In this work, the effect of synthesizing process on the morphology, structure, and magnetic properties of Fe3O4 magnetic nanoparticles have been studied by performing X-ray diffraction, scanning electronic microscopy, and vibrating sample magnetometer measurements. Fe3O4 nanoparticles were synthesized by hydrothermal and solvothermal methods. X-ray diffraction analysis revealed that both samples have cubic crystal phase. However, Fe2O3 impurity peaks were observed in the sample synthesized by hydrothermal method. The crystallite sizes of samples synthesized by hydrothermal and solvothermal methods were approximately 38 and 24 nm, respectively. The scanning electron microscope images show that spherical porous and cubic shape Fe3O4 nanoparticles were obtained by solvothermal and hydrothermal method, respectively. The average particle sizes of Fe3O4 samples synthesized by hydrothermal and solvothermal methods were determined as 220 and 450 nm, respectively. Both samples behave a soft ferromagnetic characteristic having almost zero coercive field. The magnetic saturation values of Fe3O4 nanoparticles synthesized by hydrothermal and solvothermal methods were determined as 28.78 and 77.31 emu/g, respectively. As a result of the characterizations, porous Fe3O4 nanoparticles synthesized by solvothermal method show better crystal structure, morphological and magnetic properties than Fe3O4 nanoparticles synthesized by hydrothermal method.
{"title":"Effect of Synthesizing Process on the Formation of Fe3O4 Magnetic Nanoparticles","authors":"AKA, Cemal\u0000 , AKYOL, Mustafa\u0000 ","doi":"10.17776/csj.1284327","DOIUrl":"https://doi.org/10.17776/csj.1284327","url":null,"abstract":"In this work, the effect of synthesizing process on the morphology, structure, and magnetic properties of Fe3O4 magnetic nanoparticles have been studied by performing X-ray diffraction, scanning electronic microscopy, and vibrating sample magnetometer measurements. Fe3O4 nanoparticles were synthesized by hydrothermal and solvothermal methods. X-ray diffraction analysis revealed that both samples have cubic crystal phase. However, Fe2O3 impurity peaks were observed in the sample synthesized by hydrothermal method. The crystallite sizes of samples synthesized by hydrothermal and solvothermal methods were approximately 38 and 24 nm, respectively. The scanning electron microscope images show that spherical porous and cubic shape Fe3O4 nanoparticles were obtained by solvothermal and hydrothermal method, respectively. The average particle sizes of Fe3O4 samples synthesized by hydrothermal and solvothermal methods were determined as 220 and 450 nm, respectively. Both samples behave a soft ferromagnetic characteristic having almost zero coercive field. The magnetic saturation values of Fe3O4 nanoparticles synthesized by hydrothermal and solvothermal methods were determined as 28.78 and 77.31 emu/g, respectively. As a result of the characterizations, porous Fe3O4 nanoparticles synthesized by solvothermal method show better crystal structure, morphological and magnetic properties than Fe3O4 nanoparticles synthesized by hydrothermal method.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"257 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cosmetics have been attracting the attention of humanity since it existed. Over the years, the reach of the cosmetics industry has increased exponentially. In recent years, cosmetic manufacturers have developed many formulations on cosmetic products that are brighter in color, more permanent and not easily affected by external factors. However, heavy metal powders are used while producing these formulations especially inside in dyestuffs and stabilizers. Cosmetic products can be absorbed through the skin and cause systemic toxicity. Hundreds of chemicals are used in many cosmetic products such as make-up products, shampoos, creams, aftershaves, and these chemicals may cause significant health problems. Thus, this study is designed to investigate the heavy metal content of lipstick samples which are used extensively by women. Determination of aluminum (Al), chromium (Cr), iron (Fe), nickel (Ni), copper (Cu), zinc (Zn), elements in 35 different lipstick samples (including 15 brands) were performed by Inductively Coupled Plasma-Mass Spectrophotometer (ICP-MS) device. Before the analysis, two different solubilization methods, wet solubilization and dry ashing, were applied to the samples in order to take the metals in the lipstick samples into inorganic environment
{"title":"Determination Of Some Trace Elements In Some Lipstick Products By Inductive Coupled Plasma-Mass Spectrometry","authors":"DALTABAN İNAN, Gözde Gülin\u0000 , ŞEREN, Gülay\u0000 ","doi":"10.17776/csj.1263223","DOIUrl":"https://doi.org/10.17776/csj.1263223","url":null,"abstract":"Cosmetics have been attracting the attention of humanity since it existed. Over the years, the reach of the cosmetics industry has increased exponentially. In recent years, cosmetic manufacturers have developed many formulations on cosmetic products that are brighter in color, more permanent and not easily affected by external factors. However, heavy metal powders are used while producing these formulations especially inside in dyestuffs and stabilizers. Cosmetic products can be absorbed through the skin and cause systemic toxicity. Hundreds of chemicals are used in many cosmetic products such as make-up products, shampoos, creams, aftershaves, and these chemicals may cause significant health problems. Thus, this study is designed to investigate the heavy metal content of lipstick samples which are used extensively by women. Determination of aluminum (Al), chromium (Cr), iron (Fe), nickel (Ni), copper (Cu), zinc (Zn), elements in 35 different lipstick samples (including 15 brands) were performed by Inductively Coupled Plasma-Mass Spectrophotometer (ICP-MS) device. Before the analysis, two different solubilization methods, wet solubilization and dry ashing, were applied to the samples in order to take the metals in the lipstick samples into inorganic environment","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The determination of progesterone in pure and capsule form was accomplished in this work using new, simple and quick procedures by UV spectrophotometry, first-order derivative spectrophotometry and gas chromatography. To increase the sensitivity of the suggested methods, it was necessary to optimize the solvent system, the detection wavelength, and the chromatographic conditions. The linear regression equations for the UV spectrophotometry, first-order derivative spectrophotometry and gas chromatography were y=0.0536x+0.0002, y=0.1362x+0.0014, and y=1.8217x-1.239, respectively, as determined by the least square regression approach. Under the chosen experimental conditions, no interference was found. The suggested methods are extremely accurate and precise. When the suggested methods' findings were compared to those of two published reference methods, there was statistically no discernible difference. Therefore, the methods are applicable to the measurement of progesterone in pharmaceutical formulations.
{"title":"Determination of Progesterone in Pharmaceutical Preparations by UV, First-order Derivative Spectrophotometry and Gas Chromatography","authors":"YILMAZ, Bilal\u0000 , ALBAYRAK, Mevlüt\u0000 , KADIOĞLU, Yücel\u0000 ","doi":"10.17776/csj.1303270","DOIUrl":"https://doi.org/10.17776/csj.1303270","url":null,"abstract":"The determination of progesterone in pure and capsule form was accomplished in this work using new, simple and quick procedures by UV spectrophotometry, first-order derivative spectrophotometry and gas chromatography. To increase the sensitivity of the suggested methods, it was necessary to optimize the solvent system, the detection wavelength, and the chromatographic conditions. The linear regression equations for the UV spectrophotometry, first-order derivative spectrophotometry and gas chromatography were y=0.0536x+0.0002, y=0.1362x+0.0014, and y=1.8217x-1.239, respectively, as determined by the least square regression approach. Under the chosen experimental conditions, no interference was found. The suggested methods are extremely accurate and precise. When the suggested methods' findings were compared to those of two published reference methods, there was statistically no discernible difference. Therefore, the methods are applicable to the measurement of progesterone in pharmaceutical formulations.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breast cancer is the most common type of cancer in women. Today, the radiotherapy method is widely preferred to treat cancer patients where proton therapy is a radiotherapy method used to destroy cancerous cells using proton beams with unique characteristics. Photon therapy, on the other hand, is a classical radiotherapy method that treats cancerous cells by targeting ionizing radiation. In our study, a tumor was placed in the left breast in a water phantom with the help of the Geant4 simulation program and geometry with critical organs was modeled. With this simulation, the doses received by the organs were interpreted and comparisons were made using the chi-square method as the two different source beams, proton and photon deployed. When the percentile values in the dose table are normalized for 1 Gy, the test statistic obtained as 0.467, and the H0 hypothesis is rejected at the α=0.975 Statistically, we measured the significant differences between proton and photon dose values for tumors and other organs by Geant4 simulations.
{"title":"Comparison of Proton and Photon Radiotheraphy for Left-sided Breast Cancer via Dosimetric Calculations","authors":"YEŞİLDERE, İnci\u0000 , KUDAY, Sinan\u0000 ","doi":"10.17776/csj.1061321","DOIUrl":"https://doi.org/10.17776/csj.1061321","url":null,"abstract":"Breast cancer is the most common type of cancer in women. Today, the radiotherapy method is widely preferred to treat cancer patients where proton therapy is a radiotherapy method used to destroy cancerous cells using proton beams with unique characteristics. Photon therapy, on the other hand, is a classical radiotherapy method that treats cancerous cells by targeting ionizing radiation. In our study, a tumor was placed in the left breast in a water phantom with the help of the Geant4 simulation program and geometry with critical organs was modeled. With this simulation, the doses received by the organs were interpreted and comparisons were made using the chi-square method as the two different source beams, proton and photon deployed. When the percentile values in the dose table are normalized for 1 Gy, the test statistic obtained as 0.467, and the H0 hypothesis is rejected at the α=0.975 Statistically, we measured the significant differences between proton and photon dose values for tumors and other organs by Geant4 simulations.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This work presents a collocation computational algorithm for solving linear Integro-Differential Equations (IDEs) of the Fredholm and Volterra types. The proposed method utilizes shifted Legendre polynomials and breaks down the problem into a series of linear algebraic equations. The matrix inversion technique is then employed to solve these equations. To validate the effectiveness of the suggested approach, the authors examined three numerical examples. The results obtained from the proposed method were compared with those reported in the existing literature. The findings demonstrate that the proposed algorithm is not only accurate but also efficient in solving linear IDEs. In order to present the results, the study employs tables and figures. These graphical representations aid in displaying the numerical outcomes obtained from the algorithm. All calculations were performed using Maple 18 software.
{"title":"Legendre Computational Algorithm for Linear Integro-Differential Equations","authors":"OYEDEPO, Taiye\u0000 , AYOADE, Abayomi\u0000 , AJİLEYE, Ganiyu\u0000 , IKECHUKWU, Nneoma Joyce\u0000 ","doi":"10.17776/csj.1267158","DOIUrl":"https://doi.org/10.17776/csj.1267158","url":null,"abstract":"This work presents a collocation computational algorithm for solving linear Integro-Differential Equations (IDEs) of the Fredholm and Volterra types. The proposed method utilizes shifted Legendre polynomials and breaks down the problem into a series of linear algebraic equations. The matrix inversion technique is then employed to solve these equations. To validate the effectiveness of the suggested approach, the authors examined three numerical examples. The results obtained from the proposed method were compared with those reported in the existing literature. The findings demonstrate that the proposed algorithm is not only accurate but also efficient in solving linear IDEs. In order to present the results, the study employs tables and figures. These graphical representations aid in displaying the numerical outcomes obtained from the algorithm. All calculations were performed using Maple 18 software.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Immunization is one of the most successful practices for the maintenance of public health. With the emergence pandemic, distant health services, in other words the e-Health concept, has gained importance. It was aimed to develop the COVID-19 vaccine attitude scale and to determine the effect of e-Health literacy on the impact of people's COVID-19 vaccine literacy levels on their vaccine attitudes, in this study. The COVID-19 vaccine attitude scale was developed by the researchers. The scale development process of the research started with the literature review. This process continued with creating an item pool, receiving expert opinions, piloting, and finalizing the scale. As a result of the research, the Cα value of the COVID-19 vaccine attitude scale was found to be 0.745. The total variance explanatory power of the scale was determined as 56,972. Confirmatory factor analysis was determined as χ2/sd = 4.902. In this context, the construct validity of the scale was confirmed. As a result of the research, it was determined that 90,4% of the participants had been vaccinated. It was concluded that the e-Health literacy of the participants was at a medium level (37.38±7.90), while their COVID-19 vaccine literacy was at a low level (30.88±7.34). It was concluded that the participants' attitudes towards vaccination were positive. It has been determined that the increase in the e-Health and COVID-19 vaccine literacy levels of the participants caused a positive increase in their attitudes toward the vaccine.
{"title":"The Role of COVID-19 Vaccine Literacy in The Effect of e-Health Literacy on Vaccine Attitude","authors":"ASLAN, Rukiye\u0000 , ILIMAN YALTAGİL, Ebrar\u0000 , ARSLAN, Aysel\u0000 , ALİM, Ahmet\u0000 ","doi":"10.17776/csj.1310731","DOIUrl":"https://doi.org/10.17776/csj.1310731","url":null,"abstract":"Immunization is one of the most successful practices for the maintenance of public health. With the emergence pandemic, distant health services, in other words the e-Health concept, has gained importance. It was aimed to develop the COVID-19 vaccine attitude scale and to determine the effect of e-Health literacy on the impact of people's COVID-19 vaccine literacy levels on their vaccine attitudes, in this study. The COVID-19 vaccine attitude scale was developed by the researchers. The scale development process of the research started with the literature review. This process continued with creating an item pool, receiving expert opinions, piloting, and finalizing the scale. As a result of the research, the Cα value of the COVID-19 vaccine attitude scale was found to be 0.745. The total variance explanatory power of the scale was determined as 56,972. Confirmatory factor analysis was determined as χ2/sd = 4.902. In this context, the construct validity of the scale was confirmed. As a result of the research, it was determined that 90,4% of the participants had been vaccinated. It was concluded that the e-Health literacy of the participants was at a medium level (37.38±7.90), while their COVID-19 vaccine literacy was at a low level (30.88±7.34). It was concluded that the participants' attitudes towards vaccination were positive. It has been determined that the increase in the e-Health and COVID-19 vaccine literacy levels of the participants caused a positive increase in their attitudes toward the vaccine.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to determine caffeine (CAF) in human plasma. The plasma samples were extracted by protein precipitation using CAF-D3 as an internal standard (IS). The chromatographic separation was performed on GL Sciences InertSustain C18 Column (4.6 x 50 mm, 5 µm) maintained at 40 °C with a mobile phase consisting of formic acid, water, and methanol at a 1 mL/min of flow rate using two separate lines. CAF was detected and identified by mass spectrometry with electrospray ionization (ESI) in positive ions and multiple-reaction monitoring (MRM) mode. The MRM transitions of m/z 195.10 > 138.00 for CAF and 198.10 > 141.10 for IS were used for quantification. The standard curve was linear in the range of 10 - 10000 ng/mL for CAF. The within-batch precision and accuracy were evaluated by analyzing QC samples at five different concentration levels with six replicates in a batch. The between-batch precision and accuracy were determined by analyzing three different batches. The within-batch accuracy and precision was -8.76% - 9.61% and 0.95% - 7.22%, respectively. The between-batch accuracy and precision was -7.47% -1.42% and 1.83% - 8.66%, respectively. The results of the intra- and inter-day precision and accuracy studies were within the limits. The validated method applied to a pharmacokinetic study and the test product containing 60 mg CAF administered to total of 12 subjects. The mean ± SD of maximum plasma concentration (Cmax) was found to be 147.94 ± 139.39 ng/mL and the mean ± SD of area under the plasma concentration-time curve from zero to last measurable concentration (AUC0-tlast) was found to be 1119.59 ± 1468.30 h.ng/mL for the fasting conditions. The median time to reach peak plasma concentration (Tmax) was found to be 12.00 (6.50 - 12.00). The developed and validated method can be used for bioavailability and bioequivalence studies in human plasma samples.
{"title":"Determination of Caffeine in Human Plasma by Using Liquid Chromatography-Tandem Mass Spectrometry","authors":"YERLİKAYA, Fırat\u0000 , SAĞLAM, Onursal\u0000 ","doi":"10.17776/csj.1319590","DOIUrl":"https://doi.org/10.17776/csj.1319590","url":null,"abstract":"A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to determine caffeine (CAF) in human plasma. The plasma samples were extracted by protein precipitation using CAF-D3 as an internal standard (IS). The chromatographic separation was performed on GL Sciences InertSustain C18 Column (4.6 x 50 mm, 5 µm) maintained at 40 °C with a mobile phase consisting of formic acid, water, and methanol at a 1 mL/min of flow rate using two separate lines. CAF was detected and identified by mass spectrometry with electrospray ionization (ESI) in positive ions and multiple-reaction monitoring (MRM) mode. The MRM transitions of m/z 195.10 > 138.00 for CAF and 198.10 > 141.10 for IS were used for quantification. The standard curve was linear in the range of 10 - 10000 ng/mL for CAF. The within-batch precision and accuracy were evaluated by analyzing QC samples at five different concentration levels with six replicates in a batch. The between-batch precision and accuracy were determined by analyzing three different batches. The within-batch accuracy and precision was -8.76% - 9.61% and 0.95% - 7.22%, respectively. The between-batch accuracy and precision was -7.47% -1.42% and 1.83% - 8.66%, respectively. The results of the intra- and inter-day precision and accuracy studies were within the limits. The validated method applied to a pharmacokinetic study and the test product containing 60 mg CAF administered to total of 12 subjects. The mean ± SD of maximum plasma concentration (Cmax) was found to be 147.94 ± 139.39 ng/mL and the mean ± SD of area under the plasma concentration-time curve from zero to last measurable concentration (AUC0-tlast) was found to be 1119.59 ± 1468.30 h.ng/mL for the fasting conditions. The median time to reach peak plasma concentration (Tmax) was found to be 12.00 (6.50 - 12.00). The developed and validated method can be used for bioavailability and bioequivalence studies in human plasma samples.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Using a geometric morphometrics approach, we examined shape and size variations of skull and mandible bone of two evolutionarily distantly related mice from Turkey: Mus domesticus and Mus macedonicus. PCA analyses revealed overlap in dorsal cranium and mandible shapes of both species, consistent with previous traditional morphological methods. The skull of M. macedonicus seems to be larger in size than M. domesticus according to box-plot analyses of centroid size values, however there is no obvious difference for the mandible. No difference was observed between sexes in either of the characters. We suggest that future studies focus on dental characteristics and also consider the variation among local populations and ecological variables.
{"title":"Comparative Skull and Mandible Geometric Morphometrics of Two Species of Mice, Mus domesticus and Mus macedonicus (Muridae, Rodentia) in Turkey","authors":"DEMİRTAŞ, Sadık\u0000 , ÖZMEN, Medine\u0000 , SİLSÜPÜR, Metin\u0000 , KIRAL, Damla\u0000 ","doi":"10.17776/csj.1250269","DOIUrl":"https://doi.org/10.17776/csj.1250269","url":null,"abstract":"Using a geometric morphometrics approach, we examined shape and size variations of skull and mandible bone of two evolutionarily distantly related mice from Turkey: Mus domesticus and Mus macedonicus. PCA analyses revealed overlap in dorsal cranium and mandible shapes of both species, consistent with previous traditional morphological methods. The skull of M. macedonicus seems to be larger in size than M. domesticus according to box-plot analyses of centroid size values, however there is no obvious difference for the mandible. No difference was observed between sexes in either of the characters. We suggest that future studies focus on dental characteristics and also consider the variation among local populations and ecological variables.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Copper-64 radioisotope, whose academic research continues on diagnostic and therapeutic use, was examined in this study. 64Cu radioisotope is unique among other Cu isotopes for medical usage due to its low positron energy, appropriate half-life, and short tissue penetration. In cases where experimental data are missing, cross-section calculations can be used, and the existence of the cross-section data may provide various advantages in managing time, cost, and efficiency. In this context, investigated detailed cross-section calculations of the 64Cu isotope. To this end, cross-sections acquired from various calculation codes were compared with the literature, and alternative production routes were investigated. Using the nuclear reaction codes TALYS and EMPIRE, cross-section data of the 64Cu isotope were obtained from the 64Ni(p,n)64Cu, 65Cu(p,n+p)64Cu, 68Zn(p,n+α)64Cu, 65Cu(n,2n)64Cu, 64Ni(d,2n)64Cu, and 63Cu(d,p)64Cu reactions with the equilibrium and pre-equilibrium models. The results were compared with the available literature data from the EXFOR database.
{"title":"Cross-Section Calculations of Medical Radioisotope 64Cu via some Proton, Neutron and Deuteron Reactions","authors":"GÜLÜMSER, Tuğçe\u0000 , KAPLAN, Abdullah\u0000 ","doi":"10.17776/csj.1290957","DOIUrl":"https://doi.org/10.17776/csj.1290957","url":null,"abstract":"The Copper-64 radioisotope, whose academic research continues on diagnostic and therapeutic use, was examined in this study. 64Cu radioisotope is unique among other Cu isotopes for medical usage due to its low positron energy, appropriate half-life, and short tissue penetration. In cases where experimental data are missing, cross-section calculations can be used, and the existence of the cross-section data may provide various advantages in managing time, cost, and efficiency. In this context, investigated detailed cross-section calculations of the 64Cu isotope. To this end, cross-sections acquired from various calculation codes were compared with the literature, and alternative production routes were investigated. Using the nuclear reaction codes TALYS and EMPIRE, cross-section data of the 64Cu isotope were obtained from the 64Ni(p,n)64Cu, 65Cu(p,n+p)64Cu, 68Zn(p,n+α)64Cu, 65Cu(n,2n)64Cu, 64Ni(d,2n)64Cu, and 63Cu(d,p)64Cu reactions with the equilibrium and pre-equilibrium models. The results were compared with the available literature data from the EXFOR database.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A new complex with composition [Ni(L)(PPh3)] (PPh3 = triphenylphosphine) was obtained from the reaction of 1,5-bis(salicylidene)thiocarbohydrazone (L) with an equimolar amount of [NiCl2(PPh3)2]. The complex was identified by FT-IR, 1H NMR and UV-Vis spectroscopic methods and elemental analysis. The solid state structure of [Ni(L)(PPh3)] was established by X-ray diffraction analysis. It was determined that the complex, whose nickel center has a distorted square planar configuration, crystallizes in the monoclinic space group I2/c. Bisthiocarbohydrazone (L) binds to the nickel center through its phenolate O, azomethine N and thioenolate S atoms in a dianionic tridentate mode. The antioxidant capacity of L and Ni(II) complex was examined using the CUPRAC (cupric reducing antioxidant capacity) method. Also, the DPPH (1,1-Diphenyl-2-picrylhydrazyl) method was used to test free radical scavenging activity of the compounds. Antioxidant activity results showed that L exhibited better activity than Ni(II) complex.
{"title":"A New Nickel(II) Complex Derived From Bisthiocarbohydrazone: Synthesis, Characterization, Crystal Structure and Antioxidant Activity","authors":"KAYA, Yeliz\u0000 ","doi":"10.17776/csj.1248428","DOIUrl":"https://doi.org/10.17776/csj.1248428","url":null,"abstract":"A new complex with composition [Ni(L)(PPh3)] (PPh3 = triphenylphosphine) was obtained from the reaction of 1,5-bis(salicylidene)thiocarbohydrazone (L) with an equimolar amount of [NiCl2(PPh3)2]. The complex was identified by FT-IR, 1H NMR and UV-Vis spectroscopic methods and elemental analysis. The solid state structure of [Ni(L)(PPh3)] was established by X-ray diffraction analysis. It was determined that the complex, whose nickel center has a distorted square planar configuration, crystallizes in the monoclinic space group I2/c. Bisthiocarbohydrazone (L) binds to the nickel center through its phenolate O, azomethine N and thioenolate S atoms in a dianionic tridentate mode. The antioxidant capacity of L and Ni(II) complex was examined using the CUPRAC (cupric reducing antioxidant capacity) method. Also, the DPPH (1,1-Diphenyl-2-picrylhydrazyl) method was used to test free radical scavenging activity of the compounds. Antioxidant activity results showed that L exhibited better activity than Ni(II) complex.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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