Pub Date : 2025-01-01DOI: 10.1016/j.cmi.2024.09.022
Hinpetch Daungsupawong , Viroj Wiwanitkit
{"title":"Re: ‘Nirmatrelvir/ritonavir treatment and risk for post-acute sequelae of COVID-19 infection in older Singaporeans’ by Wee et al.","authors":"Hinpetch Daungsupawong , Viroj Wiwanitkit","doi":"10.1016/j.cmi.2024.09.022","DOIUrl":"10.1016/j.cmi.2024.09.022","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 1","pages":"Page 138"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.cmi.2024.08.005
María Patricia Hernández-Mitre , Susan C. Morpeth , Balasubramanian Venkatesh , Thomas E. Hills , Joshua Davis , Robert K. Mahar , Grace McPhee , Mark Jones , James Totterdell , Steven Y.C. Tong , Jason A. Roberts
{"title":"Erratum to ‘TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate’ [Clin Microbiol Infect (30) (2024) 743–754]","authors":"María Patricia Hernández-Mitre , Susan C. Morpeth , Balasubramanian Venkatesh , Thomas E. Hills , Joshua Davis , Robert K. Mahar , Grace McPhee , Mark Jones , James Totterdell , Steven Y.C. Tong , Jason A. Roberts","doi":"10.1016/j.cmi.2024.08.005","DOIUrl":"10.1016/j.cmi.2024.08.005","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 1","pages":"Page 141"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.cmi.2024.08.014
Peng Lan , Ye Lu , Weichao Liao , Yunsong Yu , Ying Fu , Jiancang Zhou
{"title":"Cefiderocol-resistant hypervirulent Klebsiella pneumoniae with CirA deficiency and co-production of KPC-2 and SHV-12","authors":"Peng Lan , Ye Lu , Weichao Liao , Yunsong Yu , Ying Fu , Jiancang Zhou","doi":"10.1016/j.cmi.2024.08.014","DOIUrl":"10.1016/j.cmi.2024.08.014","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 1","pages":"Pages 125-127"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.cmi.2024.09.014
Paraskevi C. Fragkou , Dimitra Dimopoulou , Charalampos D. Moschopoulos , Chrysanthi Skevaki , ESCMID Study Group for Respiratory Viruses (ESGREV)
Background
Synthetic glucocorticoids are among the most commonly administered drugs due to their potent immunomodulatory properties. However, they may put patients at risk for infections. Their effect on the incidence of respiratory viral infections (RVIs) remains unclear.
Objectives
The aim of this review is to provide an insightful overview of the most up-to-date evidence regarding the extent to which the use of corticosteroids (CSs) influences the risk of RVIs.
Sources
The PubMed database was searched for studies on the association between CSs and RVIs from inception until 15 December 2023.
Content
CSs have differing impacts on the risk of RVIs in asthma and chronic obstructive pulmonary disease, influenced by both the specific virus and the type and dose of CSs. Furthermore, current data demonstrate that CSs may increase the risk of RVIs in patients with systemic lupus erythematosus, rheumatoid arthritis, vasculitis, solid tumours, haematological malignancies, and among transplant recipients.
Implications
Large-scale studies are imperative to inform a more accurate and personalized risk stratification for RVIs. This, in turn, will point towards new strategies for RVI prevention and associated morbidity and mortality in high-risk populations.
{"title":"Effects of long-term corticosteroid use on susceptibility to respiratory viruses: a narrative review","authors":"Paraskevi C. Fragkou , Dimitra Dimopoulou , Charalampos D. Moschopoulos , Chrysanthi Skevaki , ESCMID Study Group for Respiratory Viruses (ESGREV)","doi":"10.1016/j.cmi.2024.09.014","DOIUrl":"10.1016/j.cmi.2024.09.014","url":null,"abstract":"<div><h3>Background</h3><div>Synthetic glucocorticoids are among the most commonly administered drugs due to their potent immunomodulatory properties. However, they may put patients at risk for infections. Their effect on the incidence of respiratory viral infections (RVIs) remains unclear.</div></div><div><h3>Objectives</h3><div>The aim of this review is to provide an insightful overview of the most up-to-date evidence regarding the extent to which the use of corticosteroids (CSs) influences the risk of RVIs.</div></div><div><h3>Sources</h3><div>The PubMed database was searched for studies on the association between CSs and RVIs from inception until 15 December 2023.</div></div><div><h3>Content</h3><div>CSs have differing impacts on the risk of RVIs in asthma and chronic obstructive pulmonary disease, influenced by both the specific virus and the type and dose of CSs. Furthermore, current data demonstrate that CSs may increase the risk of RVIs in patients with systemic lupus erythematosus, rheumatoid arthritis, vasculitis, solid tumours, haematological malignancies, and among transplant recipients.</div></div><div><h3>Implications</h3><div>Large-scale studies are imperative to inform a more accurate and personalized risk stratification for RVIs. This, in turn, will point towards new strategies for RVI prevention and associated morbidity and mortality in high-risk populations.</div></div>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 1","pages":"Pages 43-48"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.cmi.2024.10.017
Joseph Sassine, Chrysanthi Skevaki, Roy F. Chemaly, European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV)
{"title":"Infections in immunocompromised hosts: progress made and challenges ahead","authors":"Joseph Sassine, Chrysanthi Skevaki, Roy F. Chemaly, European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV)","doi":"10.1016/j.cmi.2024.10.017","DOIUrl":"10.1016/j.cmi.2024.10.017","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 1","pages":"Pages 22-23"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.cmi.2024.08.028
Paul Loubet , Slim Fourati , Donia Bouzid
{"title":"Should multiplex PCR testing be integrated into antimicrobial stewardship programs for paediatric community-acquired pneumonia in the emergency department?","authors":"Paul Loubet , Slim Fourati , Donia Bouzid","doi":"10.1016/j.cmi.2024.08.028","DOIUrl":"10.1016/j.cmi.2024.08.028","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 1","pages":"Pages 5-7"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.cmi.2024.09.029
Brad Spellberg , Bassam Ghanem , Tom Boyles , Todd C. Lee , Emily G. McDonald
{"title":"ESR and CRP: it is time to stop the zombie tests: author's response","authors":"Brad Spellberg , Bassam Ghanem , Tom Boyles , Todd C. Lee , Emily G. McDonald","doi":"10.1016/j.cmi.2024.09.029","DOIUrl":"10.1016/j.cmi.2024.09.029","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 1","pages":"Pages 136-137"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.cmi.2024.10.010
Maiken Cavling Arendrup , Shawn R. Lockhart , Nathan Wiederhold
Objectives
Reported amphotericin B resistance rates for Candida auris vary considerably. This may reflect clinically relevant differences in susceptibility, technical issues with testing, or adoption of a clinical breakpoint that bisects the wild-type population. We compared reference methods and two gradient diffusion strips using a shared C. auris strain collection.
Methods
Forty C. auris strains from nine U.S. states and ≥3 clades were included. Fourteen MIC data sets were generated using European Committee on Antimicrobial Susceptibility Testing (EUCAST) E.Def 7.4, Clinical and Laboratory Standards Institute (CLSI) M27Ed4, Etest, and MIC gradient test strip (MTS, Liofilchem) MICs. MICs ≤1 mg/L were classified as susceptible.
Results
EUCAST and CLSI amphotericin B MIC testing were robust across the included method variables. The modal MIC was 1 mg/L, distributions unimodal and narrow with similar geometric mean (GM)-MICs (0.745–1.072); however, susceptibility classification varied (0–28% resistance). Gradient diffusion strip testing resulted in wider and bimodal distributions for 8/9 data sets. If adopting, per manufacturer's protocol, double inoculation for the Etest method, the modal MIC increased to 2–4 mg/L and resistance rates to 45–63% versus 25–30% with the single inoculation. The EUCAST, CLSI, Etest, and MTS strip MICs correlated to the optical density of drug-free control EUCAST wells, suggesting that some isolates grew better than others and that this was associated with MIC.
Discussion
: The EUCAST and CLSI MIC results were in close agreement, whereas the strip test showed wider and bimodal distributions with reader to reader and centre to centre variation. Our study adds to the concern for commercial MIC testing of amphotericin B against C. auris and suggests the current breakpoint leads to random susceptibility classification.
目的：据报道，白色念珠菌对两性霉素 B 的耐药率差异很大。这可能反映了与临床相关的药敏性差异、检测技术问题或采用了将野生型群体一分为二的临床断点（BP）。我们使用共享的 C. auris 菌株库比较了参考方法和两种梯度扩散条：方法：纳入了来自美国九个州、≥3 个支系的 40 株 C. auris 菌株。使用 EUCAST E.Def 7.4、CLSI M27Ed4、Etest 和 MTS（Liofilchem）条带 MIC 生成 14 个 MIC 数据集。MIC≤1 mg/L 被归类为易感：结果：EUCAST和CLSI两性霉素B的MIC测试在各种方法变量中都很稳健。模态 MIC 为 1 毫克/升，呈单峰分布，范围较窄，GM-MIC 相似（0.745-1.072）；但药敏性分类各不相同（0-28% 抗药）。梯度扩散带测试结果显示，8/9 个数据集的分布较宽且呈双峰分布。如果按照制造商的协议，在 Etest 方法中采用双重接种，则模态 MIC 增加到 2-4 mg/L，耐药率增加到 45-63%，而单次接种的耐药率为 25-30%。EUCAST、CLSI、Etest和MTS条带的MIC与无药对照EUCAST孔的OD相关，表明一些分离物比其他分离物生长得更好，这与MIC有关：结论：EUCAST 和 CLSI 的 MIC 结果接近一致，而条带测试则显示出更广泛的双峰分布，读者与读者之间以及中心与中心之间存在差异。我们的研究增加了人们对两性霉素 B 抗球虫商业 MIC 检测的担忧，并表明目前的断点会导致随机药敏性分类。
{"title":"Candida auris MIC testing by EUCAST and clinical and laboratory standards institute broth microdilution, and gradient diffusion strips; to be or not to be amphotericin B resistant?","authors":"Maiken Cavling Arendrup , Shawn R. Lockhart , Nathan Wiederhold","doi":"10.1016/j.cmi.2024.10.010","DOIUrl":"10.1016/j.cmi.2024.10.010","url":null,"abstract":"<div><h3>Objectives</h3><div>Reported amphotericin B resistance rates for <em>Candida auris</em> vary considerably. This may reflect clinically relevant differences in susceptibility, technical issues with testing, or adoption of a clinical breakpoint that bisects the wild-type population. We compared reference methods and two gradient diffusion strips using a shared <em>C. auris</em> strain collection.</div></div><div><h3>Methods</h3><div>Forty <em>C. auris</em> strains from nine U.S. states and ≥3 clades were included. Fourteen MIC data sets were generated using European Committee on Antimicrobial Susceptibility Testing (EUCAST) E.Def 7.4, Clinical and Laboratory Standards Institute (CLSI) M27Ed4, Etest, and MIC gradient test strip (MTS, Liofilchem) MICs. MICs ≤1 mg/L were classified as susceptible.</div></div><div><h3>Results</h3><div>EUCAST and CLSI amphotericin B MIC testing were robust across the included method variables. The modal MIC was 1 mg/L, distributions unimodal and narrow with similar geometric mean (GM)-MICs (0.745–1.072); however, susceptibility classification varied (0–28% resistance). Gradient diffusion strip testing resulted in wider and bimodal distributions for 8/9 data sets. If adopting, per manufacturer's protocol, double inoculation for the Etest method, the modal MIC increased to 2–4 mg/L and resistance rates to 45–63% versus 25–30% with the single inoculation. The EUCAST, CLSI, Etest, and MTS strip MICs correlated to the optical density of drug-free control EUCAST wells, suggesting that some isolates grew better than others and that this was associated with MIC.</div></div><div><h3>Discussion</h3><div>: The EUCAST and CLSI MIC results were in close agreement, whereas the strip test showed wider and bimodal distributions with reader to reader and centre to centre variation. Our study adds to the concern for commercial MIC testing of amphotericin B against <em>C. auris</em> and suggests the current breakpoint leads to random susceptibility classification.</div></div>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 1","pages":"Pages 108-112"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.cmi.2024.08.011
Myeongji Kim , Nischal Ranganath , Supavit Chesdachai , Ryan W. Stevens , Muhammad Rizwan Sohail , Omar M. Abu Saleh
{"title":"Which trial do we need? Combination therapy with daptomycin plus ceftaroline versus standard-of-care monotherapy in the treatment of methicillin-resistant Staphylococcus aureus bacteraemia","authors":"Myeongji Kim , Nischal Ranganath , Supavit Chesdachai , Ryan W. Stevens , Muhammad Rizwan Sohail , Omar M. Abu Saleh","doi":"10.1016/j.cmi.2024.08.011","DOIUrl":"10.1016/j.cmi.2024.08.011","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 1","pages":"Pages 18-21"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.cmi.2024.09.016
Angela Huttner , Pranita D. Tamma , Dafna Yahav
{"title":"Re: ‘ESR and CRP: it's time to stop the zombie tests’ by Spellberg et al.","authors":"Angela Huttner , Pranita D. Tamma , Dafna Yahav","doi":"10.1016/j.cmi.2024.09.016","DOIUrl":"10.1016/j.cmi.2024.09.016","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 1","pages":"Pages 134-135"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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