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Public Health Risks of PFAS-Related Immunotoxicity Are Real. 与 PFAS 相关的免疫毒性的公共健康风险是真实存在的。
IF 7.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-01 Epub Date: 2024-03-25 DOI: 10.1007/s40572-024-00441-y
Abigail P Bline, Jamie C DeWitt, Carol F Kwiatkowski, Katherine E Pelch, Anna Reade, Julia R Varshavsky

Purpose of review: The discovery of per- and polyfluoroalkyl substances (PFAS) in the environment and humans worldwide has ignited scientific research, government inquiry, and public concern over numerous adverse health effects associated with PFAS exposure. In this review, we discuss the use of PFAS immunotoxicity data in regulatory and clinical decision-making contexts and question whether recent efforts adequately account for PFAS immunotoxicity in public health decision-making.

Recent findings: Government and academic reviews confirm the strongest human evidence for PFAS immunotoxicity is reduced antibody production in response to vaccinations, particularly for tetanus and diphtheria. However, recent events, such as the economic analysis supporting the proposed national primary drinking water regulations and clinical monitoring recommendations, indicate a failure to adequately incorporate these data into regulatory and clinical decisions. To be more protective of public health, we recommend using all relevant immunotoxicity data to inform current and future PFAS-related chemical risk assessment and regulation. Biological measures of immune system effects, such as reduced antibody levels in response to vaccination, should be used as valid and informative markers of health outcomes and risks associated with PFAS exposure. Routine toxicity testing should be expanded to include immunotoxicity evaluations in adult and developing organisms. In addition, clinical recommendations for PFAS-exposed individuals and communities should be revisited and strengthened to provide guidance on incorporating immune system monitoring and other actions that can be taken to protect against adverse health outcomes.

审查目的:全氟烷基和多氟烷基物质(PFAS)在全球环境和人体中的发现引发了科学研究、政府调查以及公众对与接触 PFAS 相关的多种不良健康影响的关注。在这篇综述中,我们讨论了在监管和临床决策中使用 PFAS 免疫毒性数据的情况,并质疑近期的工作是否在公共卫生决策中充分考虑了 PFAS 免疫毒性:政府和学术界的审查证实,PFAS 免疫毒性最有力的人体证据是接种疫苗(尤其是破伤风和白喉疫苗)后抗体生成减少。然而,最近发生的一些事件,如支持拟议的国家初级饮用水法规和临床监测建议的经济分析,表明这些数据未能充分纳入监管和临床决策。为了更好地保护公众健康,我们建议使用所有相关的免疫毒性数据,为当前和未来的全氟辛烷磺酸相关化学品风险评估和监管提供信息。免疫系统影响的生物措施,如接种疫苗后抗体水平降低,应作为健康结果和与 PFAS 暴露相关的风险的有效且信息丰富的标记。应扩大常规毒性测试的范围,纳入对成年和发育中生物的免疫毒性评估。此外,应重新审查和加强针对接触全氟辛烷磺酸的个人和社区的临床建议,为纳入免疫系统监测和其他可采取的行动提供指导,以防止不良健康后果。
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引用次数: 0
Supporting Decarbonization of Health Systems-A Review of International Policy and Practice on Health Care and Climate Change. 支持医疗保健系统的去碳化--医疗保健与气候变化国际政策与实践回顾》(Supporting Decarbonization of Health Systems-A Review of International Policy and Practice on Health Care and Climate Change)。
IF 7.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-01 Epub Date: 2024-02-15 DOI: 10.1007/s40572-024-00434-x
Emily Hough, Arielle Cohen Tanugi-Carresse

Purpose of review: Healthcare is a significant contributor of carbon emissions, which contribute to climate change. There has been an increased focus on the role healthcare should play in reducing emissions in recent years. This review, completed in September and October 2022, explored national commitments among 73 countries to reduce emissions from healthcare and the policies and delivery plans that exist to support their implementation.

Recent findings: Whilst some countries such as Norway, Columbia, and Australia are working to understand current emissions and develop plans to reduce them, few have published delivery plans for meeting national targets. Broader policies and reports published to date provide a clear set of actions that healthcare can take to reduce emissions. However, more research, innovation, and service redesign will be needed to close the gap to net zero healthcare. Some health systems are already taking action to reduce their emissions. However, national incentives, including standardized metrics and reporting, can help drive broader action and pace of delivery.

审查目的:医疗保健是碳排放的重要来源,而碳排放会导致气候变化。近年来,人们越来越关注医疗保健在减排方面应发挥的作用。本次审查于 2022 年 9 月和 10 月完成,探讨了 73 个国家在减少医疗排放方面的国家承诺,以及支持其实施的现有政策和交付计划:虽然挪威、哥伦比亚和澳大利亚等国正在努力了解当前的排放量并制定减排计划,但很少有国家公布了实现国家目标的实施计划。迄今为止发布的更广泛的政策和报告提供了一套明确的医疗保健减排行动。然而,还需要更多的研究、创新和服务重新设计,才能缩小与净零医疗的差距。一些医疗系统已经在采取减排行动。然而,包括标准化指标和报告在内的国家激励措施可以帮助推动更广泛的行动和交付速度。
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引用次数: 0
Consideration on the Intergenerational Ethics on Uranium Waste Disposal. 考虑铀废物处理的代际伦理问题。
IF 7.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-01 Epub Date: 2024-03-28 DOI: 10.1007/s40572-024-00442-x
Hiroshi Yasuda, Hiromichi Fumoto, Tatsuo Saito, Shin-Etsu Sugawara, Shoji Tsuchida

Purpose of review: This review provides insights into resolving intergenerational issues related to the disposal of waste containing high amounts of uranium (uranium waste), from which distant future generations will have higher health risks than the current generation.

Recent findings: Uranium (half-life: 4.5 billion years) produces various progeny radionuclides through radioactive decay over the long term, and its radioactivity, as the sum of its contributions, continues to increase for more than 100,000 years. In contrast to high-level radioactive wastes, protective measures, such as attenuation of radiation and confinement of radionuclides from the disposal facility, cannot work effectively for uranium waste. Thus, additional considerations from the perspective of intergenerational ethics are needed in the strategy for uranium waste disposal. The current generation, which has benefited from the use and disposal of uranium waste, is responsible for protecting future generations from the potential risk of buried uranium beyond the lifetime of a disposal facility. Fulfilling this responsibility means making more creative efforts to convey critical information on buried materials to the distant future to ensure that future generations can properly take measures to reduce the harm by themselves in response to changing circumstances including people's values.

审查目的:本综述深入探讨了如何解决与处置含大量铀的废物(铀废物)有关的代际问题,因为这些废物对后代造成的健康风险高于当代人:最新发现:铀(半衰期:45 亿年)通过长期放射性衰变产生各种后代放射性核素,其放射性作为其贡献的总和,在超过 10 万年的时间里持续增加。与高放射性废物不同的是,辐射衰减和将放射性核素封闭在处置设施之外等保护措施无法对铀废物有效发挥作用。因此,在铀废料处置战略中,需要从代际伦理的角度进行额外的考虑。这一代人从铀废料的使用和处置中获益,他们有责任保护子孙后代在处置设施寿命结束后免受被掩埋铀的潜在风险。履行这一责任意味着要做出更多创造性的努力,向遥远的未来传递有关掩埋材料的重要信息,以确保后代能够根据不断变化的情况(包括人们的价值观),自行采取适当的措施来减少危害。
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引用次数: 0
Airborne Exposure to Pollutants and Mental Health: A Review with Implications for United States Veterans. 暴露于空气中的污染物与心理健康:对美国退伍军人影响的综述》。
IF 7.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-01 Epub Date: 2024-03-08 DOI: 10.1007/s40572-024-00437-8
Andrew J Hoisington, Kelly A Stearns-Yoder, Elizabeth J Kovacs, Teodor T Postolache, Lisa A Brenner

Purpose of review: Inhalation of airborne pollutants in the natural and built environment is ubiquitous; yet, exposures are different across a lifespan and unique to individuals. Here, we reviewed the connections between mental health outcomes from airborne pollutant exposures, the biological inflammatory mechanisms, and provide future directions for researchers and policy makers. The current state of knowledge is discussed on associations between mental health outcomes and Clean Air Act criteria pollutants, traffic-related air pollutants, pesticides, heavy metals, jet fuel, and burn pits.

Recent findings: Although associations between airborne pollutants and negative physical health outcomes have been a topic of previous investigations, work highlighting associations between exposures and psychological health is only starting to emerge. Research on criteria pollutants and mental health outcomes has the most robust results to date, followed by traffic-related air pollutants, and then pesticides. In contrast, scarce mental health research has been conducted on exposure to heavy metals, jet fuel, and burn pits. Specific cohorts of individuals, such as United States military members and in-turn, Veterans, often have unique histories of exposures, including service-related exposures to aircraft (e.g. jet fuels) and burn pits. Research focused on Veterans and other individuals with an increased likelihood of exposure and higher vulnerability to negative mental health outcomes is needed. Future research will facilitate knowledge aimed at both prevention and intervention to improve physical and mental health among military personnel, Veterans, and other at-risk individuals.

审查目的:在自然和建筑环境中吸入空气传播的污染物无处不在;然而,人的一生中接触到的污染物是不同的,而且因人而异。在此,我们回顾了暴露于空气传播污染物所导致的心理健康后果与生物炎症机制之间的联系,并为研究人员和政策制定者提供了未来的发展方向。我们讨论了心理健康结果与《清洁空气法案》标准污染物、交通相关空气污染物、杀虫剂、重金属、喷气燃料和焚烧坑之间关系的知识现状:尽管空气传播的污染物与负面身体健康结果之间的关联是以往调查的一个主题,但强调暴露与心理健康之间关联的工作才刚刚开始出现。迄今为止,有关标准污染物和心理健康结果的研究结果最为可靠,其次是与交通有关的空气污染物,然后是杀虫剂。相比之下,有关重金属、喷气燃料和焚烧坑暴露的心理健康研究却很少。特定人群,如美国军人和退伍军人,往往有独特的暴露历史,包括与服役有关的飞机(如喷气燃料)和焚烧坑暴露。需要对退伍军人和其他更有可能暴露于负面心理健康结果且更易受到负面心理健康结果影响的人进行重点研究。未来的研究将有助于了解预防和干预措施,以改善军人、退伍军人和其他高危人群的身心健康。
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引用次数: 0
Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence. 合成化学品对自身免疫性疾病发展和发生的贡献
IF 7.9 2区 医学 Q1 Medicine Pub Date : 2024-04-24 DOI: 10.1007/s40572-024-00444-9
Noelle N Kosarek, Emma V. Preston
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引用次数: 0
Environmental Justice and Health in Nigeria. 尼日利亚的环境正义与健康。
IF 7.9 2区 医学 Q1 Medicine Pub Date : 2024-04-23 DOI: 10.1007/s40572-024-00439-6
T. Ogunro
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引用次数: 0
The Environment and Headache: a Narrative Review. 环境与头痛:叙述性综述。
IF 7.9 2区 医学 Q1 Medicine Pub Date : 2024-04-20 DOI: 10.1007/s40572-024-00449-4
Holly Elser, Caroline F G Kruse, Brian S Schwartz, Joan A Casey
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引用次数: 0
Reproductive and Social Policies, Sociopolitical Stress, and Implications for Maternal and Child Health Equity. 生殖和社会政策、社会政治压力以及对母婴健康公平的影响。
IF 7.9 2区 医学 Q1 Medicine Pub Date : 2024-04-19 DOI: 10.1007/s40572-024-00443-w
Stephanie M. Eick, Jasmin A. Eatman, Madeline Chandler, Nina R Brooks
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引用次数: 0
Correction: The Health-Related and Learning Performance Effects of Air Pollution and Other Urban-Related Environmental Factors on School-Age Children and Adolescents-A Scoping Review of Systematic Reviews. 更正:空气污染和其他与城市相关的环境因素对学龄儿童和青少年的健康和学习成绩的影响--系统综述的范围界定。
IF 7.9 2区 医学 Q1 Medicine Pub Date : 2024-04-17 DOI: 10.1007/s40572-024-00448-5
Inés Valls Roche, Mònica Ubalde-López, Carolyn Daher, M. Nieuwenhuijsen, Mireia Gascón
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引用次数: 0
Health Disparities in the Aftermath of Flood Events: A Review of Physical and Mental Health Outcomes with Methodological Considerations in the USA. 洪灾后的健康差异:美国生理和心理健康结果回顾与方法论思考》(A Review of Physical and Mental Health Outcomes with Methodological Considerations in the USA)。
IF 7.9 2区 医学 Q1 Medicine Pub Date : 2024-04-12 DOI: 10.1007/s40572-024-00446-7
Aaron B Flores, Jonathan A Sullivan, Yilei Yu, Hannah K Friedrich
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引用次数: 0
期刊
Current Environmental Health Reports
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