Pub Date : 2024-07-22DOI: 10.2174/0113852728320798240711052115
Abdullah A. Alamri, Rita M. A. Borik, Ashraf H. F. Abd El-Wahab, Al-Anood M. Al-Dies, Hany M. Mohamed, Diaa A. Ibrahim
: A one-pot three/two-component reaction of 3-acetyl-coumarin (1), 4/3-anisaldehyde (2a,b) and malononitrile or 3-acetylcoumarin (1) and 2-(4/3-methoxybenzylidene)malononitrile (5a,b) in glacial acetic acid/ammonium acetate under reflux afforded 2-amino-4-(4/3-methoxyphenyl)-6-(2-oxo-2H-chromen-3- yl)nicotinonitrile (4a,b). Spectral data helped establish the structures of the compounds. Subsequently, an antiproliferative evaluation against a selected line of tumorous cells (HepG-2, MDA-MB-231 and A549) was performed in-vitro for the novel 2-amino-4-(4/3-methoxyphenyl)-6-(2-oxo-2H-chromen-3-yl)nicotinonitrile (4a,b). Compound 4a exhibited good efficiency against the MDA-MB-231 and A549 cell lines compared with the reference drug (Vinblastine). Furthermore, the chemical reactivity of both compounds was discussed using DFT. Lastly, a molecular docking analysis was addressed and conducted for these desired molecules.
{"title":"Heteroaromatization of Coumarin Part III: One-Pot Synthesis, Antitumor Activity, DFT Studies, and Molecular Docking of Coumarin Derivatives","authors":"Abdullah A. Alamri, Rita M. A. Borik, Ashraf H. F. Abd El-Wahab, Al-Anood M. Al-Dies, Hany M. Mohamed, Diaa A. Ibrahim","doi":"10.2174/0113852728320798240711052115","DOIUrl":"https://doi.org/10.2174/0113852728320798240711052115","url":null,"abstract":": A one-pot three/two-component reaction of 3-acetyl-coumarin (1), 4/3-anisaldehyde (2a,b) and malononitrile or 3-acetylcoumarin (1) and 2-(4/3-methoxybenzylidene)malononitrile (5a,b) in glacial acetic acid/ammonium acetate under reflux afforded 2-amino-4-(4/3-methoxyphenyl)-6-(2-oxo-2H-chromen-3- yl)nicotinonitrile (4a,b). Spectral data helped establish the structures of the compounds. Subsequently, an antiproliferative evaluation against a selected line of tumorous cells (HepG-2, MDA-MB-231 and A549) was performed in-vitro for the novel 2-amino-4-(4/3-methoxyphenyl)-6-(2-oxo-2H-chromen-3-yl)nicotinonitrile (4a,b). Compound 4a exhibited good efficiency against the MDA-MB-231 and A549 cell lines compared with the reference drug (Vinblastine). Furthermore, the chemical reactivity of both compounds was discussed using DFT. Lastly, a molecular docking analysis was addressed and conducted for these desired molecules.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141754129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The development of effective therapeutics to control the infections of drug-resistant bacterial strains is the thrust area in medicinal chemistry. The glycoconjugate containing O-antigenic oligosaccharide and a carrier protein linked through a linker can develop an antigen against gram-negative bacteria like Escherichia coli (E. coli), Shigella, Providencia, and Salmonella. Therefore, the chemical synthesis of glycoconjugate vaccine candidates against these bacterial strains is a growing demand of modern-day research. The synthesis of carbohydrate parts that are oligosaccharides is the most challenging. Significant developments in oligosaccharide synthesis have occurred over the past few decades. This review will focus on the chemical synthesis of different complex oligosaccharides related to different strains of E. coli. This review concludes with a summary of synthetic developments and prospects.
开发有效的疗法来控制耐药菌株的感染是药物化学的重点领域。含有 O 型抗原寡糖和通过连接体连接的载体蛋白的糖类共轭物可产生抗原来对抗革兰氏阴性菌,如大肠杆菌(E. coli)、志贺氏菌、普罗维登菌和沙门氏菌。因此,化学合成针对这些细菌菌株的糖结合候选疫苗是现代研究日益增长的需求。低聚糖碳水化合物部分的合成最具挑战性。在过去几十年中,寡糖合成技术取得了长足的发展。本综述将重点介绍与大肠杆菌不同菌株相关的不同复杂寡糖的化学合成。本综述最后总结了合成的发展和前景。
{"title":"Recent Insights into the Synthesis of Oligosaccharides from Escherichia coli: Review","authors":"Anjali Sharma, Padmashri Rabha, Rajib Panchadhayee","doi":"10.2174/0113852728322510240711045944","DOIUrl":"https://doi.org/10.2174/0113852728322510240711045944","url":null,"abstract":"The development of effective therapeutics to control the infections of drug-resistant bacterial strains is the thrust area in medicinal chemistry. The glycoconjugate containing O-antigenic oligosaccharide and a carrier protein linked through a linker can develop an antigen against gram-negative bacteria like Escherichia coli (E. coli), Shigella, Providencia, and Salmonella. Therefore, the chemical synthesis of glycoconjugate vaccine candidates against these bacterial strains is a growing demand of modern-day research. The synthesis of carbohydrate parts that are oligosaccharides is the most challenging. Significant developments in oligosaccharide synthesis have occurred over the past few decades. This review will focus on the chemical synthesis of different complex oligosaccharides related to different strains of E. coli. This review concludes with a summary of synthetic developments and prospects.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141754208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inulin is a naturally occurring polydisperse and flexible polysaccharide. It is a non-toxic, biocompatible, water-soluble, biodegradable, and affordable polymer. Furthermore, because of its unique properties, inulin has piqued the interest of many researchers. Studies have revealed that inulin demonstrates a broad range of biological activities such as antioxidant, antifungal, antibacterial, anticancer, antidiabetic, and immunological modulating properties in the pharmaceutical industry. Inulin has been demonstrated to function as a sweetener, fat replacer, water-holding agent, thickener, texture modifier, and browning agent in dairy and bakery food items. Inulin has produced EMF, a biofuel that is one of the most desirable gasoline substitutes. Today, inulin is widely used in the chemical, food, and pharmaceutical industries. Chemical modification of inulin is an important methodology for expanding its applications in a variety of fields. This article discusses the numerous synthesis methods used to modify the inulin structure, including conventional and non-conventional methods such as microwave and ultrasonication, as well as the diverse applications of inulin and its derivatives in several industries. This review article seeks to explore the current state of research on synthetic modifications of inulin and its wide array of applications.
{"title":"Synthetic Development in Inulin Modification and its Applications","authors":"Mahendra Singh, Himanshu Rani, Harish Kumar Chopra","doi":"10.2174/0113852728318805240627112106","DOIUrl":"https://doi.org/10.2174/0113852728318805240627112106","url":null,"abstract":"Inulin is a naturally occurring polydisperse and flexible polysaccharide. It is a non-toxic, biocompatible, water-soluble, biodegradable, and affordable polymer. Furthermore, because of its unique properties, inulin has piqued the interest of many researchers. Studies have revealed that inulin demonstrates a broad range of biological activities such as antioxidant, antifungal, antibacterial, anticancer, antidiabetic, and immunological modulating properties in the pharmaceutical industry. Inulin has been demonstrated to function as a sweetener, fat replacer, water-holding agent, thickener, texture modifier, and browning agent in dairy and bakery food items. Inulin has produced EMF, a biofuel that is one of the most desirable gasoline substitutes. Today, inulin is widely used in the chemical, food, and pharmaceutical industries. Chemical modification of inulin is an important methodology for expanding its applications in a variety of fields. This article discusses the numerous synthesis methods used to modify the inulin structure, including conventional and non-conventional methods such as microwave and ultrasonication, as well as the diverse applications of inulin and its derivatives in several industries. This review article seeks to explore the current state of research on synthetic modifications of inulin and its wide array of applications.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141612238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.2174/0113852728304957240628180342
Danish Khan, Beauty kumari, Abdullah Yahya Abdullah Alzahrani, Neha Dua, Shaily, Nirma Maurya
This study outlines the development of a novel approach utilizing microwave assistance for the alcohol dehydrogenative reaction. The process is catalyzed by manganese (II) and cobalt (II) in conjunction with chroman-4-one amino ligands. This research introduces a unique catalytic system capable of synthesizing various heterocyclic compounds, including pyrroles, pyridines, Betti bases, chromenes, and coumarins via alcohol dehydrogenation. The synthesis involved the preparation and characterization of a series of chroman-4-one amino ligands (C1-C6) using standard analytical techniques. These ligands, in combination with MnCl2‧4H2O and CoCl2, demonstrated remarkable catalytic activity, effectively driving alcohol dehydrogenation. The catalytic cycle was initiated by the in-situ formation of metal complexes with the ligands during the reaction. Characterization using ESI-MS confirmed the presence of metal complexes (Int-1) and other intermediates (Int-II and Int-III) throughout the catalytic cycle. Additionally, the controlled experiment corroborated the efficacy of the catalytic system, evidenced by the evolution of H2 gas.
{"title":"Microwave-assisted Synthesis of Pyrroles, Pyridines, Chromenes, Coumarins, and\u0000Betti Bases via Alcohol Dehydrogenation with Chroman-4-one Amino Ligands","authors":"Danish Khan, Beauty kumari, Abdullah Yahya Abdullah Alzahrani, Neha Dua, Shaily, Nirma Maurya","doi":"10.2174/0113852728304957240628180342","DOIUrl":"https://doi.org/10.2174/0113852728304957240628180342","url":null,"abstract":"\u0000\u0000This study outlines the development of a novel approach utilizing microwave assistance for the alcohol dehydrogenative reaction. The process is catalyzed by manganese (II) and cobalt (II) in conjunction with\u0000chroman-4-one amino ligands. This research introduces a unique catalytic system capable of synthesizing various heterocyclic compounds, including pyrroles, pyridines, Betti bases, chromenes, and coumarins via alcohol\u0000dehydrogenation. The synthesis involved the preparation and characterization of a series of chroman-4-one\u0000amino ligands (C1-C6) using standard analytical techniques. These ligands, in combination with MnCl2‧4H2O\u0000and CoCl2, demonstrated remarkable catalytic activity, effectively driving alcohol dehydrogenation. The catalytic cycle was initiated by the in-situ formation of metal complexes with the ligands during the reaction. Characterization using ESI-MS confirmed the presence of metal complexes (Int-1) and other intermediates (Int-II\u0000and Int-III) throughout the catalytic cycle. Additionally, the controlled experiment corroborated the efficacy of\u0000the catalytic system, evidenced by the evolution of H2 gas.\u0000","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}