S. Moralıoğlu, I. Ozen, B. Demiroğulları, A. Başaklar
Pyosalpinx and hydrosalpinx are conditions mainly seen in adult women, but also among sexually active adolescents and can bring added hazard to fertility. However these conditions are very rare in childhood, as well as in adolescent girls who are not sexually active. We are presenting two rare cases of young girls in early puberty with hydrosalpinx and pyosalpinx. Both girls had a history of abdomino-pelvic surgery in childhood for congenital bowel anomalies and fecal incontinence. Such cases are good reminders that girls with known abdomino-pelvic anomalies and surgical procedures in childhood need long term follow-up, in particular when entering puberty and maturation. The two cases show how fallopian tubes can be indirectly affected and present in adolescence with serious problems needing surgical procedures and potentially threatening future reproductive system performances.
{"title":"Pyosalpinx and hydrosalpinx in virginal adolescents: report of two cases.","authors":"S. Moralıoğlu, I. Ozen, B. Demiroğulları, A. Başaklar","doi":"10.7727/WIMJ.2012.093","DOIUrl":"https://doi.org/10.7727/WIMJ.2012.093","url":null,"abstract":"Pyosalpinx and hydrosalpinx are conditions mainly seen in adult women, but also among sexually active adolescents and can bring added hazard to fertility. However these conditions are very rare in childhood, as well as in adolescent girls who are not sexually active. We are presenting two rare cases of young girls in early puberty with hydrosalpinx and pyosalpinx. Both girls had a history of abdomino-pelvic surgery in childhood for congenital bowel anomalies and fecal incontinence. Such cases are good reminders that girls with known abdomino-pelvic anomalies and surgical procedures in childhood need long term follow-up, in particular when entering puberty and maturation. The two cases show how fallopian tubes can be indirectly affected and present in adolescence with serious problems needing surgical procedures and potentially threatening future reproductive system performances.","PeriodicalId":104133,"journal":{"name":"The West Indian medical journal","volume":"53 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133321543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this report, operative treatment of chronic elbow dislocation using Speed's technique is described. Reports on this phenomenon are infrequent. This clinically important pathology is quite uncommon but impacts negatively on a patient's functionality and normal daily activities. We present the case of a 53-year old woman with a missed diagnosis of elbow dislocation. The patient was unable to function because of pain, stiffness and loss of motion. Her diagnosis was missed in the emergency department and in a general practitioner's office. A correct diagnosis was made three months later. The consultant organized an early date for surgery. The definitive treatment entailed open reduction, VY plasty of triceps and supplementary fixation using K wires through the elbow joint (Speed's Procedure). The occurrence, patho-mechanics, operative technique and its outcome are discussed.
{"title":"Speed's Procedure Used to Treat Chronic Elbow Dislocation.","authors":"D. Thomas","doi":"10.7727/wimj.2015.091","DOIUrl":"https://doi.org/10.7727/wimj.2015.091","url":null,"abstract":"In this report, operative treatment of chronic elbow dislocation using Speed's technique is described. Reports on this phenomenon are infrequent. This clinically important pathology is quite uncommon but impacts negatively on a patient's functionality and normal daily activities. We present the case of a 53-year old woman with a missed diagnosis of elbow dislocation. The patient was unable to function because of pain, stiffness and loss of motion. Her diagnosis was missed in the emergency department and in a general practitioner's office. A correct diagnosis was made three months later. The consultant organized an early date for surgery. The definitive treatment entailed open reduction, VY plasty of triceps and supplementary fixation using K wires through the elbow joint (Speed's Procedure). The occurrence, patho-mechanics, operative technique and its outcome are discussed.","PeriodicalId":104133,"journal":{"name":"The West Indian medical journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115191737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Kucukesmen, A. Usumez, B. Uludag, B. Gunduz, C H Kucukesmen, O. Acar
Objective To determine the efficacy of polymerization for two different curing units by examining the degree of conversion (DC) of seven different composite materials. Materials and methods Conventional halogen light (40 s) and a light-emitting diode curing unit (LED) [20 s] were used to polymerize seven different composite brands. A total number of 70 specimens were evaluated (n = 5). To determine the degree of conversion, Fourier transformation infrared spectroscopy was used. For statistical analysis, two-way analysis of variance (ANOVA) and Tukey's HSD post hoc test were applied (α = 0.05). Results Degree of conversion varied with both the light unit and type of composite, with significant interactions. Charisma (67.0 ± 6.0) and Z-250 (65.2 ± 3.3) showed the highest DC when cured using the LED, whereas Grandio (38.2 ± 3.5) showed the lowest when exposed to the conventional halogen light. Conclusion Degree of conversion was affected by the type of light curing units and results varied greatly with respect to composite brand and type (nonofilled, macrofilled, hybrid, microhybrid and ormocer).
{"title":"Effect of Light Curing Mode and Type on Conversion of Resin Composites.","authors":"C Kucukesmen, A. Usumez, B. Uludag, B. Gunduz, C H Kucukesmen, O. Acar","doi":"10.7727/wimj.2015.031","DOIUrl":"https://doi.org/10.7727/wimj.2015.031","url":null,"abstract":"Objective\u0000To determine the efficacy of polymerization for two different curing units by examining the degree of conversion (DC) of seven different composite materials.\u0000\u0000\u0000Materials and methods\u0000Conventional halogen light (40 s) and a light-emitting diode curing unit (LED) [20 s] were used to polymerize seven different composite brands. A total number of 70 specimens were evaluated (n = 5). To determine the degree of conversion, Fourier transformation infrared spectroscopy was used. For statistical analysis, two-way analysis of variance (ANOVA) and Tukey's HSD post hoc test were applied (α = 0.05).\u0000\u0000\u0000Results\u0000Degree of conversion varied with both the light unit and type of composite, with significant interactions. Charisma (67.0 ± 6.0) and Z-250 (65.2 ± 3.3) showed the highest DC when cured using the LED, whereas Grandio (38.2 ± 3.5) showed the lowest when exposed to the conventional halogen light.\u0000\u0000\u0000Conclusion\u0000Degree of conversion was affected by the type of light curing units and results varied greatly with respect to composite brand and type (nonofilled, macrofilled, hybrid, microhybrid and ormocer).","PeriodicalId":104133,"journal":{"name":"The West Indian medical journal","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124789184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction To the modern surgeon in training, the acquisition of laparoscopic skills is essential. Laparoscopic simulators are effective but in the often resource poor setting of the Caribbean, the cost of these simulators is often prohibitive. We describe the construction of a simulator which is cheap, easy to assemble and effective. It is also relatively easy to mass produce for use in training programmes across the region. Materials and methods The simulator is constructed using a semi-transparent plastic box. Realistic access ports are fashioned using gel type shoe inserts and excellent vision is achieved by mounting a high definition camera on the inside of the box. As the box readily transmits light, a light source is not a necessity. The total cost of this unit is US$48 and construction time is approximately 30 minutes. Results This trainer was easy to construct and offered a realistic laparoscopic experience. We believe construction is easily reproducible. Conclusion This simulator is effective and is easy to construct. It may have applications in surgical training programs within the Caribbean region and beyond.
{"title":"Construction of a Low Cost Homemade Laparoscopic Simulator for Use in a Caribbean Setting.","authors":"S. Persaud, I. Hosein, D. Dan, PS Griffith","doi":"10.7727/wimj.2015.047","DOIUrl":"https://doi.org/10.7727/wimj.2015.047","url":null,"abstract":"Introduction\u0000To the modern surgeon in training, the acquisition of laparoscopic skills is essential. Laparoscopic simulators are effective but in the often resource poor setting of the Caribbean, the cost of these simulators is often prohibitive. We describe the construction of a simulator which is cheap, easy to assemble and effective. It is also relatively easy to mass produce for use in training programmes across the region.\u0000\u0000\u0000Materials and methods\u0000The simulator is constructed using a semi-transparent plastic box. Realistic access ports are fashioned using gel type shoe inserts and excellent vision is achieved by mounting a high definition camera on the inside of the box. As the box readily transmits light, a light source is not a necessity. The total cost of this unit is US$48 and construction time is approximately 30 minutes.\u0000\u0000\u0000Results\u0000This trainer was easy to construct and offered a realistic laparoscopic experience. We believe construction is easily reproducible.\u0000\u0000\u0000Conclusion\u0000This simulator is effective and is easy to construct. It may have applications in surgical training programs within the Caribbean region and beyond.","PeriodicalId":104133,"journal":{"name":"The West Indian medical journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126300504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Failed Tracheal Intubation in a Child with Unrecognized Hunter's Syndrome having Emergency Surgery.","authors":"F. Meng, Y. Li, G. Wang, Q. Wang","doi":"10.7727/wimj.2015.059","DOIUrl":"https://doi.org/10.7727/wimj.2015.059","url":null,"abstract":"","PeriodicalId":104133,"journal":{"name":"The West Indian medical journal","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114998690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ahıskalıoğlu, O. Ahiskalioglu, A. Dostbil, C. Abdullah, A. Megnet, M. Çelik, I. Ilker, K. Husnu
Objective The perioperative stress response of patients who were scheduled to have percutaneous nephrolithotomy under epidural anaesthesia with opioids and local anaesthetics has not been investigated in detail yet. Our hypothesis is that the stress response following percutaneous nephrolithotomy can be lessened by epidural analgesia. Methods A total of 48 patients, between 18-65 years of age and ASA I-II, for whom elective percutaneous nephrolithotomy was planned, were randomly divided into two groups namely: Group GA (n = 24): general anaesthesia by sevoflurane and fentanyl and postoperative intravenous PCA; Group GE (n = 24): epidural anaesthesia and general anaesthesia together with postoperative epidural analgesia (0.125% levobupivacaine + fentanyl). Blood levels for glucose, insulin, prolactin and cortisol were evaluated prior to anaesthesia, after surgical incision, immediately following percutaneous dilatation and postoperative 24th hour. Intraoperative hemodynamic parameters and postoperative pain scores together with preoperative and postoperative hematocrit values were recorded. Results Postoperative pain scores were found to be statistically significantly lower (p < 0.05) in Group GE at all measurement times. Intraoperative blood loss was statistically significantly lower in Group GE (p = 0.011). When hemodynamic parameters were compared, at all time intervals except baseline measurement, blood pressure and heart rate were significantly lower in Group GE (p < 0.05). Levels of stress hormones, glucose, cortisol, insulin and prolactin remained significantly lower in Group GE. Conclusion We think that epidural anaesthesia, performed in addition to general anaesthesia, may be a comfortable anaesthesia method with its suppressive effects on intraoperative and postoperative stress response together with reduced pain scores in the postoperative period.
{"title":"The Effect of Epidural Levobupivacaine and Fentanyl on Stress Response and Pain Management in Patients Undergoing Percutaneous Nephrolithotomy.","authors":"A. Ahıskalıoğlu, O. Ahiskalioglu, A. Dostbil, C. Abdullah, A. Megnet, M. Çelik, I. Ilker, K. Husnu","doi":"10.7727/wimj.2015.095","DOIUrl":"https://doi.org/10.7727/wimj.2015.095","url":null,"abstract":"Objective\u0000The perioperative stress response of patients who were scheduled to have percutaneous nephrolithotomy under epidural anaesthesia with opioids and local anaesthetics has not been investigated in detail yet. Our hypothesis is that the stress response following percutaneous nephrolithotomy can be lessened by epidural analgesia.\u0000\u0000\u0000Methods\u0000A total of 48 patients, between 18-65 years of age and ASA I-II, for whom elective percutaneous nephrolithotomy was planned, were randomly divided into two groups namely: Group GA (n = 24): general anaesthesia by sevoflurane and fentanyl and postoperative intravenous PCA; Group GE (n = 24): epidural anaesthesia and general anaesthesia together with postoperative epidural analgesia (0.125% levobupivacaine + fentanyl). Blood levels for glucose, insulin, prolactin and cortisol were evaluated prior to anaesthesia, after surgical incision, immediately following percutaneous dilatation and postoperative 24th hour. Intraoperative hemodynamic parameters and postoperative pain scores together with preoperative and postoperative hematocrit values were recorded.\u0000\u0000\u0000Results\u0000Postoperative pain scores were found to be statistically significantly lower (p < 0.05) in Group GE at all measurement times. Intraoperative blood loss was statistically significantly lower in Group GE (p = 0.011). When hemodynamic parameters were compared, at all time intervals except baseline measurement, blood pressure and heart rate were significantly lower in Group GE (p < 0.05). Levels of stress hormones, glucose, cortisol, insulin and prolactin remained significantly lower in Group GE.\u0000\u0000\u0000Conclusion\u0000We think that epidural anaesthesia, performed in addition to general anaesthesia, may be a comfortable anaesthesia method with its suppressive effects on intraoperative and postoperative stress response together with reduced pain scores in the postoperative period.","PeriodicalId":104133,"journal":{"name":"The West Indian medical journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126325510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective HIV prevention programs such as Jamaica AIDS Support for Life (JASL) work to lower the rate of HIV among marginalized groups. Thus, the objective of this study was to evaluate condom use and HIV status in JASL's Sex Worker (SW) population with the intent to identify behavioral differences between this self-selected group and the general SW population in Jamaica. We hypothesized that JASL's SW population would demonstrate higher condom use and a lower prevalence of HIV, potentially attributable to their prevention and education endeavours. Methods This cross-sectional study (n=459) uses 2011-2014 data from three cities: Kingston, Montego Bay and Ocho Rios. Data was obtained through voluntary counseling and testing (VCT) forms. Primary outcomes were HIV status and condom use. Frequencies and bivariate analyses were employed. Results SW HIV prevalence was 1.3%, as compared to the Jamaican SW rate of 4.6%. Most participants reported always using a condom with an outside partner, while only 22% reported always using a condom with their regular partner. Conclusion Emphasis on condom use within long-term relationships should be considered when planning HIV prevention programs for SWs. This requires addressing gender roles within noncommercial relationships and more discussions surrounding sexual behavior outside paid sex work. Although, causality may not be inferred through cross-sectional data, the lower HIV prevalence in JASL's SWs is promising and highlights opportunities for further analysis, specifically around the impact of JASL's work.
{"title":"Condom Use and HIV Status: A Study of Sex Workers Engaged with the Jamaican AIDS Support for Life (JASL).","authors":"H. Budhwani, S. Newton, K. Hearld, K. Levermore","doi":"10.7727/wimj.2015.067","DOIUrl":"https://doi.org/10.7727/wimj.2015.067","url":null,"abstract":"Objective\u0000HIV prevention programs such as Jamaica AIDS Support for Life (JASL) work to lower the rate of HIV among marginalized groups. Thus, the objective of this study was to evaluate condom use and HIV status in JASL's Sex Worker (SW) population with the intent to identify behavioral differences between this self-selected group and the general SW population in Jamaica. We hypothesized that JASL's SW population would demonstrate higher condom use and a lower prevalence of HIV, potentially attributable to their prevention and education endeavours.\u0000\u0000\u0000Methods\u0000This cross-sectional study (n=459) uses 2011-2014 data from three cities: Kingston, Montego Bay and Ocho Rios. Data was obtained through voluntary counseling and testing (VCT) forms. Primary outcomes were HIV status and condom use. Frequencies and bivariate analyses were employed.\u0000\u0000\u0000Results\u0000SW HIV prevalence was 1.3%, as compared to the Jamaican SW rate of 4.6%. Most participants reported always using a condom with an outside partner, while only 22% reported always using a condom with their regular partner.\u0000\u0000\u0000Conclusion\u0000Emphasis on condom use within long-term relationships should be considered when planning HIV prevention programs for SWs. This requires addressing gender roles within noncommercial relationships and more discussions surrounding sexual behavior outside paid sex work. Although, causality may not be inferred through cross-sectional data, the lower HIV prevalence in JASL's SWs is promising and highlights opportunities for further analysis, specifically around the impact of JASL's work.","PeriodicalId":104133,"journal":{"name":"The West Indian medical journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114895624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background There is a claim in folklore medicine in Nigeria that trona (a sesquicarbonate or hydrated carbonate of sodium) causes fetal loss. However, this has not been substantiated or refuted by any scientific evidence. Aim This study evaluates whether or not trona causes fetal loss in pregnant female Wistar rats. Methods Pregnant Wistar rats of comparable weights were randomized into three groups. Group A (control) was given a single dose of 1.25 mL/kg body weight of lime while groups B and C were given 250 mg/kg and 500 mg/kg body weight of trona, respectively. Results There was no significant difference in the body weight gained across all the groups. The dose of 250 mg/kg body weight of trona decreased the number of live fetus, while 500 mg/kg body weight produced no live fetus; 250 mg/kg and 500 mg/kg body weight of trona led to fetal loss rate of 83.33% and 100%, respectively. Trona also reduced the concentrations of serum progesterone and cholesterol, and increased serum oestradiol. Conclusion This study revealed that trona causes fetal loss. This is possibly via an oestrogen-dependent mechanism, and attributed to the chemical constituents of trona.
{"title":"Trona Causes Fetal Loss in Pregnant Rat via an Oestrogen-dependent Mechanism.","authors":"A. Ajayi, R. Akhigbe","doi":"10.7727/wimj.2014.254","DOIUrl":"https://doi.org/10.7727/wimj.2014.254","url":null,"abstract":"Background\u0000There is a claim in folklore medicine in Nigeria that trona (a sesquicarbonate or hydrated carbonate of sodium) causes fetal loss. However, this has not been substantiated or refuted by any scientific evidence.\u0000\u0000\u0000Aim\u0000This study evaluates whether or not trona causes fetal loss in pregnant female Wistar rats.\u0000\u0000\u0000Methods\u0000Pregnant Wistar rats of comparable weights were randomized into three groups. Group A (control) was given a single dose of 1.25 mL/kg body weight of lime while groups B and C were given 250 mg/kg and 500 mg/kg body weight of trona, respectively.\u0000\u0000\u0000Results\u0000There was no significant difference in the body weight gained across all the groups. The dose of 250 mg/kg body weight of trona decreased the number of live fetus, while 500 mg/kg body weight produced no live fetus; 250 mg/kg and 500 mg/kg body weight of trona led to fetal loss rate of 83.33% and 100%, respectively. Trona also reduced the concentrations of serum progesterone and cholesterol, and increased serum oestradiol.\u0000\u0000\u0000Conclusion\u0000This study revealed that trona causes fetal loss. This is possibly via an oestrogen-dependent mechanism, and attributed to the chemical constituents of trona.","PeriodicalId":104133,"journal":{"name":"The West Indian medical journal","volume":"28 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134371289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nil Özbilüm, Serdal Arslan, M. Yanartaş, Z. Yilmaz, Ö. Berkan
Objective Coroner artery disease, the leading cause of morbidity and mortality worldwide, is an inflammatory disease. XRCC1 gene is playing the role of scaffolding protein for the base excision repair (BER) and single strand break (SSB) repair. Methods The study population consisted of 402 participants living in the same region, classified into case group (n=201) and control group (n=201). Phenol-chloroform method was used to extract DNA from blood samples of the study participants. XRCC1 genotypes were determined using PCR/RFLP methods. Results No statistically significant difference was found between the study groups in terms of allele and genotype frequencies in XRCC1 Arg194Trp polymorphism. However, distribution of XRCC1 399Gln allele frequency was found to differ at a statistically significant level between the case and control groups (p=0.003; OR=1.56). Regarding the Arg/Arg genotype in Arg399Gln polymorphism, a statistically significant difference was detected in the distribution of Gln/Gln genotype (p=0.017; adj OR=3.11). Statistically significant differences were also recorded for Arg399Gln polymorphism among the smoking male participants with hypertension (p=0.009; p=0.031; p=0.032, respectively). Conclusion The study suggests that XRCC1 399Gln/Gln genotype may be a significant risk factor for coronary artery disease.
{"title":"Arg399Gln Polymorphism of the XRCC1 Gene is Associated with Coronary Artery Disease in a Turkish Population.","authors":"Nil Özbilüm, Serdal Arslan, M. Yanartaş, Z. Yilmaz, Ö. Berkan","doi":"10.7727/wimj.2015.057","DOIUrl":"https://doi.org/10.7727/wimj.2015.057","url":null,"abstract":"Objective\u0000Coroner artery disease, the leading cause of morbidity and mortality worldwide, is an inflammatory disease. XRCC1 gene is playing the role of scaffolding protein for the base excision repair (BER) and single strand break (SSB) repair.\u0000\u0000\u0000Methods\u0000The study population consisted of 402 participants living in the same region, classified into case group (n=201) and control group (n=201). Phenol-chloroform method was used to extract DNA from blood samples of the study participants. XRCC1 genotypes were determined using PCR/RFLP methods.\u0000\u0000\u0000Results\u0000No statistically significant difference was found between the study groups in terms of allele and genotype frequencies in XRCC1 Arg194Trp polymorphism. However, distribution of XRCC1 399Gln allele frequency was found to differ at a statistically significant level between the case and control groups (p=0.003; OR=1.56). Regarding the Arg/Arg genotype in Arg399Gln polymorphism, a statistically significant difference was detected in the distribution of Gln/Gln genotype (p=0.017; adj OR=3.11). Statistically significant differences were also recorded for Arg399Gln polymorphism among the smoking male participants with hypertension (p=0.009; p=0.031; p=0.032, respectively).\u0000\u0000\u0000Conclusion\u0000The study suggests that XRCC1 399Gln/Gln genotype may be a significant risk factor for coronary artery disease.","PeriodicalId":104133,"journal":{"name":"The West Indian medical journal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114477334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective Obesity is a major modifiable risk factor for atherosclerosis. Thus, early risk markers are needed to identify obese subjects. The objective of this study was to examine the relationship between body composition and arterial stiffness documented by Doppler-derived renal resistive index (RRI). Materials/Subjects and Methods We enrolled 120 new-diagnosed hypertensive patients (mean age 45±8 years) who were admitted to our nephrology clinic. Body fat percentage (BFP) was measured by bioelectrical impedance (BIA). Doppler examinations performed and RRI was calculated for all participants. Results The female patients had higher RRI than male patients (0.69 vs. 0.65, p ≤ 0.05). The study patients were divided into three groups according to their BFP defined by BIA. Group 3 patients, who exhibited higher body fat, had significantly higher BMI (p < 0.05), total leukocyte count (p < 0.05), CRP (p < 0.05), triglyceride (p < 0.05), and female predominance. Group 3 patients were statistically older than group 1 patients (46.2 vs. 40.6 years, p < 0.05). Additionally, RRI levels were higher in Group 3 than in Group 1 [0.69 vs 0.65, p < 0.05] (Table 3). In logistic regression analysis, independent factors affecting RRI were age, gender, BFP and CRP levels (all p values were < 0.05). Conclusions Body fat percentage was associated with higher RRI, in hypertensive patients. Altered renal hemodynamic profile is involved in the long-term renal risk associated with body fat distribution.
肥胖是动脉粥样硬化的主要可改变危险因素。因此，需要早期风险标记来识别肥胖受试者。本研究的目的是检查多普勒肾阻力指数(RRI)记录的身体成分与动脉硬度之间的关系。材料/对象和方法我们招募了120例新诊断的高血压患者(平均年龄45±8岁)。采用生物电阻抗法测定体脂率(BFP)。对所有参与者进行多普勒检查并计算RRI。结果女性患者RRI高于男性患者(0.69比0.65,p≤0.05)。根据BIA定义的BFP将研究患者分为三组。3组患者体脂较高，BMI (p < 0.05)、白细胞总数(p < 0.05)、CRP (p < 0.05)、甘油三酯(p < 0.05)、女性优势均显著增高。3组患者比1组患者年龄大(46.2岁比40.6岁，p < 0.05)。此外，第3组RRI水平高于第1组[0.69 vs 0.65, p < 0.05](表3)。在logistic回归分析中，影响RRI的独立因素为年龄、性别、BFP和CRP水平(p值均< 0.05)。结论高血压患者体脂率与较高的RRI相关。肾脏血流动力学改变与体脂分布相关的长期肾脏风险有关。
{"title":"The Relationship between Body Composition and Renal Resistive Index in New-diagnosed Hypertensive Patients.","authors":"S. Karakan, B. İnan, A. Aktas, H. Yavuz","doi":"10.7727/wimj.2015.054","DOIUrl":"https://doi.org/10.7727/wimj.2015.054","url":null,"abstract":"Objective\u0000Obesity is a major modifiable risk factor for atherosclerosis. Thus, early risk markers are needed to identify obese subjects. The objective of this study was to examine the relationship between body composition and arterial stiffness documented by Doppler-derived renal resistive index (RRI).\u0000\u0000\u0000Materials/Subjects and Methods\u0000We enrolled 120 new-diagnosed hypertensive patients (mean age 45±8 years) who were admitted to our nephrology clinic. Body fat percentage (BFP) was measured by bioelectrical impedance (BIA). Doppler examinations performed and RRI was calculated for all participants.\u0000\u0000\u0000Results\u0000The female patients had higher RRI than male patients (0.69 vs. 0.65, p ≤ 0.05). The study patients were divided into three groups according to their BFP defined by BIA. Group 3 patients, who exhibited higher body fat, had significantly higher BMI (p < 0.05), total leukocyte count (p < 0.05), CRP (p < 0.05), triglyceride (p < 0.05), and female predominance. Group 3 patients were statistically older than group 1 patients (46.2 vs. 40.6 years, p < 0.05). Additionally, RRI levels were higher in Group 3 than in Group 1 [0.69 vs 0.65, p < 0.05] (Table 3). In logistic regression analysis, independent factors affecting RRI were age, gender, BFP and CRP levels (all p values were < 0.05).\u0000\u0000\u0000Conclusions\u0000Body fat percentage was associated with higher RRI, in hypertensive patients. Altered renal hemodynamic profile is involved in the long-term renal risk associated with body fat distribution.","PeriodicalId":104133,"journal":{"name":"The West Indian medical journal","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126143624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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