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68 Ga-Pentixafor PET in Combination With MRI Improves the Differential Diagnosis of Glioblastoma and Primary Central Nervous System Lymphoma.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-01 Epub Date: 2025-01-06 DOI: 10.1097/RLU.0000000000005657
Zhenying Chen, Huimin Liu, Apeng Yang, Jingwei Liao, Zanyi Wu, Junmin Chen, Weibing Miao

Purposes: This study aims to investigate the diagnostic performance of combining 68 Ga-pentixafor PET with MRI to differentiate primary central nervous system lymphoma (PCNSL) from glioblastoma (GBM), particularly focusing on atypical lymphoma identification.

Patients and methods: Seventy-one PCNSL and 53 GBM patients who underwent both 68 Ga-pentixafor PET/CT and MRI were retrospectively included. We evaluated the quantitative imaging parameters and MRI features of positive lesions, identifying atypical PCNSL by hemorrhage, necrosis, or heterogeneous enhancement. Logistic regression identified key variables, and the ROC-AUC evaluated their diagnostic value. Immunohistochemistry for CXCR4 was performed.

Results: PCNSLs, including 23 atypical cases, showed higher SUV max and TBR, and lower MTV, ADC min , and relative ADC min (rADC min ) than GBMs (all P 's < 0.05). The CXCR4 staining in PCNSL was also more pronounced in GBM ( P = 0.048). Multivariate logistic regression indicated that a combination of TBR, MTV, and ADC min (quantitative model 1) had a superior AUC of 0.913 in distinguishing PCNSL from GBM, outperforming single parameters (all P 's < 0.05). For differentiating atypical PCNSL from GBM, single quantitatively parameters showed moderate performance (AUC, 0.655-0.767). Further combining TBR with ADC min (quantitative model 2) significantly improve the AUC to 0.883. Multiparameter models, incorporating significant quantitative and qualitative MRI features, achieved AUCs of 0.953 (PCNSL vs GBM) and 0.902 (atypical PCNSL vs GBM), significantly outperforming single parameters (all P 's < 0.05).

Conclusions: 68 Ga-pentixafor PET in combination with MRI provides valuable diagnostic information in differentiating PCNSL from GBM, especially for atypical PCNSL.

{"title":"68 Ga-Pentixafor PET in Combination With MRI Improves the Differential Diagnosis of Glioblastoma and Primary Central Nervous System Lymphoma.","authors":"Zhenying Chen, Huimin Liu, Apeng Yang, Jingwei Liao, Zanyi Wu, Junmin Chen, Weibing Miao","doi":"10.1097/RLU.0000000000005657","DOIUrl":"10.1097/RLU.0000000000005657","url":null,"abstract":"<p><strong>Purposes: </strong>This study aims to investigate the diagnostic performance of combining 68 Ga-pentixafor PET with MRI to differentiate primary central nervous system lymphoma (PCNSL) from glioblastoma (GBM), particularly focusing on atypical lymphoma identification.</p><p><strong>Patients and methods: </strong>Seventy-one PCNSL and 53 GBM patients who underwent both 68 Ga-pentixafor PET/CT and MRI were retrospectively included. We evaluated the quantitative imaging parameters and MRI features of positive lesions, identifying atypical PCNSL by hemorrhage, necrosis, or heterogeneous enhancement. Logistic regression identified key variables, and the ROC-AUC evaluated their diagnostic value. Immunohistochemistry for CXCR4 was performed.</p><p><strong>Results: </strong>PCNSLs, including 23 atypical cases, showed higher SUV max and TBR, and lower MTV, ADC min , and relative ADC min (rADC min ) than GBMs (all P 's < 0.05). The CXCR4 staining in PCNSL was also more pronounced in GBM ( P = 0.048). Multivariate logistic regression indicated that a combination of TBR, MTV, and ADC min (quantitative model 1) had a superior AUC of 0.913 in distinguishing PCNSL from GBM, outperforming single parameters (all P 's < 0.05). For differentiating atypical PCNSL from GBM, single quantitatively parameters showed moderate performance (AUC, 0.655-0.767). Further combining TBR with ADC min (quantitative model 2) significantly improve the AUC to 0.883. Multiparameter models, incorporating significant quantitative and qualitative MRI features, achieved AUCs of 0.953 (PCNSL vs GBM) and 0.902 (atypical PCNSL vs GBM), significantly outperforming single parameters (all P 's < 0.05).</p><p><strong>Conclusions: </strong>68 Ga-pentixafor PET in combination with MRI provides valuable diagnostic information in differentiating PCNSL from GBM, especially for atypical PCNSL.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":"50 4","pages":"324-331"},"PeriodicalIF":9.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Value of 18 F-FDG PET in Primary Central Nervous System Lymphoma : Assessing Interim Metabolic Response for Improving Patient Stratification.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-01 Epub Date: 2025-02-17 DOI: 10.1097/RLU.0000000000005703
Ga-Young Song, Ho Cheol Jang, Mihee Kim, Seo-Yeon Ahn, Sung-Hoon Jung, Jae-Sook Ahn, Je-Jung Lee, Hyeoung-Joon Kim, Jang Bae Moon, Su Woong Yoo, Seong-Young Kwon, Jung-Joon Min, Hee-Seung Bom, Sae-Ryung Kang, Deok-Hwan Yang

Purpose of the report: The usefulness of brain 18 F-FDG PET/CT in primary central nervous system lymphoma (PCNSL) remains underexplored. This study investigated whether early metabolic responses in interim brain FDG PET/CT serve as a prognostic indicator of PCNSL treatment outcomes.

Patients and methods: This prospective study included 53 patients with PCNSL who underwent a high-dose methotrexate-based treatment. Brain FDG PET was performed at diagnosis (baseline PET) and after induction chemotherapy (interim PET), assessing interim PET parameters such as the highest maximum standardized uptake value (hSUV max ), sum of SUV max (sumSUV max ), highest tumor-to-normal ratio (hTNR max ), sum of TNR max (sumTNR max ), highest metabolic tumor volume (MTV) (hMTV), and sum of MTV (sumMTV) across all PET-positive lesions.

Results: High interim hTNR max (hazards ratio: 9.76, 95% confidence interval: 1.90-50.11, P = 0.01) was an independently significant predictor of poor progression-free survival in multivariate analysis. Patients with low interim hTNR max (≤1.0) had a significantly longer median progression-free survival than those with high interim hTNR max (>1.0) (25.0 vs 3.6 months, P < 0.001). Incorporating interim MRI-based clinical response assessments and hTNR max allowed the classification of partial response subgroups with markedly different prognoses ( P < 0.001). High interim hTNR max (hazards ratio: 2.76, 95% confidence interval: 1.39-5.48, P = 0.004) was an independently significant predictor of poor overall survival in multivariate analysis.

Conclusions: The hTNR max measurement from interim brain FDG PET scans emerges as an important prognostic marker in PCNSL. These findings underscore the potential of interim FDG PET evaluations to refine response assessments and inform tailored therapeutic strategies.

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引用次数: 0
18 F-FAZA, 18 F-FDG, and 123 I-IMP Imaging Reveal Hypoxia and Metabolism in Acute MOGAD. 18F-FAZA, 18F-FDG和123I-IMP成像揭示急性MOGAD的缺氧和代谢
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-01 Epub Date: 2025-01-09 DOI: 10.1097/RLU.0000000000005671
Kota Yokoyama, Junichi Tsuchiya, Hiroya Kuwahara, Motoki Inaji, Ukihide Tateishi

Abstract: We report the first case of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) evaluated with hypoxic imaging using 18 F-FAZA PET/CT. A healthy woman in her 20s presented to our hospital with seizures, headaches, and vomiting. MRI and CT scans suggested a wide range of differential diagnoses, from neoplastic lesions, such as malignant lymphoma, to inflammatory diseases, such as vasculitis, making her case challenging to diagnose. MOGAD was confirmed by positive myelin oligodendrocyte glycoprotein antibodies, and her condition improved with steroid therapy. The 18 F-FAZA PET/CT findings in this case may aid in understanding the pathogenesis of MOGAD.

摘要:我们报告第一例髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD),使用18F-FAZA PET/CT进行缺氧成像评估。一名20多岁的健康女性因癫痫、头痛和呕吐来到我们医院。MRI和CT扫描显示了广泛的鉴别诊断,从肿瘤病变,如恶性淋巴瘤,到炎症性疾病,如血管炎,使她的病例难以诊断。髓鞘少突胶质细胞糖蛋白抗体阳性证实MOGAD,类固醇治疗后病情好转。本病例的18F-FAZA PET/CT表现可能有助于了解MOGAD的发病机制。
{"title":"18 F-FAZA, 18 F-FDG, and 123 I-IMP Imaging Reveal Hypoxia and Metabolism in Acute MOGAD.","authors":"Kota Yokoyama, Junichi Tsuchiya, Hiroya Kuwahara, Motoki Inaji, Ukihide Tateishi","doi":"10.1097/RLU.0000000000005671","DOIUrl":"10.1097/RLU.0000000000005671","url":null,"abstract":"<p><strong>Abstract: </strong>We report the first case of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) evaluated with hypoxic imaging using 18 F-FAZA PET/CT. A healthy woman in her 20s presented to our hospital with seizures, headaches, and vomiting. MRI and CT scans suggested a wide range of differential diagnoses, from neoplastic lesions, such as malignant lymphoma, to inflammatory diseases, such as vasculitis, making her case challenging to diagnose. MOGAD was confirmed by positive myelin oligodendrocyte glycoprotein antibodies, and her condition improved with steroid therapy. The 18 F-FAZA PET/CT findings in this case may aid in understanding the pathogenesis of MOGAD.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e236-e237"},"PeriodicalIF":9.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyomyositis Due to a Rare Fungal Infection-Findings on 68 Ga-NOTA UBI PET/CT. 68Ga-NOTA UBI PET/CT显示罕见真菌感染所致脓性肌炎。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-01 Epub Date: 2024-12-13 DOI: 10.1097/RLU.0000000000005621
Shubha Gadde Ravindra, Nishikant Avinash Damle, Pyata Vikram Babu, Danveer Bhadu, Gagandeep Singh

Abstract: It is very rare to see fungal arthritis and pyomyositis in immunocompetent patients. Here, we report a case of Scedosporium infection in an immunocompetent patient with interesting 18 F-FDG PET/CT and 68 Ga-NOTA UBI PET/CT findings.

摘要:免疫功能正常的患者患真菌性关节炎和脓毒血症的情况非常罕见。在此,我们报告了一例免疫功能正常的患者感染头孢菌素的病例,该病例的 18F-FDG PET/CT 和 68Ga-NOTA UBI PET/CT 发现非常有趣。
{"title":"Pyomyositis Due to a Rare Fungal Infection-Findings on 68 Ga-NOTA UBI PET/CT.","authors":"Shubha Gadde Ravindra, Nishikant Avinash Damle, Pyata Vikram Babu, Danveer Bhadu, Gagandeep Singh","doi":"10.1097/RLU.0000000000005621","DOIUrl":"10.1097/RLU.0000000000005621","url":null,"abstract":"<p><strong>Abstract: </strong>It is very rare to see fungal arthritis and pyomyositis in immunocompetent patients. Here, we report a case of Scedosporium infection in an immunocompetent patient with interesting 18 F-FDG PET/CT and 68 Ga-NOTA UBI PET/CT findings.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e207-e208"},"PeriodicalIF":9.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Translation of a Dual-Integrin αvβ3- and CD13-Targeting PET Tracer.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-01 Epub Date: 2025-01-20 DOI: 10.1097/RLU.0000000000005647
Xiao Zhang, Biao Yang, Chunxia Qin, Xiangming Song, Xiaoying Lv, Dexing Zeng, Yongkang Gai, Xiaoli Lan

Purpose: Angiogenesis is essential in the development and progression of tumors. This study aimed to investigate the clinical application of 68 Ga-labeled heterodimeric peptide ( 68 Ga-HX01) targeting integrin αvβ3 and CD13 in tumor neovascularization.

Patients and methods: Six healthy volunteers were recruited to study the biodistribution, pharmacokinetics, and radiation of 68 Ga-HX01. Twelve patients with various malignancies were enrolled to seek the preliminary clinical value of 68 Ga-HX01. In healthy volunteers, SUVs of each major organ on 68 Ga-HX01 PET were measured. The clinical data, lesion numbers, and uptake were recorded in patients. The integrin αvβ3 and CD13 expression of the resected tumors was checked via immunohistochemistry staining.

Results: With a mean injected dose of 167.98 ± 26.32 MBq, 68 Ga-HX01 was well tolerated and safe without side effects in 6 healthy volunteers. The radiation absorbed effective dose of 68 Ga-HX01 was 1.94 × 10 -2 mSv/MBq, and the urinary bladder wall held the highest absorbed effective dose (0.15 ± 5.87 × 10 -2 mSv/MBq). In 12 patients with various malignancies, 68 Ga-HX01 PET could clearly visualize the lesions from the surrounding tissues. The SUV max values in tumors were significantly higher than those in the surrounding tissues ( P < 0.05). A positive correlation trend between tumor SUV max and semiquantitative integrin αvβ3 and CD13 expression was determined ( P < 0.05).

Conclusions: For clinical use, 68 Ga-HX01 is safe with low radiation absorbed effective dose. It also indicates the efficiency of dual integrin αvβ3 and CD13-targeting PET radiotracer in tumor diagnosis, which may assist in patient prognosis and selecting eligible patients for antiangiogenic therapy.

{"title":"Clinical Translation of a Dual-Integrin αvβ3- and CD13-Targeting PET Tracer.","authors":"Xiao Zhang, Biao Yang, Chunxia Qin, Xiangming Song, Xiaoying Lv, Dexing Zeng, Yongkang Gai, Xiaoli Lan","doi":"10.1097/RLU.0000000000005647","DOIUrl":"10.1097/RLU.0000000000005647","url":null,"abstract":"<p><strong>Purpose: </strong>Angiogenesis is essential in the development and progression of tumors. This study aimed to investigate the clinical application of 68 Ga-labeled heterodimeric peptide ( 68 Ga-HX01) targeting integrin αvβ3 and CD13 in tumor neovascularization.</p><p><strong>Patients and methods: </strong>Six healthy volunteers were recruited to study the biodistribution, pharmacokinetics, and radiation of 68 Ga-HX01. Twelve patients with various malignancies were enrolled to seek the preliminary clinical value of 68 Ga-HX01. In healthy volunteers, SUVs of each major organ on 68 Ga-HX01 PET were measured. The clinical data, lesion numbers, and uptake were recorded in patients. The integrin αvβ3 and CD13 expression of the resected tumors was checked via immunohistochemistry staining.</p><p><strong>Results: </strong>With a mean injected dose of 167.98 ± 26.32 MBq, 68 Ga-HX01 was well tolerated and safe without side effects in 6 healthy volunteers. The radiation absorbed effective dose of 68 Ga-HX01 was 1.94 × 10 -2 mSv/MBq, and the urinary bladder wall held the highest absorbed effective dose (0.15 ± 5.87 × 10 -2 mSv/MBq). In 12 patients with various malignancies, 68 Ga-HX01 PET could clearly visualize the lesions from the surrounding tissues. The SUV max values in tumors were significantly higher than those in the surrounding tissues ( P < 0.05). A positive correlation trend between tumor SUV max and semiquantitative integrin αvβ3 and CD13 expression was determined ( P < 0.05).</p><p><strong>Conclusions: </strong>For clinical use, 68 Ga-HX01 is safe with low radiation absorbed effective dose. It also indicates the efficiency of dual integrin αvβ3 and CD13-targeting PET radiotracer in tumor diagnosis, which may assist in patient prognosis and selecting eligible patients for antiangiogenic therapy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"332-337"},"PeriodicalIF":9.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of [ 68 Ga]FAPI PET/CT in Diagnosing Thymoma and Its Implications.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-01 Epub Date: 2025-01-23 DOI: 10.1097/RLU.0000000000005650
Paul Martin Dahlke, Carolin Senger, Jens-Carsten Rückert, Jens Neudecker, Christian Furth

Abstract: We report the case of a 71-year-old woman with recurrence of type B3 thymoma in which the diagnostic accuracy has benefited considerably from the additional use of [ 68 Ga]FAPI PET/CT when compared with the standard [ 18 F]FDG PET. [ 68 Ga]FAPI PET/CT confirmed the known lesions with higher lesion-to-background ratio and additionally identified a previously undetected lesion near the FDG-avid apex of the heart. This case demonstrates a potential superiority of [ 68 Ga]FAPI PET/CT in patients suffering from thymoma as detection of local recurrence close to metabolically active organs (ie, liver, heart) is improved. An improved planning of subsequent treatments (ie, lesion delineation for radiotherapy) appears possible.

{"title":"Role of [ 68 Ga]FAPI PET/CT in Diagnosing Thymoma and Its Implications.","authors":"Paul Martin Dahlke, Carolin Senger, Jens-Carsten Rückert, Jens Neudecker, Christian Furth","doi":"10.1097/RLU.0000000000005650","DOIUrl":"10.1097/RLU.0000000000005650","url":null,"abstract":"<p><strong>Abstract: </strong>We report the case of a 71-year-old woman with recurrence of type B3 thymoma in which the diagnostic accuracy has benefited considerably from the additional use of [ 68 Ga]FAPI PET/CT when compared with the standard [ 18 F]FDG PET. [ 68 Ga]FAPI PET/CT confirmed the known lesions with higher lesion-to-background ratio and additionally identified a previously undetected lesion near the FDG-avid apex of the heart. This case demonstrates a potential superiority of [ 68 Ga]FAPI PET/CT in patients suffering from thymoma as detection of local recurrence close to metabolically active organs (ie, liver, heart) is improved. An improved planning of subsequent treatments (ie, lesion delineation for radiotherapy) appears possible.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"338-340"},"PeriodicalIF":9.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biodistribution and Dosimetry Evaluation of the Radiolabeled Somatostatin Receptor Antagonist 68 Ga-DATA 5m LM4 in Molecular Imaging of Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors Patients.
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-01 Epub Date: 2025-01-06 DOI: 10.1097/RLU.0000000000005649
Sanjana Ballal, Parvind Sheokand, Madhav P Yadav, Frank Roesch, Rahul Viswanathan, Swayamjeet Satapathy, Madhavi Tripathi, Euy Sung Moon, Prashant Mishra, Sameer Rastogi, Shipra Agarwal, Chandrasekhar Bal

Purpose: This study aimed to assess the biodistribution and radiation dosimetry of 68 Ga-DATA 5m LM4 in patients with gastroenteropancreatic neuroendocrine tumors.

Patients and methods: Eight patients (5 females and 3 males) with various gastroenteropancreatic neuroendocrine tumors were included in the study. Each patient underwent 3 whole-body PET scans at 10, 60, and 120 minutes after receiving an IV injection of approximately 162.5 MBq of 68 Ga-DATA 5m LM4. Organs considered for dosimetric analysis included the liver, heart, spleen, kidneys, adrenal glands, and lumbar vertebrae (L2 to L4). Dosimetric calculations were performed using the OLINDA/EXM 2.2 software.

Results: Physiological uptake of 68 Ga-DATA 5m LM4 was observed in the pituitary gland, spleen, liver, adrenal glands, and the urinary tract (kidneys and urinary bladder) for all patients. The kidneys received the highest absorbed doses at (4.77E-02 ± 1.49E-02 mSv/MBq). The mean effective dose was 2.61E-03 ± 5.99E-04 mSv/MBq.

Conclusions: 68 Ga-DATA 5m LM4 injection is safe and is primarily excreted through urine, delivering the highest radiation dose to the kidneys.

{"title":"Biodistribution and Dosimetry Evaluation of the Radiolabeled Somatostatin Receptor Antagonist 68 Ga-DATA 5m LM4 in Molecular Imaging of Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors Patients.","authors":"Sanjana Ballal, Parvind Sheokand, Madhav P Yadav, Frank Roesch, Rahul Viswanathan, Swayamjeet Satapathy, Madhavi Tripathi, Euy Sung Moon, Prashant Mishra, Sameer Rastogi, Shipra Agarwal, Chandrasekhar Bal","doi":"10.1097/RLU.0000000000005649","DOIUrl":"10.1097/RLU.0000000000005649","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the biodistribution and radiation dosimetry of 68 Ga-DATA 5m LM4 in patients with gastroenteropancreatic neuroendocrine tumors.</p><p><strong>Patients and methods: </strong>Eight patients (5 females and 3 males) with various gastroenteropancreatic neuroendocrine tumors were included in the study. Each patient underwent 3 whole-body PET scans at 10, 60, and 120 minutes after receiving an IV injection of approximately 162.5 MBq of 68 Ga-DATA 5m LM4. Organs considered for dosimetric analysis included the liver, heart, spleen, kidneys, adrenal glands, and lumbar vertebrae (L2 to L4). Dosimetric calculations were performed using the OLINDA/EXM 2.2 software.</p><p><strong>Results: </strong>Physiological uptake of 68 Ga-DATA 5m LM4 was observed in the pituitary gland, spleen, liver, adrenal glands, and the urinary tract (kidneys and urinary bladder) for all patients. The kidneys received the highest absorbed doses at (4.77E-02 ± 1.49E-02 mSv/MBq). The mean effective dose was 2.61E-03 ± 5.99E-04 mSv/MBq.</p><p><strong>Conclusions: </strong>68 Ga-DATA 5m LM4 injection is safe and is primarily excreted through urine, delivering the highest radiation dose to the kidneys.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":"50 4","pages":"e194-e201"},"PeriodicalIF":9.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant Phyllodes Tumor With Sphenoid Bone Metastasis Detected on 99m Tc-MDP SPECT/CT and 18 F-FDG PET/CT. 99mTc-MDP SPECT/CT和18F-FDG PET/CT检测恶性叶状瘤伴蝶骨转移。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-01 Epub Date: 2024-12-06 DOI: 10.1097/RLU.0000000000005632
Ritwik Wakankar, Yamini Dharmashaktu, Akhil Venugopal, Rakesh Kumar

Abstract: Phyllodes tumors (PTs) are rare fibroepithelial tumors accounting for less than 1% of all breast neoplasms. They are malignant in 20% of cases. Only a few cases of malignant PT metastatic to bone have been reported. We report a case of metastatic malignant PT of the breast involving the greater wing of the sphenoid bone and discuss the radiological findings of 99m Tc-methylene diphosphonate skeletal scintigraphy, SPECT/CT, and 18 F-FDG PET/CT. To our knowledge, this is the first time such a case has been reported in literature.

摘要:叶状瘤(PTs)是一种罕见的纤维上皮肿瘤,占乳腺肿瘤的不到1%。它们在20%的病例中是恶性的。只有少数恶性PT转移到骨的病例被报道。我们报告一例涉及蝶骨大翼的乳腺转移性恶性PT,并讨论99mtc -二膦酸亚甲基骨骼显像、SPECT/CT和18F-FDG PET/CT的放射学表现。据我们所知,这是文献中第一次报道这样的病例。
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引用次数: 0
18 F-DCFPyL in the Detection of Prostate Cancer Spread to the Lumbosacral Plexus. 18F-DCFPyL在前列腺癌腰骶丛扩散中的检测价值。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-01 Epub Date: 2024-12-13 DOI: 10.1097/RLU.0000000000005472
Silmara R Segala, Duncan Sutherland, Glenn Bauman, Brandon Driscoll, Joseph Chin, Jonathan Romsa, Katherine A Zukotynski

Abstract: In most cases, prostate cancer spreads locally to the seminal vesicles, via lymphatics to pelvic and abdominal lymph nodes, and hematogenously to the bones. Direct invasion along nerve roots is exceptionally rare but can occur. Here, we present a case with 18 F-DCFPyL PET/CT images showing neoplastic involvement of the lumbosacral plexus in a patient with recurrent prostate cancer.

摘要:在大多数情况下,前列腺癌局部扩散到精囊,通过淋巴管扩散到盆腔和腹腔淋巴结,并通过血源性扩散到骨骼。沿神经根直接侵犯极为罕见,但也可能发生。在此,我们报告一例复发性前列腺癌患者的18F-DCFPyL PET/CT图像显示肿瘤累及腰骶神经丛。
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引用次数: 0
225 Ac-PSMA-617 Augmentation After Insufficient Response Under 177 Lu-PSMA-617 Radioligand Therapy in mCRPC: Evaluation of Outcome and Safety From a Prospective Registry (REALITY Study). 在mCRPC的177Lu-PSMA-617放射治疗中,反应不足后的225Ac-PSMA-617增强:来自前瞻性注册表的结果和安全性评估(REALITY研究)。
IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-04-01 Epub Date: 2024-12-31 DOI: 10.1097/RLU.0000000000005640
Florian Rosar, Fadi Khreish, Lea Sophie Nagel, Arne Blickle, Caroline Burgard, Sven Petto, Moritz B Bastian, Tilman Speicher, Mark Bartholomä, Stephan Maus, Andrea Schaefer-Schuler, Samer Ezziddin

Background: Even though the introduction of 177 Lu-PSMA-617 RLT represents a major milestone in the treatment of mCRPC, there are still patients who do not respond adequately to this therapy and for whom there are only limited options left. Augmenting 177 Lu-PSMA-617 RLT with the alpha-emitter 225 Ac-PSMA-617 may present an escalating treatment option to increase efficacy. In this study, we aim to evaluate outcome and safety of 225 Ac-PSMA-617 augmentation to 177 Lu-PSMA-617 RLT in patients who present insufficient response to monotherapy with 177 Lu-PSMA-617 RLT.

Patients and methods: The study included n = 51 mCRPC patients enrolled in a prospective registry receiving 177 Lu-PSMA-617 monotherapy and showing insufficient response, followed by initiation of 225 Ac-PSMA-617 augmentation, with adjusted activities depending on individual patient characteristics. Biochemical response, progression-free survival, and overall survival were assessed. Adverse events were evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE v.5.0).

Results: After initiation of 225 Ac-PSMA-617 augmentation to 177 Lu-PSMA-617 RLT, 24/51 patients (47.1%) exhibited partial remission, 16/51 (31.4%) stable disease, and 11/51 (21.6%) progressive disease. The median progression-free survival and overall survival rates were 6.3 months and 9.1 months, respectively. The majority of CTCAE gradings remained stable after initiating augmentation. Severe adverse events were rare, and no treatment termination due to side effects was recorded.

Conclusions: 225 Ac-PSMA-617 augmented 177 Lu-PSMA-617 radioligand therapy seems to be an effective escalating treatment option in patients after failure of conventional 177 Lu-PSMA-617 RLT and represents a promising approach balancing antitumor effect and tolerable side effects.

背景:尽管177Lu-PSMA-617 RLT的引入是mCRPC治疗的一个重要里程碑,但仍然有患者对这种治疗没有充分的反应,他们的选择有限。增强177Lu-PSMA-617 RLT与α -发射器225Ac-PSMA-617可能是一种逐步升级的治疗选择,以提高疗效。在这项研究中,我们的目标是评估对177Lu-PSMA-617 RLT单药治疗反应不足的患者将225Ac-PSMA-617增强到177Lu-PSMA-617 RLT的结果和安全性。患者和方法:该研究纳入了n = 51例mCRPC患者,纳入前瞻性登记,接受177u - psma -617单药治疗,反应不足,随后开始225Ac-PSMA-617增强治疗,根据患者个体特征调整活性。评估生化反应、无进展生存期和总生存期。根据不良事件通用术语标准(CTCAE v.5.0)评估不良事件。结果:开始225Ac-PSMA-617增强至177Lu-PSMA-617 RLT后,24/51例(47.1%)患者出现部分缓解,16/51例(31.4%)病情稳定,11/51例(21.6%)病情进展。中位无进展生存期和总生存期分别为6.3个月和9.1个月。大多数CTCAE分级在初始强化后保持稳定。严重不良事件罕见,无因副作用终止治疗的记录。结论:225Ac-PSMA-617增强177Lu-PSMA-617放射配体治疗似乎是常规177Lu-PSMA-617 RLT失败后患者的有效升级治疗选择,是一种平衡抗肿瘤效果和可耐受副作用的有希望的方法。
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引用次数: 0
期刊
Clinical Nuclear Medicine
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