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Advancing lipid nanoparticles: A pioneering technology in cosmetic and dermatological treatments 推进脂质纳米颗粒:美容和皮肤治疗的先驱技术
IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL Pub Date : 2025-01-01 Epub Date: 2024-12-07 DOI: 10.1016/j.colcom.2024.100814
Anil Pareek , Devesh U. Kapoor , Sandeep Kumar Yadav , Summya Rashid , Mohammad Fareed , Mohammad Suhail Akhter , Ghazala Muteeb , Madan Mohan Gupta , Bhupendra G. Prajapati
Lipid nanoparticles (LNPs) represent a groundbreaking advancement in the realms of cosmetics and dermatology, providing advantages over traditional formulations. This paper explores the revolutionary potential of LNPs, particularly Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs), in enhancing cosmetic and dermatological applications. The review highlights the advantages of LNPs, including improved skin penetration, improved bioavailability and controlled release of active ingredients, which together contribute to their superior performance compared to conventional formulations. Notable applications discussed include their roles in acne treatment, anti-aging solutions, wound healing, skin-lightening products, and sunscreens. This study examines the structural features and formulation techniques of LNPs, highlighting biocompatibility, and targeted delivery capabilities. We also explore emerging uses such as genetic medicine and mRNA vaccine delivery, alongside market trends and consumer acceptance. By summarizing recent developments and identifying existing challenges, this paper offers a thorough overview of LNPs for future research in pharmaceutical and cosmetic advancements.
脂质纳米颗粒(LNPs)代表了化妆品和皮肤病学领域的突破性进步,提供了传统配方的优势。本文探讨了LNPs的革命性潜力,特别是固体脂质纳米颗粒(sln)和纳米结构脂质载体(NLCs),在增强化妆品和皮肤病学应用方面。这篇综述强调了LNPs的优点,包括改善皮肤渗透,提高生物利用度和控制活性成分的释放,这些共同促进了它们与传统配方相比的优越性能。值得注意的应用包括它们在痤疮治疗、抗衰老解决方案、伤口愈合、美白产品和防晒霜中的作用。本研究考察了LNPs的结构特征和配方技术,强调了生物相容性和靶向递送能力。除了市场趋势和消费者接受程度外,我们还探讨了遗传医学和mRNA疫苗递送等新兴用途。通过总结最近的发展和确定存在的挑战,本文提供了LNPs的全面概述,为未来的研究在制药和化妆品的进步。
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引用次数: 0
Multi-layer kagome lattices assembled with isotropic spherical colloids via heteroepitaxial growth 通过异质外延生长,由各向同性球形胶体组装而成的多层kagome晶格
IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL Pub Date : 2025-01-01 Epub Date: 2024-12-19 DOI: 10.1016/j.colcom.2024.100815
Jun Nozawa , Masahide Sato , Satoshi Uda , Kozo Fujiwara
The control of structure is crucial for diverse applications of colloidal crystals. Open-structure colloidal crystals are promising in their novel optical or mechanical properties, yet fabrication remains a significant challenge. Here, we demonstrate fabrication of multi-layer colloidal kagome lattices via heteroepitaxial growth. Unlike previous methods that rely on anisotropic particles, such as Janus particles, our approach utilizes common isotropic spherical polystyrene particles. We fabricated multi-layered kagome lattices, in contrast to techniques that were limited to forming single layers. The first layer in the kagome lattice formation on a substrate was a multi-step process, as revealed by in situ-observations. Then repeated stacking of kagome lattice layers occurred stably. This heteroepitaxial growth technique offers a feasible approach to self-assemble open-structure colloidal crystals.
胶体晶体的结构控制是胶体晶体多种应用的关键。开放结构胶体晶体在其新的光学或机械性能方面很有前途,但制造仍然是一个重大挑战。在这里,我们展示了通过异质外延生长制备多层胶态kagome晶格。与之前依赖于各向异性粒子(如Janus粒子)的方法不同,我们的方法利用了普通的各向同性球形聚苯乙烯粒子。我们制造了多层的kagome晶格,而不是局限于形成单层的技术。原位观察表明,在衬底上形成kagome晶格的第一层是一个多步骤的过程。然后稳定地重复堆叠kagome晶格层。这种异质外延生长技术为自组装开放结构胶体晶体提供了一种可行的方法。
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引用次数: 0
Honeycomb BiFeO3 catalysts harvest mechanical energy from ultrasonic vibrations for efficient piezoelectric-catalyzed degradation of antibiotics 蜂窝状BiFeO3催化剂从超声波振动中获取机械能,用于有效的压电催化抗生素降解
IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1016/j.colcom.2024.100813
Jun Teng , Du Tao , Feng Li , Taohai Li
Piezocatalysis has attracted much attention for its efficient performance in removing pharmaceuticals and dyes from wastewater. In this work, the piezoelectric system was applied by environmental-benign BiFeO3 catalysis for the removal of antibiotics in the water. The irregular honeycomb-like BiFeO3 was prepared through a simple co-precipitation route with composite precipitants. The results demonstrated that BiFeO3 exhibited excellent piezoelectric catalytic degradation performance for metronidazole under ultrasonic vibration. The effects of catalyst dosage, initial metronidazole concentration, solution pH, and ultrasonic power on piezoelectric catalytic efficiency were systematically investigated. It was found that the highest piezoelectric catalytic degradation efficiency of metronidazole was 98.87 %. The catalyst stability of the catalyst showed that it had excellent piezoelectric catalytic degradation Finally, the degradation efficiency of metronidazole was only reduced by 4 % through four cycles, which demonstrated the good stability and reusability of BiFeO3.
压电催化以其高效的脱除废水中的药物和染料而备受关注。在这项工作中,压电系统应用于环境友好的BiFeO3催化去除水中的抗生素。采用复合沉淀剂的简单共沉淀法制备了不规则蜂窝状BiFeO3。结果表明,在超声振动下,BiFeO3对甲硝唑具有优异的压电降解性能。系统考察了催化剂用量、甲硝唑初始浓度、溶液pH、超声功率对压电催化效率的影响。结果表明,甲硝唑的压电催化降解效率最高可达98.87%。催化剂的稳定性表明,该催化剂具有优异的压电催化降解性能。最后,经过4次循环,对甲硝唑的降解效率仅降低4%,证明了BiFeO3具有良好的稳定性和可重复使用性。
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引用次数: 0
Adhesion mechanisms and design strategies for bioadhesives 生物粘合剂的粘合机制和设计策略
IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-11-01 Epub Date: 2024-10-30 DOI: 10.1016/j.colcom.2024.100809
Yihang Ding , Lisha Yu , Zhengwei Mao
Bioadhesives are widely used in medical fields due to their compatibility with biological soft tissues and their ability to facilitate non-invasive wound closure. Despite their widespread clinical applications, the inadequate adhesion performance highlights the need for further refinement and innovation of these materials. A profound comprehension of the underlying mechanisms of tissue adhesion is essential for the successful development of bioadhesives. This review elucidates adhesion mechanisms and design principles for bioadhesives, emphasizing strategies to enhance interfacial adhesion and cohesion performance. We also provide a forward-looking perspective on the challenges and emerging trends for the development of next-generation bioadhesives. The progress of bioadhesives has significant potential to revolutionize wound management.
生物粘合剂因其与生物软组织的兼容性和促进非侵入性伤口闭合的能力而广泛应用于医疗领域。尽管生物粘合剂在临床上得到了广泛应用,但其粘合性能的不足凸显了进一步改进和创新这些材料的必要性。深刻理解组织粘附的基本机制对于成功开发生物粘合剂至关重要。本综述阐明了生物粘合剂的粘附机理和设计原则,强调了增强界面粘附和内聚性能的策略。我们还从前瞻性的角度探讨了开发下一代生物粘合剂所面临的挑战和新趋势。生物粘合剂的进步具有彻底改变伤口管理的巨大潜力。
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引用次数: 0
Spongosome-based co-delivery of curcumin and Piperine: A novel strategy for mitigating pollution-induced skin damage 以海绵为基础的姜黄素和胡椒碱的共同递送:减轻污染引起的皮肤损伤的新策略
IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-11-01 Epub Date: 2024-11-29 DOI: 10.1016/j.colcom.2024.100811
Agnese Bondi , Francesca Ferrara , Walter Pula , Paolo Mariani , Alessia Pepe , Markus Drechsler , Leda Montesi , Stefano Manfredini , Giuseppe Valacchi , Elisabetta Esposito
The present study aims to explore the potential role of curcumin and piperine loaded spongosomes to protect the skin against pollution-induced damage. The hydration of a glyceryl monooleate and sodium cholate thin film, followed by homogenization, led to dispersions with an internal spongiform structure, as demonstrated by cryogenic transmission electron microscopy and small angle X-ray scattering. Spongosome mean diameter measured by photon correlation spectroscopy was roughly 200 nm. Curcumin and piperine were efficiently encapsulated in spongosomes, as demonstrated by ultrafiltration and HPLC analysis. In vitro permeation tests revealed that piperine enhances the penetration of curcumin, suggesting a further improved bioavailability and sustained release. Ex vivo studies using human skin biopsies showed that curcumin and piperine-loaded spongosomes protect the skin against diesel exhaust emissions, preserving the levels of key skin barrier proteins, as filaggrin and involucrin. The formulations exhibited non-irritating properties in human patch tests, supporting their suitability for topical application.
本研究旨在探讨姜黄素和胡椒碱负载的海绵体在保护皮肤免受污染损伤中的潜在作用。单油酸甘油酯和胆酸钠薄膜的水合作用,随后均质化,导致具有内部海绵状结构的分散体,如低温透射电子显微镜和小角度x射线散射所示。光子相关光谱测得海绵体平均直径约为200 nm。超滤和高效液相色谱分析表明,姜黄素和胡椒碱被有效地包裹在海绵体中。体外渗透试验表明,胡椒碱增强了姜黄素的渗透,进一步提高了姜黄素的生物利用度和缓释。利用人体皮肤活检进行的离体研究表明,姜黄素和装载胡椒碱的海绵体可以保护皮肤免受柴油废气排放的影响,保持关键皮肤屏障蛋白的水平,如聚丝蛋白和天花苷。该配方在人体贴片试验中表现出无刺激性,支持其局部应用的适用性。
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引用次数: 0
From dairy waste to value-added bio-based surfactants 从乳制品废料到高附加值的生物基表面活性剂
IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-11-01 Epub Date: 2024-09-21 DOI: 10.1016/j.colcom.2024.100807
Giorgia Ballabio , Sara Sangiorgio , Eleonora Pargoletti , Rita Gelli , Massimo Bonini , Marco Rabuffetti , Giuseppe Cappelletti , Giovanna Speranza
Cheese whey permeate, the main waste stream of dairy industry, was used as a starting material for the production of bio-based surfactants (SFAEs). Specifically, the first step in the sustainable chemoenzymatic synthesis of n-butyl 6-O-palmitoyl-D-glycosides (Fischer glycosylation followed by enzymatic esterification) was optimized by a chemometric study. The surfactancy of the prepared isomeric mixtures was deeply investigated in terms of static and dynamic interfacial tension and emulsifying capability over time.
奶酪乳清渗透物是乳制品工业的主要废弃物,被用作生产生物基表面活性剂(SFAEs)的起始原料。具体而言,通过化学计量学研究优化了正丁基 6-O-棕榈酰-D-糖苷可持续化学合成的第一步(费舍糖基化,然后酶法酯化)。通过静态和动态界面张力以及随时间变化的乳化能力,对制备的异构混合物的表面活性剂进行了深入研究。
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引用次数: 0
Icariin-loaded multilayered films deposited onto micro/nanostructured titanium enhances osteogenesis and reduces inflammation under diabetic conditions 沉积在微/纳米结构钛上的淫羊藿苷多层膜可促进骨生成并减轻糖尿病条件下的炎症反应
IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-11-01 Epub Date: 2024-10-28 DOI: 10.1016/j.colcom.2024.100808
Xiaojing Zhang , Jia Chen , Junxiao Li , Weina Wang , Xi Chen , Xingtang Fang , Chunlei Zhang , Yanhua Hou , Min Lai
Disordered bone metabolism and the associated inflammatory microenvironment in diabetic patients make treating bone fractures difficult in this patient population. However, the inherent bioinert properties of titanium implants result in insufficient osseointegration, making it important to develop an efficient surface modification strategy to provide titanium implants with enhanced osseointegration capabilities in diabetic conditions. Here, a micro/nanostructure was constructed on titanium through acid etching and anodic oxidation, followed by an addition of a multilayered film of chitosan (CHI), gelatin (GEL) and icariin (ICA) onto the surface of micro/nanostructured titanium using a layer-by-layer self-assembly technology. The characterization results indicated that the icariin-loaded multilayered film was successfully deposited onto titanium surface and achieved a long-term sustainable release of ICA. Cell experiments showed that the icariin-loaded multilayered films modified titanium promoted osteogenesis, inhibited osteoclast generation, and reduced inflammatory reaction under diabetic conditions. This study provides an avenue for treating fractures in patients with diabetes.
糖尿病患者的骨代谢紊乱和相关的炎症微环境使这一患者群体的骨折治疗变得困难。然而,钛植入物固有的生物惰性导致其骨结合能力不足,因此开发一种高效的表面改性策略以增强钛植入物在糖尿病患者中的骨结合能力非常重要。本文通过酸蚀刻和阳极氧化在钛上构建了微/纳米结构,然后利用逐层自组装技术在微/纳米结构钛表面添加了壳聚糖(CHI)、明胶(GEL)和冰片苷(ICA)的多层薄膜。表征结果表明,成功地在钛表面沉积了冰醋酸多层膜,并实现了冰醋酸的长期持续释放。细胞实验结果表明,在糖尿病条件下,改性钛表面的冰片素多层膜能促进成骨,抑制破骨细胞生成,减轻炎症反应。这项研究为治疗糖尿病患者的骨折提供了一种途径。
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引用次数: 0
Colloidal photonic crystals with tunable reflection wavelengths or intensities derived from their reconfigurable structures 具有可调反射波长或强度的可重构结构胶体光子晶体
IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-09-01 Epub Date: 2024-09-07 DOI: 10.1016/j.colcom.2024.100806
Hikaru Namigata , Kanako Watanabe , Tom A.J. Welling , Keishi Suga , Daisuke Nagao

Colloidal photonic crystals (CPCs), which are the ordered assemblies of colloidal particles, can reflect specific wavelengths of light. In particular, CPCs with controllable optical properties are promising materials for advanced photonic applications. Principally, the optical properties of CPCs, i.e., reflection wavelengths and reflection intensities, are controllable. These two characteristics are closely related to the assembled structures of CPCs, especially interplanar spacing and regularity of the assembled structures. The reflection wavelength is proportional to the interplanar spacing of the structure; thus, uniform expanding/contracting of particle-to-particle distance causes red/blue shift of reflection peaks. On the other hand, the regularity affects the reflection intensity; reversible order–disorder transitions enable tuning of the reflection peak intensities. To control the structures of CPCs, various stimuli-responsive polymers and electromagnetic interactions of colloids have been employed. This review explains the above methods and clarifies the future perspectives.

胶体光子晶体(CPCs)是胶体粒子的有序组合,可以反射特定波长的光。特别是,具有可控光学特性的 CPCs 是先进光子应用的理想材料。主要而言,CPC 的光学特性,即反射波长和反射强度是可控的。这两个特性与 CPC 的组装结构密切相关,尤其是组装结构的平面间距和规则性。反射波长与结构的平面间距成正比;因此,粒子与粒子间距的均匀扩展/收缩会导致反射峰的红色/蓝色偏移。另一方面,规则性也会影响反射强度;可逆的有序-无序转变可以调整反射峰强度。为了控制 CPC 的结构,人们采用了各种刺激响应聚合物和胶体的电磁相互作用。本综述解释了上述方法,并阐明了未来的发展前景。
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引用次数: 0
Molecular dynamic simulation (MD) for COF-based membrane in water treatment 基于 COF 的膜在水处理中的分子动力学模拟 (MD)
IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-09-01 Epub Date: 2024-08-12 DOI: 10.1016/j.colcom.2024.100798
Samaneh Bandehali , Sajad Moradi , Maryam Khalili , Meysam Bandehali , Arash Alimadadi

COF-based membranes represent a new class of porous materials utilized in water treatment. A comprehensive exploration of these membranes, encompassing their properties and transport mechanisms, is crucial for elucidating the underlying principles and unresolved issues in membrane processes. Molecular dynamics (MD) simulations offer a molecular-level exploration of membrane properties, both static and dynamic. This paper investigates the role of MD simulations in enhancing our understanding of COF-based membranes for water treatment processes.

This study discusses the structure and properties of COF materials, synthesis strategies, and their applications in water treatment. Furthermore, it explores the fundamental principles of MD simulation and various simulation methods pertinent to water treatment using COF-based membranes. By reviewing existing literature on MD simulations of COF-based membranes, this paper proposes future research directions in this promising field of membrane technology.

基于 COF 的膜是水处理中使用的一类新型多孔材料。全面探索这些膜的特性和传输机制,对于阐明膜过程的基本原理和悬而未决的问题至关重要。分子动力学(MD)模拟可从分子层面探索膜的静态和动态特性。本研究讨论了 COF 材料的结构和特性、合成策略及其在水处理中的应用。此外,它还探讨了 MD 模拟的基本原理以及与使用 COF 基膜进行水处理相关的各种模拟方法。通过回顾有关 COF 基膜 MD 模拟的现有文献,本文提出了这一前景广阔的膜技术领域的未来研究方向。
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引用次数: 0
Hydrogel stiffness mediates the PI3K-AKT signaling of mouse bone marrow stromal cells through cellular traction force 水凝胶硬度通过细胞牵引力介导小鼠骨髓基质细胞的 PI3K-AKT 信号转导
IF 4.7 3区 材料科学 Q2 CHEMISTRY, PHYSICAL Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.1016/j.colcom.2024.100797
Man Zhang , Xiangyu Dong , Qiang Wei , Yuanxin Ye , Hui Zhou

Adhesive interface stiffness significantly influences physiological processes by altering cell behaviors and signaling pathways. In particular, phosphoinositide 3-kinase (PI3K)-AKT pathway, one of the most important pathways that cell division, survival, and differentiation, can be affected. However, the detailed mechanism of this interaction remains unclear. In this study, we used gelatin methacrylate (GelMA) hydrogels with varying stiffness to mimic cellular mechanical environments and examine their effects on PI3K-AKT signaling. Cells cultured on stiff hydrogels showed increased spreading, focal adhesion formation, and contractility compared to those on softer hydrogels. Furthermore, mechanotransduction activation on stiff hydrogels upregulated PIP3, PI3K, and phosphorylated AKT (pAKT) expression. Notably, inhibiting myosin II, a key regulator of contractility, reduced PI3K-AKT signaling, suggesting a link between force generation and pathway activation. These findings reveal that how PI3K-AKT signaling can be mediated by cell adhesion interface stiffness through cell contractility, which provides new insights for developing therapies targeting PI3K-AKT-associated diseases.

粘合界面硬度通过改变细胞行为和信号传导途径对生理过程产生重大影响。尤其是磷脂肌醇3-激酶(PI3K)-AKT通路,它是细胞分裂、存活和分化的最重要通路之一,会受到影响。然而,这种相互作用的详细机制仍不清楚。在这项研究中,我们使用不同硬度的甲基丙烯酸明胶(GelMA)水凝胶来模拟细胞机械环境,并研究它们对 PI3K-AKT 信号传导的影响。与在较软水凝胶上培养的细胞相比,在较硬水凝胶上培养的细胞显示出更强的扩散、病灶粘附形成和收缩能力。此外,硬水凝胶上的机械传导激活上调了 PIP3、PI3K 和磷酸化 AKT(pAKT)的表达。值得注意的是,抑制肌球蛋白 II(收缩力的关键调节因子)可减少 PI3K-AKT 信号传导,这表明力的产生与通路激活之间存在联系。这些发现揭示了PI3K-AKT信号如何通过细胞收缩性介导细胞粘附界面硬度,为开发针对PI3K-AKT相关疾病的疗法提供了新的见解。
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引用次数: 0
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Colloid and Interface Science Communications
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