首页 > 最新文献

Contraception: X最新文献

英文 中文
Breaking the silence in the primary care office: patients' attitudes toward discussing abortion during contraceptive counseling 打破初级保健办公室的沉默:患者对避孕咨询中讨论堕胎的态度
Q2 Medicine Pub Date : 2020-01-01 DOI: 10.1016/j.conx.2020.100029
Shokoufeh Dianat , Ilana A Silverstein , Kelsey Holt , Jody Steinauer , Christine Dehlendorf

Objectives

Abortions are common health experiences in the United States, yet they are siloed from mainstream health care. To provide guidance on how clinicians could break down these silos, normalize conversations about abortion, and potentially improve patient experience and contraceptive decision-making, we sought to understand patient attitudes regarding discussing abortion during contraceptive counseling.

Study design

In 2018, we completed in-depth semi-structured interviews with reproductive-aged women recruited from primary care clinics of two politically disparate regions within California. We elicited acceptability, preferences, and implications of clinicians mentioning abortion during contraceptive counseling. Using directed content analysis, we coded transcripts for inductive and deductive themes.

Results

We achieved thematic saturation after 49 interviews. Interviewees were diverse in reproductive history, race/ethnicity, religiosity, and abortion attitudes. Participants with diverse attitudes about abortion reported that having abortion mentioned during contraceptive counseling was generally viewed as acceptable, and even helpful, when delivered in a non-directive manner focused on information provision. For some patients, mentioning abortion may reduce abortion stigma and help contraceptive decision-making. Careful attention to a non-judgmental communication style is critical to safeguard against potential contraceptive coercion.

Conclusions

Discussing abortion during contraceptive counseling was acceptable among this diverse population, and our findings suggest ways to best structure such counseling. Coupled with research on clinician perspectives, our findings can inform development of patient-centered contraceptive counseling approaches that integrate abortion in an attempt to facilitate patient care and reduce stigma.

Implications

Mentioning abortion during contraceptive counseling can be acceptable, and even helpful, to patients when delivered in a non-directive manner focused on information provision, even among patients who believed abortion should be illegal in all or most cases. For some patients, mentioning abortion may reduce abortion stigma and help contraceptive decision-making.

在美国,堕胎是一种常见的健康经历,但却被主流医疗保健所孤立。为了指导临床医生如何打破这些孤岛,使堕胎对话正常化,并潜在地改善患者体验和避孕决策,我们试图了解患者在避孕咨询期间对讨论堕胎的态度。研究设计2018年,我们完成了对从加州两个政治不同地区的初级保健诊所招募的育龄妇女的深度半结构化访谈。我们引出了可接受性,偏好,和临床医生提及流产在避孕咨询的含义。使用定向内容分析,我们为归纳和演绎主题编码文本。结果49次访谈达到主题饱和。受访者的生育史、种族/民族、宗教信仰和堕胎态度各不相同。对堕胎持不同态度的参与者报告说,在避孕咨询中提到堕胎通常被认为是可以接受的,甚至是有帮助的,如果以非指示的方式侧重于提供信息。对一些患者来说,提及堕胎可能会减少堕胎的耻辱感,并有助于避孕决策。注意非评判性的沟通方式对于防止潜在的强制避孕至关重要。结论在这一多样化的人群中,在避孕咨询中讨论堕胎是可以接受的,我们的研究结果为最好地组织这种咨询提供了方法。结合对临床医生观点的研究,我们的发现可以为以患者为中心的避孕咨询方法的发展提供信息,这些方法将流产整合在一起,试图促进患者护理并减少耻辱感。在避孕咨询中提及堕胎是可以接受的,甚至是有帮助的,如果以非指示的方式提供信息,即使是那些认为堕胎在所有或大多数情况下都是非法的患者。对一些患者来说,提及堕胎可能会减少堕胎的耻辱感,并有助于避孕决策。
{"title":"Breaking the silence in the primary care office: patients' attitudes toward discussing abortion during contraceptive counseling","authors":"Shokoufeh Dianat ,&nbsp;Ilana A Silverstein ,&nbsp;Kelsey Holt ,&nbsp;Jody Steinauer ,&nbsp;Christine Dehlendorf","doi":"10.1016/j.conx.2020.100029","DOIUrl":"10.1016/j.conx.2020.100029","url":null,"abstract":"<div><h3>Objectives</h3><p>Abortions are common health experiences in the United States, yet they are siloed from mainstream health care. To provide guidance on how clinicians could break down these silos, normalize conversations about abortion, and potentially improve patient experience and contraceptive decision-making, we sought to understand patient attitudes regarding discussing abortion during contraceptive counseling.</p></div><div><h3>Study design</h3><p>In 2018, we completed in-depth semi-structured interviews with reproductive-aged women recruited from primary care clinics of two politically disparate regions within California. We elicited acceptability, preferences, and implications of clinicians mentioning abortion during contraceptive counseling. Using directed content analysis, we coded transcripts for inductive and deductive themes.</p></div><div><h3>Results</h3><p>We achieved thematic saturation after 49 interviews. Interviewees were diverse in reproductive history, race/ethnicity, religiosity, and abortion attitudes. Participants with diverse attitudes about abortion reported that having abortion mentioned during contraceptive counseling was generally viewed as acceptable, and even helpful, when delivered in a non-directive manner focused on information provision. For some patients, mentioning abortion may reduce abortion stigma and help contraceptive decision-making. Careful attention to a non-judgmental communication style is critical to safeguard against potential contraceptive coercion.</p></div><div><h3>Conclusions</h3><p>Discussing abortion during contraceptive counseling was acceptable among this diverse population, and our findings suggest ways to best structure such counseling. Coupled with research on clinician perspectives, our findings can inform development of patient-centered contraceptive counseling approaches that integrate abortion in an attempt to facilitate patient care and reduce stigma.</p></div><div><h3>Implications</h3><p>Mentioning abortion during contraceptive counseling can be acceptable, and even helpful, to patients when delivered in a non-directive manner focused on information provision, even among patients who believed abortion should be illegal in all or most cases. For some patients, mentioning abortion may reduce abortion stigma and help contraceptive decision-making.</p></div>","PeriodicalId":10655,"journal":{"name":"Contraception: X","volume":"2 ","pages":"Article 100029"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.conx.2020.100029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38165155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Unsatisfied contraceptive preferences due to cost among women in the United States 不满意的避孕选择在美国妇女中由于成本
Q2 Medicine Pub Date : 2020-01-01 DOI: 10.1016/j.conx.2020.100032
Kristen Lagasse Burke , Joseph E. Potter , Kari White

Objectives

To examine prevalence and characteristics associated with cost barriers to preferred contraceptive use.

Study design

Among a nationally representative sample of women at risk of unplanned pregnancy in 2015–2017, we used Poisson regression to assess characteristics associated preferring a(nother) method in the absence of cost.

Results

Overall, 22% preferred to use a(nother) method. Women using less-effective methods, who were Black or Hispanic, ages 15–24 and had low incomes, were more likely to report cost barriers.

Conclusions

Using a preferred method is an indicator of access to care and reproductive autonomy. These results provide a benchmark to track the impact of policy changes.

目的探讨首选避孕药具使用成本障碍的患病率和特点。研究设计在2015-2017年具有全国代表性的有意外怀孕风险的女性样本中,我们使用泊松回归来评估在没有成本的情况下偏好(另一种)方法的相关特征。结果总体而言,22%的人倾向于使用另一种方法。使用效果较差的方法的女性,年龄在15-24岁、收入较低的黑人或西班牙裔女性,更有可能报告成本障碍。结论择优避孕是获得护理和生殖自主的一个指标。这些结果为跟踪政策变化的影响提供了一个基准。
{"title":"Unsatisfied contraceptive preferences due to cost among women in the United States","authors":"Kristen Lagasse Burke ,&nbsp;Joseph E. Potter ,&nbsp;Kari White","doi":"10.1016/j.conx.2020.100032","DOIUrl":"10.1016/j.conx.2020.100032","url":null,"abstract":"<div><h3>Objectives</h3><p>To examine prevalence and characteristics associated with cost barriers to preferred contraceptive use.</p></div><div><h3>Study design</h3><p>Among a nationally representative sample of women at risk of unplanned pregnancy in 2015–2017, we used Poisson regression to assess characteristics associated preferring a(nother) method in the absence of cost.</p></div><div><h3>Results</h3><p>Overall, 22% preferred to use a(nother) method. Women using less-effective methods, who were Black or Hispanic, ages 15–24 and had low incomes, were more likely to report cost barriers.</p></div><div><h3>Conclusions</h3><p>Using a preferred method is an indicator of access to care and reproductive autonomy. These results provide a benchmark to track the impact of policy changes.</p></div>","PeriodicalId":10655,"journal":{"name":"Contraception: X","volume":"2 ","pages":"Article 100032"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.conx.2020.100032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38204025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Health insurance coverage and contraceptive use at the state level: findings from the 2017 Behavioral Risk Factor Surveillance System 州一级的医疗保险覆盖率和避孕药具使用:2017年行为风险因素监测系统的调查结果
Q2 Medicine Pub Date : 2020-01-01 DOI: 10.1016/j.conx.2019.100014
Megan L. Kavanaugh, Ayana Douglas-Hall, Sean M. Finn

Objective

To examine associations between health insurance coverage, income level and contraceptive use — overall and most/moderately effective method use — among women ages 18–44 at risk of pregnancy, within and across 41 United States jurisdictions in 2017.

Study design

Using data from the 2017 Behavioral Risk Factor Surveillance System, we calculated the proportions of women using any contraceptive method and using a most or moderately effective method for each state/territory and across all jurisdictions, categorized by health insurance coverage and income groups. For both contraceptive use outcomes, we ran simple and multivariable logistic regression models to test for significant differences in outcomes between insured and uninsured individuals.

Results

Across jurisdictions, compared to uninsured women, those who had health care coverage had higher levels of contraceptive use (65% versus 59%; p < .001) and most/moderately effective contraceptive use (43% compared to 35%; p < .001); low-income women with coverage also had higher levels of contraceptive use (64% versus 61%; p < .05) and most or moderately effective contraceptive use (42% versus 36%; p < .01) than their uninsured counterparts. Controlling for individual-level demographic characteristics, health insurance coverage was associated with increased odds of most or moderately effective contraceptive use across jurisdictions (adjusted odds ratio = 1.33, p < .01). In 11 states, insured women had significantly higher odds of at least one contraceptive use metric than their uninsured counterparts.

Conclusions

Variation in contraceptive use across the states likely reflects broader demographic, social and structural differences across state and local populations. States' political will and support around contraceptive access likely play a role in individuals' ability to obtain and use contraception.

Implications

Our key finding that insurance coverage is significantly associated with use of most/moderately effective contraceptive methods across the states but not any contraceptive use underscores the importance of health insurance in aiding access to methods that are more costly and often require a visit to a health care provider.

目的研究2017年美国41个司法管辖区内18-44岁有怀孕风险的妇女的健康保险覆盖率、收入水平和避孕药具使用(总体和最有效/中等有效的方法使用)之间的关系。研究设计使用2017年行为风险因素监测系统的数据,我们计算了每个州/地区和所有司法管辖区使用任何避孕方法并使用最有效或中等有效方法的女性比例,并按健康保险覆盖范围和收入群体进行了分类。对于这两种避孕措施的使用结果,我们运行了简单和多变量逻辑回归模型来检验参保和未参保个体之间的结果是否存在显著差异。结果在各个司法管辖区,与没有保险的妇女相比,有医疗保险的妇女使用避孕药具的水平更高(65%对59%;P < .001)和最有效/中等有效的避孕措施使用(43%对35%;p & lt; 措施);低收入妇女的避孕药具使用率也较高(64%对61%;P < .05)和最有效或中等有效的避孕措施使用(42%对36%;P < .01)。在控制了个人层面的人口统计学特征后,健康保险覆盖率与各司法管辖区使用最有效或中等有效避孕措施的几率增加相关(调整后的优势比 = 1.33,p < .01)。在11个州,有保险的妇女使用至少一种避孕措施的几率明显高于没有保险的妇女。结论:各州避孕药具使用的差异可能反映了州和地方人口在人口、社会和结构上的广泛差异。各国在获取避孕药具方面的政治意愿和支持可能在个人获得和使用避孕药具的能力方面发挥作用。含义我们的关键发现是,保险覆盖率与各州使用最有效/中等有效的避孕方法显著相关,但与任何避孕方法的使用无关,这突显了健康保险在帮助获得费用较高且往往需要前往保健提供者处就诊的方法方面的重要性。
{"title":"Health insurance coverage and contraceptive use at the state level: findings from the 2017 Behavioral Risk Factor Surveillance System","authors":"Megan L. Kavanaugh,&nbsp;Ayana Douglas-Hall,&nbsp;Sean M. Finn","doi":"10.1016/j.conx.2019.100014","DOIUrl":"10.1016/j.conx.2019.100014","url":null,"abstract":"<div><h3>Objective</h3><p>To examine associations between health insurance coverage, income level and contraceptive use — overall and most/moderately effective method use — among women ages 18–44 at risk of pregnancy, within and across 41 United States jurisdictions in 2017.</p></div><div><h3>Study design</h3><p>Using data from the 2017 Behavioral Risk Factor Surveillance System, we calculated the proportions of women using any contraceptive method and using a most or moderately effective method for each state/territory and across all jurisdictions, categorized by health insurance coverage and income groups. For both contraceptive use outcomes, we ran simple and multivariable logistic regression models to test for significant differences in outcomes between insured and uninsured individuals.</p></div><div><h3>Results</h3><p>Across jurisdictions, compared to uninsured women, those who had health care coverage had higher levels of contraceptive use (65% versus 59%; p &lt; .001) and most/moderately effective contraceptive use (43% compared to 35%; p &lt; .001); low-income women with coverage also had higher levels of contraceptive use (64% versus 61%; p &lt; .05) and most or moderately effective contraceptive use (42% versus 36%; p &lt; .01) than their uninsured counterparts. Controlling for individual-level demographic characteristics, health insurance coverage was associated with increased odds of most or moderately effective contraceptive use across jurisdictions (adjusted odds ratio = 1.33, p &lt; .01). In 11 states, insured women had significantly higher odds of at least one contraceptive use metric than their uninsured counterparts.</p></div><div><h3>Conclusions</h3><p>Variation in contraceptive use across the states likely reflects broader demographic, social and structural differences across state and local populations. States' political will and support around contraceptive access likely play a role in individuals' ability to obtain and use contraception.</p></div><div><h3>Implications</h3><p>Our key finding that insurance coverage is significantly associated with use of most/moderately effective contraceptive methods across the states but not any contraceptive use underscores the importance of health insurance in aiding access to methods that are more costly and often require a visit to a health care provider.</p></div>","PeriodicalId":10655,"journal":{"name":"Contraception: X","volume":"2 ","pages":"Article 100014"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.conx.2019.100014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38054527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Abortion patients' preferences for care and experiences accessing services in Louisiana 路易斯安那州堕胎患者对护理的偏好和获得服务的经历
Q2 Medicine Pub Date : 2020-01-01 DOI: 10.1016/j.conx.2019.100016
Erin Carroll , Kari White

Objective

The objective was to compare abortion patients' expectations and preferences for care with their experiences accessing services in Louisiana where there are numerous restrictive abortion laws.

Study design

Between June 2018 and January 2019, we conducted in-depth interviews with 35 English-speaking Louisiana residents who were ≥ 18 years of age and seeking care from the three in-state facilities to explore their perspectives and experiences locating, obtaining and paying for abortion services. We analyzed interview transcripts using a theme-based approach and categorized themes into dimensions of health care access: availability/accessibility, accommodation, acceptability and affordability.

Results

Participants were surprised to learn that there were so few facilities providing abortion, which required some of them to drive between 1 and 3 h to the nearest clinic. Many were unable to schedule their visits at a convenient time or obtain care as early in pregnancy as desired because the next available appointment was often a week or more away. Protestor activity and congested waiting rooms did not provide most patients their desired level of privacy, but participants expressed diverse views about other approaches to care that would maintain their confidentiality. To pay for an unplanned health care expense that was not covered by insurance, many participants deferred paying monthly bills and borrowed money, which contributed to financial hardships and additional delays in care.

Conclusions

Many Louisiana abortion patients' expectations and preferences for care are not being met across multiple dimensions of health care access assessed in this study, and the state's highly regulated policy environment may limit options for tailoring services to patients' needs.

Implications

Abortion patients in Louisiana value accessible, timely, private and affordable services, but a constrained network of providers and medically unnecessary requirements make it difficult for them to obtain patient-centered care. Federal- and state-level policy changes, as well as local initiatives, could ensure abortion patients have access to quality, evidence-based services.

目的比较堕胎患者对护理的期望和偏好与他们在路易斯安那州获得服务的经历,那里有许多限制性堕胎法。研究设计在2018年6月至2019年1月期间,我们对35名说英语的路易斯安那州居民进行了深入访谈,他们的年龄为 ≥18 岁,并在三家州内机构寻求护理,以探讨他们的观点和经验寻找,获得和支付堕胎服务。我们使用基于主题的方法分析访谈记录,并将主题分类为医疗保健获取的维度:可用性/可及性、住宿、可接受性和可负担性。结果参与者惊讶地发现,提供堕胎服务的机构如此之少,他们中的一些人需要开车1到3小时到最近的诊所。许多人无法在方便的时间安排就诊,也无法在期望的怀孕早期获得护理,因为下一次可预约的时间往往是一周或更长时间之后。抗议活动和拥挤的候诊室并没有为大多数病人提供他们想要的隐私,但参与者对其他可以保护他们隐私的护理方法表达了不同的看法。为了支付保险未涵盖的计划外医疗费用,许多参与者推迟支付每月账单并借钱,这造成了经济困难和额外的医疗延误。结论:许多路易斯安那州堕胎患者对护理的期望和偏好在本研究评估的医疗保健可及性的多个维度上没有得到满足,并且该州高度管制的政策环境可能限制了根据患者需求定制服务的选择。路易斯安那州的堕胎患者重视可获得、及时、私人和负担得起的服务,但有限的提供者网络和医疗上不必要的要求使他们难以获得以患者为中心的护理。联邦和州一级的政策变化,以及地方的倡议,可以确保堕胎患者获得高质量的、基于证据的服务。
{"title":"Abortion patients' preferences for care and experiences accessing services in Louisiana","authors":"Erin Carroll ,&nbsp;Kari White","doi":"10.1016/j.conx.2019.100016","DOIUrl":"10.1016/j.conx.2019.100016","url":null,"abstract":"<div><h3>Objective</h3><p>The objective was to compare abortion patients' expectations and preferences for care with their experiences accessing services in Louisiana where there are numerous restrictive abortion laws.</p></div><div><h3>Study design</h3><p>Between June 2018 and January 2019, we conducted in-depth interviews with 35 English-speaking Louisiana residents who were ≥<!--> <!-->18 years of age and seeking care from the three in-state facilities to explore their perspectives and experiences locating, obtaining and paying for abortion services. We analyzed interview transcripts using a theme-based approach and categorized themes into dimensions of health care access: availability/accessibility, accommodation, acceptability and affordability.</p></div><div><h3>Results</h3><p>Participants were surprised to learn that there were so few facilities providing abortion, which required some of them to drive between 1 and 3 h to the nearest clinic. Many were unable to schedule their visits at a convenient time or obtain care as early in pregnancy as desired because the next available appointment was often a week or more away. Protestor activity and congested waiting rooms did not provide most patients their desired level of privacy, but participants expressed diverse views about other approaches to care that would maintain their confidentiality. To pay for an unplanned health care expense that was not covered by insurance, many participants deferred paying monthly bills and borrowed money, which contributed to financial hardships and additional delays in care.</p></div><div><h3>Conclusions</h3><p>Many Louisiana abortion patients' expectations and preferences for care are not being met across multiple dimensions of health care access assessed in this study, and the state's highly regulated policy environment may limit options for tailoring services to patients' needs.</p></div><div><h3>Implications</h3><p>Abortion patients in Louisiana value accessible, timely, private and affordable services, but a constrained network of providers and medically unnecessary requirements make it difficult for them to obtain patient-centered care. Federal- and state-level policy changes, as well as local initiatives, could ensure abortion patients have access to quality, evidence-based services.</p></div>","PeriodicalId":10655,"journal":{"name":"Contraception: X","volume":"2 ","pages":"Article 100016"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.conx.2019.100016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38059125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
A 1-year prospective, open-label, single-arm, multicenter, phase 3 trial of the contraceptive efficacy and safety of the oral progestin-only pill drospirenone 4 mg using a 24/4-day regimen 这是一项为期1年的前瞻性、开放标签、单臂、多中心、3期临床试验,目的是研究口服孕激素单药4mg drospirenone的避孕效果和安全性,采用24/4天的治疗方案
Q2 Medicine Pub Date : 2020-01-01 DOI: 10.1016/j.conx.2020.100020
Thomas Kimble , Anne E. Burke , Kurt T. Barnhart , David F. Archer , Enrico Colli , Carolyn L. Westhoff

Objectives

To evaluate contraceptive effectiveness and safety of oral drospirenone 4 mg 24/4-day regimen in the United States.

Study design

We performed a prospective, single-arm, multicenter phase 3 trial in sexually active women for up to thirteen 28-day treatment cycles. Primary outcome was the Pearl index, calculated using confirmed on-drug pregnancies and evaluable cycles in nonbreastfeeding women aged ≤ 35 years. We assessed adverse events (AEs), including hyperkalemia and venous thromboembolism.

Results

Of 1006 women who received at least one dose of drospirenone, 352 women (35.0%) completed the trial and 654 (65.0%) women discontinued before trial end. Most participants (92.2%) were ≤ 35 years; one third had a body mass index (BMI) ≥ 30 kg/m2. Among nonbreastfeeding women aged ≤ 35 years, there were 17 pregnancies (Pearl index: 4.0; 95% confidence interval [CI], 2.3–6.4; n = 953), of which three were unconfirmed and two were from sites excluded from the main analysis for major breaches of Food and Drug Administration regulations. The Pearl index was 2.9 (95% CI: 1.5–5.1) for confirmed pregnancies among 915 nonbreastfeeding women aged ≤ 35 years from sites with no protocol violations. Nearly all (95.4%) treatment-emergent AEs were mild or moderate in intensity. No cases of venous thromboembolism were reported. The frequency of hyperkalemia was 0.5%. Women with baseline systolic/diastolic blood pressure ≥ 130/85 mmHg had a mean reduction from baseline in blood pressure at exit visit (− 8.5/− 4.9 mmHg; n = 119). No other clinically relevant changes were observed. Participant satisfaction was high.

Conclusion

Drospirenone 4 mg 24/4 regimen provides effective contraception with a good safety/tolerability profile in a broad group of women, including overweight or obese women.

Implications

This new progestin-only contraceptive, drospirenone 4 mg in a 24/4 regimen, provides a contraceptive option for the majority of women regardless of blood pressure or BMI.

目的评价美国口服螺螺酮4 mg / 24 - 4天方案的避孕效果和安全性。研究设计:我们在性活跃的女性中进行了一项前瞻性、单臂、多中心的3期试验,为期13个28天的治疗周期。主要终点是Pearl指数,使用年龄≤35 岁的非母乳喂养妇女中确认的非药物妊娠和可评估周期来计算。我们评估了不良事件(ae),包括高钾血症和静脉血栓栓塞。结果1006名接受至少一剂屈螺酮治疗的女性中,352名(35.0%)完成了试验,654名(65.0%)在试验结束前停止了治疗。大多数参与者(92.2%)年龄 ≤35 岁;1 / 3体重指数(BMI)≥30 kg/m2。年龄≤35 岁的非母乳喂养妇女中,有17例妊娠(Pearl指数:4.0;95%置信区间[CI], 2.3-6.4;n = 953),其中3个未经证实,2个来自因严重违反食品药品监督管理局规定而被排除在主要分析之外的站点。在915名年龄≤35 岁的非母乳喂养妇女中确认怀孕的Pearl指数为2.9 (95% CI: 1.5-5.1)。几乎所有(95.4%)治疗后出现的ae都是轻度或中度的。无静脉血栓栓塞病例报告。高钾血症发生率为0.5%。基线收缩压/舒张压 ≥ 130/85 mmHg的女性在出院时血压平均较基线降低(- 8.5/ - 4.9 mmHg;n = 119)。未观察到其他临床相关的变化。参与者的满意度很高。结论吡螺酮4 mg 24/4方案在包括超重或肥胖妇女在内的广泛妇女群体中具有良好的安全性/耐受性,是一种有效的避孕方案。这种新的纯孕激素避孕药,螺螺酮4 mg, 24/4疗程,为大多数女性提供了一种避孕选择,无论血压或体重指数如何。
{"title":"A 1-year prospective, open-label, single-arm, multicenter, phase 3 trial of the contraceptive efficacy and safety of the oral progestin-only pill drospirenone 4 mg using a 24/4-day regimen","authors":"Thomas Kimble ,&nbsp;Anne E. Burke ,&nbsp;Kurt T. Barnhart ,&nbsp;David F. Archer ,&nbsp;Enrico Colli ,&nbsp;Carolyn L. Westhoff","doi":"10.1016/j.conx.2020.100020","DOIUrl":"10.1016/j.conx.2020.100020","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate contraceptive effectiveness and safety of oral drospirenone 4 mg 24/4-day regimen in the United States.</p></div><div><h3>Study design</h3><p>We performed a prospective, single-arm, multicenter phase 3 trial in sexually active women for up to thirteen 28-day treatment cycles. Primary outcome was the Pearl index, calculated using confirmed on-drug pregnancies and evaluable cycles in nonbreastfeeding women aged ≤<!--> <!-->35 years. We assessed adverse events (AEs), including hyperkalemia and venous thromboembolism.</p></div><div><h3>Results</h3><p>Of 1006 women who received at least one dose of drospirenone, 352 women (35.0%) completed the trial and 654 (65.0%) women discontinued before trial end. Most participants (92.2%) were ≤<!--> <!-->35 years; one third had a body mass index (BMI) ≥<!--> <!-->30 kg/m<sup>2</sup>. Among nonbreastfeeding women aged ≤<!--> <!-->35 years, there were 17 pregnancies (Pearl index: 4.0; 95% confidence interval [CI], 2.3–6.4; <em>n</em> = 953), of which three were unconfirmed and two were from sites excluded from the main analysis for major breaches of Food and Drug Administration regulations. The Pearl index was 2.9 (95% CI: 1.5–5.1) for confirmed pregnancies among 915 nonbreastfeeding women aged ≤<!--> <!-->35 years from sites with no protocol violations. Nearly all (95.4%) treatment-emergent AEs were mild or moderate in intensity. No cases of venous thromboembolism were reported. The frequency of hyperkalemia was 0.5%. Women with baseline systolic/diastolic blood pressure ≥ 130/85 mmHg had a mean reduction from baseline in blood pressure at exit visit (−<!--> <!-->8.5/−<!--> <!-->4.9 mmHg; <em>n</em> = 119). No other clinically relevant changes were observed. Participant satisfaction was high.</p></div><div><h3>Conclusion</h3><p>Drospirenone 4 mg 24/4 regimen provides effective contraception with a good safety/tolerability profile in a broad group of women, including overweight or obese women.</p></div><div><h3>Implications</h3><p>This new progestin-only contraceptive, drospirenone 4 mg in a 24/4 regimen, provides a contraceptive option for the majority of women regardless of blood pressure or BMI.</p></div>","PeriodicalId":10655,"journal":{"name":"Contraception: X","volume":"2 ","pages":"Article 100020"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.conx.2020.100020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38059129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Medical regimens for abortion at 12 weeks and above: a systematic review and meta-analysis 12 周及以上流产的医疗方案:系统回顾和荟萃分析
Q2 Medicine Pub Date : 2020-01-01 DOI: 10.1016/j.conx.2020.100037
Katherine Whitehouse , Ashley Brant , Marita Sporstol Fonhus , Antonella Lavelanet , Bela Ganatra

Background

Mifepristone and misoprostol are recommended for second-trimester medical abortion, but consensus is unclear on the ideal regimen.

Objectives

The objectives were to systematically review randomized controlled trials (RCTs) investigating efficacy, safety and satisfaction of medical abortion at ≥ 12 weeks' gestation.

Data sources

We searched PubMed, Popline, Embase, Global Index Medicus, Cochrane Controlled Register of Trials and International Clinical Trials Registry Platform from January 2008 to May 2017.

Study eligibility, participants and interventions

We included RCTs on medical abortion at ≥ 12 weeks' gestation using mifepristone and/or misoprostol. We excluded studies with spontaneous abortion, fetal demise and mechanical cervical ripening and those not reporting ongoing pregnancy (OP).

Study appraisal and synthesis methods

After extracting prespecified data and assessing risk of bias in accordance with the Cochrane handbook, we used Revman5 software to combine data and GRADE to assess certainty of evidence.

Results

We included 43 of the 1894 references identified. Combination mifepristone–misoprostol had lower rates of OP [risk ratio (RR) 0.12, 95% confidence interval (CI) 0.04–0.35] vs. misoprostol only. A 24-h interval between mifepristone and misoprostol had lower OP rate at 24 h than simultaneous dosing (RR 3.13, 95% CI 1.23–7.94). Every 3-h dosing had lower OP rate at 48 h (RR 0.39, 95% CI 0.17–0.88).

Limitations

Direct comparisons of buccal misoprostol to sublingual or vaginal routes after mifepristone were limited. Evidence from clinical trials on how to best manage women with prior uterine incisions was lacking.

Conclusion

Our analysis supports the use of mifepristone 200 mg 1 to 2 days before misoprostol 400 mcg vaginally every 3 h at ≥ 12 weeks' gestation.

Implications

Where available, providers should use mifepristone plus misoprostol for second-trimester medical abortion. Vaginal misoprostol appears to be most efficacious with fewest side effects, but sublingual and buccal routes are also acceptable.

背景:米非司酮和米索前列醇被推荐用于中期妊娠药物流产,但对于理想方案的共识尚不明确。目的系统回顾研究妊娠≥12 周药物流产的疗效、安全性和满意度的随机对照试验(rct)。我们检索了2008年1月至2017年5月的PubMed、Popline、Embase、Global Index Medicus、Cochrane Controlled Register of Trials和国际临床试验注册平台。研究资格、参与者和干预措施我们纳入了妊娠≥12 周使用米非司酮和/或米索前列醇进行药物流产的随机对照试验。我们排除了自然流产、胎儿死亡、机械宫颈成熟和未报告妊娠的研究。研究评价和综合方法在提取预先指定的数据并根据Cochrane手册评估偏倚风险后,我们使用Revman5软件将数据和GRADE结合起来评估证据的确定性。结果纳入1894篇文献中的43篇。米非司酮-米索前列醇联合治疗的OP发生率较单用米索前列醇低[风险比(RR) 0.12, 95%可信区间(CI) 0.04-0.35]。米非司酮和米索前列醇之间间隔24 h,在24 h时的OP率低于同时给药(RR 3.13, 95% CI 1.23-7.94)。每给药3 h,在48 h时OP率降低(RR 0.39, 95% CI 0.17-0.88)。局限性:米非司酮后口腔米索前列醇与舌下或阴道途径的直接比较是有限的。缺乏关于如何最好地处理既往子宫切口妇女的临床试验证据。结论:我们的分析支持在妊娠≥12 周时,米非司酮200 mg先于米索前列醇400 mcg每3 h阴道使用1 - 2天。在可能的情况下,提供者应使用米非司酮加米索前列醇进行中期妊娠药物流产。阴道米索前列醇似乎是最有效的,副作用最少,但舌下和口腔途径也是可以接受的。
{"title":"Medical regimens for abortion at 12 weeks and above: a systematic review and meta-analysis","authors":"Katherine Whitehouse ,&nbsp;Ashley Brant ,&nbsp;Marita Sporstol Fonhus ,&nbsp;Antonella Lavelanet ,&nbsp;Bela Ganatra","doi":"10.1016/j.conx.2020.100037","DOIUrl":"10.1016/j.conx.2020.100037","url":null,"abstract":"<div><h3>Background</h3><p>Mifepristone and misoprostol are recommended for second-trimester medical abortion, but consensus is unclear on the ideal regimen.</p></div><div><h3>Objectives</h3><p>The objectives were to systematically review randomized controlled trials (RCTs) investigating efficacy, safety and satisfaction of medical abortion at ≥<!--> <!-->12 weeks' gestation.</p></div><div><h3>Data sources</h3><p>We searched PubMed, Popline, Embase, Global Index Medicus, Cochrane Controlled Register of Trials and International Clinical Trials Registry Platform from January 2008 to May 2017.</p></div><div><h3>Study eligibility, participants and interventions</h3><p>We included RCTs on medical abortion at ≥<!--> <!-->12 weeks' gestation using mifepristone and/or misoprostol. We excluded studies with spontaneous abortion, fetal demise and mechanical cervical ripening and those not reporting ongoing pregnancy (OP).</p></div><div><h3>Study appraisal and synthesis methods</h3><p>After extracting prespecified data and assessing risk of bias in accordance with the Cochrane handbook, we used Revman5 software to combine data and GRADE to assess certainty of evidence.</p></div><div><h3>Results</h3><p>We included 43 of the 1894 references identified. Combination mifepristone–misoprostol had lower rates of OP [risk ratio (RR) 0.12, 95% confidence interval (CI) 0.04–0.35] vs. misoprostol only. A 24-h interval between mifepristone and misoprostol had lower OP rate at 24 h than simultaneous dosing (RR 3.13, 95% CI 1.23–7.94). Every 3-h dosing had lower OP rate at 48 h (RR 0.39, 95% CI 0.17–0.88).</p></div><div><h3>Limitations</h3><p>Direct comparisons of buccal misoprostol to sublingual or vaginal routes after mifepristone were limited. Evidence from clinical trials on how to best manage women with prior uterine incisions was lacking.</p></div><div><h3>Conclusion</h3><p>Our analysis supports the use of mifepristone 200 mg 1 to 2 days before misoprostol 400 mcg vaginally every 3 h at ≥<!--> <!-->12 weeks' gestation.</p></div><div><h3>Implications</h3><p>Where available, providers should use mifepristone plus misoprostol for second-trimester medical abortion. Vaginal misoprostol appears to be most efficacious with fewest side effects, but sublingual and buccal routes are also acceptable.</p></div>","PeriodicalId":10655,"journal":{"name":"Contraception: X","volume":"2 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.conx.2020.100037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38500942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Trends in medication abortion and the role of low-volume and nonmetropolitan mifepristone purchasers: 2008–2011 and 2014–2017 药物流产的趋势以及小批量和非大都市米非司酮购买者的作用:2008-2011年和2014-2017年
Q2 Medicine Pub Date : 2020-01-01 DOI: 10.1016/j.conx.2020.100042
Rachel K. Jones

Objective

The objective was to examine trends in the number of low-volume and nonmetropolitan mifepristone purchasers and their role in the expansion of medication abortion.

Methods

We use deidentified data from Danco Laboratories, the sole distributor of mifepristone during the study period, to examine trends in mifepristone distribution. We focus on customers who purchased < 100 doses a year and a subset of those who purchased < 10 doses for the periods of 2008–2011 and 2014–2017. We use data from the Guttmacher Institute Abortion Provider Census (APC) studies in 2008 and 2017 to examine the extent to which some facilities that purchased mifepristone may be missing from Guttmacher's APC.

Results

Between 2008 and 2017, the number of medication abortions increased 73%, though the number of mifepristone purchasers only increased 15%. The number of low-volume mifepristone customers, or those who purchased < 100 tablets of mifepristone per year, decreased 8% over the study period, while the number purchasing < 10 tablets per year decreased 14%. However, in recent years, low-volume customers were more likely to have purchased mifepristone in multiple years. In nonmetropolitan areas, the number of sites purchasing mifepristone increased slightly but the amount of mifepristone that was purchased more than doubled between 2008 and 2017.

Conclusions

While reliance on medication abortion increased substantially between 2008 and 2017, there is no evidence that this was due to an increase in the number of facilities that purchased low volumes of mifepristone.

Implications

While their numbers declined, abortion providers purchasing low volumes of mifepristone likely played an important role for the individuals they cared for. Access to abortion could increase if a wider network of health care practitioners, especially those in settings that do not currently provide abortions, was able to offer medication abortion.

目的:目的是检查小容量和非大都市米非司酮购买者数量的趋势及其在药物流产扩大中的作用。方法我们使用研究期间米非司酮唯一经销商Danco实验室的鉴定数据来检查米非司酮的分布趋势。我们专注于购买<每年100剂,一部分购买了<2008-2011年和2014-2017年期间接种10剂。我们使用2008年和2017年古特马赫研究所堕胎提供者普查(APC)研究的数据来检查购买米非司酮的一些设施在多大程度上可能从古特马赫的APC中缺失。结果2008年至2017年,药物流产数量增加了73%,但米非司酮购买者数量仅增加了15%。小批量米非司酮客户的数量,或购买米非司酮的数量;在研究期间,每年购买100片米非司酮的人数减少了8%,而购买<每年10片减少14%。然而,近年来,小批量客户更有可能在多年内购买米非司酮。在非大都市地区,购买米非司酮的地点数量略有增加,但购买的米非司酮数量在2008年至2017年期间增加了一倍多。虽然对药物流产的依赖在2008年至2017年期间大幅增加,但没有证据表明这是由于购买低剂量米非司酮的机构数量增加所致。当他们的数量下降时,堕胎提供者购买低剂量的米非司酮可能对他们所照顾的个体起了重要作用。如果更广泛的保健从业人员网络,特别是目前不提供堕胎的环境中的从业人员能够提供药物堕胎,那么堕胎的机会就会增加。
{"title":"Trends in medication abortion and the role of low-volume and nonmetropolitan mifepristone purchasers: 2008–2011 and 2014–2017","authors":"Rachel K. Jones","doi":"10.1016/j.conx.2020.100042","DOIUrl":"10.1016/j.conx.2020.100042","url":null,"abstract":"<div><h3>Objective</h3><p>The objective was to examine trends in the number of low-volume and nonmetropolitan mifepristone purchasers and their role in the expansion of medication abortion.</p></div><div><h3>Methods</h3><p>We use deidentified data from Danco Laboratories, the sole distributor of mifepristone during the study period, to examine trends in mifepristone distribution. We focus on customers who purchased &lt;<!--> <!-->100 doses a year and a subset of those who purchased &lt;<!--> <!-->10 doses for the periods of 2008–2011 and 2014–2017. We use data from the Guttmacher Institute Abortion Provider Census (APC) studies in 2008 and 2017 to examine the extent to which some facilities that purchased mifepristone may be missing from Guttmacher's APC.</p></div><div><h3>Results</h3><p>Between 2008 and 2017, the number of medication abortions increased 73%, though the number of mifepristone purchasers only increased 15%. The number of low-volume mifepristone customers, or those who purchased &lt;<!--> <!-->100 tablets of mifepristone per year, decreased 8% over the study period, while the number purchasing &lt;<!--> <!-->10 tablets per year decreased 14%. However, in recent years, low-volume customers were more likely to have purchased mifepristone in multiple years. In nonmetropolitan areas, the number of sites purchasing mifepristone increased slightly but the amount of mifepristone that was purchased more than doubled between 2008 and 2017.</p></div><div><h3>Conclusions</h3><p>While reliance on medication abortion increased substantially between 2008 and 2017, there is no evidence that this was due to an increase in the number of facilities that purchased low volumes of mifepristone.</p></div><div><h3>Implications</h3><p>While their numbers declined, abortion providers purchasing low volumes of mifepristone likely played an important role for the individuals they cared for. Access to abortion could increase if a wider network of health care practitioners, especially those in settings that do not currently provide abortions, was able to offer medication abortion.</p></div>","PeriodicalId":10655,"journal":{"name":"Contraception: X","volume":"2 ","pages":"Article 100042"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.conx.2020.100042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38605847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound assessment of postplacental copper intrauterine device position 6 months after placement during cesarean delivery 剖宫产中放置铜质宫内节育器6个月后位置的超声评估
Q2 Medicine Pub Date : 2020-01-01 DOI: 10.1016/j.conx.2020.100040
Elizabeth P. Gurney , Arden McAllister, Britt Lang, Courtney A. Schreiber, Sarita Sonalkar

Objective

The objective was to describe the sonographic position of copper intrauterine devices (IUDs) 6 months after insertion during cesarean delivery.

Study design

This prospective, observational study followed participants who received a copper IUD during cesarean delivery. We performed pelvic examination at 6 weeks and 6 months and sonography at 6 months to determine IUD position. Patients had additional examinations as needed to address complications.

Results

Sixty-nine participants provided outcomes through 6 months: 41 (59%) had correctly positioned IUDs, 21 (30%) had malpositioned intrauterine IUDs, 5 experienced expulsion (3 partial, 2 complete), and 2 had elective removal; 52 (75%) had missing strings. Missing strings at 6 weeks predicted an incorrect IUD position in 22 of 52 participants (positive predictive value 42%), and visible or palpable strings predicted a correct IUD position in 7 of 12 participants (negative predictive value 58%).

Conclusion

Although 59% of copper IUDs placed during cesarean were correctly positioned at 6 months, nearly one third were malpositioned.

Implications

Ultrasound may be indicated for patients receiving a copper IUD during cesarean delivery as checking IUD strings alone does not assure correct placement. Providers offering postpartum IUDs should ensure that appropriate processes for the evaluation and management of devices with missing strings or abnormal position are available to all patients regardless of insurance status.

目的探讨剖宫产术中铜质宫内节育器置入6个月后的超声位置。研究设计:这项前瞻性观察性研究随访了剖宫产期间接受铜宫内节育器的参与者。在6 周和6 个月时进行盆腔检查,6 个月时进行超声检查以确定宫内节育器的位置。根据需要对患者进行额外检查以解决并发症。结果69名参与者提供了6个月的结果:41人(59%)放置了正确的宫内节育器,21人(30%)放置了错误的宫内节育器,5人被排出(3人部分排出,2人完全排出),2人选择性取出;52个(75%)缺少字符串。在52名参与者中,6周时缺失的字符串预测了22个不正确的宫内节育器位置(阳性预测值为42%),在12名参与者中,可见或可触及的字符串预测了7个正确的宫内节育器位置(阴性预测值为58%)。结论剖宫产术中放置的铜宫内节育器在6 个月时定位正确的占59%,但有近1 / 3放置错误。意义在剖宫产过程中接受铜宫内节育器的患者可能需要超声检查,因为仅检查宫内节育器串并不能保证正确放置。提供产后宫内节育器的提供者应确保所有患者都能获得适当的评估和管理程序,无论其保险状况如何。
{"title":"Ultrasound assessment of postplacental copper intrauterine device position 6 months after placement during cesarean delivery","authors":"Elizabeth P. Gurney ,&nbsp;Arden McAllister,&nbsp;Britt Lang,&nbsp;Courtney A. Schreiber,&nbsp;Sarita Sonalkar","doi":"10.1016/j.conx.2020.100040","DOIUrl":"10.1016/j.conx.2020.100040","url":null,"abstract":"<div><h3>Objective</h3><p>The objective was to describe the sonographic position of copper intrauterine devices (IUDs) 6 months after insertion during cesarean delivery.</p></div><div><h3>Study design</h3><p>This prospective, observational study followed participants who received a copper IUD during cesarean delivery. We performed pelvic examination at 6 weeks and 6 months and sonography at 6 months to determine IUD position. Patients had additional examinations as needed to address complications.</p></div><div><h3>Results</h3><p>Sixty-nine participants provided outcomes through 6 months: 41 (59%) had correctly positioned IUDs, 21 (30%) had malpositioned intrauterine IUDs, 5 experienced expulsion (3 partial, 2 complete), and 2 had elective removal; 52 (75%) had missing strings. Missing strings at 6 weeks predicted an incorrect IUD position in 22 of 52 participants (positive predictive value 42%), and visible or palpable strings predicted a correct IUD position in 7 of 12 participants (negative predictive value 58%).</p></div><div><h3>Conclusion</h3><p>Although 59% of copper IUDs placed during cesarean were correctly positioned at 6 months, nearly one third were malpositioned.</p></div><div><h3>Implications</h3><p>Ultrasound may be indicated for patients receiving a copper IUD during cesarean delivery as checking IUD strings alone does not assure correct placement. Providers offering postpartum IUDs should ensure that appropriate processes for the evaluation and management of devices with missing strings or abnormal position are available to all patients regardless of insurance status.</p></div>","PeriodicalId":10655,"journal":{"name":"Contraception: X","volume":"2 ","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.conx.2020.100040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38615956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The predictive utility of unmet need on time to contraceptive adoption: a panel study of non-contracepting Ugandan women 未满足需求对避孕措施及时采用的预测效用:一项对乌干达非避孕妇女的小组研究
Q2 Medicine Pub Date : 2020-01-01 DOI: 10.1016/j.conx.2020.100022
Dana Sarnak , Amy Tsui , Fredrick Makumbi , Simon P.S Kibira , Saifuddin Ahmed

Objective

The predictive utility of the unmet contraceptive need indicator is not well known, despite being recognized as a key family planning indicator for showing the extant demand for birth control. This study assesses the dynamic influence of unmet need on time to contraceptive adoption, as compared with that of contraceptive intentions and their concordance.

Study design

This observational study analyzed survey data, including a contraceptive calendar, reported by a panel of 747 non-contracepting, fecund and sexually active Ugandan women, first interviewed in a 2014 national survey and re-interviewed in 2018. We conducted descriptive, survival and multivariate Cox regression analysis of the influence of women's baseline measures of unmet need, self-reported intention to contracept and their concordance with time to adoption of modern contraception over 36 months.

Results

The study found women classified as having unmet need were slower to adopt contraception than those without unmet need, after adjustment for background covariates (aHR = 0.79, 95% CI = 0.57–1.10). Women intending future contraceptive use were significantly faster to adopt (aHR = 1.45, 95% CI = 1.22–1.73) than those not intending. Women with no unmet need but intending to use had the highest rate of adoption compared to those with no need and no intention to use (aHR = 2.78, 95% CI = 1.48–5.25).

Conclusions

The unmet need indicator underperforms in predicting future contraceptive adoption compared to contraceptive intentions, which merits further consideration as a complementary predictor of future use. Non-contracepting women with unmet need but no intention to use contraception in particular warrant programmatic attention.

Implications

A non-contracepting woman wanting to limit or space her births is defined as having unmet need, but little is known if she subsequently adopts contraception. By contrasting a woman's unmet need with her expressed intention to use, we offer reasons to further consider self-reported contraceptive intentions as a better predictor of adoption and the underlying latent demand for volitional regulation of fertility.

目的未满足避孕需求指标是反映现有避孕需求的关键计划生育指标,但其预测效用尚不清楚。本研究评估了未满足需求对避孕措施采用时间的动态影响,与避孕意图及其一致性相比。这项观察性研究分析了调查数据,包括避孕日历,由747名不避孕、生育和性活跃的乌干达妇女组成的小组报告,这些妇女在2014年的一次全国调查中首次接受采访,并在2018年再次接受采访。我们对36 个月内妇女未满足需求的基线测量、自我报告的避孕意图及其与采用现代避孕方法时间的一致性的影响进行了描述性、生存和多变量Cox回归分析。结果本研究发现,在调整背景协变量后,被归类为未满足需求的妇女比未满足需求的妇女采取避孕措施的速度慢(aHR = 0.79, 95% CI = 0.57-1.10)。打算将来使用避孕措施的妇女比不打算使用避孕措施的妇女接受避孕措施的速度要快得多(aHR = 1.45, 95% CI = 1.22-1.73)。没有未满足需求但打算使用的妇女与那些没有需要和无意使用的妇女相比,采用率最高(aHR = 2.78, 95% CI = 1.48-5.25)。结论与避孕意向相比,未满足需求指标在预测未来避孕措施采用方面表现不佳,值得进一步考虑将其作为未来使用的补充预测指标。需要未得到满足但不打算特别使用避孕措施的未避孕妇女需要得到方案上的注意。想要限制或间隔生育的未避孕妇女被定义为需求未得到满足,但她随后是否采取避孕措施则鲜为人知。通过对比女性未满足的需求和她表达的使用意愿,我们提供了进一步考虑自我报告避孕意图的理由,作为更好的预测收养和潜在的自愿调节生育的需求。
{"title":"The predictive utility of unmet need on time to contraceptive adoption: a panel study of non-contracepting Ugandan women","authors":"Dana Sarnak ,&nbsp;Amy Tsui ,&nbsp;Fredrick Makumbi ,&nbsp;Simon P.S Kibira ,&nbsp;Saifuddin Ahmed","doi":"10.1016/j.conx.2020.100022","DOIUrl":"10.1016/j.conx.2020.100022","url":null,"abstract":"<div><h3>Objective</h3><p>The predictive utility of the unmet contraceptive need indicator is not well known, despite being recognized as a key family planning indicator for showing the extant demand for birth control. This study assesses the dynamic influence of unmet need on time to contraceptive adoption, as compared with that of contraceptive intentions and their concordance.</p></div><div><h3>Study design</h3><p>This observational study analyzed survey data, including a contraceptive calendar, reported by a panel of 747 non-contracepting, fecund and sexually active Ugandan women, first interviewed in a 2014 national survey and re-interviewed in 2018. We conducted descriptive, survival and multivariate Cox regression analysis of the influence of women's baseline measures of unmet need, self-reported intention to contracept and their concordance with time to adoption of modern contraception over 36 months.</p></div><div><h3>Results</h3><p>The study found women classified as having unmet need were slower to adopt contraception than those without unmet need, after adjustment for background covariates (aHR<!--> <!-->=<!--> <!-->0.79, 95% CI<!--> <!-->=<!--> <!-->0.57–1.10). Women intending future contraceptive use were significantly faster to adopt (aHR<!--> <!-->=<!--> <!-->1.45, 95% CI<!--> <!-->=<!--> <!-->1.22–1.73) than those not intending. Women with no unmet need but intending to use had the highest rate of adoption compared to those with no need and no intention to use (aHR<!--> <!-->=<!--> <!-->2.78, 95% CI<!--> <!-->=<!--> <!-->1.48–5.25).</p></div><div><h3>Conclusions</h3><p>The unmet need indicator underperforms in predicting future contraceptive adoption compared to contraceptive intentions, which merits further consideration as a complementary predictor of future use. Non-contracepting women with unmet need but no intention to use contraception in particular warrant programmatic attention.</p></div><div><h3>Implications</h3><p>A non-contracepting woman wanting to limit or space her births is defined as having unmet need, but little is known if she subsequently adopts contraception. By contrasting a woman's unmet need with her expressed intention to use, we offer reasons to further consider self-reported contraceptive intentions as a better predictor of adoption and the underlying latent demand for volitional regulation of fertility.</p></div>","PeriodicalId":10655,"journal":{"name":"Contraception: X","volume":"2 ","pages":"Article 100022"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.conx.2020.100022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38059603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Validation of the Interpersonal Quality of Family Planning Scale in a rural Indian setting 印度农村计划生育量表人际关系质量的验证
Q2 Medicine Pub Date : 2020-01-01 DOI: 10.1016/j.conx.2020.100035
Nicole E. Johns , Anvita Dixit , Mohan Ghule , Shahina Begum , Madhusudana Battala , Gennifer Kully , Jay Silverman , Christine Dehlendorf , Anita Raj , Sarah Averbach

Objectives

The provision of high-quality family planning (FP) counseling can both enhance clients' experience of care and improve their ability to make and act on their contraceptive decisions. The Interpersonal Quality of Family Planning (IQFP) scale measures FP counseling quality and has been validated in the United States. We aimed to explore whether it remains appropriate for use in a low-/middle-income country (LMIC).

Study design

We surveyed 1201 nonsterilized married women ages 18–29 in Maharashtra, India, between September 2018 and June 2019. Respondents rated their FP provider from “poor” (1) to “excellent” (5) across 11 IQFP items. We assessed scale reliability via Cronbach's α test and used exploratory factor analysis to evaluate unidimensionality and regression models of plausibly related outcomes to assess construct validity.

Results

Five hundred four women (42%) had seen an FP provider within the past year, 491 (97%) of whom answered all items. Mean IQFP score was 2.62 out of 5 (SD 0.94, range 1–5). Scale reliability was high (α = 0.97). Exploratory factor analyses support unidimensionality (all factor loadings > 0.4). A 1-point increase in average IQFP score was associated with nearly double the odds of current modern contraceptive use (adjusted odds ratio = 1.73, 95% confidence interval = 1.36–2.19).

Conclusions

The IQFP scale shows good reliability and construct validity in this context, and its use in LMIC settings should be broadly considered. A higher IQFP score was associated with greater odds of contraceptive use. The reported FP counseling quality was low, so future public health efforts should aim to increase counseling quality to better meet the needs of women in low-resource settings like rural India. Measurement tools like IQFP can support success evaluation of the quality of care provided by family planning programs.

Implications

The Interpersonal Quality of Family Planning scale is a useful tool in rural India, a different context than the one in which it was developed. Use of the IQFP scale should be considered in other low-/middle-income countries to better measure the quality of family planning care provided.

目的提供高质量的计划生育咨询服务,既能提高患者的护理体验,又能提高患者的避孕决策能力和行动能力。计划生育人际质量(IQFP)量表衡量计划生育咨询质量,并已在美国得到验证。我们的目的是探讨它是否仍然适用于中低收入国家(LMIC)。我们在2018年9月至2019年6月期间调查了印度马哈拉施特拉邦1201名18-29岁未绝育的已婚女性。受访者在11个IQFP项目中将他们的计划生育提供者评为“差”(1)到“优秀”(5)。我们通过Cronbach's α检验评估量表信度,并使用探索性因子分析评估单维性,并使用回归模型评估似然相关结果的结构效度。结果在过去一年中,有5400名妇女(42%)就诊过计划生育服务提供者,其中491名(97%)回答了所有问题。平均IQFP得分为2.62 (SD 0.94,范围1-5)。量表信度高(α = 0.97)。探索性因子分析支持单维度(所有因子负载);0.4)。平均IQFP得分每增加1分,使用现代避孕药具的几率就增加近一倍(调整后的优势比= 1.73,95%可信区间= 1.36-2.19)。结论IQFP量表具有良好的信度和结构效度,应广泛考虑其在低mic环境中的应用。IQFP得分越高,使用避孕措施的几率越大。报告的计划生育咨询质量较低,因此未来的公共卫生工作应致力于提高咨询质量,以更好地满足印度农村等资源匮乏地区妇女的需求。像IQFP这样的测量工具可以支持对计划生育项目提供的护理质量的成功评估。计划生育人际关系质量量表在印度农村是一个有用的工具,这与它开发的背景不同。其他低收入/中等收入国家应考虑使用IQFP量表,以便更好地衡量所提供的计划生育护理的质量。
{"title":"Validation of the Interpersonal Quality of Family Planning Scale in a rural Indian setting","authors":"Nicole E. Johns ,&nbsp;Anvita Dixit ,&nbsp;Mohan Ghule ,&nbsp;Shahina Begum ,&nbsp;Madhusudana Battala ,&nbsp;Gennifer Kully ,&nbsp;Jay Silverman ,&nbsp;Christine Dehlendorf ,&nbsp;Anita Raj ,&nbsp;Sarah Averbach","doi":"10.1016/j.conx.2020.100035","DOIUrl":"10.1016/j.conx.2020.100035","url":null,"abstract":"<div><h3>Objectives</h3><p>The provision of high-quality family planning (FP) counseling can both enhance clients' experience of care and improve their ability to make and act on their contraceptive decisions. The Interpersonal Quality of Family Planning (IQFP) scale measures FP counseling quality and has been validated in the United States. We aimed to explore whether it remains appropriate for use in a low-/middle-income country (LMIC).</p></div><div><h3>Study design</h3><p>We surveyed 1201 nonsterilized married women ages 18–29 in Maharashtra, India, between September 2018 and June 2019. Respondents rated their FP provider from “poor” (1) to “excellent” (5) across 11 IQFP items. We assessed scale reliability via Cronbach's <em>α</em> test and used exploratory factor analysis to evaluate unidimensionality and regression models of plausibly related outcomes to assess construct validity.</p></div><div><h3>Results</h3><p>Five hundred four women (42%) had seen an FP provider within the past year, 491 (97%) of whom answered all items. Mean IQFP score was 2.62 out of 5 (SD 0.94, range 1–5). Scale reliability was high (<em>α</em> <!-->=<!--> <!-->0.97). Exploratory factor analyses support unidimensionality (all factor loadings &gt;<!--> <!-->0.4). A 1-point increase in average IQFP score was associated with nearly double the odds of current modern contraceptive use (adjusted odds ratio<!--> <!-->=<!--> <!-->1.73, 95% confidence interval<!--> <!-->=<!--> <!-->1.36–2.19).</p></div><div><h3>Conclusions</h3><p>The IQFP scale shows good reliability and construct validity in this context, and its use in LMIC settings should be broadly considered. A higher IQFP score was associated with greater odds of contraceptive use. The reported FP counseling quality was low, so future public health efforts should aim to increase counseling quality to better meet the needs of women in low-resource settings like rural India. Measurement tools like IQFP can support success evaluation of the quality of care provided by family planning programs.</p></div><div><h3>Implications</h3><p>The Interpersonal Quality of Family Planning scale is a useful tool in rural India, a different context than the one in which it was developed. Use of the IQFP scale should be considered in other low-/middle-income countries to better measure the quality of family planning care provided.</p></div>","PeriodicalId":10655,"journal":{"name":"Contraception: X","volume":"2 ","pages":"Article 100035"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.conx.2020.100035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38264540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
期刊
Contraception: X
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1