Purpose: To investigate the relationship between the systemic immune-inflammatory index (SII) and acute appendicitis (AA). Materials and Methods: We retrospectively evaluated patients aged over 18 years who were diagnosed with AA and underwent surgery at our clinic from January 1, 2019, through July 31, 2022. The patients were divided into three groups: complicated acute appendicitis (CAA), uncomplicated acute appendicitis (UAA), and control. The clinical and laboratory characteristics of the patients evaluated at the emergency department were recorded. The neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and SII (neutrophil count x platelet count/lymphocyte count) were calculated. Results: The study included a total of 1,456 patients, of whom 628 had UAA, 104 had CAA, and 714 were controls. The NLR, PLR, and SII values were statistically significantly higher in the CAA group than in the control group and the UAA group. The multivariate logistic regression analysis revealed that SII was an independent predictor of CAA development (odds ratio [OR]: 4.65; 95% confidence interval [CI]: 2.31–10.17). The predictive power of SII in the prediction of CAA (area under the curve [AUC]: 0.809) was much higher than that of NLR (AUC: 0.729), neutrophil count (AUC: 0.696), and C-reactive protein (AUC: 0.732) alone. It was determined that an SII value greater than 1,989.2 had a sensitivity of 78.4% and a specificity of 88.5% in predicting CAA development. Conclusion: SII is a simple, inexpensive, and promising marker that could predict both the diagnosis and severity of appendicitis.
{"title":"Sistemik immün inflamasyon indeksi, akut apandisitli hastalarında komlikasyonun doğru erken tahmini için yeni ve güçlü bir belirteç olabilir","authors":"Hüseyin Mutlu, E. Sert, Kamil Kokulu, Yakup Uslu","doi":"10.17826/cumj.1276128","DOIUrl":"https://doi.org/10.17826/cumj.1276128","url":null,"abstract":"Purpose: To investigate the relationship between the systemic immune-inflammatory index (SII) and acute appendicitis (AA). \u0000Materials and Methods: We retrospectively evaluated patients aged over 18 years who were diagnosed with AA and underwent surgery at our clinic from January 1, 2019, through July 31, 2022. The patients were divided into three groups: complicated acute appendicitis (CAA), uncomplicated acute appendicitis (UAA), and control. The clinical and laboratory characteristics of the patients evaluated at the emergency department were recorded. The neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and SII (neutrophil count x platelet count/lymphocyte count) were calculated. \u0000Results: The study included a total of 1,456 patients, of whom 628 had UAA, 104 had CAA, and 714 were controls. The NLR, PLR, and SII values were statistically significantly higher in the CAA group than in the control group and the UAA group. The multivariate logistic regression analysis revealed that SII was an independent predictor of CAA development (odds ratio [OR]: 4.65; 95% confidence interval [CI]: 2.31–10.17). The predictive power of SII in the prediction of CAA (area under the curve [AUC]: 0.809) was much higher than that of NLR (AUC: 0.729), neutrophil count (AUC: 0.696), and C-reactive protein (AUC: 0.732) alone. It was determined that an SII value greater than 1,989.2 had a sensitivity of 78.4% and a specificity of 88.5% in predicting CAA development. \u0000Conclusion: SII is a simple, inexpensive, and promising marker that could predict both the diagnosis and severity of appendicitis.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"31 8","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72442685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To investigate the impact of neurogenic lower urinary tract dysfunction (NLUTD) and sexual dysfunction (SD) on multiple sclerosis (MS) patients' quality of life and health perceptions and evaluate the possible relationship with disease parameters. Materials and Methods: A total of 192 patients with MS were included in the study. Along with the King's Health (KHQ) and COOP/WONCA questionnaires, Arizona Sexual Experience Scale (ASEX), Beck Depression Scale (BDI), Monitoring My Multiple Sclerosis Scale (MMMS) were used to evaluate the patients’ quality of life and self-perception of health. Results: The median age of the patients was 39.5 years (18–66 years). In contrast, SD was present in 34.4%, 51.6% of the patients presented with NLUTD. Patients with NLUTD had significant differences in terms of age, education level, duration of disease, EDSS, BDI, ASEX, and MMMS scores. The majority of the study group had minor disability (82.8% had an EDSS score less than 3). Patients with SD showed higher disability, depression, and disrupted self-perception of their health status. In addition, quality of life measures correlated with the presence of NLUTD, SD and depression along with higher disability and altered self perception of their health status. Conclusion: NLUTD and SD significantly effect quality of life and well being. Increasing awareness about the impact of NLUTD and SD symptoms in patients with MS will provide a comprehensive approach in clinical practice.
目的:探讨神经源性下尿路功能障碍(NLUTD)和性功能障碍(SD)对多发性硬化症(MS)患者生活质量和健康感知的影响，并评价其与疾病参数的可能关系。材料与方法:共纳入192例多发性硬化症患者。采用King’s Health (KHQ)、COOP/WONCA问卷、亚利桑那性经验量表(ASEX)、贝克抑郁量表(BDI)、监测我的多发性硬化症量表(MMMS)评估患者的生活质量和健康自我感知。结果:患者年龄中位数为39.5岁(18 ~ 66岁)。相反，出现NLUTD的患者中有34.4%出现SD, 51.6%出现SD。NLUTD患者在年龄、受教育程度、病程、EDSS、BDI、ASEX、MMMS评分方面存在显著差异。大多数研究组有轻微残疾(82.8%的EDSS评分低于3分)。SD患者表现出更高的残疾、抑郁和对健康状况的自我认知中断。此外，生活质量测量与NLUTD、SD和抑郁的存在相关，同时伴有更高的残疾程度和对健康状况的自我认知改变。结论:NLUTD和SD显著影响患者的生活质量和幸福感。提高对NLUTD和SD症状在MS患者中的影响的认识将为临床实践提供全面的方法。
{"title":"Cinsel ve nörojenik alt üriner sistem disfonksiyonunun multipl skleroz hastalarının yaşam kalitesi ve sağlık algıları üzerindeki etkisi","authors":"Neslihan Eşkut, Aslı Köşkdereli̇oğlu","doi":"10.17826/cumj.1239533","DOIUrl":"https://doi.org/10.17826/cumj.1239533","url":null,"abstract":"Purpose: To investigate the impact of neurogenic lower urinary tract dysfunction (NLUTD) and sexual dysfunction (SD) on multiple sclerosis (MS) patients' quality of life and health perceptions and evaluate the possible relationship with disease parameters. \u0000Materials and Methods: A total of 192 patients with MS were included in the study. Along with the King's Health (KHQ) and COOP/WONCA questionnaires, Arizona Sexual Experience Scale (ASEX), Beck Depression Scale (BDI), Monitoring My Multiple Sclerosis Scale (MMMS) were used to evaluate the patients’ quality of life and self-perception of health. \u0000Results: The median age of the patients was 39.5 years (18–66 years). In contrast, SD was present in 34.4%, 51.6% of the patients presented with NLUTD. Patients with NLUTD had significant differences in terms of age, education level, duration of disease, EDSS, BDI, ASEX, and MMMS scores. The majority of the study group had minor disability (82.8% had an EDSS score less than 3). Patients with SD showed higher disability, depression, and disrupted self-perception of their health status. In addition, quality of life measures correlated with the presence of NLUTD, SD and depression along with higher disability and altered self perception of their health status. \u0000Conclusion: NLUTD and SD significantly effect quality of life and well being. Increasing awareness about the impact of NLUTD and SD symptoms in patients with MS will provide a comprehensive approach in clinical practice.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"152 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75934994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Hyponatremia is associated with high morbidity and mortality in elderly patients. This study aimed to investigate the incidence of hyponatremia and its effects on the duration of hospitalization, in-hospital and 1-year mortality in elderly patients admitted to the hospital due to hip fracture. Materials and Methods: After the approval of the ethics committee, patients over the age 65 and had hip surgery between January-December 2020 were retrospectively analyzed. The age, gender, fracture type, current comorbidities, and American Society of Anesthesiology physical status scores of the patients were recorded. Plasma Na, K, and Ca values in admission to hospital were recorded. Patients with hyponatremia and normonatremia were compared in terms of demographic data, comorbidities, duration of hospitalization, in-hospital, and 1-year mortality rates. Results: Of the total 253 patients, 52(%20.5) had hyponatremia at hospital admission. Demographic data were similar in hyponatremic and normonatremic patients. In hyponatremia group mean Na values were 131.13±3.96 mmol/L and significantly lower than normonatremia group (138.73±2.27). In the hyponatremic group, diabetes mellitus was observed in 23 (44%) patients, and congestive heart failure was observed in 9 (17%) patients, which was higher than the normonatremic group. The preoperative and total duration of hospitalization was 5.21±2.68 and 9.92±4.49 days respectively and higher in patients with hyponatremia. In-hospital and 1-year mortality rates were similar between the groups. Conclusion: The incidence of hyponatremia was found to be 20.5% in patients with hip fractures, and both the preoperative and total hospital stays were prolonged in these patients. Although mortality rates were similar in this study, hyponatremia requires careful follow-up and early treatment in these patients, since it is known that the length of hospital stay increases mortality.
{"title":"The incidence of hyponatremia in hospitalized patients due to hip fracture and its effect on mortality","authors":"K. Kayaokay, D. ARSLAN YURTLU","doi":"10.17826/cumj.1284848","DOIUrl":"https://doi.org/10.17826/cumj.1284848","url":null,"abstract":"Purpose: Hyponatremia is associated with high morbidity and mortality in elderly patients. This study aimed to investigate the incidence of hyponatremia and its effects on the duration of hospitalization, in-hospital and 1-year mortality in elderly patients admitted to the hospital due to hip fracture. \u0000Materials and Methods: After the approval of the ethics committee, patients over the age 65 and had hip surgery between January-December 2020 were retrospectively analyzed. The age, gender, fracture type, current comorbidities, and American Society of Anesthesiology physical status scores of the patients were recorded. Plasma Na, K, and Ca values in admission to hospital were recorded. Patients with hyponatremia and normonatremia were compared in terms of demographic data, comorbidities, duration of hospitalization, in-hospital, and 1-year mortality rates. \u0000Results: Of the total 253 patients, 52(%20.5) had hyponatremia at hospital admission. Demographic data were similar in hyponatremic and normonatremic patients. In hyponatremia group mean Na values were 131.13±3.96 mmol/L and significantly lower than normonatremia group (138.73±2.27). In the hyponatremic group, diabetes mellitus was observed in 23 (44%) patients, and congestive heart failure was observed in 9 (17%) patients, which was higher than the normonatremic group. The preoperative and total duration of hospitalization was 5.21±2.68 and 9.92±4.49 days respectively and higher in patients with hyponatremia. In-hospital and 1-year mortality rates were similar between the groups. \u0000Conclusion: The incidence of hyponatremia was found to be 20.5% in patients with hip fractures, and both the preoperative and total hospital stays were prolonged in these patients. Although mortality rates were similar in this study, hyponatremia requires careful follow-up and early treatment in these patients, since it is known that the length of hospital stay increases mortality.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"18 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78529779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Although it has been shown that vitamin K administration does not benefit patients with INR levels between 4.5 to 10, there are studies in the literature showing that some complications including the risk of bleeding in these patients increase significantly. For this reason, it is crucial to select high-risk patients who present with elevated INR to apply closer follow-up and monitoring. The primary objective of our study is to define the predictors for 30-day mortality of the patients with an INR between 4.5 to 10 due to warfarin-related overanticoagulation. The secondary objective of our study is to derive a regression model which can predict mortality in 30 days and to compare the performance of this model with the National Early Warning Score-2(NEWS-2). Materials and Methods: We included patients older than 18 years old, admitted between the dates 01.01.2016 - 01.01.2022 who are using warfarin as medication and with an INR between 4.5 – 10 in our study. We excluded patients with trauma, major bleeding on admission or patients with missing data. For the regression model, backward-wald stepwise method was utilized. We used the Hosmer-Lemeshow test for the goodness of fit. For the overall performance of the model, we evaluated the Nagelkerke R Square, and the Reciever Operating Characteristics test. DeLong test was used to compare the area under the curves (AUC). Results: A total of 263 patients were examined in the statistical analysis. Mean arterial pressure, SpO2, pulse rate, and age were the independent predictors of 30-day mortality. The model have classified 81.4% of the patients correctly. The AUC of the regression model was 0.848 (0.799 to 0.898). The sensitivity of the model as a tool for mortality prediction was 94.1%, specificity 66.5%, and accuracy 71.9%. The AUC of the NEWS-2 score for 30-day mortality was calculated as 0.782 (95%CI = 0.715 to 0.849). The difference between the AUCs of our model and the NEWS-2 score was statistically significant. Conclusion: Mean arterial pressure, SpO2, heart rate, and age were the independent predictors for the 30-day mortality of patients with an INR between 4.5 to 10 due to overanticoagulation because of warfarin medication. The regression model we derived showed good overall discrimination and performed significantly better than NEWS-2 score.
{"title":"Predictors of 30-day mortality in patients with an international normalized ratio of 4.5 - 10 due to warfarin-related overanticoagulation: a retrospective cohort study","authors":"Mehmet Muzaffer Islam","doi":"10.17826/cumj.1247794","DOIUrl":"https://doi.org/10.17826/cumj.1247794","url":null,"abstract":"Purpose: Although it has been shown that vitamin K administration does not benefit patients with INR levels between 4.5 to 10, there are studies in the literature showing that some complications including the risk of bleeding in these patients increase significantly. For this reason, it is crucial to select high-risk patients who present with elevated INR to apply closer follow-up and monitoring. The primary objective of our study is to define the predictors for 30-day mortality of the patients with an INR between 4.5 to 10 due to warfarin-related overanticoagulation. The secondary objective of our study is to derive a regression model which can predict mortality in 30 days and to compare the performance of this model with the National Early Warning Score-2(NEWS-2). \u0000Materials and Methods: We included patients older than 18 years old, admitted between the dates 01.01.2016 - 01.01.2022 who are using warfarin as medication and with an INR between 4.5 – 10 in our study. We excluded patients with trauma, major bleeding on admission or patients with missing data. For the regression model, backward-wald stepwise method was utilized. We used the Hosmer-Lemeshow test for the goodness of fit. For the overall performance of the model, we evaluated the Nagelkerke R Square, and the Reciever Operating Characteristics test. DeLong test was used to compare the area under the curves (AUC). \u0000Results: A total of 263 patients were examined in the statistical analysis. Mean arterial pressure, SpO2, pulse rate, and age were the independent predictors of 30-day mortality. The model have classified 81.4% of the patients correctly. The AUC of the regression model was 0.848 (0.799 to 0.898). The sensitivity of the model as a tool for mortality prediction was 94.1%, specificity 66.5%, and accuracy 71.9%. The AUC of the NEWS-2 score for 30-day mortality was calculated as 0.782 (95%CI = 0.715 to 0.849). The difference between the AUCs of our model and the NEWS-2 score was statistically significant. \u0000Conclusion: Mean arterial pressure, SpO2, heart rate, and age were the independent predictors for the 30-day mortality of patients with an INR between 4.5 to 10 due to overanticoagulation because of warfarin medication. The regression model we derived showed good overall discrimination and performed significantly better than NEWS-2 score.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"55 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87531243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Identifying the factors that affect sleep quality will help minimize potential health risks. This study aimed to evaluate the association of sleep quality with dietary habits, nutritional status and body mass index (BMI) in adults. Materials and Methods: This study was conducted on 576 healthy individuals, 293 males and 283 females, aged between 18-65 years. The study did not include individuals with chronic diseases, pregnant and lactating women. The participants' descriptive information, dietary habits, and some anthropometric measurements were questioned. Additionally, Pittsburgh Sleep Quality Index (PSQI) was applied to the participants and 24-hour dietary recalls were recorded. Results: In both male and total participants, the rate of good sleep quality of those with a BMI between 18.50-24.99 kg/m2 was lower than those with a BMI ≥25 kg/m2. The number of cigarette smoked in a day and the total PSQI score of the male and total participants were positively correlated. Additionally, there was a positive correlation between the percentage of saturated fatty acids in the diet and the total PSQI scores in female and total participants, while a negative relationship was found between dietary niacin (mg) and copper (mg) intakes and total PSQI scores in female. Conclusion: The results of the study indicate that there is a relationship between sleep quality and nutritional status, and BMI. It can be concluded that some lifestyle modifications such as smoking cessation/reduction and the acquisition of healthy eating habits can be used to improve sleep quality.
{"title":"Association of sleep quality with nutritional status and body mass index in adults","authors":"M. Icer, M. Gezmen Karadağ","doi":"10.17826/cumj.1282132","DOIUrl":"https://doi.org/10.17826/cumj.1282132","url":null,"abstract":"Purpose: Identifying the factors that affect sleep quality will help minimize potential health risks. This study aimed to evaluate the association of sleep quality with dietary habits, nutritional status and body mass index (BMI) in adults. \u0000Materials and Methods: This study was conducted on 576 healthy individuals, 293 males and 283 females, aged between 18-65 years. The study did not include individuals with chronic diseases, pregnant and lactating women. The participants' descriptive information, dietary habits, and some anthropometric measurements were questioned. Additionally, Pittsburgh Sleep Quality Index (PSQI) was applied to the participants and 24-hour dietary recalls were recorded. \u0000Results: In both male and total participants, the rate of good sleep quality of those with a BMI between 18.50-24.99 kg/m2 was lower than those with a BMI ≥25 kg/m2. The number of cigarette smoked in a day and the total PSQI score of the male and total participants were positively correlated. Additionally, there was a positive correlation between the percentage of saturated fatty acids in the diet and the total PSQI scores in female and total participants, while a negative relationship was found between dietary niacin (mg) and copper (mg) intakes and total PSQI scores in female. \u0000Conclusion: The results of the study indicate that there is a relationship between sleep quality and nutritional status, and BMI. It can be concluded that some lifestyle modifications such as smoking cessation/reduction and the acquisition of healthy eating habits can be used to improve sleep quality.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"116 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79625574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burcu SIRLIER EMİR, Sevler Yildiz, Aslı KAZĞAN KILIÇASLAN, Kerim Uğur, Osman Kurt
Purpose: Generalized anxiety disorder (GAD) is a psychiatric condition where both physical and mental symptoms are observed due to the activation of the sympathetic system. It is known that the disorder affects the cardiovascular system. The present study aimed to analyze arterial stiffness in GAD patients and compare the findings with healthy controls. Materials and Methods: 40 patients diagnosed with GAD and 40 healthy individuals were included in the study. Carotid and femoral artery intima-medial thickness (IMT) and arterial thickness parameters were measured with Doppler ultrasonography. Results: The femoral IMT of the patients was significantly low. Although the carotid IMT was higher in patients when compared to the controls, the difference was not statistically significant. A significant negative correlation was determined between fluoxetine equivalent dose and femoral IMT. There was a correlation between femoral IMT and fluoxetine equivalent dose. Conclusion: Arterial stiffness should be investigated for its potential to indicate cardiovascular risk in GAD. Further comprehensive studies should be conducted to clarify whether atherosclerosis symptoms were associated with the nature of the GAD or prescription medicine.
{"title":"Yaygın anksiyete bozukluğu olan hastalarda arteriyel sertliğin değerlendirilmesi","authors":"Burcu SIRLIER EMİR, Sevler Yildiz, Aslı KAZĞAN KILIÇASLAN, Kerim Uğur, Osman Kurt","doi":"10.17826/cumj.1219982","DOIUrl":"https://doi.org/10.17826/cumj.1219982","url":null,"abstract":"Purpose: Generalized anxiety disorder (GAD) is a psychiatric condition where both physical and mental symptoms are observed due to the activation of the sympathetic system. It is known that the disorder affects the cardiovascular system. The present study aimed to analyze arterial stiffness in GAD patients and compare the findings with healthy controls. \u0000Materials and Methods: 40 patients diagnosed with GAD and 40 healthy individuals were included in the study. Carotid and femoral artery intima-medial thickness (IMT) and arterial thickness parameters were measured with Doppler ultrasonography. \u0000Results: The femoral IMT of the patients was significantly low. Although the carotid IMT was higher in patients when compared to the controls, the difference was not statistically significant. A significant negative correlation was determined between fluoxetine equivalent dose and femoral IMT. There was a correlation between femoral IMT and fluoxetine equivalent dose. \u0000Conclusion: Arterial stiffness should be investigated for its potential to indicate cardiovascular risk in GAD. Further comprehensive studies should be conducted to clarify whether atherosclerosis symptoms were associated with the nature of the GAD or prescription medicine.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"6 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77055129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gökçe Yağmur Efendi̇, R. Temeltürk, Işık Batuhan Çakmak
Purpose: This study aimed to evaluate the sociodemographic and clinical characteristics of cases who have applied to a research and training hospital for special needs reports for children. Materials and Methods: Retrospective analysis was performed on the medical records of children and adolescents aged 0 to 18 who applied to the Medical Board of the Şanlurfa Mehmet Akif İnan Training and Research Hospital and underwent psychiatric evaluations between June 2022 and December 2022. Results: The research covered 600 cases, of whom 39% (n=234) were female and 61% (n=366) were male, and the mean age at the time that patients applied to the child psychiatry outpatient clinic was 7.87±4.43. When the child psychiatry diagnoses in the special needs reports were examined, it was found that 78% of the cases (n=468) had at least one psychiatric diagnosis, and 86.3% (n=518) of all patients had no previous psychiatric drug use. The most common psychiatric disorder was Borderline Intellectual Functioning (n=110), followed by Specific Learning Disorder (n=64). Autism Spectrum Disorder was more common in boys whereas Severe Intellectual Disability was significantly more common in girls. There was no significant difference between the 3 different age groups in terms of the frequency of Mild Intellectual Disability, Severe Intellectual Disability, and Autism Spectrum Disorder diagnoses. Conclusion: Psychiatrists and other medical professionals can greatly benefit from knowing the characteristics of children and adolescents who apply to the medical boards for special needs reports in various parts of Turkey. To fully address this matter, further research with larger numbers of samples from various centers are required
目的:本研究旨在评估向研究和培训医院申请儿童特殊需要报告的病例的社会人口学和临床特征。材料和方法:对2022年6月至2022年12月期间向Şanlurfa Mehmet Akif İnan培训和研究医院医学委员会申请并接受精神病学评估的0至18岁儿童和青少年的医疗记录进行回顾性分析。结果:本研究共纳入600例，其中女性占39% (n=234)，男性占61% (n=366)，患者到儿童精神病学门诊就诊时平均年龄为7.87±4.43岁。对特殊需要报告中的儿童精神病学诊断进行检查，发现78% (n=468)的病例至少有一种精神病学诊断，86.3% (n=518)的患者既往没有使用过精神科药物。最常见的精神障碍是边缘性智力功能障碍(n=110)，其次是特殊学习障碍(n=64)。自闭症谱系障碍在男孩中更为常见，而严重智力残疾在女孩中更为常见。轻度智力残疾、重度智力残疾和自闭症谱系障碍的诊断频率在三个不同年龄组之间无显著差异。结论:了解土耳其各地向医疗委员会提交特殊需要报告的儿童和青少年的特点，对精神科医生和其他医疗专业人员大有裨益。为了充分解决这一问题，需要从各个中心进行更多样本的进一步研究
{"title":"Şanlıurfa'da bir eğitim ve araştırma hastanesine özel gereksinim raporu için başvuran çocukların sosyodemografik ve klinik özelliklerinin değerlendirilmesi","authors":"Gökçe Yağmur Efendi̇, R. Temeltürk, Işık Batuhan Çakmak","doi":"10.17826/cumj.1240228","DOIUrl":"https://doi.org/10.17826/cumj.1240228","url":null,"abstract":"Purpose: This study aimed to evaluate the sociodemographic and clinical characteristics of cases who have applied to a research and training hospital for special needs reports for children. \u0000Materials and Methods: Retrospective analysis was performed on the medical records of children and adolescents aged 0 to 18 who applied to the Medical Board of the Şanlurfa Mehmet Akif İnan Training and Research Hospital and underwent psychiatric evaluations between June 2022 and December 2022. \u0000Results: The research covered 600 cases, of whom 39% (n=234) were female and 61% (n=366) were male, and the mean age at the time that patients applied to the child psychiatry outpatient clinic was 7.87±4.43. When the child psychiatry diagnoses in the special needs reports were examined, it was found that 78% of the cases (n=468) had at least one psychiatric diagnosis, and 86.3% (n=518) of all patients had no previous psychiatric drug use. The most common psychiatric disorder was Borderline Intellectual Functioning (n=110), followed by Specific Learning Disorder (n=64). Autism Spectrum Disorder was more common in boys whereas Severe Intellectual Disability was significantly more common in girls. There was no significant difference between the 3 different age groups in terms of the frequency of Mild Intellectual Disability, Severe Intellectual Disability, and Autism Spectrum Disorder diagnoses. \u0000Conclusion: Psychiatrists and other medical professionals can greatly benefit from knowing the characteristics of children and adolescents who apply to the medical boards for special needs reports in various parts of Turkey. To fully address this matter, further research with larger numbers of samples from various centers are required","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"64 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89107172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aylin Sariyildiz, H. Kaplan, Ergin Şi̇ngi̇ri̇k, Erkan Kozanoglu
Purpose: The effect of Hypericum perforatum (HP), which is a medicinal plant, on sciatic nerve injury-induced peripheral neuropathy has been less studied so far. The current experimental study aimed to investigate the neuroprotective and antinociceptive effects of Hypericum perforatum (HP) extract on sciatic nerve injury-induced peripheral neuropathy in mice. Materials and Methods: In the present study, 18 Balb/C albino mice were allocated equally into three groups. The first group was determined as controls, and no procedure was performed on these mice. Neuropathy was generated by the partial sciatic nerve ligation method on mice allocated to the second and third groups. Mice in the third group received HP extract at a dose of 70 mg/kg per day for fourteen days. Nociception (cold allodynia) was evaluated using the cold plate test at the end of the experimental period. Tumor necrosis factor –αlpha (TNF-α) and interleukin-6 (IL-6) in plasma; inducible nitric oxide synthase (iNOS), phospholipase A2, cyclooxygenase-2 (COX-2), nuclear factor-kappa B (NF-κB), caspase-3, Bcl-2, and Bax levels in sciatic nerve were measured by enzyme-linked immunosorbent assay test. Results: Cold plate latencies (sec) of the neuropathy + HP, neuropathy, and control groups were 8.33 ± 0.67, 5.17 ± 0.60, and 13 ± 0.73, respectively. Plasma TNF-α, IL-6 levels, and sciatic nerve iNOS, COX-2, NF-κB, caspase-3, and Bax levels were significantly decreased after HP supplementation. Bcl-2 levels of the neuropathy + HP, neuropathy, and control groups were 9.92 ± 0.71, 5.37 ± 0.53, and 13.65 ± 0.68, respectively. Conclusion: HP has improved oxidative, inflammatory, and apoptotic responses, as well as cytokine levels in plasma and sciatic nerves of mice. It has been concluded that HP provided neuroprotective, anti-inflammatory, and antinociceptive effects in experimental mice with sciatic nerve injury models, which is suggested to guide future studies on neuropathic pain management.
{"title":"Hypericum perforatum ekstresinin siyatik sinir hasarı ile indüklenen periferik nöropati üzerindeki düzenleyici etkisi: fareler üzerinde deneysel bir çalışma","authors":"Aylin Sariyildiz, H. Kaplan, Ergin Şi̇ngi̇ri̇k, Erkan Kozanoglu","doi":"10.17826/cumj.1259761","DOIUrl":"https://doi.org/10.17826/cumj.1259761","url":null,"abstract":"Purpose: The effect of Hypericum perforatum (HP), which is a medicinal plant, on sciatic nerve injury-induced peripheral neuropathy has been less studied so far. The current experimental study aimed to investigate the neuroprotective and antinociceptive effects of Hypericum perforatum (HP) extract on sciatic nerve injury-induced peripheral neuropathy in mice. \u0000Materials and Methods: In the present study, 18 Balb/C albino mice were allocated equally into three groups. The first group was determined as controls, and no procedure was performed on these mice. Neuropathy was generated by the partial sciatic nerve ligation method on mice allocated to the second and third groups. Mice in the third group received HP extract at a dose of 70 mg/kg per day for fourteen days. Nociception (cold allodynia) was evaluated using the cold plate test at the end of the experimental period. Tumor necrosis factor –αlpha (TNF-α) and interleukin-6 (IL-6) in plasma; inducible nitric oxide synthase (iNOS), phospholipase A2, cyclooxygenase-2 (COX-2), nuclear factor-kappa B (NF-κB), caspase-3, Bcl-2, and Bax levels in sciatic nerve were measured by enzyme-linked immunosorbent assay test. \u0000Results: Cold plate latencies (sec) of the neuropathy + HP, neuropathy, and control groups were 8.33 ± 0.67, 5.17 ± 0.60, and 13 ± 0.73, respectively. Plasma TNF-α, IL-6 levels, and sciatic nerve iNOS, COX-2, NF-κB, caspase-3, and Bax levels were significantly decreased after HP supplementation. Bcl-2 levels of the neuropathy + HP, neuropathy, and control groups were 9.92 ± 0.71, 5.37 ± 0.53, and 13.65 ± 0.68, respectively. \u0000Conclusion: HP has improved oxidative, inflammatory, and apoptotic responses, as well as cytokine levels in plasma and sciatic nerves of mice. It has been concluded that HP provided neuroprotective, anti-inflammatory, and antinociceptive effects in experimental mice with sciatic nerve injury models, which is suggested to guide future studies on neuropathic pain management.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"26 6 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89838097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Unhealthy lifestyle factors make up a significant proportion of the factors that cause high morbidity and mortality risk. The life span of patients with schizophrenia is 10–20 years less than that of the general population due to lifestyle-related diseases. The aim of this study is to compare with healthy individuals the nutritional habits, nutritional status, and physical activity levels of schizophrenic patients. Materials and Methods: The study was conducted on 25–55-year-old 40 patients diagnosed with schizophrenia or schizoaffective disorders and 30 healthy controls matched for age and gender. Data on sociodemographic characteristics and nutritional habits, three-day food consumption and a 24-hour retrospective physical activity records were collected. Results: Dietary energy, protein, total fat, cholesterol, and fiber intakes were found to be lower only in female schizophrenia patients than in their healthy counterparts. Patients with schizophrenia presented with lower intakes of dietary thiamine, niacin, iron, and zinc compared to healthy controls. Patients with schizophrenia recorded lower physical activity levels compared to healthy controls (1.59±0.22 and 1.77±0.17 respectively ). Conclusion: Unhealthy diet and sedentary life observed in patients with schizophrenia can lead to the development of serious medical comorbidities and to an increase in the side effects of antipsychotic medications. Therefore, patients with schizophrenia should be encouraged to consume healthy diets and undertake more physical activities requires the multidisciplinary approach of specialized professionals.
{"title":"Şizofreni tanılı hastaların besin tüketimi ve fiziksel aktivite durumlarının değerlendirilmesi","authors":"Gülbin Karagöl, Emrah Songur, Neslişah Rakıcıoğlu","doi":"10.17826/cumj.1239968","DOIUrl":"https://doi.org/10.17826/cumj.1239968","url":null,"abstract":"Purpose: Unhealthy lifestyle factors make up a significant proportion of the factors that cause high morbidity and mortality risk. The life span of patients with schizophrenia is 10–20 years less than that of the general population due to lifestyle-related diseases. The aim of this study is to compare with healthy individuals the nutritional habits, nutritional status, and physical activity levels of schizophrenic patients. \u0000Materials and Methods: The study was conducted on 25–55-year-old 40 patients diagnosed with schizophrenia or schizoaffective disorders and 30 healthy controls matched for age and gender. Data on sociodemographic characteristics and nutritional habits, three-day food consumption and a 24-hour retrospective physical activity records were collected. \u0000Results: Dietary energy, protein, total fat, cholesterol, and fiber intakes were found to be lower only in female schizophrenia patients than in their healthy counterparts. Patients with schizophrenia presented with lower intakes of dietary thiamine, niacin, iron, and zinc compared to healthy controls. Patients with schizophrenia recorded lower physical activity levels compared to healthy controls (1.59±0.22 and 1.77±0.17 respectively ). \u0000Conclusion: Unhealthy diet and sedentary life observed in patients with schizophrenia can lead to the development of serious medical comorbidities and to an increase in the side effects of antipsychotic medications. Therefore, patients with schizophrenia should be encouraged to consume healthy diets and undertake more physical activities requires the multidisciplinary approach of specialized professionals.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"22 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87387204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Infertility is the situation in which pregnancy cannot be achieved despite unprotected sexual intercourse within at least one year. Male infertility can range from the entire absence of spermatozoa in the testicles (azoospermia) to noticeable variations in sperm quality. The patients with a mutation in the leptin (LEP) gene have been reported to be infertile and the patients with a mutation in the Leptin Receptor (LEPR) gene were shown to lack pubertal development. This study was performed to state if there is a relationship between azoospermic male infertility and LEP gene -2548G>A and LEPR gene Q223R polymorphisms. Materials and Methods: One hundred thirty-seven azoospermic infertile men and a hundred fertile men were included in this study. DNAs obtained from peripheral blood of participants were analyzed by polymerase chain reaction (PCR) along with restriction fragment length polymorphism (RFLP) technics.. Results: In terms of LEP -2548G>A (rs7799039) and LEPR Q223R (rs1137101) polymorphisms, no statistically remarkable distinction was observed in the genotype and allele distributions of azoospermic infertile and fertile men. In the composite genotype analysis, it was determined that the GGQR composite genotype was approximately 9 times more common in azoospermic infertile men than in fertile men (8.8% vs. 1.0%). Conclusion: It has been determined that LEP -2548G>A and LEPR Q223R polymorphisms may have a dual effect in azoospermic male infertility. We believe that more efficient and precise results can be obtained by conducting these studies in larger populations.
{"title":"Türk popülasyonunda azoospermik erkek infertilitesi için bir risk faktörü olarak LEP -2548G>A (rs7799039) ve LEPR Q223R (rs1137101) polimorfizmlerinin ikili etkisi","authors":"M. Akman, Nevin Karakuş, Hüsniye Rüstemoğlu","doi":"10.17826/cumj.1245822","DOIUrl":"https://doi.org/10.17826/cumj.1245822","url":null,"abstract":"Purpose: Infertility is the situation in which pregnancy cannot be achieved despite unprotected sexual intercourse within at least one year. Male infertility can range from the entire absence of spermatozoa in the testicles (azoospermia) to noticeable variations in sperm quality. The patients with a mutation in the leptin (LEP) gene have been reported to be infertile and the patients with a mutation in the Leptin Receptor (LEPR) gene were shown to lack pubertal development. This study was performed to state if there is a relationship between azoospermic male infertility and LEP gene -2548G>A and LEPR gene Q223R polymorphisms. \u0000Materials and Methods: One hundred thirty-seven azoospermic infertile men and a hundred fertile men were included in this study. DNAs obtained from peripheral blood of participants were analyzed by polymerase chain reaction (PCR) along with restriction fragment length polymorphism (RFLP) technics.. \u0000Results: In terms of LEP -2548G>A (rs7799039) and LEPR Q223R (rs1137101) polymorphisms, no statistically remarkable distinction was observed in the genotype and allele distributions of azoospermic infertile and fertile men. In the composite genotype analysis, it was determined that the GGQR composite genotype was approximately 9 times more common in azoospermic infertile men than in fertile men (8.8% vs. 1.0%). \u0000Conclusion: It has been determined that LEP -2548G>A and LEPR Q223R polymorphisms may have a dual effect in azoospermic male infertility. We believe that more efficient and precise results can be obtained by conducting these studies in larger populations.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"58 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85517175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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