Pub Date : 2024-04-09DOI: 10.2174/0113852728295939240315040152
Reema Abu Khalaf, Lama Jaradat, Maha Habash
: Cardiovascular disease is one of the primary causes of death. Atherosclerosis produces artery constriction or obstruction, which can lead to a heart attack or stroke. Cholesteryl Ester Transfer Protein (CETP) is a protein that aids in reverse cholesterol transport. It promotes cholesteryl ester transfer from HDL to LDL and VLDL. So, inhibition of CETP by drugs limits cardiovascular disease by decreasing LDL and increasing HDL cholesterol. In this study, ten ortho-fluoro substituted benzenesulfonamides 6a-6j were prepared, and their structure was fully determined using 1H NMR, 13C NMR, HR-MS, and IR. In vitro biological evaluation showed that compound 6d has the highest inhibitory activity with 100% inhibition, while compounds 6a-6c and 6e-6j had activities ranged from 29% - 83% at 10 μM concentration. Interestingly, para-substituted derivatives (6d, 6g, and 6j) were observed to have greater CETP inhibitory activities than their ortho- and meta- analogues irrespective to the nature of substituent, i.e., CH3, Cl, or NO2. Ligandfit docking experiment revealed the difference in the binding mode among the synthesized compounds, which is reflected in their CETP inhibitory activity. background: Cardiovascular disease is one of the primary causes of death. Atherosclerosis produces artery constriction or obstruction, which can lead to a heart attack or stroke. Cholesteryl ester transfer protein (CETP) is a protein that aids in reverse cholesterol transport. It promotes cholesteryl ester transfer from HDL to LDL and VLDL. So, inhibition of CETP by drugs limits cardiovascular disease by decreasing LDL and increasing HDL cholesterol. method: and their structure was fully determined using 1H-NMR, 13C-NMR, HR-MS, and IR. conclusion: Ligandfit docking experiment revealed the difference in the binding mode among the synthesized compounds which is reflected on their CETP inhibitory activity.
{"title":"Synthesis and In-Silico Studies of Ortho-Fluorinated Benzenesulfonamides as Putative Anti-CETP Agents","authors":"Reema Abu Khalaf, Lama Jaradat, Maha Habash","doi":"10.2174/0113852728295939240315040152","DOIUrl":"https://doi.org/10.2174/0113852728295939240315040152","url":null,"abstract":": Cardiovascular disease is one of the primary causes of death. Atherosclerosis produces artery constriction or obstruction, which can lead to a heart attack or stroke. Cholesteryl Ester Transfer Protein (CETP) is a protein that aids in reverse cholesterol transport. It promotes cholesteryl ester transfer from HDL to LDL and VLDL. So, inhibition of CETP by drugs limits cardiovascular disease by decreasing LDL and increasing HDL cholesterol. In this study, ten ortho-fluoro substituted benzenesulfonamides 6a-6j were prepared, and their structure was fully determined using 1H NMR, 13C NMR, HR-MS, and IR. In vitro biological evaluation showed that compound 6d has the highest inhibitory activity with 100% inhibition, while compounds 6a-6c and 6e-6j had activities ranged from 29% - 83% at 10 μM concentration. Interestingly, para-substituted derivatives (6d, 6g, and 6j) were observed to have greater CETP inhibitory activities than their ortho- and meta- analogues irrespective to the nature of substituent, i.e., CH3, Cl, or NO2. Ligandfit docking experiment revealed the difference in the binding mode among the synthesized compounds, which is reflected in their CETP inhibitory activity. background: Cardiovascular disease is one of the primary causes of death. Atherosclerosis produces artery constriction or obstruction, which can lead to a heart attack or stroke. Cholesteryl ester transfer protein (CETP) is a protein that aids in reverse cholesterol transport. It promotes cholesteryl ester transfer from HDL to LDL and VLDL. So, inhibition of CETP by drugs limits cardiovascular disease by decreasing LDL and increasing HDL cholesterol. method: and their structure was fully determined using 1H-NMR, 13C-NMR, HR-MS, and IR. conclusion: Ligandfit docking experiment revealed the difference in the binding mode among the synthesized compounds which is reflected on their CETP inhibitory activity.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"1 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.2174/0113852728296785240308054135
Tanzeela Qadir, Shoaib Shaikh, Saadat A. Kanth, Jyotika Singh, Maria Baby, Praveen Kumar Sharma
: Andrographolide, derived from the plant Andrographis paniculata (AP), exhibits a diverse range of biological activities, encompassing anti-bacterial, anti-tumor, anti-inflammatory, anti-obesity, anti-viral, antifibrotic, hypoglycemic, and immunomodulatory properties. Notably, numerous analogs of andrographolide have been synthesized, incorporating significant chemical structural modifications to enhance bioavailability and druggability. A comprehensive exploration into their molecular and cellular mechanisms of action has also been undertaken, enriching our understanding. The investigation highlights the potential of related terpenoid analogs from Andrographis paniculata, beyond the diterpene lactone andrographolide, to hold promise in disease treatment due to structural similarities and diverse pharmacological effects. This review offers insights into the anticipated synthesis and therapeutic applications of andrographolide derivatives across a spectrum of disorders.
{"title":"Exploring Synthesis and Medicinal Applications of Andrographolide Derivatives: A Review","authors":"Tanzeela Qadir, Shoaib Shaikh, Saadat A. Kanth, Jyotika Singh, Maria Baby, Praveen Kumar Sharma","doi":"10.2174/0113852728296785240308054135","DOIUrl":"https://doi.org/10.2174/0113852728296785240308054135","url":null,"abstract":": Andrographolide, derived from the plant Andrographis paniculata (AP), exhibits a diverse range of biological activities, encompassing anti-bacterial, anti-tumor, anti-inflammatory, anti-obesity, anti-viral, antifibrotic, hypoglycemic, and immunomodulatory properties. Notably, numerous analogs of andrographolide have been synthesized, incorporating significant chemical structural modifications to enhance bioavailability and druggability. A comprehensive exploration into their molecular and cellular mechanisms of action has also been undertaken, enriching our understanding. The investigation highlights the potential of related terpenoid analogs from Andrographis paniculata, beyond the diterpene lactone andrographolide, to hold promise in disease treatment due to structural similarities and diverse pharmacological effects. This review offers insights into the anticipated synthesis and therapeutic applications of andrographolide derivatives across a spectrum of disorders.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"111 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.2174/0113852728300082240308163721
Md. Mohinuddin, Kajol Ahmed, Izarul Islam, Anamul Hossain, Harendra N. Roy
:: An efficient direct oxidation method was developed to oxidize some aromatic and aliphatic aldehydes to esters by the dual utilization of NaIO4 and Pd-C. At ambient conditions, various aldehydes were employed in a clean esterification reaction to afford numerous esters in good to excellent yields. By this adopted method, some multifunctional aldehydes, high-energy-containing aromatic and unsaturated aldehydes, were advantageously oxidized to esters without noticeable difficulties. Moreover, no over-oxidation occurred to alcohols, and most byproducts were not formed during this oxidation process. Conventional and some modern methods lag behind owing to their easier operability and easy work-up process. This investigation has proven that the required oxidant (NaIO4) or catalyst (Pd-C) is useless to employ in excess, although some current methods utilize hugely expensive reagents for such conversions. Mundane reaction set-up, easy product recovery technique, non-toxic catalyst, and cheap and available starting materials are the noteworthy advantages of this method.
{"title":"Palladium-charcoal Catalyzed Direct Esterification of Aldehydes to Esters by NaIO4","authors":"Md. Mohinuddin, Kajol Ahmed, Izarul Islam, Anamul Hossain, Harendra N. Roy","doi":"10.2174/0113852728300082240308163721","DOIUrl":"https://doi.org/10.2174/0113852728300082240308163721","url":null,"abstract":":: An efficient direct oxidation method was developed to oxidize some aromatic and aliphatic aldehydes to esters by the dual utilization of NaIO4 and Pd-C. At ambient conditions, various aldehydes were employed in a clean esterification reaction to afford numerous esters in good to excellent yields. By this adopted method, some multifunctional aldehydes, high-energy-containing aromatic and unsaturated aldehydes, were advantageously oxidized to esters without noticeable difficulties. Moreover, no over-oxidation occurred to alcohols, and most byproducts were not formed during this oxidation process. Conventional and some modern methods lag behind owing to their easier operability and easy work-up process. This investigation has proven that the required oxidant (NaIO4) or catalyst (Pd-C) is useless to employ in excess, although some current methods utilize hugely expensive reagents for such conversions. Mundane reaction set-up, easy product recovery technique, non-toxic catalyst, and cheap and available starting materials are the noteworthy advantages of this method.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"2015 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-03DOI: 10.2174/0113852728301737240307111549
Elisa Leyva, Silvia E. Loredo-Carrillo
:: For several decades, aromatic azides have been applied in diverse areas of research like synthesis of organic compounds, novel materials and photoaffinity labeling of biomolecules. The discovery of click chemistry and bioorthogonal chemistry expanded their applications. Currently, they are extensively used in biology, biochemistry and medicine. For many years, aromatic azides were usually prepared using nucleophilic substitution. In this classical procedure, commercially available anilines are first converted into aryl diazonium salts which in turn are transformed into aromatic azides by nucleophilic substitution with sodium azide. However, this procedure is rather inconvenient experimentally since it requires the use of strong acids and low temperatures. In recent years, several alternative procedures have been developed. In the present review, we present the synthesis of aromatic azides by means of different experimental methodologies.
{"title":"Synthesis of Aromatic Azides using Different Methodologies","authors":"Elisa Leyva, Silvia E. Loredo-Carrillo","doi":"10.2174/0113852728301737240307111549","DOIUrl":"https://doi.org/10.2174/0113852728301737240307111549","url":null,"abstract":":: For several decades, aromatic azides have been applied in diverse areas of research like synthesis of organic compounds, novel materials and photoaffinity labeling of biomolecules. The discovery of click chemistry and bioorthogonal chemistry expanded their applications. Currently, they are extensively used in biology, biochemistry and medicine. For many years, aromatic azides were usually prepared using nucleophilic substitution. In this classical procedure, commercially available anilines are first converted into aryl diazonium salts which in turn are transformed into aromatic azides by nucleophilic substitution with sodium azide. However, this procedure is rather inconvenient experimentally since it requires the use of strong acids and low temperatures. In recent years, several alternative procedures have been developed. In the present review, we present the synthesis of aromatic azides by means of different experimental methodologies.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"8 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.2174/0113852728299173240302041524
Ashlesha P. Kawale, Nishant Shekhar, Arti Srivastava, Subhash Banerjee
:: This comprehensive review explores the advancements in catalytic transformation, focusing on the use of heterogeneous catalytic systems with a particular emphasis on polymeric-supported palladium (Pd) complexes. This study explores the limitations associated with conventional homogeneous reagents, emphasizes the transition to eco-friendly catalytic systems, and emphasizes the importance of Pd nanoparticles. These nanoparticles are particularly noteworthy for their distinctive properties, including elevated catalytic activity, making them promising for various applications in organic synthesis. The review thoroughly examines the design and synthesis of heterogeneous catalysts, emphasizing the crucial selection of safe and recyclable supports to augment the longevity and reusability of metallic catalysts. Diverse polymer varieties, including polystyrene (PS), polyethylene (PE), polyacrylate derivatives, polyethylene glycol (PEG), and grafted polymers, are investigated as viable supports for Pd complexes. The authors intricately describe the synthesis techniques for these polymer-supported Pd catalysts and furnish illustrative examples showcasing their effectiveness in organic transformation. This comprehensive review additionally highlights the synthesis of polymer-supported palladium (Pd) materials and discusses their applications in electrochemistry. The focus extends to the electrocatalytic properties of Pdbased polymeric nanomaterials, showcasing their effectiveness in glucose sensing, hydrogen peroxide detection, and the sensing of other biological analytes. Furthermore, the catalytic capabilities of Pd nanoparticles in various electrochemical applications, including wastewater treatment and electrochemical capacitors, are explored. Integrating polymer-supported Pd materials into these electrochemical processes underscores their versatility and potential contributions to advancements in catalysis and electrochemical sensing. Catalytic applications featuring polymer-supported palladium complexes with polymeric ligands in organic synthesis processes use the Sonogashira reaction, Suzuki-Miyaura coupling, Heck reaction, Catalytic asymmetric transformations, etc. The subsequent section of the paper focuses on the creation of polymeric palladium complexes, achieved by the complexation of polymeric ligands with palladium precursors. It delves into noteworthy examples of catalytic processes employing polymer-supported palladium complexes featuring polymeric ligands, emphasizing distinct polymers, such as PS, PE, polyacrylate derivatives, PEG, and grafting polymers. The review concludes by exploring catalytic asymmetric transformations using chiral palladium complexes immobilized on polymer supports and discusses various chiral ligands and their immobilization on polymer supports, emphasizing their application in asymmetric allylic alkylation. The review furnishes a comprehensive summary of recent advancements, challenges, and prospective avenues in
{"title":"A Review on the Development of Polymer Supported Heterogeneous Palladium Materials for Organic Synthesis and Electrochemical Applications","authors":"Ashlesha P. Kawale, Nishant Shekhar, Arti Srivastava, Subhash Banerjee","doi":"10.2174/0113852728299173240302041524","DOIUrl":"https://doi.org/10.2174/0113852728299173240302041524","url":null,"abstract":":: This comprehensive review explores the advancements in catalytic transformation, focusing on the use of heterogeneous catalytic systems with a particular emphasis on polymeric-supported palladium (Pd) complexes. This study explores the limitations associated with conventional homogeneous reagents, emphasizes the transition to eco-friendly catalytic systems, and emphasizes the importance of Pd nanoparticles. These nanoparticles are particularly noteworthy for their distinctive properties, including elevated catalytic activity, making them promising for various applications in organic synthesis. The review thoroughly examines the design and synthesis of heterogeneous catalysts, emphasizing the crucial selection of safe and recyclable supports to augment the longevity and reusability of metallic catalysts. Diverse polymer varieties, including polystyrene (PS), polyethylene (PE), polyacrylate derivatives, polyethylene glycol (PEG), and grafted polymers, are investigated as viable supports for Pd complexes. The authors intricately describe the synthesis techniques for these polymer-supported Pd catalysts and furnish illustrative examples showcasing their effectiveness in organic transformation. This comprehensive review additionally highlights the synthesis of polymer-supported palladium (Pd) materials and discusses their applications in electrochemistry. The focus extends to the electrocatalytic properties of Pdbased polymeric nanomaterials, showcasing their effectiveness in glucose sensing, hydrogen peroxide detection, and the sensing of other biological analytes. Furthermore, the catalytic capabilities of Pd nanoparticles in various electrochemical applications, including wastewater treatment and electrochemical capacitors, are explored. Integrating polymer-supported Pd materials into these electrochemical processes underscores their versatility and potential contributions to advancements in catalysis and electrochemical sensing. Catalytic applications featuring polymer-supported palladium complexes with polymeric ligands in organic synthesis processes use the Sonogashira reaction, Suzuki-Miyaura coupling, Heck reaction, Catalytic asymmetric transformations, etc. The subsequent section of the paper focuses on the creation of polymeric palladium complexes, achieved by the complexation of polymeric ligands with palladium precursors. It delves into noteworthy examples of catalytic processes employing polymer-supported palladium complexes featuring polymeric ligands, emphasizing distinct polymers, such as PS, PE, polyacrylate derivatives, PEG, and grafting polymers. The review concludes by exploring catalytic asymmetric transformations using chiral palladium complexes immobilized on polymer supports and discusses various chiral ligands and their immobilization on polymer supports, emphasizing their application in asymmetric allylic alkylation. The review furnishes a comprehensive summary of recent advancements, challenges, and prospective avenues in","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"12 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.2174/0113852728298472240305110906
Monik Gohil, Siva Prasad Das, Jeena Jyoti Boruah
:: In this work, we present the synthesis of a newer series of 15 chalcone-based pyrimidine compounds 4a-o. All the compounds were characterized by elemental analysis, melting point determination, mass, FTIR, and NMR analysis. We have evaluated the antimicrobial activity of these compounds. The compounds showed good inhibition activity towards different bacterial and fungal species such as S. aureus, S. pneumonia, E. coli, P. aeruginosa, Candida albicans, Aspergillus niger, and Alternaria alternata. Compounds 4c, 4h, 4k, and 4g showed comparable activities to those of commercially available drugs. Molecular docking study showed good interaction between each of the compounds and DNA gyrase enzyme. The docking score of the compounds ranges between -8.0 to -8.9 kcal/mol. Further, the ADMET analysis indicated the potential of the compounds as a drug candidate.
{"title":"Synthesis, Characterization, Antimicrobial Activity, and Molecular Docking Study of Newer Chalcone-based Triazolo Pyrimidine Compounds","authors":"Monik Gohil, Siva Prasad Das, Jeena Jyoti Boruah","doi":"10.2174/0113852728298472240305110906","DOIUrl":"https://doi.org/10.2174/0113852728298472240305110906","url":null,"abstract":":: In this work, we present the synthesis of a newer series of 15 chalcone-based pyrimidine compounds 4a-o. All the compounds were characterized by elemental analysis, melting point determination, mass, FTIR, and NMR analysis. We have evaluated the antimicrobial activity of these compounds. The compounds showed good inhibition activity towards different bacterial and fungal species such as S. aureus, S. pneumonia, E. coli, P. aeruginosa, Candida albicans, Aspergillus niger, and Alternaria alternata. Compounds 4c, 4h, 4k, and 4g showed comparable activities to those of commercially available drugs. Molecular docking study showed good interaction between each of the compounds and DNA gyrase enzyme. The docking score of the compounds ranges between -8.0 to -8.9 kcal/mol. Further, the ADMET analysis indicated the potential of the compounds as a drug candidate.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"19 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.2174/0113852728292501240301062823
Abhik Paul, Subhadip Roy
: Chirality is a widespread structural characteristic found in nature and plays a vital role in the structure and functioning of almost all biological systems. Nevertheless, the translation of chirality into synthetic systems is highly intricate yet captivating, as it not only applies fundamental understanding but also has the potential to tackle significant difficulties in biochemistry and medicine. Structurally, the process of coordination- driven self-assembly involves the organization of basic molecular components into well-defined porous homochiral metal-organic cages (MOCs). This allows for a systematic investigation of the enantioselective processes occurring within the nanocavities, which have limited space and specific chiral microenvironments. This article aims to provide a comprehensive summary of the recent advancements in supramolecular chirality generated in the fascinating class of porous MOCs. It will cover the synthesis and characterization of these materials, as well as the implications of their stereochemical information in terms of chiral recognition and enantio- separation. Subsequently, a subjective viewpoint will be presented regarding the potential, possibilities, and significant challenges in the future advancement of this domain, aiming to expand the progress in creating novel chiral functional materials in the realm of chemistry and beyond.
{"title":"Chirality Sensing in Coordination-driven Supramolecular Assemblies","authors":"Abhik Paul, Subhadip Roy","doi":"10.2174/0113852728292501240301062823","DOIUrl":"https://doi.org/10.2174/0113852728292501240301062823","url":null,"abstract":": Chirality is a widespread structural characteristic found in nature and plays a vital role in the structure and functioning of almost all biological systems. Nevertheless, the translation of chirality into synthetic systems is highly intricate yet captivating, as it not only applies fundamental understanding but also has the potential to tackle significant difficulties in biochemistry and medicine. Structurally, the process of coordination- driven self-assembly involves the organization of basic molecular components into well-defined porous homochiral metal-organic cages (MOCs). This allows for a systematic investigation of the enantioselective processes occurring within the nanocavities, which have limited space and specific chiral microenvironments. This article aims to provide a comprehensive summary of the recent advancements in supramolecular chirality generated in the fascinating class of porous MOCs. It will cover the synthesis and characterization of these materials, as well as the implications of their stereochemical information in terms of chiral recognition and enantio- separation. Subsequently, a subjective viewpoint will be presented regarding the potential, possibilities, and significant challenges in the future advancement of this domain, aiming to expand the progress in creating novel chiral functional materials in the realm of chemistry and beyond.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"6 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140323401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-25DOI: 10.2174/0113852728293437240227065230
Babak Mikaeeli Kangarshahi, Seyed Morteza Naghib
: Cartilage tissue presents challenges in terms of repair and regeneration due to its inherent limitations in self-healing and the scarcity of available donors. Cartilage damage can result in the development of joint problems characterized by symptoms, such as pain, swelling, and osteoarthritis. Collagen scaffolds are extensively used as biomimetic substances for cartilage engineering due to their ability to offer structural, biochemical, and mechanical signals for chondrocytes. Nevertheless, traditional techniques for producing collagen scaffolds frequently yield inadequate pore architecture, diminished mechanical robustness, and restricted form accuracy. Hence, 3D printing is a developing method that can surpass these restrictions by allowing accurate manipulation of the shape, porousness, and makeup of the scaffold. 3D printing has the capability to include various materials and cells in the scaffolds, resulting in the production of intricate and personalized tissue structures. This research examines the latest progress in utilizing 3D printing to create collagen scaffolds for the purpose of regenerating cartilage. This text discusses the different sources of collagen, methods of cross-linking, techniques for printing, and strategies for post-processing that are employed to improve the performance of scaffolds. Furthermore, it discusses the difficulties and potential future paths of utilizing 3D printing to create collagen scaffolds for the purpose of regenerating cartilage.
{"title":"Multicomponent 3D-printed Collagen-based Scaffolds for Cartilage Regeneration: Recent Progress, Developments, and Emerging Technologies","authors":"Babak Mikaeeli Kangarshahi, Seyed Morteza Naghib","doi":"10.2174/0113852728293437240227065230","DOIUrl":"https://doi.org/10.2174/0113852728293437240227065230","url":null,"abstract":": Cartilage tissue presents challenges in terms of repair and regeneration due to its inherent limitations in self-healing and the scarcity of available donors. Cartilage damage can result in the development of joint problems characterized by symptoms, such as pain, swelling, and osteoarthritis. Collagen scaffolds are extensively used as biomimetic substances for cartilage engineering due to their ability to offer structural, biochemical, and mechanical signals for chondrocytes. Nevertheless, traditional techniques for producing collagen scaffolds frequently yield inadequate pore architecture, diminished mechanical robustness, and restricted form accuracy. Hence, 3D printing is a developing method that can surpass these restrictions by allowing accurate manipulation of the shape, porousness, and makeup of the scaffold. 3D printing has the capability to include various materials and cells in the scaffolds, resulting in the production of intricate and personalized tissue structures. This research examines the latest progress in utilizing 3D printing to create collagen scaffolds for the purpose of regenerating cartilage. This text discusses the different sources of collagen, methods of cross-linking, techniques for printing, and strategies for post-processing that are employed to improve the performance of scaffolds. Furthermore, it discusses the difficulties and potential future paths of utilizing 3D printing to create collagen scaffolds for the purpose of regenerating cartilage.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"1 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140300813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-25DOI: 10.2174/0113852728274519240228105518
Mostafa Badreldin, Pedro Salas-Ambrosio, Marcela Ayala, Simon Harrisson, Colin Bonduelle
: The most economical and efficient route to prepare polypeptides from synthetic chemistry is through the Ring-Opening Polymerization (ROP) of amino acids using N-carboxyanhydride (NCA) monomers. Peptide polymers, in contrast to proteins, consist of repeated amino acid units and are comparatively simpler macromolecules. Despite their simplicity, these polypeptides offer a unique combination of beneficial traits found in both synthetic polymers (such as solubility, processability, and rubber elasticity) and natural proteins (including secondary structure, functionality, and biocompatibility). Nevertheless, NCA polymerization faces significant challenges, including intricate monomer purification and the necessity for processing toxic solvents. In this context, this review presents the fundamental principles of this polymer chemistry, the synthesis of NCA monomers, and the different methodologies to access polypeptides by ROP. It also explores the most recent advances in this field of research, with a focus on how new methods enable the use of more reactive initiators and the development of original processes, including the use of aqueous solvents.
{"title":"Synthesis of Polypeptides by Ring-opening Polymerization: A Concise Review","authors":"Mostafa Badreldin, Pedro Salas-Ambrosio, Marcela Ayala, Simon Harrisson, Colin Bonduelle","doi":"10.2174/0113852728274519240228105518","DOIUrl":"https://doi.org/10.2174/0113852728274519240228105518","url":null,"abstract":": The most economical and efficient route to prepare polypeptides from synthetic chemistry is through the Ring-Opening Polymerization (ROP) of amino acids using N-carboxyanhydride (NCA) monomers. Peptide polymers, in contrast to proteins, consist of repeated amino acid units and are comparatively simpler macromolecules. Despite their simplicity, these polypeptides offer a unique combination of beneficial traits found in both synthetic polymers (such as solubility, processability, and rubber elasticity) and natural proteins (including secondary structure, functionality, and biocompatibility). Nevertheless, NCA polymerization faces significant challenges, including intricate monomer purification and the necessity for processing toxic solvents. In this context, this review presents the fundamental principles of this polymer chemistry, the synthesis of NCA monomers, and the different methodologies to access polypeptides by ROP. It also explores the most recent advances in this field of research, with a focus on how new methods enable the use of more reactive initiators and the development of original processes, including the use of aqueous solvents.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"26 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140300928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-19DOI: 10.2174/0113852728295698240220081550
Hany M. Abd El-Lateef, Thomas Nady A. Eskander, Mohammad Saleh Hussein Alzubi, Mai M. Khalaf, Mahmoud Abd El Aleem Ali El-Remaily
: In this study, we successfully synthesized the CoPHrn complex as an efficient and recyclable catalyst for the one-pot, three-component reaction of aromatic aldehydes, 2,4-thiazolidenedione, and hydroxylamine hydrochloride, leading to the synthesis of tetrahydro-2-oxa-4-thia-diazapentalen-5-one derivatives under environmentally friendly conditions. The structures of the newly formed compounds were determined through elemental and spectral analyses. This methodology offers significant advantages, including its eco-friendliness, cost-effectiveness, operational simplicity, extensive reusability, and applicability, as well as the easy recovery of the catalyst using straightforward methods. Additionally, a series of tetrahydro-2-oxa-4-thia-diazapentalen-5- one derivatives were successfully synthesized. Notably, this novel procedure demonstrates remarkable benefits in terms of safety, simplicity, stability, mild reaction conditions, short reaction times, excellent yields, and high purity, all achieved without the use of hazardous solvents.
{"title":"Cobalt (III)–porphyrin Complex as an Efficient and Recyclable Homogeneous Catalyst for the Synthesis of Tetrahydro-2-oxa-4-thia-diazapentalen-5-one Derivatives in Aqueous Medium","authors":"Hany M. Abd El-Lateef, Thomas Nady A. Eskander, Mohammad Saleh Hussein Alzubi, Mai M. Khalaf, Mahmoud Abd El Aleem Ali El-Remaily","doi":"10.2174/0113852728295698240220081550","DOIUrl":"https://doi.org/10.2174/0113852728295698240220081550","url":null,"abstract":": In this study, we successfully synthesized the CoPHrn complex as an efficient and recyclable catalyst for the one-pot, three-component reaction of aromatic aldehydes, 2,4-thiazolidenedione, and hydroxylamine hydrochloride, leading to the synthesis of tetrahydro-2-oxa-4-thia-diazapentalen-5-one derivatives under environmentally friendly conditions. The structures of the newly formed compounds were determined through elemental and spectral analyses. This methodology offers significant advantages, including its eco-friendliness, cost-effectiveness, operational simplicity, extensive reusability, and applicability, as well as the easy recovery of the catalyst using straightforward methods. Additionally, a series of tetrahydro-2-oxa-4-thia-diazapentalen-5- one derivatives were successfully synthesized. Notably, this novel procedure demonstrates remarkable benefits in terms of safety, simplicity, stability, mild reaction conditions, short reaction times, excellent yields, and high purity, all achieved without the use of hazardous solvents.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"14 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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