Giant cell tumor (GCT) arises from undifferentiated mesenchymal cells of the bone marrow. GCT, a benign and locally aggressive tumor, is more commonly seen in the metaphysis of long bones. It may cause local bone destruction, recurrence, and pulmonary metastases (~1%). A 15-year-old male patient was admitted with complaints of swelling on the right face, a headache that has persisted for one year and progressively worsened in the last three months, and hearing loss. Craniotomy and total tumor excision were performed. Histopathological examination revealed a giant cell tumor of the bone. We present a case of temporal bone GCT with its clinical and radiologic features.
{"title":"Temporal kemiğin dev hücreli tümörü","authors":"Hatice Kaplanoğlu, A. Turan, Veysel Kaplanoğlu","doi":"10.17826/cumj.1279648","DOIUrl":"https://doi.org/10.17826/cumj.1279648","url":null,"abstract":"Giant cell tumor (GCT) arises from undifferentiated mesenchymal cells of the bone marrow. GCT, a benign and locally aggressive tumor, is more commonly seen in the metaphysis of long bones. It may cause local bone destruction, recurrence, and pulmonary metastases (~1%). A 15-year-old male patient was admitted with complaints of swelling on the right face, a headache that has persisted for one year and progressively worsened in the last three months, and hearing loss. Craniotomy and total tumor excision were performed. Histopathological examination revealed a giant cell tumor of the bone. We present a case of temporal bone GCT with its clinical and radiologic features.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"31 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82780820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The efficacy and safety of pramipexole have been reported both in the treatment of unipolar/bipolar depression and anxiety/depression in patients with Parkison disease. But, there is no evidence for its clinical effect in seasonal depressive disorder. In this case report, the patient with seasonal depression responded to pramipexole is presented.
{"title":"Pramipeksolün mevsimsel depresyon üzerindeki etkinliği: olgu sunumu","authors":"O. Ozdemi̇r","doi":"10.17826/cumj.1276024","DOIUrl":"https://doi.org/10.17826/cumj.1276024","url":null,"abstract":"The efficacy and safety of pramipexole have been reported both in the treatment of unipolar/bipolar depression and anxiety/depression in patients with Parkison disease. But, there is no evidence for its clinical effect in seasonal depressive disorder. In this case report, the patient with seasonal depression responded to pramipexole is presented.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"48 2 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83140014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Coronary artery disease is defined as complications that develop in proportion to the prevalence of ischemia due to occlusion of the coronary arteries and the resulting cell death. The development of atherosclerosis is significantly influenced by endothelial cell dysfunction. Kruppel-like factor 2, a transcription factor, has been shown to regulate critical biological events in endothelial biology, such as vascular tone, migration, proliferation, vasoreactivity, and angiogenesis. In our study, it was aimed to clarify the relationship between coronary artery disease and Kruppel-like factor 2 protein levels and C1239A polymorphisms. Materials and Methods: 191 individuals who underwent coronary angiography at Mersin University Faculty of Medicine, Department of Cardiology, Health, Research and Application Center were included in the study. Measurements of serum fasting blood glucose, HDL cholesterol, total cholesterol, and triglyceride levels were performed on the AU5800 (Beckman Coulter, United States) autoanalyzer. Serum LDL levels were calculated using the Friedwald equation. Serum Kruppel-like factor 2 protein levels were measured by sandwich enzyme-linked immunoassay method on the Multiskan GO (Thermo Scientific, Finland) device. Kruppel-like factor 2 C1239A variations were detected on the Applied Biosystem VIIA™ 7 Real-Time PCR (Life Technologies Co., United States) device by TaqMan® single nucleotide polymorphism (SNP) genotyping method. Results: Men had a 3.8-fold higher risk of CAD than women. (Odd’s ratio 3.83, 95% Confidence interval 1.98-7.39; p
目的:冠状动脉疾病被定义为与冠状动脉闭塞引起的缺血发生率及由此导致的细胞死亡成比例的并发症。动脉粥样硬化的发生与内皮细胞功能障碍密切相关。kruppel样因子2是一种转录因子，已被证明可调节内皮生物学中的关键生物学事件，如血管张力、迁移、增殖、血管反应性和血管生成。本研究旨在阐明冠状动脉疾病与kruppel样因子2蛋白水平及C1239A多态性的关系。材料与方法:在梅尔辛大学医学院、心内科、健康、研究与应用中心接受冠状动脉造影的191例患者纳入研究。在AU5800 (Beckman Coulter，美国)自动分析仪上测量空腹血糖、高密度脂蛋白胆固醇、总胆固醇和甘油三酯水平。使用Friedwald方程计算血清LDL水平。在Multiskan GO (Thermo Scientific, Finland)设备上，采用三明治酶联免疫分析法检测血清克虏伯样因子2蛋白水平。采用TaqMan®单核苷酸多态性(SNP)基因分型方法，在Applied Biosystem VIIA™7 Real-Time PCR (Life Technologies Co.， United States)设备上检测kruppel样因子2 C1239A变异。结果:男性患冠心病的风险是女性的3.8倍。(奇数比3.83,95%置信区间1.98-7.39;p
{"title":"Kruppel benzeri faktör 2 polimorfizmlerinin koroner arter hastalığı riski ile ilişkisi","authors":"Ulaş Deği̇rmenci̇, Metin Yildirim, Merih Akkapulu, Ali Yalin, Dilek çiçek DİLEK ÇİÇEK, Ragıp Onur Öztornaci, Bahar Taşdelen, Serap Yalin","doi":"10.17826/cumj.1283236","DOIUrl":"https://doi.org/10.17826/cumj.1283236","url":null,"abstract":"Purpose: Coronary artery disease is defined as complications that develop in proportion to the prevalence of ischemia due to occlusion of the coronary arteries and the resulting cell death. The development of atherosclerosis is significantly influenced by endothelial cell dysfunction. Kruppel-like factor 2, a transcription factor, has been shown to regulate critical biological events in endothelial biology, such as vascular tone, migration, proliferation, vasoreactivity, and angiogenesis. In our study, it was aimed to clarify the relationship between coronary artery disease and Kruppel-like factor 2 protein levels and C1239A polymorphisms. \u0000Materials and Methods: 191 individuals who underwent coronary angiography at Mersin University Faculty of Medicine, Department of Cardiology, Health, Research and Application Center were included in the study. Measurements of serum fasting blood glucose, HDL cholesterol, total cholesterol, and triglyceride levels were performed on the AU5800 (Beckman Coulter, United States) autoanalyzer. Serum LDL levels were calculated using the Friedwald equation. Serum Kruppel-like factor 2 protein levels were measured by sandwich enzyme-linked immunoassay method on the Multiskan GO (Thermo Scientific, Finland) device. Kruppel-like factor 2 C1239A variations were detected on the Applied Biosystem VIIA™ 7 Real-Time PCR (Life Technologies Co., United States) device by TaqMan® single nucleotide polymorphism (SNP) genotyping method. \u0000Results: Men had a 3.8-fold higher risk of CAD than women. (Odd’s ratio 3.83, 95% Confidence interval 1.98-7.39; p","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"19 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90553451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The focus has been on the hematological complications of iron deficiency, while the nonhematological complications have been less studied. Its effects on cognitive functions were mostly investigated in children and adolescents. The purpose of this study is to compare the executive functioning of persons with iron deficiency anemia to healthy controls in order to determine whether they have any comorbid psychiatric disorders. Materials and Methods: 42 patients with iron deficiency anemia and 44 healthy controls participated in this study. To investigate whether any psychiatric disorders existed, the individuals were given a Structured Clinical Interview for DSM-5 Clinician's Version. Executive functioning was assessed using the Stroop Test and the Number Sequence Learning Test. Results: When compared to the control group, the IDA group took longer on average to complete parts 1–5 of the Stroop Test. There was no difference between the groups with regards to the results of number sequence learning test. Psychiatric illnesses were more common (43%) in the IDA group than they were in the control group (13.6%). The difference was significant when the groups were compared in terms of psychiatric disorders. Conclusion: According to the study's findings, those with iron deficiency anemia have worse executive functioning scores than healthy controls and are more likely to have psychiatric disorders. An extensive assessment of the health consequences of iron deficiency anemia is extremely important.
{"title":"Executive functions and psychiatric disorders in adults with iron deficiency anemia","authors":"Yavuz Yilmaz, Hatice Terzi, Burak Taşova","doi":"10.17826/cumj.1252790","DOIUrl":"https://doi.org/10.17826/cumj.1252790","url":null,"abstract":"Purpose: The focus has been on the hematological complications of iron deficiency, while the nonhematological complications have been less studied. Its effects on cognitive functions were mostly investigated in children and adolescents. The purpose of this study is to compare the executive functioning of persons with iron deficiency anemia to healthy controls in order to determine whether they have any comorbid psychiatric disorders. \u0000Materials and Methods: 42 patients with iron deficiency anemia and 44 healthy controls participated in this study. To investigate whether any psychiatric disorders existed, the individuals were given a Structured Clinical Interview for DSM-5 Clinician's Version. Executive functioning was assessed using the Stroop Test and the Number Sequence Learning Test. \u0000Results: When compared to the control group, the IDA group took longer on average to complete parts 1–5 of the Stroop Test. There was no difference between the groups with regards to the results of number sequence learning test. Psychiatric illnesses were more common (43%) in the IDA group than they were in the control group (13.6%). The difference was significant when the groups were compared in terms of psychiatric disorders. \u0000Conclusion: According to the study's findings, those with iron deficiency anemia have worse executive functioning scores than healthy controls and are more likely to have psychiatric disorders. An extensive assessment of the health consequences of iron deficiency anemia is extremely important.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"8 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82684734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Risperidone is an antipsychotic commonly used in children and adolescents. The use of risperidone is mostly safe in children, but it can cause some side effects. Few cases of enuresis with risperidone have been reported in the literature so far, some of these cases have been associated with the use of antidepressants or other antipsychotics in combination with risperidone. We present an 8.5-year-old patient with enuresis with risperidone.
{"title":"Sekiz yaşında bir çocukta risperidona bağlı enürezis","authors":"Nur Seda GÜLCÜ ÜSTÜN","doi":"10.17826/cumj.1244903","DOIUrl":"https://doi.org/10.17826/cumj.1244903","url":null,"abstract":"Risperidone is an antipsychotic commonly used in children and adolescents. The use of risperidone is mostly safe in children, but it can cause some side effects. Few cases of enuresis with risperidone have been reported in the literature so far, some of these cases have been associated with the use of antidepressants or other antipsychotics in combination with risperidone. We present an 8.5-year-old patient with enuresis with risperidone.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"86 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75820412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Serdar Kalemci̇, Huriye Gülistan BOZDAĞ BAŞKAYA, Arife Zeybek
Dear Editor; We read with interest the article titled “CYB mtDNA mutations and the expression status of genes in the PI3K/AKT/mTOR signaling pathway in patients with schizophrenia” published in Cukurova Medical Journal by Dirican et al.
亲爱的编辑器;我们饶有兴趣地阅读了Dirican等人在Cukurova Medical Journal上发表的题为“精神分裂症患者中CYB mtDNA突变和PI3K/AKT/mTOR信号通路中基因的表达状态”的文章。
{"title":"Şizofrenide gen ifadeleri ve mutasyon analizleri","authors":"Serdar Kalemci̇, Huriye Gülistan BOZDAĞ BAŞKAYA, Arife Zeybek","doi":"10.17826/cumj.1278390","DOIUrl":"https://doi.org/10.17826/cumj.1278390","url":null,"abstract":"Dear Editor; \u0000We read with interest the article titled “CYB mtDNA mutations and the expression status of genes in the PI3K/AKT/mTOR signaling pathway in patients with schizophrenia” published in Cukurova Medical Journal by Dirican et al.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"325 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77835384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Yapicioğlu, M. Özdemir, Tugay Tepe, Tolga Akbaş, F. Özlü, Sevcan Erdem
Neonatal lupus syndrome (NLS) is a rare disease with dermatological, cardiac, hepatic and hematologic involvement due to placental transfer of anti-Ro/ SSA and anti-La/ SSB antibodies in infants of mothers with autoimmune diseases. Multisystemic involvement is common in infants. Here we present a baby with neonatal lupus syndrome whose mother had Sjögren's syndrome. He presented with thrombocytopenia, then convulsion and cardiac arrest due to pericardial tamponade. So, the risk of NLS should be kept in mind in infants of mothers with autoimmune diseases.
{"title":"A neonatal lupus syndrome with pericardial tamponade due to maternal Sjögren’s syndrome","authors":"H. Yapicioğlu, M. Özdemir, Tugay Tepe, Tolga Akbaş, F. Özlü, Sevcan Erdem","doi":"10.17826/cumj.1241756","DOIUrl":"https://doi.org/10.17826/cumj.1241756","url":null,"abstract":"Neonatal lupus syndrome (NLS) is a rare disease with dermatological, cardiac, hepatic and hematologic involvement due to placental transfer of anti-Ro/ SSA and anti-La/ SSB antibodies in infants of mothers with autoimmune diseases. Multisystemic involvement is common in infants. Here we present a baby with neonatal lupus syndrome whose mother had Sjögren's syndrome. He presented with thrombocytopenia, then convulsion and cardiac arrest due to pericardial tamponade. So, the risk of NLS should be kept in mind in infants of mothers with autoimmune diseases.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86985292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mucocele is a commonly occurring pathology in the oral cavity and especially found on labial mucosa. It is commonly seen in the younger population peaking in the 10–20-year age group. In most cases the patient will give a positive history of recent trauma caused due to lip biting. The clinical picture will be of a soft, clear swelling with a bluish color. The size can vary from a few mm to few centimeters at times. A diagnosis can be reached many times just on the basis of a proper history and the clinical features alone. This report depicts the successful management of a case of mucocele which in turn would assist the dental practitioner for diagnosing and managing this condition.
{"title":"Oral mukosel: olgu sunumu","authors":"Shreyas Shah, Rahul RAVİRAJ SHETTY","doi":"10.17826/cumj.1240546","DOIUrl":"https://doi.org/10.17826/cumj.1240546","url":null,"abstract":"Mucocele is a commonly occurring pathology in the oral cavity and especially found on labial mucosa. It is commonly seen in the younger population peaking in the 10–20-year age group. In most cases the patient will give a positive history of recent trauma caused due to lip biting. The clinical picture will be of a soft, clear swelling with a bluish color. The size can vary from a few mm to few centimeters at times. A diagnosis can be reached many times just on the basis of a proper history and the clinical features alone. This report depicts the successful management of a case of mucocele which in turn would assist the dental practitioner for diagnosing and managing this condition.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"18 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87746838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabry is a multisystemic disease mainly affecting heart, kidney, central nervous system and endocrine system with intralysosomal glycolipid accumulation. Although thyroid and adrenal gland involvement has been demonstrated in limited studies, glycolipid accumulation in the pituitary could not be exhibited. A 66-year-old female patient diagnosed with Fabry Disease revealed a low level of pituitary hormone levels. Moreover, an empty sella was found in pituitary MRI. We argued that pituitary function seems impaired due to Fabry Disease, and endocrine workup should be periodically performed in patients with Fabry Disease
{"title":"Hipofizer disfonksiyonu olan Fabry hastası: alışılmadık bir görünüm","authors":"Gamze AKKUŞ, Saime PAYDAS","doi":"10.17826/cumj.1219901","DOIUrl":"https://doi.org/10.17826/cumj.1219901","url":null,"abstract":"Fabry is a multisystemic disease mainly affecting heart, kidney, central nervous system and endocrine system with intralysosomal glycolipid accumulation. Although thyroid and adrenal gland involvement has been demonstrated in limited studies, glycolipid accumulation in the pituitary could not be exhibited. A 66-year-old female patient diagnosed with Fabry Disease revealed a low level of pituitary hormone levels. Moreover, an empty sella was found in pituitary MRI. We argued that pituitary function seems impaired due to Fabry Disease, and endocrine workup should be periodically performed in patients with Fabry Disease","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135800339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The healthcare sector has been impacted by the COVID-19 outbreak. The prevention of COVID-19 infections was given priority, and personnel and resources for the healthcare industry were reassigned. How the COVID-19 pandemic might impact common screening practices in public healthcare is an intriguing subject. Prior studies have amply demonstrated the value of regular cancer screening and cervical cancer screening1-2. Alternative cancer screening methods are used in addition to the standard public health laboratory tests in different parts of the world, depending on the problem that is present at that area.
{"title":"COVID-19 pandemisinin Çin Hindi'ndeki rutin doğum öncesi idrar iyot tarama programına etkisi","authors":"Pathum Sookaromdee, V. Wi̇wani̇tki̇t","doi":"10.17826/cumj.1241109","DOIUrl":"https://doi.org/10.17826/cumj.1241109","url":null,"abstract":"The healthcare sector has been impacted by the COVID-19 outbreak. The prevention of COVID-19 infections was given priority, and personnel and resources for the healthcare industry were reassigned. How the COVID-19 pandemic might impact common screening practices in public healthcare is an intriguing subject. Prior studies have amply demonstrated the value of regular cancer screening and cervical cancer screening1-2. Alternative cancer screening methods are used in addition to the standard public health laboratory tests in different parts of the world, depending on the problem that is present at that area.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"50 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90861191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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