Purpose: The aim of this study was to determine the relationship between obsessional dissociation, family accommodation, and anxiety sensitivity in individuals with obsessive-compulsive disorder (OCD).
Materials and Methods: The participants of this descriptive and relationship-seeking study were 62 individuals with OCD and 43 healthy controls. We collected data using a sociodemographic data form, the Yale-Brown Obsessive Compulsive Scale (YBOCS), the Family Accommodation Scale-Patient Version (FAS-PV), the Anxiety Sensitivity Index-3 (ASI-3), and the Van Obsessional Dissociation Questionnaire (VOD-Q).
Results: Both the ASI-3 and VOD-Q subscale and global scores of the patients participating in the study were higher than those of the healthy controls, and there was a statistically significant difference between the two groups. Sixty-two percent of the total score of VOD-Q was explained by the ASI-3 total and subscale scores, 16% by the YBOCS total and subscale scores, and 11% by the FAS-PV total and subscale scores (F:38.622; F:6.797; and F:2.941, respectively).
Conclusion: In our study, individuals diagnosed with OCD had higher levels of obsessional dissociation than healthy individuals and anxiety sensitivity, obsessive-compulsive symptoms, and family accommodation are effective in the development of obsessional dissociation in individuals diagnosed with OCD.
{"title":"Relationship between obsessional dissociation and family adjustment and anxiety sensitivity in individuals with obsessive-compulsive disorder","authors":"Hatice POLAT, Fatma KARTAL, Kerim UĞUR","doi":"10.17826/cumj.1310149","DOIUrl":"https://doi.org/10.17826/cumj.1310149","url":null,"abstract":"Purpose: The aim of this study was to determine the relationship between obsessional dissociation, family accommodation, and anxiety sensitivity in individuals with obsessive-compulsive disorder (OCD).
 Materials and Methods: The participants of this descriptive and relationship-seeking study were 62 individuals with OCD and 43 healthy controls. We collected data using a sociodemographic data form, the Yale-Brown Obsessive Compulsive Scale (YBOCS), the Family Accommodation Scale-Patient Version (FAS-PV), the Anxiety Sensitivity Index-3 (ASI-3), and the Van Obsessional Dissociation Questionnaire (VOD-Q).
 Results: Both the ASI-3 and VOD-Q subscale and global scores of the patients participating in the study were higher than those of the healthy controls, and there was a statistically significant difference between the two groups. Sixty-two percent of the total score of VOD-Q was explained by the ASI-3 total and subscale scores, 16% by the YBOCS total and subscale scores, and 11% by the FAS-PV total and subscale scores (F:38.622; F:6.797; and F:2.941, respectively).
 Conclusion: In our study, individuals diagnosed with OCD had higher levels of obsessional dissociation than healthy individuals and anxiety sensitivity, obsessive-compulsive symptoms, and family accommodation are effective in the development of obsessional dissociation in individuals diagnosed with OCD.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The aim of this study is to evaluate the frequency of sexual dysfunction in male and female panic disorder (PD) patients and to make a comparison between genders. Materials and Methods: A total of 57 cases, including 33 females aged 36±6 years and 24 males aged 35±7 years, who were sexually active, did not use psychotropic drugs, with primary diagnosis of PD according to DSM-5, were included in the study. Individual information collection forms and the Arizona Sexual Experiences Scale (ASEX) were applied to all cases, and sexual dysfunctions (SD) were questioned. Results: According to the suggested cut-off score of the Turkish version of the Arizona Sexual Experiences Scale, 77.2% of all participants had SD. SD was detected in 81.8% of women and 70.8% of men. There was a significant difference between men and women in terms of ASEX total scores. There was no significant difference between men and women in terms of sexual desire and orgasm satisfaction. Sub-dimension scores of arousal, lubrication/erection, and reaching orgasm were significantly higher in females. Sexual reluctance was the most common in both genders, with 30.4% of women and 36.5% of men. Conclusion: Sexual dysfunction is common among PD patients. Sexual reluctance is the most common in male and female patients with PD. Arousal and orgasm problems are more common in female PD patients than in male PD patients.
{"title":"Panik bozukluk hastalarında cinsel işlev bozukluğu sıklığının cinsiyet açısından karşılaştırması","authors":"Munever TÜNEL","doi":"10.17826/cumj.1322169","DOIUrl":"https://doi.org/10.17826/cumj.1322169","url":null,"abstract":"Purpose: The aim of this study is to evaluate the frequency of sexual dysfunction in male and female panic disorder (PD) patients and to make a comparison between genders. \u0000Materials and Methods: A total of 57 cases, including 33 females aged 36±6 years and 24 males aged 35±7 years, who were sexually active, did not use psychotropic drugs, with primary diagnosis of PD according to DSM-5, were included in the study. Individual information collection forms and the Arizona Sexual Experiences Scale (ASEX) were applied to all cases, and sexual dysfunctions (SD) were questioned. \u0000Results: According to the suggested cut-off score of the Turkish version of the Arizona Sexual Experiences Scale, 77.2% of all participants had SD. SD was detected in 81.8% of women and 70.8% of men. There was a significant difference between men and women in terms of ASEX total scores. There was no significant difference between men and women in terms of sexual desire and orgasm satisfaction. Sub-dimension scores of arousal, lubrication/erection, and reaching orgasm were significantly higher in females. Sexual reluctance was the most common in both genders, with 30.4% of women and 36.5% of men. \u0000Conclusion: Sexual dysfunction is common among PD patients. Sexual reluctance is the most common in male and female patients with PD. Arousal and orgasm problems are more common in female PD patients than in male PD patients.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: This retrospective analysis aimed to elucidate the key factors influencing survival outcomes in patients diagnosed with lymphoma and admitted to an Intensive Care Unit (ICU).
Materials and Methods: The study cohort comprised individuals aged 18 or older diagnosed with lymphoma and admitted to the ICU between November 2015 and February 2023. Data were collected on patients' demographic characteristics, primary hematological diagnoses, reasons for ICU admission, laboratory parameters, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, Sequential Organ Failure Assessment (SOFA) scores, clinical trajectory, and 28-day mortality rates. Patients were stratified into two categories based on their mortality outcomes: Survivors and non-survivors.
Results: A total of 165 patients were included in the study, with a mean age of 52.41 ± 17.99 years; 63% were male. Table 1 summarizes the demographic characteristics, clinical trajectories, and 28-day mortality rates. The APACHE II and SOFA scores of the patients were 34 (7–53) and 12 (10–14), respectively. The predominant reasons for ICU admission were sepsis (58.2%) and acute respiratory failure (57.6%). Vasopressor necessity prior to and during ICU stay was 23.6% and 92.4%, respectively. During ICU monitoring, thrombocytopenia, and acute kidney injury (AKI) were observed in 77.6% and 66.4% of patients, respectively; 10% required renal replacement therapy. The 28-day mortality rate was 84.8%. Kaplan-Meier analysis revealed that patients with a SOFA score ≥ 9 had a significantly reduced survival time of 4.5 ± 0.4 days compared to those with lower SOFA scores (14.3 ± 2.6 days). Patients with AKI and those requiring invasive mechanical ventilation (IMV) exhibited reduced survival times of 4.7 ± 0.5 days and 5.6 ± 0.5 days, respectively. Elevated SOFA scores (HR 2.355, 95% CI 1.485–3.734), presence of AKI (HR 1.511, 95% CI 1.055–2.163), and the need for IMV (HR 5.721, 95% CI 1.377–23.770) were significantly correlated with increased 28-day mortality. Receiver Operating Characteristic (ROC) curve analysis identified the optimal SOFA cut-off point for predicting 28-day mortality as nine, with an Area Under the Curve (AUC) of 0.897, sensitivity 83.6% and specificity 92%.
Conclusions: The findings of this study underscore the elevated mortality rates among lymphoma patients admitted to the ICU. Our data suggest that several factors serve as significant predictors of 28-day mortality in this patient population. Specifically, elevated APACHE II scores, SOFA scores, the presence of AKI, and the requirement for IMV emerged as crucial indicators associated with adverse survival outcomes. Consequently, these factors warrant meticulous monitoring and could inform targeted interventions to improve survival rates among lymphoma patients in critical care settings.
目的:本回顾性分析旨在阐明影响诊断为淋巴瘤并入住重症监护病房(ICU)患者生存结局的关键因素。& # x0D;材料和方法:研究队列包括2015年11月至2023年2月期间入住ICU的18岁及以上淋巴瘤患者。收集患者的人口统计学特征、原发性血液学诊断、ICU入院原因、实验室参数、急性生理和慢性健康评估(APACHE) II评分、顺序器官衰竭评估(SOFA)评分、临床轨迹和28天死亡率等数据。根据患者的死亡率结果将患者分为两类:幸存者和非幸存者。
结果:共纳入165例患者，平均年龄52.41±17.99岁;63%是男性。表1总结了人口统计学特征、临床轨迹和28天死亡率。患者APACHE II评分为34分(7-53分)，SOFA评分为12分(10-14分)。ICU住院的主要原因是败血症(58.2%)和急性呼吸衰竭(57.6%)。在ICU住院前和住院期间，血管加压素必要性分别为23.6%和92.4%。ICU监测期间，血小板减少症和急性肾损伤(AKI)发生率分别为77.6%和66.4%;10%需要肾脏替代治疗。28天死亡率为84.8%。Kaplan-Meier分析显示，与SOFA评分较低的患者(14.3±2.6天)相比，SOFA评分≥9的患者的生存时间显著减少(4.5±0.4天)。AKI患者和需要有创机械通气(IMV)的患者的生存时间分别缩短了4.7±0.5天和5.6±0.5天。SOFA评分升高(HR 2.355, 95% CI 1.485-3.734)、AKI的存在(HR 1.511, 95% CI 1.055-2.163)和IMV的需要(HR 5.721, 95% CI 1.377-23.770)与28天死亡率增加显著相关。受试者工作特征(ROC)曲线分析确定预测28天死亡率的最佳SOFA截止点为9，曲线下面积(AUC)为0.897，灵敏度为83.6%，特异性为92%。结论:本研究的发现强调了ICU收治的淋巴瘤患者死亡率升高。我们的数据表明，有几个因素可以作为该患者人群28天死亡率的重要预测因素。具体而言，APACHE II评分、SOFA评分、AKI的存在和IMV的要求成为与不良生存结果相关的关键指标。因此，这些因素需要细致的监测，并可以为有针对性的干预提供信息，以提高重症淋巴瘤患者的生存率。
{"title":"Yoğun bakım ünitesinde lenfoma tanısı ile takip edilen hastalarda sağkalımı etkileyen faktörler","authors":"Kaniye AYDIN, Ömer DOĞAN","doi":"10.17826/cumj.1344207","DOIUrl":"https://doi.org/10.17826/cumj.1344207","url":null,"abstract":"Purpose: This retrospective analysis aimed to elucidate the key factors influencing survival outcomes in patients diagnosed with lymphoma and admitted to an Intensive Care Unit (ICU). 
 Materials and Methods: The study cohort comprised individuals aged 18 or older diagnosed with lymphoma and admitted to the ICU between November 2015 and February 2023. Data were collected on patients' demographic characteristics, primary hematological diagnoses, reasons for ICU admission, laboratory parameters, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, Sequential Organ Failure Assessment (SOFA) scores, clinical trajectory, and 28-day mortality rates. Patients were stratified into two categories based on their mortality outcomes: Survivors and non-survivors.
 Results: A total of 165 patients were included in the study, with a mean age of 52.41 ± 17.99 years; 63% were male. Table 1 summarizes the demographic characteristics, clinical trajectories, and 28-day mortality rates. The APACHE II and SOFA scores of the patients were 34 (7–53) and 12 (10–14), respectively. The predominant reasons for ICU admission were sepsis (58.2%) and acute respiratory failure (57.6%). Vasopressor necessity prior to and during ICU stay was 23.6% and 92.4%, respectively. During ICU monitoring, thrombocytopenia, and acute kidney injury (AKI) were observed in 77.6% and 66.4% of patients, respectively; 10% required renal replacement therapy. The 28-day mortality rate was 84.8%. Kaplan-Meier analysis revealed that patients with a SOFA score ≥ 9 had a significantly reduced survival time of 4.5 ± 0.4 days compared to those with lower SOFA scores (14.3 ± 2.6 days). Patients with AKI and those requiring invasive mechanical ventilation (IMV) exhibited reduced survival times of 4.7 ± 0.5 days and 5.6 ± 0.5 days, respectively. Elevated SOFA scores (HR 2.355, 95% CI 1.485–3.734), presence of AKI (HR 1.511, 95% CI 1.055–2.163), and the need for IMV (HR 5.721, 95% CI 1.377–23.770) were significantly correlated with increased 28-day mortality. Receiver Operating Characteristic (ROC) curve analysis identified the optimal SOFA cut-off point for predicting 28-day mortality as nine, with an Area Under the Curve (AUC) of 0.897, sensitivity 83.6% and specificity 92%.
 Conclusions: The findings of this study underscore the elevated mortality rates among lymphoma patients admitted to the ICU. Our data suggest that several factors serve as significant predictors of 28-day mortality in this patient population. Specifically, elevated APACHE II scores, SOFA scores, the presence of AKI, and the requirement for IMV emerged as crucial indicators associated with adverse survival outcomes. Consequently, these factors warrant meticulous monitoring and could inform targeted interventions to improve survival rates among lymphoma patients in critical care settings.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esra YAKIŞIK, Çiğdem YÜCEL, Murat KIZILGÜN, Işıl ÖZKOÇAK TURAN
Purpose: This study investigated the predictive value of thyroid hormones in septic patients.
Materials and Methods: Our study was conducted in patients with sepsis in intensive care unit (ICU). Free triiodothyronine (fT3) and free thyroxine (fT4) levels taken at the time of hospitalization and at the 48th hours were measured and the fT3 / fT4 ratio was calculated. Calculated fT3 and fT4 change between first and 48th hours.
Results: 192 patients with sepsis were included in the study. In non-survivor patients, first fT3 (1.60±0.57 ng/dL v.s. 2.01±0.41 ng/dL) and fT3 / fT4 ratio (1.34±0.88 v.s. 1.79±0.91) were found to be significantly lower than 48th hours fT3 (0.77±0.39 ng/dL v.s. 1.87±0.49 ng/dL) and fT3 / fT4 ratio (0.60±0.51 v.s. 1.66±1.21) survivors. It was found that the first fT3 levels (-0.83±0.45 v.s. -0.23±0.14) and fT3 / fT4 ratio (-0.73±0.62 v.s. -0.12±0.11) decreased significantly more at 48th hour in non-survivors than survivors. The 48th hours fT3 level and the change in fT3 between the first and 48th hour were found to be the most significant parameters for the mortality indicator.
Conclusion: fT3 / fT4 ratio has predictive value for mortality in patients with sepsis in ICU. In addition, fT3 was found to be an indicator for mortality predictivity both at admission and at 48th hours.
目的:探讨甲状腺激素对脓毒症患者的预测价值。
材料与方法:本研究在重症监护病房(ICU)脓毒症患者中进行。测定住院时和48小时游离三碘甲状腺原氨酸(fT3)和游离甲状腺素(fT4)水平，并计算fT3 / fT4比值。计算fT3和fT4在第1小时和第48小时的变化。
结果:192例脓毒症患者纳入研究。在非存活患者中，首次fT3(1.60±0.57 ng/dL vs . 2.01±0.41 ng/dL)和fT3 / fT4比值(1.34±0.88 vs . 1.79±0.91)明显低于第48小时存活患者fT3(0.77±0.39 ng/dL vs . 1.87±0.49 ng/dL)和fT3 / fT4比值(0.60±0.51 vs . 1.66±1.21)。结果发现，第48小时，非幸存者的fT3水平(-0.83±0.45 vs . -0.23±0.14)和fT3 / fT4比值(-0.73±0.62 vs . -0.12±0.11)明显低于幸存者。发现第48小时fT3水平和第1 ~ 48小时fT3变化是死亡率指标最显著的参数。
结论:fT3 / fT4比值对ICU脓毒症患者的死亡率具有预测价值。此外，fT3被发现是入院时和48小时死亡率预测的指标。
{"title":"A new marker in determining the relationship between the clinical outcomes of patients with sepsis and thyroid function tests: free triiodothyronine to free thyroxine ratio","authors":"Esra YAKIŞIK, Çiğdem YÜCEL, Murat KIZILGÜN, Işıl ÖZKOÇAK TURAN","doi":"10.17826/cumj.1310083","DOIUrl":"https://doi.org/10.17826/cumj.1310083","url":null,"abstract":"Purpose: This study investigated the predictive value of thyroid hormones in septic patients.
 Materials and Methods: Our study was conducted in patients with sepsis in intensive care unit (ICU). Free triiodothyronine (fT3) and free thyroxine (fT4) levels taken at the time of hospitalization and at the 48th hours were measured and the fT3 / fT4 ratio was calculated. Calculated fT3 and fT4 change between first and 48th hours.
 Results: 192 patients with sepsis were included in the study. In non-survivor patients, first fT3 (1.60±0.57 ng/dL v.s. 2.01±0.41 ng/dL) and fT3 / fT4 ratio (1.34±0.88 v.s. 1.79±0.91) were found to be significantly lower than 48th hours fT3 (0.77±0.39 ng/dL v.s. 1.87±0.49 ng/dL) and fT3 / fT4 ratio (0.60±0.51 v.s. 1.66±1.21) survivors. It was found that the first fT3 levels (-0.83±0.45 v.s. -0.23±0.14) and fT3 / fT4 ratio (-0.73±0.62 v.s. -0.12±0.11) decreased significantly more at 48th hour in non-survivors than survivors. The 48th hours fT3 level and the change in fT3 between the first and 48th hour were found to be the most significant parameters for the mortality indicator.
 Conclusion: fT3 / fT4 ratio has predictive value for mortality in patients with sepsis in ICU. In addition, fT3 was found to be an indicator for mortality predictivity both at admission and at 48th hours.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sema ÖZANDAÇ POLAT, Emir İbrahim IŞIK, Ezcan TUTUŞ, Pınar GÖKER
Purpose: This paper aimed to evaluate the manual dexterity tests and hand morphometry, and to research whether the dexterity tests and hand lengths were affected by gender and body mass index (BMI) or not.
Materials and Methods: This study was carried out on 114 adult subjects aged between 18 and 25 years (37 males and 77 females). Demographic characteristics including gender, age, dominant hand, height, weight, and body mass index (BMI) of all subjects were recorded. Additionally, hand morphometric measurements and manual dexterity tests called as O’Connor Finger Dexterity Test and Purdue Pegboard Test were applied.
Results: Some values such as the hand length (right and left), palmar length (right and left), dominant and non-dominant hand finger, and O’Connor Finger Dexterity Test-Left side showed significant differences between genders. Additionally, O’Connor Finger Dexterity Test scores for both sides were lower in males than in females. Purdue Pegboard-Right, and Purdue Pegboard-Left, Purdue Pegboard-Both Hands, Purdue Pegboard total were higher in males, whereas Purdue Pegboard (Assembly) was higher in females than in males. However, Purdue Pegboard measurement scores did not show a significant difference between genders.
Conclusion: Hand morphometric measurements and manual dexterity tests showed some changes in terms of gender and BMI. Additionally, the data obtained can provide crucial information for therapists and clinicians about hand rehabilitation.
{"title":"Sağlık Hizmetleri Meslek Yüksekokulu öğrencilerinde el morfometrik ölçümlerinin el becerisine etkisi","authors":"Sema ÖZANDAÇ POLAT, Emir İbrahim IŞIK, Ezcan TUTUŞ, Pınar GÖKER","doi":"10.17826/cumj.1323882","DOIUrl":"https://doi.org/10.17826/cumj.1323882","url":null,"abstract":"Purpose: This paper aimed to evaluate the manual dexterity tests and hand morphometry, and to research whether the dexterity tests and hand lengths were affected by gender and body mass index (BMI) or not. 
 Materials and Methods: This study was carried out on 114 adult subjects aged between 18 and 25 years (37 males and 77 females). Demographic characteristics including gender, age, dominant hand, height, weight, and body mass index (BMI) of all subjects were recorded. Additionally, hand morphometric measurements and manual dexterity tests called as O’Connor Finger Dexterity Test and Purdue Pegboard Test were applied.
 Results: Some values such as the hand length (right and left), palmar length (right and left), dominant and non-dominant hand finger, and O’Connor Finger Dexterity Test-Left side showed significant differences between genders. Additionally, O’Connor Finger Dexterity Test scores for both sides were lower in males than in females. Purdue Pegboard-Right, and Purdue Pegboard-Left, Purdue Pegboard-Both Hands, Purdue Pegboard total were higher in males, whereas Purdue Pegboard (Assembly) was higher in females than in males. However, Purdue Pegboard measurement scores did not show a significant difference between genders.
 Conclusion: Hand morphometric measurements and manual dexterity tests showed some changes in terms of gender and BMI. Additionally, the data obtained can provide crucial information for therapists and clinicians about hand rehabilitation.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lütfiye ÖZPAK, Murat ŞAHİN, İbrahim Seyfettin ÇELİK, Bekir Mehmet KELLECİ, Mustafa ÇELİK
Purpose: Like Alzheimer's disease, a disease of the aging world, and metastasis in cancer, it is very important to elucidate the etiology of Type 2 diabetes, which causes tissue and organ damage by systematically spreading throughout. In this study, we aimed to examine whether markers used as biomarkers in Alzheimer's pathogenesis are effective in the pathogenesis of diabetes.
Materials and Methods: In our study, 30 type 2 diabetics, 30 type 2 diabetics individuals with the risk of dementia as a result of mini-mental test, and 28 healthy individuals aged 50-70 years were included, and brain-derived neurotrophic factor (BDNF), dual-specificity tyrosine-regulated kinase 1 (DYRK1A), Tau, fatty acid binding proteins 7 (FABP7) levels were measured from plasma samples.
Results: There was a significant difference between the diabetes group with a high risk of dementia (MMSE < 24) and the other groups in Tau, and FABP7 levels, but no significant differences were found in BDNF and DYRK1A levels.
Conclusion: These biomarkers might be used to diagnose Alzheimer's disease in patients with T2D and at risk of dementia before resorting to other more expensive and invasive diagnostic methods.
{"title":"The level of dementia biomarkers in type 2 diabetes mellitus","authors":"Lütfiye ÖZPAK, Murat ŞAHİN, İbrahim Seyfettin ÇELİK, Bekir Mehmet KELLECİ, Mustafa ÇELİK","doi":"10.17826/cumj.1311596","DOIUrl":"https://doi.org/10.17826/cumj.1311596","url":null,"abstract":"Purpose: Like Alzheimer's disease, a disease of the aging world, and metastasis in cancer, it is very important to elucidate the etiology of Type 2 diabetes, which causes tissue and organ damage by systematically spreading throughout. In this study, we aimed to examine whether markers used as biomarkers in Alzheimer's pathogenesis are effective in the pathogenesis of diabetes.
 Materials and Methods: In our study, 30 type 2 diabetics, 30 type 2 diabetics individuals with the risk of dementia as a result of mini-mental test, and 28 healthy individuals aged 50-70 years were included, and brain-derived neurotrophic factor (BDNF), dual-specificity tyrosine-regulated kinase 1 (DYRK1A), Tau, fatty acid binding proteins 7 (FABP7) levels were measured from plasma samples.
 Results: There was a significant difference between the diabetes group with a high risk of dementia (MMSE < 24) and the other groups in Tau, and FABP7 levels, but no significant differences were found in BDNF and DYRK1A levels.
 Conclusion: These biomarkers might be used to diagnose Alzheimer's disease in patients with T2D and at risk of dementia before resorting to other more expensive and invasive diagnostic methods.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The objective of this study is to identify antibiotic-related adverse events and risk factors in hospitalized patients.
Materials and Methods: This prospective cohort study included 776 inpatients who received antibiotic treatment between January 2019 and December 2020. Patients who experienced "definite" or "probable" adverse drug events (ADE) were examined using the World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria. The definition and severity criteria for antibiotic-related adverse events were determined according to the Common Terminology Criteria for Adverse Events (CTCAE).
Results: The overall rate of antibiotic-associated ADE was 7.9 (95%CI, 6.8-9.1) per 1000 person-days. The study identified a total of 152 adverse events in 125 patients who experienced ADE. Among the 152 adverse events, 63 (41.4%) were severe, and 89 (58.6%) were non-severe. Independent risk factors for ADE included the number of comorbidities (up to 4 times higher increased risk), number of drugs used, and duration of antibiotic administration (up to 12.3 times higher and 8% increased risk for each additional day). The most common side effects were hematological, with 45 (29.6%) cases reported in the hematological system advers events.
Conclusion: The management of antibiotic durations, which is a controllable factor in the development of antibiotic-related adverse events, is crucial. Rational use of antibiotics is essential, not only in terms of preventing the development of resistance but also in terms of reducing the frequency of adverse events that may become life-threatening.
{"title":"Antibiotic-related adverse events and risk factors in hospitalized patients: a prospective cohort study","authors":"Orcun SOYSAL, İrfan ŞENCAN, Nesibe KORKMAZ","doi":"10.17826/cumj.1311112","DOIUrl":"https://doi.org/10.17826/cumj.1311112","url":null,"abstract":"Purpose: The objective of this study is to identify antibiotic-related adverse events and risk factors in hospitalized patients.
 Materials and Methods: This prospective cohort study included 776 inpatients who received antibiotic treatment between January 2019 and December 2020. Patients who experienced \"definite\" or \"probable\" adverse drug events (ADE) were examined using the World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria. The definition and severity criteria for antibiotic-related adverse events were determined according to the Common Terminology Criteria for Adverse Events (CTCAE).
 Results: The overall rate of antibiotic-associated ADE was 7.9 (95%CI, 6.8-9.1) per 1000 person-days. The study identified a total of 152 adverse events in 125 patients who experienced ADE. Among the 152 adverse events, 63 (41.4%) were severe, and 89 (58.6%) were non-severe. Independent risk factors for ADE included the number of comorbidities (up to 4 times higher increased risk), number of drugs used, and duration of antibiotic administration (up to 12.3 times higher and 8% increased risk for each additional day). The most common side effects were hematological, with 45 (29.6%) cases reported in the hematological system advers events.
 Conclusion: The management of antibiotic durations, which is a controllable factor in the development of antibiotic-related adverse events, is crucial. Rational use of antibiotics is essential, not only in terms of preventing the development of resistance but also in terms of reducing the frequency of adverse events that may become life-threatening.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The aim of this study was to investigate the presence of the mcr-1 gene, which is responsible for colistin resistance, in carbapenem-resistant Gram-negative bacteria that cause difficult-to-treat infections in a research hospital in Turkey.
Materials and Methods: The mcr-1 gene was examined using PCR in 103 carbapenem-resistant isolates, including 75 Acinetobacter baumannii, 19 Pseudomonas aeruginosa, and 9 Klebsiella pneumoniae. DNA sequencing was performed to confirm the mcr-1 positivity. Other antimicrobial resistance genes were investigated in isolates that were found to be mcr-1-positive by PCR and colistin-resistant isolates.
Results: Four (3.9% of the 103 carbapenem-resistant isolates and 5.3% of the 75 A. baumannii isolates) A. baumannii isolates, all susceptible to colistin, were found to be mcr-1-positive by PCR, whereas mcr-1 was not detected in four colistin-resistant isolates, one in A. baumannii and three in K. pneumoniae. DNA sequencing analysis determined that none of the amplification products was the targeted fragment, but they matched more than 70% with the chromosomal DNA fragments of A. baumannii strains. Therefore, these results were considered false-positive. Although these false-positive isolates were susceptible to colistin, they were extensively drug-resistant (XDR). Two of them were found to carry blaOXA23-like and blaTEM genes, another blaOXA23-like, blaTEM and blaOXA48-like genes, and the fourth one to have blaOXA23-like and blaCTXM genes.
Conclusion: Although the specificity of the primers used to detect the mcr-1 gene by PCR was reported as 100% in most studies, we concluded that PCR tests are insufficient yet to use alone or with antibiotic susceptibility tests in rapid routine diagnosis. Confirming at least PCR-positive samples using DNA sequence analysis would be appropriate for a certain period.
{"title":"Kolistin direncinin moleküler tespitinde yanlış tanı: kolistine duyarlı Acinetobacter baumannii izolatlarında yanlış mcr-1-PCR pozitifliği","authors":"Toğrul NAĞIYEV, Tülay KANDEMİR, Fatih KÖKSAL","doi":"10.17826/cumj.1348548","DOIUrl":"https://doi.org/10.17826/cumj.1348548","url":null,"abstract":"Purpose: The aim of this study was to investigate the presence of the mcr-1 gene, which is responsible for colistin resistance, in carbapenem-resistant Gram-negative bacteria that cause difficult-to-treat infections in a research hospital in Turkey. 
 Materials and Methods: The mcr-1 gene was examined using PCR in 103 carbapenem-resistant isolates, including 75 Acinetobacter baumannii, 19 Pseudomonas aeruginosa, and 9 Klebsiella pneumoniae. DNA sequencing was performed to confirm the mcr-1 positivity. Other antimicrobial resistance genes were investigated in isolates that were found to be mcr-1-positive by PCR and colistin-resistant isolates. 
 Results: Four (3.9% of the 103 carbapenem-resistant isolates and 5.3% of the 75 A. baumannii isolates) A. baumannii isolates, all susceptible to colistin, were found to be mcr-1-positive by PCR, whereas mcr-1 was not detected in four colistin-resistant isolates, one in A. baumannii and three in K. pneumoniae. DNA sequencing analysis determined that none of the amplification products was the targeted fragment, but they matched more than 70% with the chromosomal DNA fragments of A. baumannii strains. Therefore, these results were considered false-positive. Although these false-positive isolates were susceptible to colistin, they were extensively drug-resistant (XDR). Two of them were found to carry blaOXA23-like and blaTEM genes, another blaOXA23-like, blaTEM and blaOXA48-like genes, and the fourth one to have blaOXA23-like and blaCTXM genes. 
 Conclusion: Although the specificity of the primers used to detect the mcr-1 gene by PCR was reported as 100% in most studies, we concluded that PCR tests are insufficient yet to use alone or with antibiotic susceptibility tests in rapid routine diagnosis. Confirming at least PCR-positive samples using DNA sequence analysis would be appropriate for a certain period.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136278552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Cardiac risk factors are among the most important determinants of postoperative outcomes in elderly surgical patients. This study aimed to determine the effect of perioperative cardiac risk factors on postoperative adverse outcomes in elderly patients undergoing total hip replacement surgery.
Materials and Methods: Patients aged 65 and older who underwent total hip replacement surgery at Cukurova University Hospital between 2014 and 2019 were analyzed retrospectively. The primary outcome measures were postoperative adverse outcomes and mortality rate.
Results: Two hundred twenty-three patients with total hip replacement surgery within five years of experience in our hospital were screened. 34.5% had postoperative cardiac, pulmonary, cerebral, and infectious morbidity and systemic inflammatory response syndrome, and the in-hospital mortality rate was 2.2%. On multivariate analysis, perioperative risk factors associated with postoperative adverse outcomes included American Society of Anesthesiologists (ASA) II physical status (aOR 5.63, 95% CI 1.75-18.11), preoperative poor functional capacity (aOR 9.50, 95% CI 3.14-28.79), traumatic fracture (aOR 2.75, 95% CI 1.22-6.24), preoperative anemia (aOR 2.15, 95% CI 1.05-4.37), and prolonged surgery (aOR 1.02, 95% CI 1.01-1.02).
Conclusion: A significant relationship was determined between preoperative poor functional capacity, pre-existing anemia, traumatic hip fracture, ASA II physical status, prolonged case duration and the risk of postoperative complications in elderly patients undergoing total hip replacement surgery.
目的:心脏危险因素是老年外科患者术后预后最重要的决定因素之一。本研究旨在确定围手术期心脏危险因素对老年全髋关节置换术患者术后不良结局的影响。
材料与方法:回顾性分析2014年至2019年在库库罗娃大学医院行全髋关节置换术的65岁及以上患者。主要观察指标为术后不良结局和死亡率。
结果:筛选了我院5年内行全髋关节置换术的患者223例。34.5%的患者术后出现心、肺、脑、感染性疾病及全身炎症反应综合征，住院死亡率为2.2%。在多因素分析中，与术后不良结果相关的围手术期危险因素包括美国麻醉医师学会(ASA) II身体状况(aOR 5.63, 95% CI 1.75-18.11)、术前功能能力差(aOR 9.50, 95% CI 3.14-28.79)、外伤性骨折(aOR 2.75, 95% CI 1.22-6.24)、术前贫血(aOR 2.15, 95% CI 1.05-4.37)和手术时间延长(aOR 1.02, 95% CI 1.01-1.02)。结论:老年全髋关节置换术患者术前功能能力差、既往性贫血、外伤性髋部骨折、ASA II级身体状况、病例持续时间延长与术后并发症风险有显著关系。
{"title":"The effect of perioperative cardiac risk factors on postoperative outcomes in the elderly patients undergoing hip replacement surgery","authors":"Demet LAFLI TUNAY, Murat Türkeün ILGINEL","doi":"10.17826/cumj.1329179","DOIUrl":"https://doi.org/10.17826/cumj.1329179","url":null,"abstract":"Purpose: Cardiac risk factors are among the most important determinants of postoperative outcomes in elderly surgical patients. This study aimed to determine the effect of perioperative cardiac risk factors on postoperative adverse outcomes in elderly patients undergoing total hip replacement surgery.
 Materials and Methods: Patients aged 65 and older who underwent total hip replacement surgery at Cukurova University Hospital between 2014 and 2019 were analyzed retrospectively. The primary outcome measures were postoperative adverse outcomes and mortality rate.
 Results: Two hundred twenty-three patients with total hip replacement surgery within five years of experience in our hospital were screened. 34.5% had postoperative cardiac, pulmonary, cerebral, and infectious morbidity and systemic inflammatory response syndrome, and the in-hospital mortality rate was 2.2%. On multivariate analysis, perioperative risk factors associated with postoperative adverse outcomes included American Society of Anesthesiologists (ASA) II physical status (aOR 5.63, 95% CI 1.75-18.11), preoperative poor functional capacity (aOR 9.50, 95% CI 3.14-28.79), traumatic fracture (aOR 2.75, 95% CI 1.22-6.24), preoperative anemia (aOR 2.15, 95% CI 1.05-4.37), and prolonged surgery (aOR 1.02, 95% CI 1.01-1.02).
 Conclusion: A significant relationship was determined between preoperative poor functional capacity, pre-existing anemia, traumatic hip fracture, ASA II physical status, prolonged case duration and the risk of postoperative complications in elderly patients undergoing total hip replacement surgery.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Özay GÜLEŞ, Esra BİLİCİ, Emira KURBASEVIC, Ömer Faruk LENGER, Murat BOYACIOĞLU, Erkmen Tuğrul EPİKMEN
Purpose: Intracellular calcium (Ca2+) signaling plays a role in many cellular events, such as cell proliferation and differentiation, gene transcription, oxidative stress, the antioxidant system, and apoptosis. Transient receptor potential vanilloid 4 (TRPV4) channels are non-selective cation (Ca2+) channels. The present study aims to investigate the cytotoxic activity of RN-1734, a transient receptor potential vanilloid 4 (TRPV4) antagonist, in the G361 human melanoma cancer cell line.
Materials and Methods: The effects of RN-1734 on G361 cell viability at concentrations of 1, 5, 25, 50, and 100 μM were measured using the 3-(4,5-dimethylthiazol-2-il)-2,5-diphenyltetrazolium bromide (MTT) method. Total antioxidant status (TAS) and total oxidant status (TOS) levels were determined using a ready-made commercial kit, after which oxidative stress index (OSI) values were calculated. To determine the apoptotic effects of RN-1734, Bcl-2, Bax, and p53 expression levels, caspase-3 and -8 activities were examined via quantitative real-time PCR analysis.
Results: G361 cell viability significantly decreased to 82.72, 72.81, 56.36, 39.16 and 18.96% in RN-1734 groups (1, 5, 25, 50 and 100 μM) compared to the control group (100.00%). At IC50 concentration (39.48 μM), RN-1734 application (3.35 mmol/g prot.-TAS, 45.87 μmol/g prot.-TOS, and 1501.97 AU-OSI) increased the TAS level (2.17 mmol/g prot.) and decreased the TOS level (55.41 μmol/g prot.) and OSI value (3142.76 AU) compared to the control group.
Conclusion: Our findings show that RN-1734 may be a novel therapeutic approach to treating melanoma by decreasing the cell viability of G361 human melanoma cancer cells.
{"title":"Cytotoxic activity of TRPV4 antagonist RN-1734 in G-361 human melanoma cancer cell line","authors":"Özay GÜLEŞ, Esra BİLİCİ, Emira KURBASEVIC, Ömer Faruk LENGER, Murat BOYACIOĞLU, Erkmen Tuğrul EPİKMEN","doi":"10.17826/cumj.1324675","DOIUrl":"https://doi.org/10.17826/cumj.1324675","url":null,"abstract":"Purpose: Intracellular calcium (Ca2+) signaling plays a role in many cellular events, such as cell proliferation and differentiation, gene transcription, oxidative stress, the antioxidant system, and apoptosis. Transient receptor potential vanilloid 4 (TRPV4) channels are non-selective cation (Ca2+) channels. The present study aims to investigate the cytotoxic activity of RN-1734, a transient receptor potential vanilloid 4 (TRPV4) antagonist, in the G361 human melanoma cancer cell line. 
 Materials and Methods: The effects of RN-1734 on G361 cell viability at concentrations of 1, 5, 25, 50, and 100 μM were measured using the 3-(4,5-dimethylthiazol-2-il)-2,5-diphenyltetrazolium bromide (MTT) method. Total antioxidant status (TAS) and total oxidant status (TOS) levels were determined using a ready-made commercial kit, after which oxidative stress index (OSI) values were calculated. To determine the apoptotic effects of RN-1734, Bcl-2, Bax, and p53 expression levels, caspase-3 and -8 activities were examined via quantitative real-time PCR analysis. 
 Results: G361 cell viability significantly decreased to 82.72, 72.81, 56.36, 39.16 and 18.96% in RN-1734 groups (1, 5, 25, 50 and 100 μM) compared to the control group (100.00%). At IC50 concentration (39.48 μM), RN-1734 application (3.35 mmol/g prot.-TAS, 45.87 μmol/g prot.-TOS, and 1501.97 AU-OSI) increased the TAS level (2.17 mmol/g prot.) and decreased the TOS level (55.41 μmol/g prot.) and OSI value (3142.76 AU) compared to the control group. 
 Conclusion: Our findings show that RN-1734 may be a novel therapeutic approach to treating melanoma by decreasing the cell viability of G361 human melanoma cancer cells.","PeriodicalId":10748,"journal":{"name":"Cukurova Medical Journal","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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