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Antitraction sutures and indocyanine green fluorescence imaging to prevent anastomotic leakage in left-sided colorectal surgery—A video vignette
IF 2.9 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-06 DOI: 10.1111/codi.17293
Toshinori Kobayashi, Hisanori Miki, Uehara Hiroki, I. Shoichiro, Norikazu Yamada, Jun Watanabe
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引用次数: 0
Sigmoido-rectal intussusception anastomosis in the Altemeier procedure for incarcerated rectal prolapse—A video vignette and 13 case reports
IF 2.9 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-06 DOI: 10.1111/codi.17277
Yuze Zhai, Benjun Wang, Congcong Liu
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引用次数: 0
Long-term prognostic outcomes in high-risk T1 colorectal cancer: A multicentre retrospective comparison of surgery versus observation postendoscopic treatment
IF 2.9 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-06 DOI: 10.1111/codi.17269
Yosuke Atsumi, Masakatsu Numata, Jun Watanabe, Atsuhiko Sugiyama, Atsushi Ishibe, Yuichiro Ozeki, Kingo Hirasawa, Keiichi Ashikari, Takuma Higurashi, Akio Higuchi, Shinpei Kondo, Naoya Okada, Hideyuki Chiba, Hirokazu Suwa, Hiroaki Kaneko, Kanji Okuma, Teni Godai, Itaru Endo, Shin Maeda, Atsushi Nakajima, Yasushi Rino, Aya Saito

Aim

The risk of lymph node metastasis after endoscopic resection of high-risk T1 colorectal cancer prompts additional resection. However, age and comorbidities are considered in decision-making and some surgeons opt for observation. We compared the long-term outcomes of these approaches with the aim of clarifying the need for additional resection.

Method

This multicentre retrospective study included high-risk T1 colorectal cancer patients treated with endoscopic submucosal dissection (ESD) between January 2013 and April 2021. Patients who met one or more of the following criteria were eligible for inclusion: submucosal invasion depth ≥1000 μm, vessel invasion, poor differentiation, budding grade 2/3 or a positive vertical margin. Patients were divided into resection (R) and observation (O) groups. Outcomes were evaluated based on overall survival (OS) and 5-year cancer-specific survival (CSS), with an additional stratified analysis using the age-adjusted Charlson comorbidity index (ACCI).

Results

The study included 178 patients (group R, n = 131; group O, n = 47). Patients in group O were significantly older and had more comorbidities. Group R showed better 5-year OS and CSS (OS 87.0% vs. 58.9%, p = 0.001; CSS 98.8% vs. 78.4%, p = 0.002). Stratification by ACCI revealed that benefits of additional resection remained for patients with ACCI ≤ 6 (OS 91.2% vs. 58.3%, p = 0.013; CSS 98.4% vs. 61.7%, p < 0.001) but not for those with ACCI ≥7 (OS 75.9% vs. 59.8%, p = 0.289; CSS 100% vs. 100%, p = 0.617).

Conclusions

Significant survival benefits were demonstrated in group R patients with high-risk T1 cancer. However, the survival benefit of additional surgical resection was unconfirmed in patients with ACCI ≥ 7.

{"title":"Long-term prognostic outcomes in high-risk T1 colorectal cancer: A multicentre retrospective comparison of surgery versus observation postendoscopic treatment","authors":"Yosuke Atsumi,&nbsp;Masakatsu Numata,&nbsp;Jun Watanabe,&nbsp;Atsuhiko Sugiyama,&nbsp;Atsushi Ishibe,&nbsp;Yuichiro Ozeki,&nbsp;Kingo Hirasawa,&nbsp;Keiichi Ashikari,&nbsp;Takuma Higurashi,&nbsp;Akio Higuchi,&nbsp;Shinpei Kondo,&nbsp;Naoya Okada,&nbsp;Hideyuki Chiba,&nbsp;Hirokazu Suwa,&nbsp;Hiroaki Kaneko,&nbsp;Kanji Okuma,&nbsp;Teni Godai,&nbsp;Itaru Endo,&nbsp;Shin Maeda,&nbsp;Atsushi Nakajima,&nbsp;Yasushi Rino,&nbsp;Aya Saito","doi":"10.1111/codi.17269","DOIUrl":"https://doi.org/10.1111/codi.17269","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The risk of lymph node metastasis after endoscopic resection of high-risk T1 colorectal cancer prompts additional resection. However, age and comorbidities are considered in decision-making and some surgeons opt for observation. We compared the long-term outcomes of these approaches with the aim of clarifying the need for additional resection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This multicentre retrospective study included high-risk T1 colorectal cancer patients treated with endoscopic submucosal dissection (ESD) between January 2013 and April 2021. Patients who met one or more of the following criteria were eligible for inclusion: submucosal invasion depth ≥1000 μm, vessel invasion, poor differentiation, budding grade 2/3 or a positive vertical margin. Patients were divided into resection (R) and observation (O) groups. Outcomes were evaluated based on overall survival (OS) and 5-year cancer-specific survival (CSS), with an additional stratified analysis using the age-adjusted Charlson comorbidity index (ACCI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 178 patients (group R, <i>n</i> = 131; group O, <i>n</i> = 47). Patients in group O were significantly older and had more comorbidities. Group R showed better 5-year OS and CSS (OS 87.0% vs. 58.9%, <i>p</i> = 0.001; CSS 98.8% vs. 78.4%, <i>p</i> = 0.002). Stratification by ACCI revealed that benefits of additional resection remained for patients with ACCI ≤ 6 (OS 91.2% vs. 58.3%, <i>p</i> = 0.013; CSS 98.4% vs. 61.7%, <i>p</i> &lt; 0.001) but not for those with ACCI ≥7 (OS 75.9% vs. 59.8%, <i>p</i> = 0.289; CSS 100% vs. 100%, <i>p</i> = 0.617).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Significant survival benefits were demonstrated in group R patients with high-risk T1 cancer. However, the survival benefit of additional surgical resection was unconfirmed in patients with ACCI ≥ 7.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the efficacy of natural orifice specimen extraction surgery versus conventional laparoscopic surgery for colorectal cancers: A systematic review and meta-analysis
IF 2.9 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-06 DOI: 10.1111/codi.17279
Yu Cao, Mingze He, Zheng Liu, Kuo Chen, Khlusov Denis I, Jin Zhang, Jinqi Zou, Bagdan S. Semchenko, Sergey K. Efetov
<div> <section> <h3> Aim</h3> <p>Natural orifice specimen extraction surgery (NOSES) has gained significant importance in treating cancers. The current study is a meta-analysis that aimed to assess the short-term efficacy and long-term prognostic impact of NOSES and conventional laparoscopic (CL) surgery in the treatment of colorectal cancer (CRC).</p> </section> <section> <h3> Method</h3> <p>Published reports in several medical databases up to February 2024 were searched and information pertinent to outcomes of NOSES and CL in retrospective and randomized studies to treat CRC was collected. Pooled weighted/standardized mean difference (WMD/SMD), odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) were calculated using a fixed-effects model or random-effects model, and meta-analysis was subsequently performed using Stata.</p> </section> <section> <h3> Results</h3> <p>Thirty-one studies with a total of 4637 patients were included in this meta-analysis. When compared with CL, NOSES had significant advantages in several indicators, such as wound infection [OR = 0.22 (95% CI 0.13–0.38); <i>Z</i> = 5.56, <i>p</i> = 0], incisional hernia [OR = 0.24 (95% CI 0.11–0.54); <i>Z</i> = 3.44, <i>p</i> = 0.001], blood loss [WMD = −10.17 (95% CI −14.75 to −5.60); <i>Z</i> = 4.36, <i>p</i> = 0], incision length [WMD = −4.94 (95% CI −5.27 to −4.60); <i>Z</i> = 29.10, <i>p</i> = 0.00], postoperative pain [WMD = −1.43 (95% CI −1.69 to −1.18); <i>Z</i> = 11.02, <i>p</i> = 0.00], use of additional analgesics [OR = 0.57 (95% CI 0.39–0.82); <i>Z</i> = 3.06, <i>p</i> = 0.002], hospital stay [WMD = –1.25 (95% CI −1.58 to –0.93); <i>Z</i> = 7.65, <i>p</i> = 0.00], gastrointestinal recovery [WMD = −13.42 (95% CI −17.77 to −9.07); <i>Z</i> = 6.05, <i>p</i> = 0.00], first flatus [WMD = −0.50 (95% CI −0.68 to −0.32); <i>Z</i> = 5.34, <i>p</i> = 0.00] and cosmetic result [WMD = 2.11 (95% CI 0.92–3.30); <i>Z</i> = 3.47, <i>p</i> = 0.001]. However, NOSES required a significantly longer duration of surgery [WMD = 14.13 (95% CI 6.70–21.56); <i>Z</i> = 3.73, <i>p</i> = 0.00]. There were no significant differences in postoperative anastomotic leakage, intra-abdominal infection, lymph node harvest, proximal and distal margins, 5-year disease-free and 5-year overall survival and pelvic floor function.</p> </section> <section> <h3> Conclusion</h3> <p>NOSES is considered an efficient surgical method of treatment for CRC that allows patients to have long-term favourable oncological outcomes while recovering faster with minimal pain. However, these findings still require confirmation through studies on large population cohorts.</p> </section>
{"title":"Evaluation of the efficacy of natural orifice specimen extraction surgery versus conventional laparoscopic surgery for colorectal cancers: A systematic review and meta-analysis","authors":"Yu Cao,&nbsp;Mingze He,&nbsp;Zheng Liu,&nbsp;Kuo Chen,&nbsp;Khlusov Denis I,&nbsp;Jin Zhang,&nbsp;Jinqi Zou,&nbsp;Bagdan S. Semchenko,&nbsp;Sergey K. Efetov","doi":"10.1111/codi.17279","DOIUrl":"https://doi.org/10.1111/codi.17279","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Natural orifice specimen extraction surgery (NOSES) has gained significant importance in treating cancers. The current study is a meta-analysis that aimed to assess the short-term efficacy and long-term prognostic impact of NOSES and conventional laparoscopic (CL) surgery in the treatment of colorectal cancer (CRC).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Published reports in several medical databases up to February 2024 were searched and information pertinent to outcomes of NOSES and CL in retrospective and randomized studies to treat CRC was collected. Pooled weighted/standardized mean difference (WMD/SMD), odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) were calculated using a fixed-effects model or random-effects model, and meta-analysis was subsequently performed using Stata.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Thirty-one studies with a total of 4637 patients were included in this meta-analysis. When compared with CL, NOSES had significant advantages in several indicators, such as wound infection [OR = 0.22 (95% CI 0.13–0.38); &lt;i&gt;Z&lt;/i&gt; = 5.56, &lt;i&gt;p&lt;/i&gt; = 0], incisional hernia [OR = 0.24 (95% CI 0.11–0.54); &lt;i&gt;Z&lt;/i&gt; = 3.44, &lt;i&gt;p&lt;/i&gt; = 0.001], blood loss [WMD = −10.17 (95% CI −14.75 to −5.60); &lt;i&gt;Z&lt;/i&gt; = 4.36, &lt;i&gt;p&lt;/i&gt; = 0], incision length [WMD = −4.94 (95% CI −5.27 to −4.60); &lt;i&gt;Z&lt;/i&gt; = 29.10, &lt;i&gt;p&lt;/i&gt; = 0.00], postoperative pain [WMD = −1.43 (95% CI −1.69 to −1.18); &lt;i&gt;Z&lt;/i&gt; = 11.02, &lt;i&gt;p&lt;/i&gt; = 0.00], use of additional analgesics [OR = 0.57 (95% CI 0.39–0.82); &lt;i&gt;Z&lt;/i&gt; = 3.06, &lt;i&gt;p&lt;/i&gt; = 0.002], hospital stay [WMD = –1.25 (95% CI −1.58 to –0.93); &lt;i&gt;Z&lt;/i&gt; = 7.65, &lt;i&gt;p&lt;/i&gt; = 0.00], gastrointestinal recovery [WMD = −13.42 (95% CI −17.77 to −9.07); &lt;i&gt;Z&lt;/i&gt; = 6.05, &lt;i&gt;p&lt;/i&gt; = 0.00], first flatus [WMD = −0.50 (95% CI −0.68 to −0.32); &lt;i&gt;Z&lt;/i&gt; = 5.34, &lt;i&gt;p&lt;/i&gt; = 0.00] and cosmetic result [WMD = 2.11 (95% CI 0.92–3.30); &lt;i&gt;Z&lt;/i&gt; = 3.47, &lt;i&gt;p&lt;/i&gt; = 0.001]. However, NOSES required a significantly longer duration of surgery [WMD = 14.13 (95% CI 6.70–21.56); &lt;i&gt;Z&lt;/i&gt; = 3.73, &lt;i&gt;p&lt;/i&gt; = 0.00]. There were no significant differences in postoperative anastomotic leakage, intra-abdominal infection, lymph node harvest, proximal and distal margins, 5-year disease-free and 5-year overall survival and pelvic floor function.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;NOSES is considered an efficient surgical method of treatment for CRC that allows patients to have long-term favourable oncological outcomes while recovering faster with minimal pain. However, these findings still require confirmation through studies on large population cohorts.&lt;/p&gt;\u0000 &lt;/section&gt;","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redo Martius flap repair for pouch–vaginal fistula—A video vignette 重做马氏皮瓣修复袋阴道瘘-视频短片。
IF 2.9 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-06 DOI: 10.1111/codi.17285
Easan Anand, Shivani Joshi, Theo Pelly, Sanjay Dindyal, Kapil Sahnan, Phil Tozer
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引用次数: 0
Contemporary practices in abdominoperineal resection for early-stage rectal cancer in the United States 美国早期直肠癌腹会阴切除术的当代实践。
IF 2.9 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-02 DOI: 10.1111/codi.17281
Totadri Dhimal, Bailey K. Hilty Chu, Anthony Loria, Megan Boyer, Xueya Cai, Yue Li, Fernando Colugnati, Paula Cupertino, Erika E. Ramsdale, Fergal J. Fleming

Aim

In contrast to significant advances in organ preservation in locally advanced rectal cancer, the contemporary management of early-stage rectal cancer, including the frequency of abdominoperineal resections, remains largely unexplored in the United States. Therefore, we assessed the utilization of neoadjuvant therapy and oncological resections in early-stage rectal cancer patients.

Study design

This is a retrospective cohort study of patients with cT1–T3N0 rectal cancer who underwent proctectomies between 2016 and 2022 in the National Surgical Quality Improvement Project proctectomy files. Multivariable logistic regression was used to identify factors associated with abdominoperineal resections and Kendall's tau statistics to evaluate clinical-pathological staging agreement.

Results

In all, 3078 patients (29.6% cT1–2N0, 70.4% cT3N0) were included with 55.3% of tumours <5 cm from the anal verge. Overall, 58.2% received neoadjuvant therapy within 3 months of surgery (30.6% for cT1–T2N0 vs. 69.8% for cT3N0, P < 0.001), and 58.6% underwent abdominoperineal resection (55.5% for cT1–T2N0 vs. 59.9% for cT3N0, P = 0.058). The adjusted odds of undergoing abdominoperineal resection were associated with increasing age (OR 1.4 per every 10-year increase; 95% CI 1.2–1.5), cT3N0 tumours (OR 1.7; 95% CI 1.1–2.7) and tumour location <5 cm from the anal verge (OR 10.6; 95% CI 7.7–14.7). There was a weak clinical-pathological T staging correlation (Kendal tau coefficient 0.25; 95% CI 0.20–0.29).

Conclusion

In this large cohort of patients with early-stage rectal cancer with high rates of neoadjuvant therapy, over half of patients underwent abdominoperineal resection and one in five had a pathological complete response. These findings underscore opportunities for organ preservation in early-stage rectal cancer, suggesting that treatments typically reserved for locally advanced disease may extend to early stages with the completion of ongoing clinical trials.

目的:与局部晚期直肠癌器官保存的显著进展相比,早期直肠癌的当代管理,包括腹部-会阴切除术的频率,在美国仍未得到很大程度的探索。因此,我们评估了新辅助治疗和肿瘤切除术在早期直肠癌患者中的应用。研究设计:这是一项回顾性队列研究,研究对象为2016年至2022年间在国家外科质量改善项目中接受直肠切除术的cT1-T3N0直肠癌患者。采用多变量logistic回归来确定与腹部会阴切除术相关的因素,并使用Kendall tau统计来评估临床病理分期的一致性。结果:共纳入3078例患者(29.6%的cT1-2N0, 70.4%的cT3N0), 55.3%的肿瘤。结论:在这个新辅助治疗率高的早期直肠癌患者的大队列中,超过一半的患者接受了腹部会阴切除术,五分之一的患者病理完全缓解。这些发现强调了器官保存在早期直肠癌中的机会,表明通常用于局部晚期疾病的治疗可能随着正在进行的临床试验的完成而扩展到早期阶段。
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引用次数: 0
The ScotCap registry: An evaluation of 1000 colon capsule endoscopy procedures carried out in Scotland
IF 2.9 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-12-29 DOI: 10.1111/codi.17271
C. MacLeod, N. Rajapaksha, C. Brown, J. Hudson, Z. Asif, A. J. M. Watson, the ScotCap clinical leads

Aim

Colon capsule endoscopy (CCE) has been deployed in Scotland as an alternative to colonoscopy. The aim of this work was to report the outcomes of patients undergoing CCE in Scotland from the national CCE registry.

Method

Patients undergoing CCE in NHS Scotland between 1 August 2020 and 1 August 2021 were included in this study. Symptomatic and surveillance patients were vetted to undergo CCE by clinicians in four NHS Scotland health boards. Patient data were collected prospectively by an eHealth system managing CCE referral and report sign off. CCE procedural data were collected by a managed service carrying out CCE procedures. Data from both sources were compiled in the national CCE registry managed by Public Health Scotland.

Results

One thousand and eighty-seven patients were included in this study. The median age of patients was 60 years and 58.3% of patients were female. A haemoglobin(Hb) count was available for 657 (60.4%) patients and the mean value was 139 g/L. Faecal immunochemical test results were available for 762 (70.1%) patients, and of those with a test result 79.0% had a result ≥10 μgHb/g. The rates of complete test, adequate bowel preparation and successful test were 57.0%, 59.2% and 56.9%, respectively. Following CCE, no further test, colonoscopy, flexible sigmoidoscopy or gastroscopy were required for 42.0%, 34.1%, 22.7% and 2.6% of patients, respectively. Two (0.2%) patients experienced capsule retention with obstruction.

Conclusion

These are the first reported outcomes from the ScotCap registry; they demonstrate that CCE is a safe alternative to colonoscopy and a significant proportion of patients avoid colonoscopy when CCE is implemented nationally.

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{"title":"Laparoscopic subtotal colectomy with end ileostomy—A video vignette","authors":"Maaz Yusufi,&nbsp;Rasa Sadoughi,&nbsp;Andrew Wells,&nbsp;Najaf Siddiqi","doi":"10.1111/codi.17283","DOIUrl":"10.1111/codi.17283","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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{"title":"Local excision for organ preservation in low rectal cancer: Video technique and case report applying GRECCAR 2 and GRECCAR 12 trial principles—A video vignette","authors":"María Sánchez-Rodríguez,&nbsp;Chee Hoe Koo,&nbsp;Vincent Assenat,&nbsp;Marco-Olivier François,&nbsp;Patricia Tejedor,&nbsp;Quentin Denost","doi":"10.1111/codi.17284","DOIUrl":"10.1111/codi.17284","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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期刊
Colorectal Disease
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