Pub Date : 2021-02-17DOI: 10.1007/s12281-021-00412-y
H. Jensen
{"title":"Histopathology in the Diagnosis of Invasive Fungal Diseases","authors":"H. Jensen","doi":"10.1007/s12281-021-00412-y","DOIUrl":"https://doi.org/10.1007/s12281-021-00412-y","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2021-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-021-00412-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47911089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/s12281-021-00421-x
P Lewis White, Jessica S Price, Alan Cordey, Matthijs Backx
Purpose of review: The use of molecular tests to aid the diagnosis of invasive yeast infection, in particular invasive candidosis, has been described for over two decades, yet widespread application is limited, and diagnosis remains heavily dependent on classical microbiology. This article will review developments from the past decade in attempt to build on existing knowledge. It will highlight clinical performance and limitations while reviewing developments on recognized procedures; it will also provide insight into novel approaches incorporated in response to clinical demand (e.g. C. auris and antifungal resistance) or technological advances (e.g. next-generation sequencing).
Recent findings: Limited methodological standardization and, until recently, unavailability of commercial options have hindered the integration of molecular diagnostics for yeasts. The development of certain, novel commercial methods has received considerable evaluation allowing a greater understanding of individual assay performance, but widespread multicentre evaluation of most commercial kits is lacking. The detection of emerging pathogens (e.g. C. auris) has been enhanced by the development of molecular tests. Molecular methods are providing a better understanding of the mycobiome, mechanisms of resistance and epidemiology/phylogeny.
Summary: Despite over two decades of use, the incorporation of molecular methods to enhance the diagnosis of yeast infections remains limited to certain specialist centres. While the development of commercial tests will provide stimulus for broader application, further validation and reduced costs are required. Over the same period of time, Aspergillus PCR has become more widely accepted driven by international efforts to standardize methodology; it is critical that yeast PCR follows suit. Next-generation sequencing will provide significant information on the mycobiome, antifungal resistance mechanism and even broad-range detection directly from the specimen, which may be critical for the molecular detection of yeasts other than Candida species, which is currently limited.
{"title":"Molecular Diagnosis of Yeast Infections.","authors":"P Lewis White, Jessica S Price, Alan Cordey, Matthijs Backx","doi":"10.1007/s12281-021-00421-x","DOIUrl":"https://doi.org/10.1007/s12281-021-00421-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>The use of molecular tests to aid the diagnosis of invasive yeast infection, in particular invasive candidosis, has been described for over two decades, yet widespread application is limited, and diagnosis remains heavily dependent on classical microbiology. This article will review developments from the past decade in attempt to build on existing knowledge. It will highlight clinical performance and limitations while reviewing developments on recognized procedures; it will also provide insight into novel approaches incorporated in response to clinical demand (e.g. <i>C. auris</i> and antifungal resistance) or technological advances (e.g. next-generation sequencing).</p><p><strong>Recent findings: </strong>Limited methodological standardization and, until recently, unavailability of commercial options have hindered the integration of molecular diagnostics for yeasts. The development of certain, novel commercial methods has received considerable evaluation allowing a greater understanding of individual assay performance, but widespread multicentre evaluation of most commercial kits is lacking. The detection of emerging pathogens (e.g. <i>C. auris</i>) has been enhanced by the development of molecular tests. Molecular methods are providing a better understanding of the mycobiome, mechanisms of resistance and epidemiology/phylogeny.</p><p><strong>Summary: </strong>Despite over two decades of use, the incorporation of molecular methods to enhance the diagnosis of yeast infections remains limited to certain specialist centres. While the development of commercial tests will provide stimulus for broader application, further validation and reduced costs are required. Over the same period of time, <i>Aspergillus</i> PCR has become more widely accepted driven by international efforts to standardize methodology; it is critical that yeast PCR follows suit. Next-generation sequencing will provide significant information on the mycobiome, antifungal resistance mechanism and even broad-range detection directly from the specimen, which may be critical for the molecular detection of yeasts other than <i>Candida</i> species, which is currently limited.</p>","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"15 3","pages":"67-80"},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-021-00421-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10709395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-09DOI: 10.1007/s12281-020-00408-0
A. Khanina, A. Douglas, K. Thursky
{"title":"Implementation of Effective Antifungal Stewardship in Cancer Patients—A Review of Current Evidence","authors":"A. Khanina, A. Douglas, K. Thursky","doi":"10.1007/s12281-020-00408-0","DOIUrl":"https://doi.org/10.1007/s12281-020-00408-0","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"361 - 372"},"PeriodicalIF":1.4,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00408-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43852007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-06DOI: 10.1007/s12281-020-00404-4
Kathryn Dzintars, Lindsey P Toman
{"title":"Interpretation and Understanding of Clinical Drug Interactions Between Azoles and Immunosuppressants in Solid Organ Transplant Recipients","authors":"Kathryn Dzintars, Lindsey P Toman","doi":"10.1007/s12281-020-00404-4","DOIUrl":"https://doi.org/10.1007/s12281-020-00404-4","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"391 - 396"},"PeriodicalIF":1.4,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00404-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44053196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-20DOI: 10.1007/s12281-020-00403-5
M. Khalili, Seyed Mohammad Bagher Abtahi, Mehrnaz Atighehchian, S. Hosseini, M. Shirvani, E. Sadeghi, M. Ghanbari, M. Eghtedari
{"title":"Invasive Fungal Keratitis as an Uncommon Form of Mucormycosis Leading to Endophthalmitis: Report of Two Cases and Literature Review","authors":"M. Khalili, Seyed Mohammad Bagher Abtahi, Mehrnaz Atighehchian, S. Hosseini, M. Shirvani, E. Sadeghi, M. Ghanbari, M. Eghtedari","doi":"10.1007/s12281-020-00403-5","DOIUrl":"https://doi.org/10.1007/s12281-020-00403-5","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"384 - 390"},"PeriodicalIF":1.4,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00403-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48455438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-30DOI: 10.1007/s12281-020-00397-0
Dulcilena Matos Castro Silva, Raquel Keiko Luca Ito, L. Bonfietti, M. W. Szeszs, Artur Luiz Rocha, N. Viola, E. Abdala, Márcia Souza Carvalho Melhem
{"title":"Antifungal and Antibacterial Activity of Terpenes for Improvement of Indoor Air Quality","authors":"Dulcilena Matos Castro Silva, Raquel Keiko Luca Ito, L. Bonfietti, M. W. Szeszs, Artur Luiz Rocha, N. Viola, E. Abdala, Márcia Souza Carvalho Melhem","doi":"10.1007/s12281-020-00397-0","DOIUrl":"https://doi.org/10.1007/s12281-020-00397-0","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"1 1","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00397-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41784948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-29DOI: 10.1007/s12281-020-00402-6
C. Antachopoulos, E. Roilides
{"title":"Pharmacokinetics and Pharmacodynamics of Antifungal Agents in Neonates and Children","authors":"C. Antachopoulos, E. Roilides","doi":"10.1007/s12281-020-00402-6","DOIUrl":"https://doi.org/10.1007/s12281-020-00402-6","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"317-328"},"PeriodicalIF":1.4,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00402-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48782443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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