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Need for orthodontic treatment and oral health-related quality of life in children and adolescents - A systematic review. 儿童和青少年对正畸治疗和口腔健康相关生活质量的需求-一项系统综述
IF 1.7 4区 医学 Q3 Dentistry Pub Date : 2024-02-29 DOI: 10.1922/CDH_00125Theodoridou09
M-Z Theodoridou, A Herclides, D Lamnisos

Objectives: To determine the relationship between the need for orthodontic treatment and OHRQoL in children and adolescents, and to identify potential modifying factors of this relationship.

Methods: Systematic review, starting with searches of PubMed, Scopus, and EBSCO Discovery Service. Observational studies which examined the relationship between the need for orthodontic treatment and OHRQoL, in children and adolescents, were considered eligible.

Results: Eighteen studies were included, of which, one was a prospective cohort study and 17 were cross-sectional. Twelve of 18 studies reported a relationship between the need for orthodontic treatment and OHRQoL, while the remainder failed to demonstrate a clear relationship. Gender and self-esteem were found to modify this relationship.

Conclusions: Need for orthodontic treatment is associated with OHRQoL in children and adolescents. Gender and self-esteem are potential effect modifiers of this relationship.

目的:探讨儿童青少年正畸治疗需求与OHRQoL之间的关系,并探讨影响这种关系的潜在因素。方法:系统回顾,从PubMed、Scopus和EBSCO检索服务开始。检查儿童和青少年正畸治疗需求与OHRQoL之间关系的观察性研究被认为是合格的。结果:纳入18项研究,其中1项为前瞻性队列研究,17项为横断面研究。18项研究中有12项报告了正畸治疗需求与OHRQoL之间的关系,而其余研究未能证明两者之间存在明确的关系。研究发现,性别和自尊会改变这种关系。结论:儿童和青少年正畸治疗需求与OHRQoL相关。性别和自尊是影响这种关系的潜在因素。
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引用次数: 0
Oral microbiome research - a call for equity and inclusion. 口腔微生物组研究--呼吁公平与包容。
IF 1.7 4区 医学 Q3 Dentistry Pub Date : 2024-02-29 DOI: 10.1922/CDH_IADR24JamiesonIntro02
L M Jamieson

Over 700 oral bacterial species have been identified in human populations, with ~200 bacterial species identified in any given individual mouth. The relationship between the oral microbiome and health is evidenced in many studies, with dysbiosis (a shift from a healthy to less healthy state of microbial community) associated with dental caries, periodontitis, halitosis and oral cancer. However, oral microbiome research to date has focused primarily on European populations, particularly those in large urban centres housing academic institutions with access to research funding. Key anthropological perspectives examining the sociocultural, epidemiological, genetic and environmental factors that influence the oral microbiome have also been Euro-centric. Very little is known about how the oral microbiome mediates both oral and general disease risks specifically within Indigenous and other vulnerable populations. Undertaking oral microbiome research in under-served communities requires consideration of many issues often unfamiliar in the broader research community, including being acceptable, relevant and of perceived benefit to the communities being studied. Research materials need to be managed respectfully in a culturally safe way, sharing/translating the knowledge obtained. These approaches will likely provide unique insights into the complex connections between environment and biology, people and place, and culture and science in relation to the oral microbiome. The ongoing development of oral microbiome research must facilitate frameworks that are equitable and inclusive to better enable clinical and scientific expertise within marginalised communities.

在人类群体中已发现 700 多种口腔细菌,在任何特定的口腔中都能发现约 200 种细菌。许多研究都证明了口腔微生物组与健康之间的关系,菌群失调(微生物群落从健康状态向不太健康状态的转变)与龋齿、牙周炎、口臭和口腔癌有关。然而,迄今为止,口腔微生物组的研究主要集中在欧洲人群,特别是那些居住在大型城市中心、拥有学术机构并能获得研究经费的人群。研究影响口腔微生物组的社会文化、流行病学、遗传和环境因素的主要人类学观点也是以欧洲为中心。对于口腔微生物组如何介导口腔疾病和一般疾病的风险,特别是在土著和其他弱势人群中,人们知之甚少。在服务不足的社区开展口腔微生物组研究,需要考虑更广泛的研究界通常不熟悉的许多问题,包括是否可接受、是否相关以及是否能使被研究的社区获益。需要以文化安全的方式尊重地管理研究材料,分享/翻译所获得的知识。这些方法可能会对口腔微生物组方面的环境与生物、人与地方、文化与科学之间的复杂联系提供独特的见解。口腔微生物组研究的持续发展必须促进公平和包容的框架,以更好地为边缘化社区提供临床和科学专业知识。
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引用次数: 0
Oral microbiome research - working in partnership with Indigenous Australian communities. 口腔微生物组研究--与澳大利亚土著社区合作。
IF 1.7 4区 医学 Q3 Dentistry Pub Date : 2024-02-29 DOI: 10.1922/CDH_IADR24Hedges03
J Hedges, L M Jamieson

Microbiome research is currently biased towards populations of European descent, with such populations providing a weak basis upon which to understand microbiome-health relationships in under-studied populations, many of whom carry the highest burdens of disease. Most oral microbiome studies to date have been undertaken in industrialized countries. Research involving marginalised populations should be shaped by a number of guiding principles. In the Indigenous Australian context, one useful framework is the Consolidated Criteria for Strengthening Reporting of Health Research involving Indigenous Peoples (CONSIDER) statement. This paper describes how the microbiome research field is having impacts in the Indigenous Australian health space, and describes a particular project involving Indigenous Australians in which the CONSIDER statement is used as the underlying framework.

微生物组研究目前偏重于欧洲后裔人群,这些人群为了解研究不足人群的微生物组与健康之间的关系提供了薄弱的基础,而这些人群中许多人的疾病负担最高。迄今为止,大多数口腔微生物组研究都是在工业化国家进行的。涉及边缘化人群的研究应遵循一系列指导原则。在澳大利亚原住民背景下,一个有用的框架是《加强涉及原住民健康研究报告的综合标准》(CONSIDER)声明。本文介绍了微生物组研究领域如何对澳大利亚土著人的健康领域产生影响,并介绍了一个以 CONSIDER 声明为基本框架、涉及澳大利亚土著人的特定项目。
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引用次数: 0
Powered toothbrushes and toothbrushing resistance in young children: a qualitative content analysis of an online parenting forum. 电动牙刷与幼儿抗拒刷牙:对在线育儿论坛的定性内容分析。
IF 1.7 4区 医学 Q3 Dentistry Pub Date : 2024-02-29 DOI: 10.1922/CDH_00180Kettle05
J Kettle, Z Marshman

Background: Powered toothbrushes are an effective alternative to manual toothbrushes. Previous research found parents view powered toothbrushes as fun and motivating, although are less confident using them when children demonstrate resistant behaviour. Resistant child behaviour is a recognised barrier to achieving parental supervised brushing. Parents discuss strategies to address toothbrushing resistance on online parenting forums.

Objective: To explore how those posting on an online parenting forum discuss powered toothbrushes as a potential solution to toothbrushing resistance in young children.

Design: Qualitative content analysis of threads retrieved from the UK parenting forum Mumsnet.

Results: The Mumsnet sub-forums 'Behaviour/Development', 'Parenting' and 'Children's Health' were searched in April 2022. 204 relevant threads on toothbrushing resistance were identified and analysed. A further search of these threads identified posts on powered toothbrushes, yielding a sub-sample of 245 posts from 111 threads (of which 97 focused on resistant behaviour from a child/children aged under three). A coding frame was developed and included six categories: use of powered toothbrushes, descriptions of toothbrushes, positive aspects, reasons for not using, approaches to using, and discussions on Mumsnet. Posters suggested powered toothbrushes as a solution to toothbrushing resistance. Posters use Mumsnet to discuss the appropriateness of powered toothbrushes for young children.

Conclusions: Powered toothbrushes offer a potential solution to toothbrushing resistance. Discussions on parenting forums can normalise the use of powered toothbrushes with under-threes. Further research on how parents and dental professionals use and recommend using powered toothbrushes with under-threes would be useful.

背景:电动牙刷是手动牙刷的有效替代品:电动牙刷是手动牙刷的有效替代品。先前的研究发现,家长们认为电动牙刷既有趣又有激励作用,但当儿童表现出抗拒行为时,家长们就没有信心使用电动牙刷了。儿童的抗拒行为是实现家长监督刷牙的公认障碍。家长们在网上育儿论坛上讨论解决抗拒刷牙问题的策略:目的:探讨在在线育儿论坛上发帖的家长如何讨论电动牙刷作为解决幼儿抗拒刷牙的潜在方法:设计:对英国育儿论坛 Mumsnet 上的主题进行定性内容分析:2022 年 4 月,对 Mumsnet 的 "行为/发展"、"育儿 "和 "儿童健康 "分论坛进行了搜索。确定并分析了 204 个关于抗拒刷牙的相关主题。对这些主题的进一步搜索确定了有关电动牙刷的帖子,并从 111 个主题中产生了 245 个帖子的子样本(其中 97 个帖子关注的是儿童/三岁以下儿童的抗拒行为)。我们制定了一个编码框架,包括六个类别:电动牙刷的使用、牙刷的描述、积极的方面、不使用的原因、使用的方法以及在 Mumsnet 上的讨论。海报建议使用电动牙刷来解决抗拒刷牙的问题。发帖人利用 Mumsnet 讨论电动牙刷是否适合幼儿使用:结论:电动牙刷是解决抗拒刷牙问题的潜在方法。育儿论坛上的讨论可以使三岁以下儿童使用电动牙刷正常化。进一步研究家长和牙科专业人员如何使用电动牙刷以及如何建议三岁以下儿童使用电动牙刷将非常有用。
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引用次数: 0
The association between edentulism and progress of multimorbidity over 12 years among older American adults. 在美国老年人中,12 年中牙齿缺失与多病进展之间的关系。
IF 1.7 4区 医学 Q3 Dentistry Pub Date : 2024-02-29 DOI: 10.1922/CDH_00150Mira05
R Mira, J T Newton, W Sabbah

Objectives: To examine the relationship between edentulism and the progress of multimorbidity, and the role of nutritional intake and behaviours among older Americans.

Methods: We used 7 waves (2006-2018) of the Health and Retirement Study, a longitudinal survey of older Americans (number included in analysis 2,224). Edentulism was assessed in 2006 and 2012. Multimorbidity was indicated by 5 self-reported conditions: diabetes, heart conditions, lung diseases, cancer, and stroke. Behavioural factors were smoking, excessive alcohol consumption, physical activity, and body mass index. Nutritional intake was calculated by summing 10 nutrients (Protein, Vitamins C, D, B12, E, Calcium, Zinc, Polyunsaturated fatty acids, Folate and ß- carotene). Multilevel models for analysis of longitudinal data were used to assess the association between change in repeated measures of multimorbidity (between 2006 and 2018) and edentulism (2006) adjusting for nutritional intake, behavioural and socioeconomic factors.

Results: Participants who were edentate in 2006 and 2012 had higher rate-ratios (RR) for change in multimorbidity between 2006 to 2018 (RR: 1.29 and 1.28, respectively). After adjusting for socioeconomic factors, total nutrients and behavioural factors, these RR attenuated to 1.12 (95%CI: 1.06, 1.18) and 1.10 (95%CI: 1.05, 1.16), respectively. Total nutrition was negatively associated with progress of multimorbidity, but after adjusting for socioeconomic and behavioural factors the association became insignificant. Total nutrients rates in 2013 were significantly lower among those who were edentate in 2006 and 2012.

Conclusion: There was a longitudinal association between edentulism and progress of multimorbidity. The relationship appeared to be mediated be behaviours and nutrition.

目的:研究美国老年人中牙齿缺失与多病进展之间的关系,以及营养摄入和行为的作用:研究美国老年人牙齿缺失与多病进展之间的关系,以及营养摄入和行为的作用:我们使用了美国老年人纵向调查 "健康与退休研究 "的 7 个波次(2006-2018 年)(纳入分析的人数为 2,224 人)。2006年和2012年评估了蛀牙情况。多病症由 5 种自我报告的疾病表示:糖尿病、心脏病、肺病、癌症和中风。行为因素包括吸烟、过度饮酒、体力活动和体重指数。营养摄入量由 10 种营养素(蛋白质、维生素 C、D、B12、E、钙、锌、多不饱和脂肪酸、叶酸和 ß 胡萝卜素)的总和计算得出。采用多层次模型分析纵向数据,以评估重复测量的多病症(2006 年至 2018 年)与无牙齿症(2006 年)之间的关联,并对营养摄入、行为和社会经济因素进行调整:2006年和2012年无牙齿的参与者在2006年至2018年期间的多病症变化率(RR)较高(RR:分别为1.29和1.28)。在对社会经济因素、总营养素和行为因素进行调整后,这些比率分别降至 1.12(95%CI:1.06,1.18)和 1.10(95%CI:1.05,1.16)。总营养与多病进展呈负相关,但在对社会经济和行为因素进行调整后,这种关联变得不显著。在2006年和2012年无食的人群中,2013年的总营养率明显较低:结论:牙齿脱落与多病进展之间存在纵向联系。这种关系似乎以行为和营养为中介。
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引用次数: 0
Planning the future of oral health care workforce: Moving beyond demographic change. 规划口腔医疗队伍的未来:超越人口变化。
IF 1.7 4区 医学 Q3 Dentistry Pub Date : 2024-02-29 DOI: 10.1922/CDH_00145Birch05
S Birch, L Nguyen

The adoption of Universal Health Coverage for oral health care will not be sufficient to ensure that health care resources are accessible in accordance with needs for care. Government intervention in planning and allocating resources will be required to replace traditional market forces if market failure is not to be replaced by government failure. In this paper we explore the limitations of current 'fixed in time' approaches to planning the oral health care workforce and present an enhanced dynamic model for workforce planning that responds directly to changes in population, evidence-based best practice and new models of care.

对口腔保健采取全民医保不足以确保根据保健需求获得保健资源。如果市场失灵不被政府失灵所取代,就需要政府干预资源的规划和分配,以取代传统的市场力量。在本文中,我们探讨了当前 "固定时间 "口腔医疗队伍规划方法的局限性,并提出了一个强化的动态队伍规划模型,以直接应对人口变化、循证最佳实践和新的医疗模式。
{"title":"Planning the future of oral health care workforce: Moving beyond demographic change.","authors":"S Birch, L Nguyen","doi":"10.1922/CDH_00145Birch05","DOIUrl":"10.1922/CDH_00145Birch05","url":null,"abstract":"<p><p>The adoption of Universal Health Coverage for oral health care will not be sufficient to ensure that health care resources are accessible in accordance with needs for care. Government intervention in planning and allocating resources will be required to replace traditional market forces if market failure is not to be replaced by government failure. In this paper we explore the limitations of current 'fixed in time' approaches to planning the oral health care workforce and present an enhanced dynamic model for workforce planning that responds directly to changes in population, evidence-based best practice and new models of care.</p>","PeriodicalId":10647,"journal":{"name":"Community dental health","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138798721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXtraction or PREServation? EXPRESS survey of patients' preference for toothache in public health facilities of Eastern India. 提取还是保存?EXPRESS调查了东印度公共卫生机构患者对牙痛的偏好。
IF 1.7 4区 医学 Q3 Dentistry Pub Date : 2024-02-29 DOI: 10.1922/CDH_00085Narayanan07
S P Narayanan, S Mahapatra, H Rath, N N Nagarajan, M Mahakur

Objective: To investigate patients' preference for extraction or preservation for toothache and hypothetical anterior tooth pain along with the specific reason for their choice.

Basic research design: Cross-sectional analytical semi-structured interview study.

Participants: A sample of 703 adult dental outpatients visiting secondary and tertiary government health centres with toothache due to dental caries in Eastern India.

Main outcome measures: Patients preferring restorative or extraction services for toothache, specific reason, and socio-demographic background factors for anterior and posterior teeth.

Results: Half (50.1%) choose preservation for present toothache and 79.9% for hypothetical front tooth pain. Immediate relief from toothache for extraction and the motive to preserve natural teeth for preservation were the main reasons expressed. In logistic regression, participants preferring extraction were more likely to be aged 25-34 years (OR = 1.94), 55+ years (OR=33.32), have primary and below education level (OR=1.99), have had a previous extraction (OR=1.99) and be unaware of preservation options (OR=2.34). For assumed anterior tooth pain, those between 25-34 years (OR=0.39) were more likely to choose preservation. Participants with primary and below education levels (OR=1.99) and unaware of preservation options (OR=1.95) chose extraction of the front tooth irrespective of their choice of treatment for the present toothache.

Conclusion: Notable differences between the choices to preserve or extract a posterior tooth were not found. There was greater preference towards preserving anterior teeth. Future research should identify additional barriers to the preference and utilization of restorative services.

目的:探讨牙痛和假性前牙疼痛患者对拔除或保留牙体的选择及具体原因。基础研究设计:横断面分析半结构化访谈研究。参与者:在印度东部,703名因龋齿而牙痛的成人牙科门诊患者前往二级和三级政府保健中心就诊。主要结果测量:患者因牙痛倾向于修复或拔牙服务,具体原因,前牙和后牙的社会人口背景因素。结果:半数(50.1%)的患者因现时牙痛选择保存,79.9%的患者因假性前牙疼痛选择保存。拔牙的主要原因是为了立即缓解牙痛和保存天然牙齿。在logistic回归中,倾向于拔牙的参与者更有可能是25-34岁(OR= 1.94), 55岁以上(OR=33.32),小学及以下教育水平(OR=1.99),之前有过拔牙(OR=1.99),不知道保存选项(OR=2.34)。对于假定的前牙疼痛,25-34岁(OR=0.39)的患者更有可能选择保留。小学及以下教育水平的参与者(OR=1.99)和不知道保存方法的参与者(OR=1.95)选择拔除门牙,而不考虑他们目前牙痛的治疗选择。结论:保留后牙与拔除后牙的选择差异无统计学意义。更倾向于保留前牙。未来的研究应确定对偏好和利用恢复性服务的其他障碍。
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引用次数: 0
Lessons Learned from Contact Tracing COVID-19 cases in Dental Settings in East Scotland. 从种族资本主义的角度批判性地理解口腔微生物组研究中的包容性。
IF 0.9 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-02-29 DOI: 10.1922/CDH_00183McGoldrick06
N Mc Goldrick, E O'Keefe

Introduction: Dental settings were considered high risk settings for COVID-19. A Dental Public Health Team in East Scotland worked to risk assess each situation timeously to break chains of transmission.

Aim: To present learning from routine data collected from contact tracing COVID-19 cases in the dental setting.

Design: Retrospective analysis of a routine data set of COVID-19 cases associated with a dental setting reported via the national contact tracing system for two health board areas in the East of Scotland.

Methods: Descriptive statistics summarise the data collected over a 13-month period (Oct 2020-Dec 2021) during which all included COVID-19 cases were confirmed by PCR. A narrative presents output from contact tracing of all cases and includes themes identified during contact tracing that led to transmission within a dental setting. A case study illustrates impact of transmission.

Results: 752 cases are included. No evidence of staff to patient transmission or vice versa was found in this study. Staff to staff transmission occurred in non-clinical areas contributing to 33% of total staff cases with the remainder assessed to result from community transmission.

Conclusion: Transmission of COVID-19 in a dental setting, in the context of this study, appears to be confined to non-clinical areas with the majority of staff cases resulting from community transmission. Future pandemic plans should include tools to aid with implementation of guidance in non-clinical areas.

人们强烈呼吁在口腔微生物组研究中更多地纳入土著和种族化社区。本文利用种族资本主义的概念(殖民主义榨取性的延续)来批判性地审视这一纳入议程。种族资本主义明确地将资本主义剥削与更广泛的社会压迫(如种族主义、性别歧视、能力歧视)联系在一起。它不仅局限于商业领域,而且充斥着包括大学在内的白人机构。通过种族资本主义的视角,我们发现包容性议程允许白人机构从种族关系中获取社会和经济价值。具有种族包容性的研究被视为一种社会公益,因此能够吸引资金。研究开发的知识和治疗方法为大学和制药公司创造了巨大价值,但对社区本身的益处却十分有限。此外,微生物组的研究往往偏离了将其视为由社会(包括种族主义)塑造的概念,而将其视为由基因和生物学决定的概念。这种将问题置于种族化身体中的做法强化了种族压迫,并使公司进一步从种族性中获利。纳入口腔微生物组研究必须考虑减轻种族资本主义的方法。研究人员可以通过使用反种族主义实践框架来减少榨取。这包括与社区合作,共同设计研究,创造更安全的空间,赋予边缘化社区制定议程和框架的权力,通过可获取的知识发布、开放式出版物和开放式健康技术分享研究知识和治疗方法。最重要的是,包容议程绝不能取代更深层次的反压迫社会改革,这是解决健康不平等问题和创造有意义的包容所必需的。
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引用次数: 0
Capacity and needs assessment of the implementation of the toddler oral health intervention at well-baby clinics. 在健康婴儿诊所实施幼儿口腔健康干预的能力和需求评估。
IF 1.7 4区 医学 Q3 Dentistry Pub Date : 2024-02-29 DOI: 10.1922/CDH_00116Grift07
B Grift, K Jerković-Ćosić, J Bruers

Objective: To conduct a capacity and needs assessment identifying important factors for the successful implementation of an oral health coach (OHC) at well-baby clinics. This Toddler Oral Health Intervention (TOHI) provides oral health promotion to parents to prevent early childhood caries.

Methods: A two-round Delphi study was conducted with an expert panel consisting of OHCs and paediatric staff. The survey was based on the Consolidated Framework for Implementation Research (CFIR), consisting of 39 constructs divided over 5 domains: intervention characteristics (8), inner setting (14), outer setting (4), characteristics of individuals (5) and the process of implementation (8).

Results: Constructs relating to the inner setting, outer setting and implementation process were identified as essential. Availability of resources, information on how to execute or facilitate the intervention, and the integration of the intervention into existing work tasks were also essential. Alignment and partnership between OHCs and paediatric staff, along with the prioritization of parents' and children's needs were emphasized. A formally appointed internal implementation leader within each organization, capable of transferring their enthusiasm to the team, and regular meetings for progress and experience sharing were considered essential.

Conclusion: Specific strategies are needed in the implementation phase to increase the adoption, implementation and maintenance of the TOHI, ultimately leading to improved oral health in children. This study provides valuable insights into important factors for implementation of an oral health intervention in a public health setting.

目的进行能力和需求评估,确定在婴儿健康诊所成功实施口腔健康指导(OHC)的重要因素。这种幼儿口腔健康干预(TOHI)为父母提供口腔健康宣传,以预防幼儿龋齿:方法:由口腔健康指导员和儿科工作人员组成的专家小组进行了两轮德尔菲研究。调查以实施研究综合框架(CFIR)为基础,包括 5 个领域的 39 个构造:干预特点(8 个)、内部环境(14 个)、外部环境(4 个)、个人特点(5 个)和实施过程(8 个):结果:与内部环境、外部环境和实施过程有关的结构被认为是必不可少的。资源的可用性、关于如何执行或促进干预措施的信息以及将干预措施纳入现有工作任务也是至关重要的。此外,还强调了老年保健中心与儿科工作人员之间的协调与合作,以及优先考虑家长和儿童的需求。每个机构都必须正式任命一名内部执行领导,将他们的热情传递给团队,并定期召开会议,交流进展和经验:结论:在实施阶段需要具体的策略,以提高 TOHI 的采用、实施和维护,最终改善儿童的口腔健康。这项研究为在公共卫生环境中实施口腔健康干预措施的重要因素提供了宝贵的见解。
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引用次数: 0
Commercializing equitable, accessible oral microbiome transplantation therapy. 将公平、方便的口腔微生物组移植疗法商业化。
IF 1.7 4区 医学 Q3 Dentistry Pub Date : 2024-02-29 DOI: 10.1922/CDH_IADR24Weyrich06
L S Weyrich, S Nath, L M Jamieson

Chronic oral diseases, such as caries and periodontal disease, may, in future, be treated by oral microbiome transplant (OMT) technology. OMT therapy would involve collecting a donor oral microbiome and transplanting into a recipient to either prevent or treat oral diseases linked to a change (i.e., dysbiosis) in the oral microbiome. Given the great promise of this technology, we must consider the ethical and practical implications of how it is developed to maximise its accessibility and affordability. Here, we examine ways that OMT technology might be commercialized in the context of equity and accessibility in both clinical or do-it-yourself settings. We do this while assuming that the technology can be developed for humans in ways that are safe and effective at the individual and population-levels. We highlight the need for OMT therapy to be 1) cost-effective, 2) understood by end users and clinicians, 3) easy to access even in rural or remote communities, and 4) providing donors equitable compensation for their microbiomes. These key elements will only be achieved through partnerships between scientists, clinicians, investors and stakeholders throughout development. Therefore, proper acknowledgement and equitable evaluation of contributions in this team will also be critical to ensuring that this technology can be globally accessed. While OMT is likely to reshape how we prevent or treat oral disease, consciously guiding its development toward equity and accessibility to all people may significantly aid in improving health for those without access to dental care.

龋齿和牙周病等慢性口腔疾病将来可能通过口腔微生物组移植(OMT)技术来治疗。口腔微生物组移植疗法涉及收集供体的口腔微生物组,然后移植到受体体内,以预防或治疗与口腔微生物组变化(即菌群失调)有关的口腔疾病。鉴于这项技术的巨大前景,我们必须考虑如何开发这项技术的伦理和实际影响,以最大限度地提高其可获得性和可负担性。在此,我们将从公平和可及性的角度出发,研究如何在临床或 DIY 环境中将 OMT 技术商业化。我们这样做的前提是,该技术能够以在个人和群体层面安全有效的方式为人类开发。我们强调 OMT 疗法需要:1)具有成本效益;2)为最终用户和临床医生所理解;3)即使在农村或偏远社区也很容易获得;4)为捐献者的微生物组提供公平的补偿。这些关键要素只有通过科学家、临床医生、投资者和利益相关者在整个开发过程中的合作才能实现。因此,适当承认和公平评估该团队的贡献对于确保这项技术能够在全球范围内使用也至关重要。虽然口腔治疗技术可能会重塑我们预防或治疗口腔疾病的方式,但有意识地引导该技术的发展,使其面向所有人的公平性和可及性,可能会大大有助于改善那些无法获得牙科治疗的人的健康状况。
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引用次数: 0
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