The aim of this study was to synthesize Zinc oxide (ZnO) and magnetite ıron oxide (Fe3O4) nanoparticles utilizing a precipitation method, employing plant extracts from Ocimum basilica(1), Cinnamomum zeylanicum(2), Lactarius salmonicolor(3) and Paeonia kesrouanensis(4) as reduction and stabilizing agents. Additionally, the antimicrobial activity of these nanoparticles against both gram-positive (S. aureus, ATCC 25923) and gram-negative (E. coli, ATCC 25922; P. aeroginosa, PAO1), bacteria as well as fungus (C. albicans 90028) was evaluated. The nanoparticles (NPs) were characterised by various analyses, including TEM, SEM, XRD, FTIR, DSL, and zeta potential. Based on the TEM image, the ZnONPs exhibited a cluster of flower-like structures, whereas the Fe3O4NPs displayed a spherical shape with a varying size distribution. The zeta potential values for ZnO NPs ranged from -5.35 to -16.9, while for Fe3O4NPs ranged from -7.43 to -20.7. All ZnO nanoparticles exhibited antimicrobial activity exclusively against the S. aureus strain, whereas Fe3O4NPs did not demonstrate any antibacterial effect.
{"title":"Comparison of Characteristics and Antimicrobial Activity of Synthesized Zinc Oxide And Magnetite Iron Oxide Nanoparticles Using Four Different Plant Extracts","authors":"Burcu Aydoğdu, Mehmet Aytar, İlkay Ünal","doi":"10.17776/csj.1370606","DOIUrl":"https://doi.org/10.17776/csj.1370606","url":null,"abstract":"The aim of this study was to synthesize Zinc oxide (ZnO) and magnetite ıron oxide (Fe3O4) nanoparticles utilizing a precipitation method, employing plant extracts from Ocimum basilica(1), Cinnamomum zeylanicum(2), Lactarius salmonicolor(3) and Paeonia kesrouanensis(4) as reduction and stabilizing agents. Additionally, the antimicrobial activity of these nanoparticles against both gram-positive (S. aureus, ATCC 25923) and gram-negative (E. coli, ATCC 25922; P. aeroginosa, PAO1), bacteria as well as fungus (C. albicans 90028) was evaluated. The nanoparticles (NPs) were characterised by various analyses, including TEM, SEM, XRD, FTIR, DSL, and zeta potential. Based on the TEM image, the ZnONPs exhibited a cluster of flower-like structures, whereas the Fe3O4NPs displayed a spherical shape with a varying size distribution. The zeta potential values for ZnO NPs ranged from -5.35 to -16.9, while for Fe3O4NPs ranged from -7.43 to -20.7. All ZnO nanoparticles exhibited antimicrobial activity exclusively against the S. aureus strain, whereas Fe3O4NPs did not demonstrate any antibacterial effect.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"35 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140509716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The sugar industry is a significant contributor to wastewater production, primarily due to its substantial water usage. The treatment and reuse of this wastewater have become pressing concerns. In the present study, sugar industry wastewater was treated via Fenton oxidation using zero-valent iron (ZVI). The study focused on assessing the impact of key reaction parameters, namely pH, ZVI amount, [H2O2]0 on the removal of TOC. Optimal reaction conditions for the Fenton oxidation process were identified, with a pH of 3.5, 2 g/L of ZVI, and 4 mM of H2O2, resulting in nearly 65% of TOC removal. The kinetic study revealed that the observed reaction adhered to a second-order kinetic reaction model. Furthermore, the activation energy for this observed reaction was determined as 49.14 kJ/mol. These findings suggest that Fenton oxidation, utilizing ZVI, holds promise as an effective method for treating wastewater originating from the sugar industry.
{"title":"Treatment of Sugar Industry Wastewater via Fenton Oxidation with Zero-Valent Iron","authors":"Ceren Orak","doi":"10.17776/csj.1328817","DOIUrl":"https://doi.org/10.17776/csj.1328817","url":null,"abstract":"The sugar industry is a significant contributor to wastewater production, primarily due to its substantial water usage. The treatment and reuse of this wastewater have become pressing concerns. In the present study, sugar industry wastewater was treated via Fenton oxidation using zero-valent iron (ZVI). The study focused on assessing the impact of key reaction parameters, namely pH, ZVI amount, [H2O2]0 on the removal of TOC. Optimal reaction conditions for the Fenton oxidation process were identified, with a pH of 3.5, 2 g/L of ZVI, and 4 mM of H2O2, resulting in nearly 65% of TOC removal. The kinetic study revealed that the observed reaction adhered to a second-order kinetic reaction model. Furthermore, the activation energy for this observed reaction was determined as 49.14 kJ/mol. These findings suggest that Fenton oxidation, utilizing ZVI, holds promise as an effective method for treating wastewater originating from the sugar industry.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"43 1-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140514957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this work, the active ingredients of Entacapone, Levodopa and Carbidopa in drug samples used in the treatment of Parkinson's disease were quantitatively determined by Ultraviolet Visible (UV-VIS) Spectroscopy and chemometrics. Firstly, the spectra of each drug active ingredient were taken individually and then synthetic mixtures identical to the drug sample were analyzed. In our method, validation parameters were calculated for each method. Percent (%) recoveries were found on average for both the synthetic mixture and the commercial sample. The recoveries were quantitative for each method. The accuracy of the methods was tested by applying ANOVA test to the results obtained from the PLS and PCR calibration methods. The developed methods are reproducible, sensitive, and accurate, and can be recommended for the analysis of drug samples containing Entacapone, Levodopa, and Carbidopa
{"title":"Chemometric Determination of Parkinson's Drugs Containing Multiple Active Substances","authors":"Ayşe Merve Arslan, Güzide Pekcan","doi":"10.17776/csj.1351879","DOIUrl":"https://doi.org/10.17776/csj.1351879","url":null,"abstract":"In this work, the active ingredients of Entacapone, Levodopa and Carbidopa in drug samples used in the treatment of Parkinson's disease were quantitatively determined by Ultraviolet Visible (UV-VIS) Spectroscopy and chemometrics. Firstly, the spectra of each drug active ingredient were taken individually and then synthetic mixtures identical to the drug sample were analyzed. In our method, validation parameters were calculated for each method. Percent (%) recoveries were found on average for both the synthetic mixture and the commercial sample. The recoveries were quantitative for each method. The accuracy of the methods was tested by applying ANOVA test to the results obtained from the PLS and PCR calibration methods. The developed methods are reproducible, sensitive, and accurate, and can be recommended for the analysis of drug samples containing Entacapone, Levodopa, and Carbidopa","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"483 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140514684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
For the first time, electronic characteristics of potential drug candidates and their inhibitory activities have been linked thanks to this work. Synthesized copper and nickel complexes with trans-N1,N8-bis(2-cyanoethyl)-2,4,4,9,11,11-hexamethyl-1,5,8,12-tetraazacyclotetradecane (tet-bx) ligand, as well as the proposed hypothetical complexes, were properly examined by the appropriate calculation method in atomic and molecular dimensions. The appropriate calculation level was achieved by using the IR spectroscopic data of the tet-bx ligand. The experimental and calculated bond stretching frequencies were compared for synthesized complexes [Ni(tet-bx)](ClO4)2 (1), [Cu(tet-bx)](ClO4)2 (2), [Ni(tet-bx)(NCS)2] (3), and [Ni(tet-bx)(ClO4)Cl] (5). Some bond stretching frequencies of hypothetical complexes [Cu(tet-bx)(NCS)2] (4) and [Cu(tet-bx)(ClO4)Cl] (6) have also been proposed and their molecular structure were determined. To analyze the electronic behavior of the examined complexes at the atomic level, Fukui function indices (nucleophilic f+ and electrophilic f- populations) were determined. Furthermore, antibacterial and antiviral inhibition efficiency of the complexes against Crimean-Congo hemorrhagic fever has been investigated by docking studies
{"title":"Investigation of Antiviral Activities of Nickel and Copper Complexes with Macrocyclic Ligands against Crimean-Congo Hemorrhagic Fever by In Silico Calculations","authors":"S. Erkan, N. Bulut, Duran Karakaş","doi":"10.17776/csj.1375105","DOIUrl":"https://doi.org/10.17776/csj.1375105","url":null,"abstract":"For the first time, electronic characteristics of potential drug candidates and their inhibitory activities have been linked thanks to this work. Synthesized copper and nickel complexes with trans-N1,N8-bis(2-cyanoethyl)-2,4,4,9,11,11-hexamethyl-1,5,8,12-tetraazacyclotetradecane (tet-bx) ligand, as well as the proposed hypothetical complexes, were properly examined by the appropriate calculation method in atomic and molecular dimensions. The appropriate calculation level was achieved by using the IR spectroscopic data of the tet-bx ligand. The experimental and calculated bond stretching frequencies were compared for synthesized complexes [Ni(tet-bx)](ClO4)2 (1), [Cu(tet-bx)](ClO4)2 (2), [Ni(tet-bx)(NCS)2] (3), and [Ni(tet-bx)(ClO4)Cl] (5). Some bond stretching frequencies of hypothetical complexes [Cu(tet-bx)(NCS)2] (4) and [Cu(tet-bx)(ClO4)Cl] (6) have also been proposed and their molecular structure were determined. To analyze the electronic behavior of the examined complexes at the atomic level, Fukui function indices (nucleophilic f+ and electrophilic f- populations) were determined. Furthermore, antibacterial and antiviral inhibition efficiency of the complexes against Crimean-Congo hemorrhagic fever has been investigated by docking studies","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aromatic plant species of the genus thymus have an important role as they have therapeutic properties such as antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. It is also known that such plants strengthen the immune system and help cope with infectious diseases such as colds and flu. In this study, the effects of thymol, p-cymene, -terpinene, bornyl acetate, borneol, carvacrol, thymol methyl ether, thymol acetate, which are the main components of wild thyme (thymus serpyllum L.), on Covid-19 were investigated at the molecular level. Optimizations and molecular docking were done in Docking Server with the MMFF94 method. Major components of wild thyme were docked separately against 6LU7 protein representing the first gene form of Covid-19 and 7KDL protein representing the mutated form. Docking poses and binding energies between target proteins and wild thyme components were calculated. The results were compared with favipiravir, an antiviral drug developed against influenza virus and also used in the treatment of Covid-19. It was found that the thymol molecule, one of the main components of wild thyme, has the highest biological activity against both 6LU7 and 7KDL protein chains of Covid-19.
{"title":"Investigation of the Effect of Main Components of Wild Thyme on Covid-19 by Computational Methods","authors":"Serpil Kaya, S. Erkan, Duran Karakaş","doi":"10.17776/csj.1328641","DOIUrl":"https://doi.org/10.17776/csj.1328641","url":null,"abstract":"Aromatic plant species of the genus thymus have an important role as they have therapeutic properties such as antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. It is also known that such plants strengthen the immune system and help cope with infectious diseases such as colds and flu. In this study, the effects of thymol, p-cymene, -terpinene, bornyl acetate, borneol, carvacrol, thymol methyl ether, thymol acetate, which are the main components of wild thyme (thymus serpyllum L.), on Covid-19 were investigated at the molecular level. Optimizations and molecular docking were done in Docking Server with the MMFF94 method. Major components of wild thyme were docked separately against 6LU7 protein representing the first gene form of Covid-19 and 7KDL protein representing the mutated form. Docking poses and binding energies between target proteins and wild thyme components were calculated. The results were compared with favipiravir, an antiviral drug developed against influenza virus and also used in the treatment of Covid-19. It was found that the thymol molecule, one of the main components of wild thyme, has the highest biological activity against both 6LU7 and 7KDL protein chains of Covid-19.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"227 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Covid-19, emerged in Wuhan, a city of China, at the date of December 2019, it spread to the entire world soon and then by the World Health Organization (WHO) accepted as a pandemic. Today, still the coping with Covid-19 is the one of the significant topics of countries. In this study, the relative efficiencies of 15 OECD countries for coping with the pandemic is analyzed with Data Envelopment Analysis (DEA). Current health expenditure (% of GDP), Nurses and midwives (per 1 thousand people), Hospital beds (per 1 thousand people), Physicians (per 1 thousand people) variables used as inputs; Number of Total Cases (per 1 million people), Number of Deaths (per 1 million people) and Number of Tests (per 1 million people) variables used as outputs. Output oriented Charnes, Cooper and Rhodes (CCR) and Banker, Charnes and Cooper (BCC) DEA models are used, scale efficiency values are determined and potential improvement suggestions are given for inefficient countries. Austria, Mexico, South Korea, Spain and Türkiye are found to be both relative technical, total and scale efficient. It is also concluded that inefficient countries must use their input variables efficiently and number of Covid-19 tests is important for a country’s efficiency against Covid-19.
{"title":"Determining Efficiency of 15 OECD Countries Coping with Covid-19 using Data Envelopment Analysis after 2 Years of Pandemic","authors":"Esra Polat","doi":"10.17776/csj.1225208","DOIUrl":"https://doi.org/10.17776/csj.1225208","url":null,"abstract":"Covid-19, emerged in Wuhan, a city of China, at the date of December 2019, it spread to the entire world soon and then by the World Health Organization (WHO) accepted as a pandemic. Today, still the coping with Covid-19 is the one of the significant topics of countries. In this study, the relative efficiencies of 15 OECD countries for coping with the pandemic is analyzed with Data Envelopment Analysis (DEA). Current health expenditure (% of GDP), Nurses and midwives (per 1 thousand people), Hospital beds (per 1 thousand people), Physicians (per 1 thousand people) variables used as inputs; Number of Total Cases (per 1 million people), Number of Deaths (per 1 million people) and Number of Tests (per 1 million people) variables used as outputs. Output oriented Charnes, Cooper and Rhodes (CCR) and Banker, Charnes and Cooper (BCC) DEA models are used, scale efficiency values are determined and potential improvement suggestions are given for inefficient countries. Austria, Mexico, South Korea, Spain and Türkiye are found to be both relative technical, total and scale efficient. It is also concluded that inefficient countries must use their input variables efficiently and number of Covid-19 tests is important for a country’s efficiency against Covid-19.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"317 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thiazole rings are one of the most frequently used heterocyclic moieties and are found in a wide variety of biologically active chemicals. In this research project, we report the synthesis and biological activities of some new thiazole derivatives (2a-2c) as potent anti-Alzheimer’s agents. These final compounds’ structures were characterized by spectral (1H NMR, 13C NMR, and MS spectra) analyses. The highest inhibitory activity against AChE was demonstrated by compound 2c (23.73 ± 0.018 %) with chloro substitution at the meta and para positions of the phenyl ring, while the highest inhibitory activity against BuChE was produced by compound 2a (28.87± 0.003 %) with cyano substitution at the f position of the phenyl ring. Ferrous ion-chelating and DPPH techniques were also used to assess the compounds' antioxidant properties. Compound 2a showed antioxidant effect according to the DPPH method with an IC50 value of 27.18 ± 0.009 µM.
{"title":"Design, Synthesis and Evaluation of Pyrrol-thiazole Derivatives as AChE and BuChE Inhibitory and Antioxidant Activities","authors":"U. Acar Çevik, Tuğba Erçetin","doi":"10.17776/csj.1255826","DOIUrl":"https://doi.org/10.17776/csj.1255826","url":null,"abstract":"Thiazole rings are one of the most frequently used heterocyclic moieties and are found in a wide variety of biologically active chemicals. In this research project, we report the synthesis and biological activities of some new thiazole derivatives (2a-2c) as potent anti-Alzheimer’s agents. These final compounds’ structures were characterized by spectral (1H NMR, 13C NMR, and MS spectra) analyses. The highest inhibitory activity against AChE was demonstrated by compound 2c (23.73 ± 0.018 %) with chloro substitution at the meta and para positions of the phenyl ring, while the highest inhibitory activity against BuChE was produced by compound 2a (28.87± 0.003 %) with cyano substitution at the f position of the phenyl ring. Ferrous ion-chelating and DPPH techniques were also used to assess the compounds' antioxidant properties. Compound 2a showed antioxidant effect according to the DPPH method with an IC50 value of 27.18 ± 0.009 µM.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"52 s33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, photothermal effect by doping expanded graphite (EG) to smart nanofibers produced by electrospinning method was investigated. Fourier transform infrared (FT-IR) spectroscopy was exploited for chemical characterization. Thermal analysis experiments were carried out by heating and cooling curves. Surface morphology of the produced materials was investigated through scanning electron microscope (SEM). Contact angle was determined through contact angle measurement device. The appearance of the peak of the characteristic cyano group in the structure of Polyacrylonitrile (PAN) at 2237.02 cm-1 in the nanofibers having different percentages synthesized with EG and PAN was accepted as the evidence of PAN nanofibers formation. The temperature platforms in the heating/cooling curves exhibited that the temperature of the PAN and cellulose acetate (CA) nanofibers mixed with different EG percentage have higher than pristine nanofibers. The surfaces of the EG@PAN and EG@CA nanofibers were homogeneously distributed fibrous, excessive EG heterogeneously dispersed or electrosprayed in shape. The maximum contacts angles were measured as 67.96° and 52.88° for nanofibers synthesized with EG@CA and EG@PAN, respectively. As the result, the temperature of the nanofibers mixed EG at different percentages increased resulting from having the higher thermal conductivity of EG. Main goal of the study is both investigating photothermal effect in PAN and CA electrospun nanofibers doped with EG of activating heat accumulation property of the produced smart nanofibers for heat energy production from the solar. Thus, it will be possible to develop a new promising method in the production of the smart textile products that have the storage capacity of the solar energy.
本研究探讨了在电纺丝法生产的智能纳米纤维中掺杂膨胀石墨（EG）的光热效应。傅立叶变换红外（FT-IR）光谱用于化学表征。通过加热和冷却曲线进行了热分析实验。通过扫描电子显微镜（SEM）研究了所制材料的表面形态。通过接触角测量装置测定了接触角。在用 EG 和 PAN 合成的不同比例的纳米纤维中，聚丙烯腈（PAN）结构中特征氰基的峰值出现在 2237.02 cm-1 处，这被认为是 PAN 纳米纤维形成的证据。加热/冷却曲线的温度平台显示，与不同 EG 百分比的 PAN 和醋酸纤维素（CA）纳米纤维混合后的温度高于原始纳米纤维。EG@PAN 和 EG@CA 纳米纤维的表面呈均匀分布的纤维状，过量的 EG 呈异质分散或电喷状。经测量，用 EG@CA 和 EG@PAN 合成的纳米纤维的最大接触角分别为 67.96°和 52.88°。结果表明，由于 EG 的热导率较高，不同比例的 EG 混合纳米纤维的温度都有所升高。本研究的主要目的是研究掺杂 EG 的 PAN 和 CA 电纺纳米纤维的光热效应，以激活所生产的智能纳米纤维的蓄热特性，利用太阳能生产热能。因此，在生产具有太阳能储存能力的智能纺织产品方面，有可能开发出一种新的有前途的方法。
{"title":"Investigation of Electrospun Polyacrylonitrile and Cellulose Acetate Smart Nanofibers Doped with Expanded Graphite for the Structure and Photothermal Effect","authors":"Özgül Gök","doi":"10.17776/csj.1278533","DOIUrl":"https://doi.org/10.17776/csj.1278533","url":null,"abstract":"In this study, photothermal effect by doping expanded graphite (EG) to smart nanofibers produced by electrospinning method was investigated. Fourier transform infrared (FT-IR) spectroscopy was exploited for chemical characterization. Thermal analysis experiments were carried out by heating and cooling curves. Surface morphology of the produced materials was investigated through scanning electron microscope (SEM). Contact angle was determined through contact angle measurement device. The appearance of the peak of the characteristic cyano group in the structure of Polyacrylonitrile (PAN) at 2237.02 cm-1 in the nanofibers having different percentages synthesized with EG and PAN was accepted as the evidence of PAN nanofibers formation. The temperature platforms in the heating/cooling curves exhibited that the temperature of the PAN and cellulose acetate (CA) nanofibers mixed with different EG percentage have higher than pristine nanofibers. The surfaces of the EG@PAN and EG@CA nanofibers were homogeneously distributed fibrous, excessive EG heterogeneously dispersed or electrosprayed in shape. The maximum contacts angles were measured as 67.96° and 52.88° for nanofibers synthesized with EG@CA and EG@PAN, respectively. As the result, the temperature of the nanofibers mixed EG at different percentages increased resulting from having the higher thermal conductivity of EG. Main goal of the study is both investigating photothermal effect in PAN and CA electrospun nanofibers doped with EG of activating heat accumulation property of the produced smart nanofibers for heat energy production from the solar. Thus, it will be possible to develop a new promising method in the production of the smart textile products that have the storage capacity of the solar energy.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"27 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatih Yi̇ği̇t, Nurettin Tarkan, Mehmet Akdeni̇z, Figen Erek, I. Aydin
An easy and economical spectrophotometric method has been developed for the determination of atorvastatin from tablet formulation. This method is based on the formation of a blue-colored charge transfer complex of Atorvastatin with quinalizarin in methanol medium. The blue colored complex gives maximum absorbance at 573 nm. In order to develop the quantitative analysis method of atorvastatin, several parameters such as the type of solvent, the effect of reagent concentration, and the reaction time and temperature on absorbance of complex were investigated. It was determined that the optimum Quinz solution (0.5x10-³ M) was 3mL and the optimum temperature of the reaction was room temperature. Beer’s law range of proposed method is found 10-100 µg.mL-1. LOD and LOQ of the proposed method were found as 1.49 µg.mL-1 and 4.98 µg.mL-1, respectively. As a result, this proposed method can be used in the quantitative analysis of atorvastatin in tablet formulations
{"title":"Spectrophotometric Determination of Atorvastatin Based on Charge Transfer Reaction with Quinalizarin","authors":"Fatih Yi̇ği̇t, Nurettin Tarkan, Mehmet Akdeni̇z, Figen Erek, I. Aydin","doi":"10.17776/csj.1327163","DOIUrl":"https://doi.org/10.17776/csj.1327163","url":null,"abstract":"An easy and economical spectrophotometric method has been developed for the determination of atorvastatin from tablet formulation. This method is based on the formation of a blue-colored charge transfer complex of Atorvastatin with quinalizarin in methanol medium. The blue colored complex gives maximum absorbance at 573 nm. In order to develop the quantitative analysis method of atorvastatin, several parameters such as the type of solvent, the effect of reagent concentration, and the reaction time and temperature on absorbance of complex were investigated. It was determined that the optimum Quinz solution (0.5x10-³ M) was 3mL and the optimum temperature of the reaction was room temperature. Beer’s law range of proposed method is found 10-100 µg.mL-1. LOD and LOQ of the proposed method were found as 1.49 µg.mL-1 and 4.98 µg.mL-1, respectively. As a result, this proposed method can be used in the quantitative analysis of atorvastatin in tablet formulations","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"36 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The discovery of many drugs in recent years provides a definitive solution in the treatment of various diseases, but today, despite the discovery of many effective anticancer drugs, there are various types of cancer that have limitations in treatment and are still not completely curable. Since most of these limitations are due to cancer cells gaining resistance or compounds only being effective in certain types of cancer cells, the search for more effective anticancer drugs that are also effective in these types of cancer is inevitable. Cabozantinib is in medical use as a highly effective anticancer drug in various types of cancer, such as medullary thyroid cancer and kidney cancer. The anticancer properties of the Cabozantinib compound have attracted more attention in recent years, however, more studies are needed to define the anticancer activities of this compound. In our study, the interactions of Cabozantinib with topoisomerase enzymes, were demonstrated through in vitro enzyme activity tests, and the anti-proliferative effect of Cabozantinib was studied on MCF7, A549 and PC3 cell lines. By analyzing the interactions of the Cabozantinib with topoisomerases, the action mechanisms of the compound at the molecular level was evaluated.
{"title":"Evaluation of the Interactions of Cabozantinib with Topoisomerase Enzymes by in vitro Enzyme Activity Assays, and its Effects on Cancer Cell Proliferation","authors":"Feyza Oflaz, Naz Ünal, Burcin Gungor, Pakize Cantürk","doi":"10.17776/csj.1376788","DOIUrl":"https://doi.org/10.17776/csj.1376788","url":null,"abstract":"The discovery of many drugs in recent years provides a definitive solution in the treatment of various diseases, but today, despite the discovery of many effective anticancer drugs, there are various types of cancer that have limitations in treatment and are still not completely curable. Since most of these limitations are due to cancer cells gaining resistance or compounds only being effective in certain types of cancer cells, the search for more effective anticancer drugs that are also effective in these types of cancer is inevitable. Cabozantinib is in medical use as a highly effective anticancer drug in various types of cancer, such as medullary thyroid cancer and kidney cancer. The anticancer properties of the Cabozantinib compound have attracted more attention in recent years, however, more studies are needed to define the anticancer activities of this compound. In our study, the interactions of Cabozantinib with topoisomerase enzymes, were demonstrated through in vitro enzyme activity tests, and the anti-proliferative effect of Cabozantinib was studied on MCF7, A549 and PC3 cell lines. By analyzing the interactions of the Cabozantinib with topoisomerases, the action mechanisms of the compound at the molecular level was evaluated.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"16 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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