Pub Date : 2024-06-26DOI: 10.2174/0113852728323258240613061150
Vadim D. Romanenko
: The direct chlorine-free incorporation of P1 units into organic molecules has very important synthetical value owing to environmental considerations and the prospect of accessing unique compounds with fascinating structures and useful properties. This selective survey presents a panorama of phosphorus species that are synthetic equivalents of free singlet phosphinidenes [R-P] and highlights the state-of-art of the [RP]- transfer reactions with emphasis on the synthesis of molecular architectures difficult to reach using traditional methods. Among stabilized phosphinidene precursors capable of RP-transfer are terminal transition-metal phosphinidene and phosphinidenoid complexes, dibenzo-7λ3 -phosphinobornadienes, phosphinidenephosphoranes, inversely polarized phosphaalkenes, phosphaketenes, intramolecularly base-stabilized phosphinidenes, (cyclo)polyphosphines and diphosphenes
:出于对环境的考虑，以及获得具有迷人结构和有用性质的独特化合物的前景，将 P1 单元直接无氯并入有机分子具有非常重要的合成价值。本研究选择性地介绍了作为游离单亚磷酸[R-P]合成等价物的磷物种的全景，并着重介绍了[RP]-转移反应的最新进展，重点是用传统方法难以合成的分子结构。能够进行 RP 转化的稳定亚膦烯前体包括末端过渡金属亚膦烯和亚膦烯类配合物、二苯并-7λ3 -亚膦硼烷、亚膦烯磷烷、反极化亚膦烯、亚膦烯、分子内碱稳定亚膦烯、（环）多膦和二磷酸盐。
{"title":"Organophosphorus Synthesis beyond P-Cl Bond: The Development of Shelf-stable Reagents for [RP] Transfer","authors":"Vadim D. Romanenko","doi":"10.2174/0113852728323258240613061150","DOIUrl":"https://doi.org/10.2174/0113852728323258240613061150","url":null,"abstract":": The direct chlorine-free incorporation of P1 units into organic molecules has very important synthetical value owing to environmental considerations and the prospect of accessing unique compounds with fascinating structures and useful properties. This selective survey presents a panorama of phosphorus species that are synthetic equivalents of free singlet phosphinidenes [R-P] and highlights the state-of-art of the [RP]- transfer reactions with emphasis on the synthesis of molecular architectures difficult to reach using traditional methods. Among stabilized phosphinidene precursors capable of RP-transfer are terminal transition-metal phosphinidene and phosphinidenoid complexes, dibenzo-7λ3 -phosphinobornadienes, phosphinidenephosphoranes, inversely polarized phosphaalkenes, phosphaketenes, intramolecularly base-stabilized phosphinidenes, (cyclo)polyphosphines and diphosphenes","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: The triazolopyrimidine scaffold indeed holds a prominent place in medicinal chemistry due to its versatile pharmacological properties. Researchers have explored the scaffold and its derivatives for various therapeutic applications. The unique structure of triazolopyrimidine has made it a valuable template for designing medicinally active molecules. The literature is full of studies showcasing the synthesis and biological activities of compounds containing the triazolopyrimidine ring, either fused or coupled with other heterocycles. The aim of this review is to provide a comprehensive and general summary of the recent advancements in the synthesis of triazolopyrimidine derivatives (Year 2021 to present).
{"title":"Advancements in the Synthesis of Triazolopyrimidines","authors":"Sushma Singh, Raman Lakhia, Sidhant Yadav, Poonam Devi, Karmvati Yadav, Vishwas Chaudhri, Rashmi Pundeer","doi":"10.2174/0113852728313437240607095009","DOIUrl":"https://doi.org/10.2174/0113852728313437240607095009","url":null,"abstract":": The triazolopyrimidine scaffold indeed holds a prominent place in medicinal chemistry due to its versatile pharmacological properties. Researchers have explored the scaffold and its derivatives for various therapeutic applications. The unique structure of triazolopyrimidine has made it a valuable template for designing medicinally active molecules. The literature is full of studies showcasing the synthesis and biological activities of compounds containing the triazolopyrimidine ring, either fused or coupled with other heterocycles. The aim of this review is to provide a comprehensive and general summary of the recent advancements in the synthesis of triazolopyrimidine derivatives (Year 2021 to present).","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Bioactive glass (BG) shows great potential as a biomaterial for bone regeneration. Chitosan enhances the biological characteristics of BG. Chitosan is the sole commonly utilized natural polysaccharide that may be chemically altered for various purposes and roles. Composite materials formed by combining chitosan bioactive glass (BG) nanoparticles and microparticles are used in this context. Integrating bioactive glasses enhances the mechanical characteristics, bioactivity, and regenerative capacity of the end product. Research indicates that chitosan/BG composites enhance angiogenesis, cell adhesion, and proliferation. Bioglass improves biomineralization and boosts bone extracellular matrix formation by osteoblasts. The current findings demonstrate that the chitosan-glass nanofiber composites can enhance both antibacterial capabilities and bone conductivity. This review examines novel techniques for creating chitosan-based materials for engineering purposes, as well as upcoming difficulties and outlooks.
{"title":"Chitosan/Bioglass Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: An Overview of Promising Biomaterials","authors":"Khashayar Khodaverdi, Seyed Morteza Naghib, M.R. Mozafari","doi":"10.2174/0113852728314706240529052535","DOIUrl":"https://doi.org/10.2174/0113852728314706240529052535","url":null,"abstract":": Bioactive glass (BG) shows great potential as a biomaterial for bone regeneration. Chitosan enhances the biological characteristics of BG. Chitosan is the sole commonly utilized natural polysaccharide that may be chemically altered for various purposes and roles. Composite materials formed by combining chitosan bioactive glass (BG) nanoparticles and microparticles are used in this context. Integrating bioactive glasses enhances the mechanical characteristics, bioactivity, and regenerative capacity of the end product. Research indicates that chitosan/BG composites enhance angiogenesis, cell adhesion, and proliferation. Bioglass improves biomineralization and boosts bone extracellular matrix formation by osteoblasts. The current findings demonstrate that the chitosan-glass nanofiber composites can enhance both antibacterial capabilities and bone conductivity. This review examines novel techniques for creating chitosan-based materials for engineering purposes, as well as upcoming difficulties and outlooks.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.2174/0113852728312464240529050217
Taha Jafari, Seyed Morteza Naghib, M.R. Mozafari
: The complicated internal mechanical and structural qualities of normal bone tissue still prevent the development of effective therapeutic procedures for major bone lesions. It is still difficult to use tissue engineering to return damaged bones back to how they were originally intended. Due to recent advances in 3D printing, together with the introduction of new materials and technological assistance, the basis for BTE has been established. Biological 3D biomaterials have cells inside them, which allows for the creation of structures that mimic real tissues. Microextrusion, inkjet, and laser-assisted bioprinting are the three primary methods used in 3D bioprinting manufacturing. Hydrogels packed with cells, growth hormones, and bioactive ceramics are among the bioinks utilized in bone bioprinting. With the use of magnetic resonance imaging or computed tomography scanning, 3D printing offers substantial benefits for tailored treatment by enabling the creation of scaffolds with the right structural qualities, form, and dimensions. Three-dimensional (3D) bioprinting is a cutting-edge technique that has been utilized recently to create multicellular, biomimetic tissues with layers upon layers of intricate tissue microenvironment printing. We approached the use of hydrogels with great strength in 3D printing for BTE with an emphasis on first providing a thorough study about the development of 3D printing, printing techniques, and ink selection in this review. A brief prediction on how 3D printing would advance in the future was made.
:正常骨组织内部复杂的机械和结构特性仍然阻碍着针对重大骨损伤的有效治疗程序的开发。要利用组织工程学将受损骨骼恢复到原来的样子，仍有困难。由于三维打印技术的最新进展，加上新材料的引入和技术的辅助，BTE 的基础已经建立。生物三维生物材料内部有细胞，因此可以创建模仿真实组织的结构。微挤压、喷墨和激光辅助生物打印是三维生物打印制造的三种主要方法。骨生物打印中使用的生物材料包括含有细胞、生长激素和生物活性陶瓷的水凝胶。利用磁共振成像或计算机断层扫描技术，三维打印技术可以制造出具有适当结构质量、形状和尺寸的支架，从而为定制治疗带来巨大优势。三维（3D）生物打印是一种尖端技术，最近已被用于创建多细胞生物仿生组织，层层打印出错综复杂的组织微环境。我们在这篇综述中探讨了水凝胶在三维打印 BTE 中的应用，重点是首先对三维打印的发展、打印技术和油墨选择进行深入研究。我们还简要预测了未来 3D 打印技术的发展方向。
{"title":"Bio-Printing of Materials for Bone Tissue Engineering","authors":"Taha Jafari, Seyed Morteza Naghib, M.R. Mozafari","doi":"10.2174/0113852728312464240529050217","DOIUrl":"https://doi.org/10.2174/0113852728312464240529050217","url":null,"abstract":": The complicated internal mechanical and structural qualities of normal bone tissue still prevent the development of effective therapeutic procedures for major bone lesions. It is still difficult to use tissue engineering to return damaged bones back to how they were originally intended. Due to recent advances in 3D printing, together with the introduction of new materials and technological assistance, the basis for BTE has been established. Biological 3D biomaterials have cells inside them, which allows for the creation of structures that mimic real tissues. Microextrusion, inkjet, and laser-assisted bioprinting are the three primary methods used in 3D bioprinting manufacturing. Hydrogels packed with cells, growth hormones, and bioactive ceramics are among the bioinks utilized in bone bioprinting. With the use of magnetic resonance imaging or computed tomography scanning, 3D printing offers substantial benefits for tailored treatment by enabling the creation of scaffolds with the right structural qualities, form, and dimensions. Three-dimensional (3D) bioprinting is a cutting-edge technique that has been utilized recently to create multicellular, biomimetic tissues with layers upon layers of intricate tissue microenvironment printing. We approached the use of hydrogels with great strength in 3D printing for BTE with an emphasis on first providing a thorough study about the development of 3D printing, printing techniques, and ink selection in this review. A brief prediction on how 3D printing would advance in the future was made.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141512792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.2174/0113852728310711240525123954
Alexandre Almeida-Júnior, Helivaldo Diógenes da Silva Souza, Abraão Pinheiro de Sousa, Maria Vitória Oliveira Dantas, Fabio Correia Sampaio, Jose Alixandre de Sousa Luis, Valnês da Silva Rodrigues-Junior, José Maria Barbosa-Filho, Gabriela Fehn Fiss, Petrônio Filgueiras de Athayde-Filho
: According to the PLOS Neglected Tropical Diseases Journal, infection caused by the Gram-negative bacterium Escherichia coli is a neglected tropical disease. Staphylococcus aureus is the most dangerous Grampositive bacterium among staphylococcal bacteria. Moreover, resistance to Mycobacterium tuberculosis is an urgent public health issue. In this sense, cinnamic acid and acetamide derivatives have been used as strategic nuclei in the design of antimicrobial agents. With the aim of investigating whether antibacterial activity is improved with the junction of cinnamic and acetamide nuclei, cinnamic amidoesters were planned and evaluated as potential antibacterial agents. In silico (ADMET test and molecular docking) and in vitro (antibacterial and antituberculosis evaluation, and toxicity on Artemia salina larvae) studies were performed. Twelve cinnamic amidoesters were synthesized, which present positive characteristics for possible drug candidates, and showed subtle activity against E. coli, however, against S. aureus, unsubstituted and para-substituted compounds (R3 = H, Me, Cl, Br) showed significant activity, with MIC = 156.25-625 μg.mL-1. Only one para-substituted compound (R3 = Bu) showed discrete activity against M. tuberculosis, with MIC = 200 μM. For the most active compounds against S. aureus, the molecular docking study demonstrated affinity with the TtRNA enzyme, which plays a central role in the assembly of amino acids into polypeptide chains. The most active compounds against S. aureus and M. tuberculosis were non-toxic on A. salina, with LC50 > 1000 μg.mL-1. According to in silico/vitro studies, the non-toxic compound 5h (R3 = Cl) stands out as a potential antibacterial agent for further studies.
{"title":"In silico/vitro Study of Antibacterial Effects of Non-toxic Cinnamic Amidoesters on Artemia salina","authors":"Alexandre Almeida-Júnior, Helivaldo Diógenes da Silva Souza, Abraão Pinheiro de Sousa, Maria Vitória Oliveira Dantas, Fabio Correia Sampaio, Jose Alixandre de Sousa Luis, Valnês da Silva Rodrigues-Junior, José Maria Barbosa-Filho, Gabriela Fehn Fiss, Petrônio Filgueiras de Athayde-Filho","doi":"10.2174/0113852728310711240525123954","DOIUrl":"https://doi.org/10.2174/0113852728310711240525123954","url":null,"abstract":": According to the PLOS Neglected Tropical Diseases Journal, infection caused by the Gram-negative bacterium Escherichia coli is a neglected tropical disease. Staphylococcus aureus is the most dangerous Grampositive bacterium among staphylococcal bacteria. Moreover, resistance to Mycobacterium tuberculosis is an urgent public health issue. In this sense, cinnamic acid and acetamide derivatives have been used as strategic nuclei in the design of antimicrobial agents. With the aim of investigating whether antibacterial activity is improved with the junction of cinnamic and acetamide nuclei, cinnamic amidoesters were planned and evaluated as potential antibacterial agents. In silico (ADMET test and molecular docking) and in vitro (antibacterial and antituberculosis evaluation, and toxicity on Artemia salina larvae) studies were performed. Twelve cinnamic amidoesters were synthesized, which present positive characteristics for possible drug candidates, and showed subtle activity against E. coli, however, against S. aureus, unsubstituted and para-substituted compounds (R3 = H, Me, Cl, Br) showed significant activity, with MIC = 156.25-625 μg.mL-1. Only one para-substituted compound (R3 = Bu) showed discrete activity against M. tuberculosis, with MIC = 200 μM. For the most active compounds against S. aureus, the molecular docking study demonstrated affinity with the TtRNA enzyme, which plays a central role in the assembly of amino acids into polypeptide chains. The most active compounds against S. aureus and M. tuberculosis were non-toxic on A. salina, with LC50 > 1000 μg.mL-1. According to in silico/vitro studies, the non-toxic compound 5h (R3 = Cl) stands out as a potential antibacterial agent for further studies.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141512791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.2174/0113852728283702240605113835
Mitali Dewan, Sachinath Bera, Shubhankar Samanta, Debasish Kundu, Rathin Jana
: Nowadays palladium-catalyzed C–H bond activation is a useful approach for the synthetic transformation of organic compounds due to step economy, the use of non-prefunctionalized substrates and reduced chemical wastes. Among the various synthetic strategies, palladium catalyzed intra and inter-molecular C–H bond activation has recently drawn a lot of interest to synthesize the decorated π-conjugated polycyclic aromatic hydrocarbon. In this review, we have focused on recent progress along with previous strategies to synthesize various polynuclear aromatic hydrocarbons (PAHs) by the use of Pd-catalyzed C–H bond activation. We have also discussed the mechanistic details of the reaction intra and inter-molecular C–H bond activation.
{"title":"Synthesis of Polynuclear Aromatic Hydrocarbons by Palladium-catalyzed C-H Bond Functionalization","authors":"Mitali Dewan, Sachinath Bera, Shubhankar Samanta, Debasish Kundu, Rathin Jana","doi":"10.2174/0113852728283702240605113835","DOIUrl":"https://doi.org/10.2174/0113852728283702240605113835","url":null,"abstract":": Nowadays palladium-catalyzed C–H bond activation is a useful approach for the synthetic transformation of organic compounds due to step economy, the use of non-prefunctionalized substrates and reduced chemical wastes. Among the various synthetic strategies, palladium catalyzed intra and inter-molecular C–H bond activation has recently drawn a lot of interest to synthesize the decorated π-conjugated polycyclic aromatic hydrocarbon. In this review, we have focused on recent progress along with previous strategies to synthesize various polynuclear aromatic hydrocarbons (PAHs) by the use of Pd-catalyzed C–H bond activation. We have also discussed the mechanistic details of the reaction intra and inter-molecular C–H bond activation.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141512793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.2174/0113852728301376240604052622
Monika Mishra, Viney Chawla, Pooja A. Chawla
: Nonsteroidal anti-inflammatory drugs account for a sizeable fraction of the drugs prescribed worldwide. If consumed for a long time, they can cause ulcers and life-threatening side effects. Since the acidic group present in NSAIDs is mainly responsible for these side effects, the scientists try to synthesize polymer drug conjugates that avoid these side effects but still retain the potency of the parent drug. Macromolecular drug conjugates of aceclofenac were prepared by employing pectin, β cyclodextrin, deacetylated chitin (chitosan) and albumin (egg and bovine serum). The prepared conjugates were characterized and tested for their antiinflammatory, antinociceptive and antiulcerogenic activity. Further experimentation was undertaken to analyze the behavior of compounds and their stability in hydrolytic conditions. Test compound A1, a pectin conjugate of aceclofenac, exhibited significant antinociceptive and anti-inflammatory activity with a significant decrease in ulcer index (4.45±0.24) as against aceclofenac (8.61±0.40) or vehicle (12.39±0.44) treated group. A novel and safer polymer drug conjugate of aceclofenac has been synthesized and evaluated.
{"title":"Synthesis and Biological Evaluation of Gastroprotective Polymer Conjugates of Aceclofenac","authors":"Monika Mishra, Viney Chawla, Pooja A. Chawla","doi":"10.2174/0113852728301376240604052622","DOIUrl":"https://doi.org/10.2174/0113852728301376240604052622","url":null,"abstract":": Nonsteroidal anti-inflammatory drugs account for a sizeable fraction of the drugs prescribed worldwide. If consumed for a long time, they can cause ulcers and life-threatening side effects. Since the acidic group present in NSAIDs is mainly responsible for these side effects, the scientists try to synthesize polymer drug conjugates that avoid these side effects but still retain the potency of the parent drug. Macromolecular drug conjugates of aceclofenac were prepared by employing pectin, β cyclodextrin, deacetylated chitin (chitosan) and albumin (egg and bovine serum). The prepared conjugates were characterized and tested for their antiinflammatory, antinociceptive and antiulcerogenic activity. Further experimentation was undertaken to analyze the behavior of compounds and their stability in hydrolytic conditions. Test compound A1, a pectin conjugate of aceclofenac, exhibited significant antinociceptive and anti-inflammatory activity with a significant decrease in ulcer index (4.45±0.24) as against aceclofenac (8.61±0.40) or vehicle (12.39±0.44) treated group. A novel and safer polymer drug conjugate of aceclofenac has been synthesized and evaluated.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Quinoline is a general group of heterocyclic compounds that have garnered much interest in medicinal chemistry and drug development due to their wide range of pharmacological effects. Pyridine ring fused with benzene defines the class of chemical compounds known as quinolines. Quinoline is a weak tertiary base, also known as 1-aza-naphthalene. Numerous patents have been filed for the synthesis of quinoline-based compounds, discussing about their derivatives and uses. Here, we have discussed the methods of quinoline synthesis, structural alterations, and patents showing its importance in various industries. Quinolines have been investigated as antimalarial substances, with substances, like quinine and chloroquine, serving as notable examples, and they have also been investigated to possess anti-inflammatory, anti-tumor, and CNS activity. The synthesis of quinoline is also subjected to several recognized procedures. The variations in the ring system and various synthetic approaches are the key highlights of the article, and it includes the various catalysts that could be recycled and reused by the assisted technique, which increases the yield and requires less time for the synthesis (ultrasound-promoted synthesis, one-pot reaction, and microwave and photocatalytic reactions). The development of synthetic procedures can help in the sustainable synthesis of quinoline derivatives.
{"title":"Recent Innovations in Synthetic Methodologies and Patent Landscape of Quinoline Analogues: A Comprehensive Review","authors":"Tanvi Rajiv Goel, Salahuddin, Kavita Rana, Avijit Mazumder, Rajnish Kumar, Mohamed Jawed Ahsan, Mohammad Sarafroz, Pankaj Tyagi, Saurabh Singh","doi":"10.2174/0113852728311152240529082035","DOIUrl":"https://doi.org/10.2174/0113852728311152240529082035","url":null,"abstract":"Quinoline is a general group of heterocyclic compounds that have garnered much interest in medicinal chemistry and drug development due to their wide range of pharmacological effects. Pyridine ring fused with benzene defines the class of chemical compounds known as quinolines. Quinoline is a weak tertiary base, also known as 1-aza-naphthalene. Numerous patents have been filed for the synthesis of quinoline-based compounds, discussing about their derivatives and uses. Here, we have discussed the methods of quinoline synthesis, structural alterations, and patents showing its importance in various industries. Quinolines have been investigated as antimalarial substances, with substances, like quinine and chloroquine, serving as notable examples, and they have also been investigated to possess anti-inflammatory, anti-tumor, and CNS activity. The synthesis of quinoline is also subjected to several recognized procedures. The variations in the ring system and various synthetic approaches are the key highlights of the article, and it includes the various catalysts that could be recycled and reused by the assisted technique, which increases the yield and requires less time for the synthesis (ultrasound-promoted synthesis, one-pot reaction, and microwave and photocatalytic reactions). The development of synthetic procedures can help in the sustainable synthesis of quinoline derivatives.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141738414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-14DOI: 10.2174/0113852728314452240524112438
Surabhi Gupta, Charles Gauthier
1-Thiosugars and their glycosides play crucial roles in carbohydrate chemistry, primarily due to their stability and potential for mimicking O-glycosides. The synthetic methodologies for thioglycosides pose ongoing challenges. In recent years, researchers have shown a growing interest in exploring the applications of thiosugars in various fields, including the development of natural product derivatives, oligo- and polysaccharide mimics, metallodrugs, and dendrimers. Numerous approaches and protocols have been devised for the synthesis of thiosugars. This review aims to comprehensively cover the efforts towards preparing thiosugars and their application as synthetic precursors.
1 硫代糖及其糖苷在碳水化合物化学中发挥着至关重要的作用，这主要是由于它们具有模仿 O 型糖苷的易用性和潜力。硫代糖苷的合成方法一直是个难题。近年来，研究人员对探索硫代糖苷在各个领域的应用表现出越来越浓厚的兴趣，包括开发天然产物衍生物、寡糖和多糖仿生、金属药物和树枝状聚合物。硫代糖合成的方法和方案层出不穷。本综述旨在全面介绍硫代糖的制备及其作为合成前体的应用。
{"title":"1-Thiosugars: From Synthesis to Applications","authors":"Surabhi Gupta, Charles Gauthier","doi":"10.2174/0113852728314452240524112438","DOIUrl":"https://doi.org/10.2174/0113852728314452240524112438","url":null,"abstract":"\u0000\u00001-Thiosugars and their glycosides play crucial roles in carbohydrate chemistry, primarily due to their\u0000stability and potential for mimicking O-glycosides. The synthetic methodologies for thioglycosides pose ongoing\u0000challenges. In recent years, researchers have shown a growing interest in exploring the applications of thiosugars\u0000in various fields, including the development of natural product derivatives, oligo- and polysaccharide\u0000mimics, metallodrugs, and dendrimers. Numerous approaches and protocols have been devised for the synthesis\u0000of thiosugars. This review aims to comprehensively cover the efforts towards preparing thiosugars and their\u0000application as synthetic precursors.\u0000","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141343208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-12DOI: 10.2174/0113852728313865240528073519
Ravi Varala, Vittal Seema, Mohammed Mujahid Alam, Mohammed Amanullah, Beda Durga Prasad
DABCO is one of the more effective basic organocatalysts/reagents that can be used for a range of organic transformations, including C-H functionalization, formation of hetero-hetero bonds, rearrangements, the synthesis of heterocyclic compounds, cyclizations and annulations, other miscellaneous reactions. This quinquennial review aims to critically and perceptively address noteworthy contributions of non chiral catalyst DABCO for regular organic transformations from 2019 onward. The key areas of attention were the advantages and limits of the approach, in addition to the mechanistic pathway, which is required for a specific organic transformation to be performed effectively.
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