried out by the software package "Statistica 7.0". Values are statistically significant at p < 0.05. Results. The recent study has shown changes in amino acid levels in blood serum of rats under progesterone long-term administration and melanin treatment. Levels of the majority of amino acid content have decreased in rats under progesterone long-term administration and melanin treatment as compared with the control group. The obtained data have given some evidence that progesterone long-term administration has a significant influence on amino acids metabolism. Conclusion. Aromatic amino acids are the substrates for the of neurotransmit- Changes of content of aromatic amino acids can be a of disfunction of the synthesis of these neurotransmitters. The significant decrease of some amino acids, particularly BCAAs and aromatic am
{"title":"Serum Amino Acid Levels in Rats under Long-term Administration of Progesterone and Melanin Treatment","authors":"A. Aleksandrov, V. Konopelniuk, O. V. Skopenko, I. Kompanets, L. Ostapchenko","doi":"10.25040/ECPB2018.04.005","DOIUrl":"https://doi.org/10.25040/ECPB2018.04.005","url":null,"abstract":"Background. Obesity is one of the most common complex health problems in the world. Main reasons of the development of obesity are marketing the unhealthy food, passive lifestyle, hormonal disorders. Obesity can lead to the development of diabetes mellitus, ischemic heart disease and certain cancers. Numerous neuropeptides and transmitters as well as multiple peripheral hormones take part not only in the regulation of feeding but also in the physical activity. Peptides - serotonin, insulin, glucagon, hormones of hypothalamus and hypophysis, thyroid hormones are the examples of weight regulated hormones. The use of drugs based on steroid hormones, particularly progesterone, can also be one of many factors contributing to obesity. It is known that progesterone which enters the female body artificially leads to fat accumulation. Phenolic biopolymers are the most thoroughly studied natural genesis of macromolecular structures. Melanin occupies a special place among natural polymers. Melanin is chemically relatively inert, but at the same time it is the only polymer with biological properties of a stable free radical. These characteristics determine the structure of their photo- and radioprotective, antioxidant and other properties that is why melanin is widely used in medicine, pharmacology, cosmetology, agriculture and food industry. This article is focused on the molecular and clinical associations between melanin and serum amino acids under progesterone-induced obesity. Serum amino acids are a source for synthesis of hormones that have peptide and protein nature. Revealing these interactions and mechanisms of progesterone-induced obesity may improve our understanding of the complex treatment of obesity. In the current study we used white nonlinear female rats that were divided into three groups. Rats of group 1 – control; group 2 – progesterone-induced obese; group 3 – progesterone-induced obese group under melanin treatment (10 mg/kg body weight, treated daily during 28 days). Amino acid blood serum levels were determined by ion exchange chromatography analyzer (Spekman, Stein, Moore). The statistical analysis of data was carried out by the software package \"Statistica 7.0\". Values are statistically significant at p < 0.05. Results. The recent study has shown changes in amino acid levels in blood serum of rats under progesterone long-term administration and melanin treatment. Levels of the majority of amino acid content have decreased in rats under progesterone long-term administration and melanin treatment as compared with the control group. The obtained data have given some evidence that progesterone long-term administration has a significant influence on amino acids metabolism. Conclusion. Aromatic amino acids are the substrates for the of neurotransmit- Changes of content of aromatic amino acids can be a of disfunction of the synthesis of these neurotransmitters. The significant decrease of some amino acids, particularly BCAAs and aromatic am","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":"10 1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2018-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87598937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-02-10DOI: 10.25040/ECPB2018.04.054
H. Lavryk, O. Korniychuk, J. Fedechko
{"title":"The Comparative Studies of the Immune Response to Biofilm and Planktonic Forms of Staphylococci","authors":"H. Lavryk, O. Korniychuk, J. Fedechko","doi":"10.25040/ECPB2018.04.054","DOIUrl":"https://doi.org/10.25040/ECPB2018.04.054","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":"1 1","pages":"54-61"},"PeriodicalIF":0.0,"publicationDate":"2018-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80222942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.061
Z. O. Bumbar, O. Pinyazhko
{"title":"The Investigation of the Combined Application of Thiotriazolin and Urolesan in Experimental Periodontitis on the Background of Urolithiasis","authors":"Z. O. Bumbar, O. Pinyazhko","doi":"10.25040/ECPB2017.04.061","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.061","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":"21 1","pages":"61-70"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87306918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.071
A. Petik
{"title":"The Role оf Fibrin Clot Structure to Ensure its Physiological Functions","authors":"A. Petik","doi":"10.25040/ECPB2017.04.071","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.071","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":"36 1","pages":"71-79"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88305255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.052
V. Akimova
{"title":"The Content of Medium Mass Molecules and Circulating Immune Complexes in the Blood of Patients with Acute Appendicitis and Abdominal Tuberculosis in the Complex Assessment of Endogenous Intoxication","authors":"V. Akimova","doi":"10.25040/ECPB2017.04.052","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.052","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":"55 1","pages":"52-56"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87835052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.046
R. Fafula, О. Meskalo, E. Lychkovskyy, Z. Vorobets
{"title":"Effect of Hydrogen Peroxide on the Main Kinetic Parameters of ATP Hydrolysis by by Ca2 + ,Mg2 + -ATP-ase in Spermatozoa of Infertile Men","authors":"R. Fafula, О. Meskalo, E. Lychkovskyy, Z. Vorobets","doi":"10.25040/ECPB2017.04.046","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.046","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":"36 1","pages":"46-51"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77927267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.024
M. Roman'ko
{"title":"Influence of Nanoparticles of Metals on Energy Bacterium Cell Metabolism Indicators in Conditions of Their Liofilization and Rehedration","authors":"M. Roman'ko","doi":"10.25040/ECPB2017.04.024","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.024","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":"18 1","pages":"24-31"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87273854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.031
P. Lykhatskyi, L. Fira
{"title":"Possibility of Sorbent Carboline use for Correction of Disorders in the Body of Rats Infected with Sodium Nitrite on the Background of Tobacco Intoxication","authors":"P. Lykhatskyi, L. Fira","doi":"10.25040/ECPB2017.04.031","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.031","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":"97 1","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79217786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.013
Y. Hrytsak, O. Mysakovets, O. Mel’nyk, L. G. Barylyak, Hotel Spa Complex “Karpaty”
{"title":"Features of Immunity Considered in Various Constellations of Principal Adaptation Hormones and Autonomous Regulation in Rats","authors":"Y. Hrytsak, O. Mysakovets, O. Mel’nyk, L. G. Barylyak, Hotel Spa Complex “Karpaty”","doi":"10.25040/ECPB2017.04.013","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.013","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":"37 7","pages":"13-23"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91505297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-28DOI: 10.25040/ECPB2017.04.040
L. Mogylnytska
{"title":"Serum Levels of Fibronectin in Type 1 Diabetes Patients with Microangiopathy and Arterial Hypertension","authors":"L. Mogylnytska","doi":"10.25040/ECPB2017.04.040","DOIUrl":"https://doi.org/10.25040/ECPB2017.04.040","url":null,"abstract":"","PeriodicalId":10397,"journal":{"name":"Clinical physiology and biochemistry","volume":"30 1","pages":"40-45"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83378814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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