Colorectal Disease最新文献

{"title":"Complex anal fistulas and laser therapy: A critical appraisal of the FISTULASER study","authors":"Vipul D. Yagnik, Pankaj Garg, Kaushik Bhattacharya","doi":"10.1111/codi.70343","DOIUrl":"10.1111/codi.70343","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is self-reported recurrent urinary tract infection associated with anal incontinence and obstructive defecation? A multicentre case-control study using electronic PROM data","authors":"Thomas J. Curtis,&nbsp;Roberta Bugeja,&nbsp;Stephen C. Radley,&nbsp;Thomas G. Gray","doi":"10.1111/codi.70336","DOIUrl":"10.1111/codi.70336","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The accepted model for the pathogenesis of female urinary tract infection (UTI) is ascending infection with bowel flora from anus to urethra, though anal incontinence (AI) and obstructive defecation (ODS) have not previously been demonstrated to be risk factors for recurrent UTI (rUTI). This study aimed to use patient-reported outcome (PROM) data to investigate the association between AI and ODS with self-reported rUTI in women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Data obtained from 7990 completed ePAQ-Pelvic Floor PROMs at seven participating NHS hospitals between 2018 and 2022 were analysed. Essential inclusion criteria were completion of both the bowel dimension and item assessing self-reported rUTI in consenting participants. Participants were divided into cases and controls based on self-reported frequency of UTI. Mann–Whitney, logistic regression and Spearman's rank analyses were performed to assess for associations between self-reported rUTI with AI and ODS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>rUTI was reported by 931 women (11.7%). Significantly worse symptom scores for flatus incontinence (<i>p</i> &lt; 0.0001) (OR 1.24), liquid AI (<i>p</i> &lt; 0.0001) (OR 1.38), solid AI (<i>p</i> = 0.0031) (OR 1.24), passive faecal incontinence (<i>p</i> &lt; 0.0001) (OR 1.40), use of pads for AI (<i>p</i> &lt; 0.0001) (OR 1.34), perineal splinting/vaginal digitation (<i>p</i> &lt; 0.0001) (OR 1.19) and anal digitation (<i>p</i> &lt; 0.0001) (OR 1.30) were reported in participants with rUTI. Frequency of UTI weakly correlated with all AI and ODS symptoms (<i>r</i> = 0.069–0.151, <i>p</i> &lt; 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AI and ODS symptoms are significantly associated with increased rates of self-reported rUTI in this study, supporting the theory that these conditions may contribute to the pathogenesis of rUTI in women. Whilst the aetiology of rUTI is multifactorial, AI and ODS are contributory risk factors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fusion surgery for intracorporeal anastomosis in robotic colectomy: A video vignette","authors":"Fumi Hasegawa,&nbsp;Masahiro Fuse,&nbsp;Taku Sato,&nbsp;Taira Inutake,&nbsp;Yuri Kawashima,&nbsp;Megumu Enjoji","doi":"10.1111/codi.70341","DOIUrl":"10.1111/codi.70341","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual health of LGBTQ+ patients undergoing colorectal surgery for benign disease and their experience with healthcare: A scoping review","authors":"Zoe Marangoni,&nbsp;Louis Onghena,&nbsp;Maddalena Giacomozzi,&nbsp;Yves van Nieuwenhove,&nbsp;Eva Pape,&nbsp;Gabrielle H. van Ramshorst","doi":"10.1111/codi.70327","DOIUrl":"https://doi.org/10.1111/codi.70327","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Colorectal surgery for benign indications affects patients' sexual health. LGBTQ+ patients often face discrimination, resulting in unmet health needs. We aimed to investigate how colorectal surgery for benign disease affects LGBTQ+ individuals' sexual health, and which barriers exist to access healthcare.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed, Embase, Web of Science, Scopus, PsychINFO, Google Scholar, CINHAL, ProQuest, Cochrane library and Joanna Briggs Institute were systematically searched. Screening and data extraction were performed independently by two researchers. Inclusion criteria were adult patients who self-identified as LGBTQ+; colorectal or anal procedures for benign disease; outcomes of sexual health/wellbeing/pleasure. Exclusion criteria were appendicectomy, transrectal procedures or gender-affirming surgery and &gt;50% of patients treated for malignancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 719 records, eight articles were selected: one prospective cohort study, three mixed-methods surveys and four literature reviews. Ten main themes were identified: sexual function/activity and pain, anoreceptive intercourse (ARI), sexual satisfaction and pleasure, mental health and body image, obstacles and coping strategies, dating and relationships, partner response and inclusion, experience with healthcare providers, information sources, stigma and discrimination. Colorectal surgery negatively impacts sexual health and relationships. LGBTQ+ patients reported challenges in accessing care and information regarding sexual health after colorectal surgery, whilst facing discrimination and stigma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Colorectal surgery for benign disease affects LGBTQ+ patients' sexual health. Literature is scarce, with limited data stratification for sexual orientation or gender identity. Healthcare providers need to be educated about LGBTQ+ needs relating to sexual health and surgery, and inclusive clinical guidelines should be developed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bowel preserving surgery for stricturing jejunoileal Crohn's disease, part 4: Jaboulay duodenal strictureplasty: A step-by-step video vignette—A video vignette","authors":"Oscar Hernandez,&nbsp;Stefan D. Holubar,&nbsp;Daniel Joyce,&nbsp;Robert Simon","doi":"10.1111/codi.70325","DOIUrl":"10.1111/codi.70325","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of defunctioning ileostomies on postoperative kidney function in rectal cancer surgery","authors":"Gustav Sandén,&nbsp;Ida Hed Myrberg,&nbsp;Sol Erika Boman,&nbsp;Caroline Nordenvall,&nbsp;Juan-Jesus Carrero,&nbsp;Peter Matthiessen,&nbsp;Martin Rutegård","doi":"10.1111/codi.70329","DOIUrl":"10.1111/codi.70329","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate short- and long-term kidney injury incidence in patients undergoing low anterior resection for rectal cancer, comparing those with and without a defunctioning ileostomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We identified all Swedish rectal cancer patients ≤80 years old, with ASA fitness grade ≤III and tumour height ≤12 cm from the anal verge, who underwent anterior resection between 2007 and 2021 using CRCBaSe, a nationwide registry linkage. Patients who received a defunctioning ileostomy during surgery were compared with those who did not. Outcomes included chronic kidney failure, chronic kidney disease, acute kidney injury, and dehydration. Cox proportional hazards models were fitted for each outcome, using overlap weights derived from propensity scores for receiving a defunctioning ileostomy. Stoma reversal impact and mediation by anastomotic leakage were also examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 5286 patients, 4623 (87%) received a defunctioning ileostomy and 663 (13%) did not. A defunctioning ileostomy was not significantly associated with chronic kidney failure (HR 1.68, 95% CI: 0.19–15.16) or chronic kidney disease (HR 1.65, 95% CI: 0.91–2.98) but increased risks of acute kidney injury (HR 3.01, 95% CI: 1.61–5.64) and dehydration (HR 4.02, 95% CI: 2.33–6.94). Risks declined after stoma reversal. Stomas reduced anastomotic leakage with negligible mediation effects on short-term kidney damage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A defunctioning ileostomy after low anterior resection increases the risks of acute kidney injury and dehydration but not chronic kidney failure or chronic kidney disease. These risks decrease following stoma reversal, highlighting the need for careful perioperative management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12685789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High versus low take-off rectal prolapse: Outcomes of tailored surgery","authors":"Mohit Satish Gupta,&nbsp;Usman Mateen,&nbsp;Nicola Davies,&nbsp;Andrew Clarke","doi":"10.1111/codi.70330","DOIUrl":"10.1111/codi.70330","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Full-thickness rectal prolapse (FTRP) is heterogeneous, with outcomes varying despite similar anatomy. Cooper et al. proposed a radiological classification based on prolapse ‘take-off’ level on defecating proctography (DPG), hypothesising that high take-off (HTO) and low take-off (LTO) phenotypes may respond differently to abdominal versus perineal repair. This hypothesis has not previously been tested in a clinical cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective observational cohort study was performed across three hospitals over 12 years (2012–2024). Patients undergoing laparoscopic ventral mesh rectopexy (VMR), as first standardised by D'Hoore et al. [3] or Delorme's procedure with DPG-defined take-off were included. Outcomes were compared between procedures, matched versus unmatched surgery, and HTO versus LTO. The primary end-point was anatomical recurrence. Secondary end-points included radiological findings and symptom profiles by phenotype.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 108 patients, 71 (52 VMR, 19 Delorme's) had evaluable DPG and were included in phenotype analysis (HTO, <i>n</i> = 28; LTO, <i>n</i> = 43). Overall recurrence was 15.5%. Recurrence was lower after VMR than Delorme's (13.5% vs. 21.1%, <i>p</i> = 0.47) and in matched versus unmatched surgery (12.8% vs. 20.8%, <i>p</i> = 0.53), though not statistically significant. Within VMR, recurrence was lower in HTO than LTO (8.3% vs. 17.9%). HTO was significantly associated with enterocele (71.4% vs. 44.2%, <i>p</i> = 0.030) and greater perineal discomfort (85.7% vs. 55.8%, <i>p</i> = 0.010), whereas LTO more frequently presented with incontinence/urgency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This first clinical validation of the high/low take-off concept demonstrates phenotype-specific differences in radiology, symptoms, and surgical outcomes. Tailoring surgery to prolapse phenotype may reduce recurrence and guide personalised operative planning. Prospective, multicentre studies with quality-of-life outcomes are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to ‘PAVFCOS: The development of a core outcome set for pouch anal and vaginal fistula’","authors":"","doi":"10.1111/codi.70334","DOIUrl":"10.1111/codi.70334","url":null,"abstract":"<p>Reza L, Bapir L, Iqbal N, Sackitey C, Hughes S, Babbar M, et al. PAVFCOS: the development of a core outcome set for pouch anal and vaginal fistula. Colorectal Dis. 2025;27(8):e70184. https://doi.org/10.1111/codi.70184</p><p>In the Appendix section, listing all the ‘Collaborators’, Tricia Levasseur's name has now been added, as it was omitted from the original article.</p><p>We apologize for this error.</p>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/codi.70334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value of faecal calprotectin levels in patients with perianal fistula: A systematic review","authors":"Stavros Chatziisaak,&nbsp;Pascal Burri,&nbsp;Sebastian Wolf,&nbsp;Moritz Sparn,&nbsp;Dieter Hahnloser,&nbsp;Stephan Bischofberger,&nbsp;Dimitrios Chatziisaak","doi":"10.1111/codi.70331","DOIUrl":"10.1111/codi.70331","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Perianal fistula (PAF) is a common condition encountered in surgical and gastroenterological practice. Distinguishing between cryptoglandular disease (CGD) and inflammatory bowel disease (IBD)-related perianal disease is critical to ensure appropriate management. Faecal calprotectin (FC) has emerged as a promising non-invasive biomarker for IBD; however, its role in acute perianal disease is not well established. This systematic review aimed to evaluate the diagnostic accuracy of FC in distinguishing IBD-related perianal disease from CGD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A systematic literature search was conducted in PubMed, Embase and Cochrane databases following PRISMA guidelines. Studies were included if they assessed FC levels in patients with PAF and provided diagnostic accuracy metrics. Data extraction focused on study design, population characteristics, FC cut-off values, sensitivity, specificity and area under the curve (AUC) metrics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three studies met the inclusion criteria, all reporting significantly higher FC levels in IBD-related PAF compared to CGD-related fistulas. The proposed FC cut-off values varied, ranging from 110 μg/g to 344 μg/g, with corresponding sensitivities between 52% and 81%, as well as specificities between 77% and 93%. The AUC values indicated moderate to high diagnostic accuracy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>FC shows potential as a diagnostic tool for differentiating IBD-related perianal disease from CGD. A cut-off of 110–150 μg/g appears most suitable for early screening, whereas a higher threshold may be appropriate for confirmatory diagnosis. Further prospective studies with standardized protocols are necessary to refine these thresholds and validate FC as a clinical decision-making tool.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic impact of lymph node yield in deficient and proficient mismatch repair colon cancers: A retrospective national cohort study","authors":"Frederik W. Bækgaard,&nbsp;Anisoara Iordache,&nbsp;Andreas Hurup Nordholm,&nbsp;Peter-Martin Krarup,&nbsp;Nis Hallundbæk Schlesinger,&nbsp;Camilla Qvortrup,&nbsp;Henry G. Smith","doi":"10.1111/codi.70332","DOIUrl":"10.1111/codi.70332","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Lymph node yield (LNY) is a recognised prognostic factor in patients with colon cancer. Recent studies suggest LNY may reflect anti-tumour immune responses rather than surgical quality. Given the recognised difference in anti-tumour immunity according to mismatch repair (MMR) status, this study investigated whether LNY and its association with prognosis differed between colon cancers with deficient MMR (dMMR) and proficient MMR (pMMR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A national retrospective cohort study using the Danish Colorectal Cancer Group (DCCG) database. Patients diagnosed with new Stage I–III colon cancers undergoing potentially curative left or right hemicolectomies between 2016 and 2022 were included. The primary outcome was LNY according to MMR status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total of 9705 patients were included, of whom 7175 had pMMR cancers (74%). Median LNY for the whole cohort was 27. LNY &lt;12 was seen in 178 patients (2%). dMMR cancers had higher median LNY (28 vs. 26 nodes, <i>p</i> &lt; 0.001), and more patients with LNY ≥22 (73% vs. 66%, <i>p</i> &lt; 0.001). No difference in the number of lymph node metastases was seen between groups. LNY &lt;12 was associated with poorer overall survival (OS) regardless of MMR status and was independently associated with all-cause mortality. However, this effect was more marked in patients with dMMR than pMMR cancers {hazard ratio (HR) 4.23 (95% confidence interval [CI] 2.42–7.41) vs. 1.94 (1.21–3.13)}.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>LNY was significantly higher in dMMR cancers, where low LNY also has a stronger association with prognosis. These findings support the theory that LNY reflects anti-tumour immunity rather than surgical quality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}