Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.10.001
V. Krishnan, Santha Kumari Merugu, V. K. Reddy, H. Bollikolla
Under solvent-free conditions, a simple and efficient procedure has been developed for the Michael addition reaction of active methylene compounds to β-nitrostyrenes. The resulting Michael adducts are efficiently converted into functionalized pyrazole derivatives with hydrazine hydrate in excellent yields. All the compounds were well characterized by spectroscopic techniques.
{"title":"Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives","authors":"V. Krishnan, Santha Kumari Merugu, V. K. Reddy, H. Bollikolla","doi":"10.5267/j.ccl.2022.10.001","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.10.001","url":null,"abstract":"Under solvent-free conditions, a simple and efficient procedure has been developed for the Michael addition reaction of active methylene compounds to β-nitrostyrenes. The resulting Michael adducts are efficiently converted into functionalized pyrazole derivatives with hydrazine hydrate in excellent yields. All the compounds were well characterized by spectroscopic techniques.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83898128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.4.003
A. E. Rhilassi, Oumaima Oukkass, M. Bennani-Ziatni
The adsorption properties of hydroxyapatite of low crystallinity towards methionine have been examined. The chemical composition of hydroxyapatite was taken as an experimental variable in order to have a point of view on the parameters of the adsorption process and the mechanisms established between adsorbent-adsorbate. The adsorption kinetics are relatively fast, and the high amounts adsorbed at saturation are obtained for non-stoichiometric hydroxyapatite, containing more HPO42- ions and having a high specific surface area. The good agreement of the experimental data with kinetic models confirms that the mechanism can be perfectly described by pseudo-second-order kinetics. Adsorption isotherm models show that Langmuir's model gives a better fit of experimental data compared to that of Freundlich, Temkin and Dubinin-Kaganer-Radushkevich. Fourier transform infrared spectroscopy confirmed the interaction between the -COO- ions of methionine and the Ca2+ ions of hydroxyapatite. The thermodynamic parameters, the isoelectric point of methionine and the point of zero charge of hydroxyapatite with different Ca/P ratios show that the adsorption process is considered spontaneous, exothermic and often controlled by physisorption with interactions electrostatic.
{"title":"Isotherms, kinetics, and thermodynamics of methionine adsorption onto poorly crystalline hydroxyapatite with different Ca/P ratios","authors":"A. E. Rhilassi, Oumaima Oukkass, M. Bennani-Ziatni","doi":"10.5267/j.ccl.2023.4.003","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.4.003","url":null,"abstract":"The adsorption properties of hydroxyapatite of low crystallinity towards methionine have been examined. The chemical composition of hydroxyapatite was taken as an experimental variable in order to have a point of view on the parameters of the adsorption process and the mechanisms established between adsorbent-adsorbate. The adsorption kinetics are relatively fast, and the high amounts adsorbed at saturation are obtained for non-stoichiometric hydroxyapatite, containing more HPO42- ions and having a high specific surface area. The good agreement of the experimental data with kinetic models confirms that the mechanism can be perfectly described by pseudo-second-order kinetics. Adsorption isotherm models show that Langmuir's model gives a better fit of experimental data compared to that of Freundlich, Temkin and Dubinin-Kaganer-Radushkevich. Fourier transform infrared spectroscopy confirmed the interaction between the -COO- ions of methionine and the Ca2+ ions of hydroxyapatite. The thermodynamic parameters, the isoelectric point of methionine and the point of zero charge of hydroxyapatite with different Ca/P ratios show that the adsorption process is considered spontaneous, exothermic and often controlled by physisorption with interactions electrostatic.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84900273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.2.003
M. El-Gaby, Modather F. Hussein, Faraghally A. Faraghally, A. Drar, Mohamed A Gad
In our work we study the toxic effects of the prepared pyridine and pyradazine derivatives. Five compounds have been synthesized in pure state as reported procedures, and their toxicity as potential insecticidal agents against adult and nymphs of Aphis nerii were screened. The toxicity data in adults, exhibited that compound 6a is more toxic than other synthesized compounds, which LC50 was1.04 ppm while, in nymph compound 4a is more toxic than other synthesized compounds, which LC50 was 0.02 ppm. The other screened compounds showed weak to strong toxicological activity. The structure-activity relationships (SAR) for these compounds were also discussed.
{"title":"Insecticidal activity and structure activity relationship study of some synthesized hydrazone, dihydropyridine and 3-cyano-1, 4-dihydro-pyradazin-4-one derivatives against Aphis nerii","authors":"M. El-Gaby, Modather F. Hussein, Faraghally A. Faraghally, A. Drar, Mohamed A Gad","doi":"10.5267/j.ccl.2023.2.003","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.2.003","url":null,"abstract":"In our work we study the toxic effects of the prepared pyridine and pyradazine derivatives. Five compounds have been synthesized in pure state as reported procedures, and their toxicity as potential insecticidal agents against adult and nymphs of Aphis nerii were screened. The toxicity data in adults, exhibited that compound 6a is more toxic than other synthesized compounds, which LC50 was1.04 ppm while, in nymph compound 4a is more toxic than other synthesized compounds, which LC50 was 0.02 ppm. The other screened compounds showed weak to strong toxicological activity. The structure-activity relationships (SAR) for these compounds were also discussed.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82271828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.3.003
M. El-Gaby, M. Bakry, Modather F. Hussein, Faraghally A. Faraghally, A. Khalil, Mohamed A Gad, A. Drar
In this study, seven cyano-benzylidene and bisbenzylidene derivatives were designed and synthesized. All synthesized compounds were evaluated to determine their insecticidal activities as potential insecticides against nymphs and adults of Aphis nerii. These efforts led to the discovery of compounds 3a-d, 5, 7 and 10 with potent insecticidal activity (LC50 range from 0.0141 to 3.4351ppm). Compound 5 exhibited the highest insecticidal potency with 0.0141ppm. In addition, it indicated that compound 3b is less toxic than benzylidene and other precursors. Therefore, our results suggest that compound 5 has strong potential as a candidate component for developing a novel eco-friendly insecticide for control Aphids.
{"title":"Insecticidal efficacy and structure activity relationship study of some synthesized cyano-benzylidene and bisbenzylidene derivatives against Aphis nerii","authors":"M. El-Gaby, M. Bakry, Modather F. Hussein, Faraghally A. Faraghally, A. Khalil, Mohamed A Gad, A. Drar","doi":"10.5267/j.ccl.2023.3.003","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.3.003","url":null,"abstract":"In this study, seven cyano-benzylidene and bisbenzylidene derivatives were designed and synthesized. All synthesized compounds were evaluated to determine their insecticidal activities as potential insecticides against nymphs and adults of Aphis nerii. These efforts led to the discovery of compounds 3a-d, 5, 7 and 10 with potent insecticidal activity (LC50 range from 0.0141 to 3.4351ppm). Compound 5 exhibited the highest insecticidal potency with 0.0141ppm. In addition, it indicated that compound 3b is less toxic than benzylidene and other precursors. Therefore, our results suggest that compound 5 has strong potential as a candidate component for developing a novel eco-friendly insecticide for control Aphids.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79417091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.9.005
H. Prasad, A. Ananda, Amogh Mukarambi, Navyatha Prashanth Gaonkar, S. Sumathi, H. P. Spoorthy, P. Mallu
A series of piperazine-based phthalimide derivatives 5 (a-l) were synthesized and extensively characterized using a variety of spectrum methods, including LC-MS, 1H-NMR, 13C-NMR, and FT-IR. All the derivatives were examined for their physicochemical, pharmacokinetic, bio-activity score, and PASS analysis. The 5e piperazine-based phthalimide derivative demonstrated promising antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) in the in vitro antibacterial studies. In comparison to streptomycin and bacitracin (10 µg/mL), the minimum inhibitory concentration of 5e against MRSA was discovered to be 45±0.15 micro g/ml. The anti-MRSA activity was validated with membrane damage studies by using SEM, and in silico docking studies were against 3VMT and 6FTB proteins of MRSA. In the toxicity study, 5e derivatives were evaluated against L6 cell lines. The results of the studies show the synthesized 2-(2-(4-((4-chlorophenyl) sulfonyl) piperazin-1-yl) ethyl) isoindoline-1,3-dione (5e) can be used for the development of anti-MRSA drugs.
合成了一系列哌嗪类邻苯二酰亚胺衍生物5 (A -l)，并利用LC-MS、1H-NMR、13C-NMR和FT-IR等多种光谱方法对其进行了广泛的表征。对所有衍生物进行理化、药代动力学、生物活性评分和PASS分析。在体外抗菌研究中，以哌嗪为基础的邻苯二胺衍生物对耐甲氧西林金黄色葡萄球菌(MRSA)具有良好的抗菌活性。与链霉素和杆菌肽(10µg/mL)相比，5e对MRSA的最低抑制浓度为45±0.15µg/mL。通过扫描电镜对膜损伤研究验证了抗MRSA活性，并对MRSA的3VMT和6FTB蛋白进行了硅对接研究。在毒性研究中，5e衍生物对L6细胞株进行了毒性评价。研究结果表明，合成的2-(2-(4-(4-氯苯基)磺酰基)哌嗪-1-基)乙基)异吲哚-1,3-二酮(5e)可用于抗mrsa药物的开发。
{"title":"Design, synthesis, and anti-bacterial activities of piperazine based phthalimide derivatives against superbug-Methicillin-Resistant Staphylococcus aureus","authors":"H. Prasad, A. Ananda, Amogh Mukarambi, Navyatha Prashanth Gaonkar, S. Sumathi, H. P. Spoorthy, P. Mallu","doi":"10.5267/j.ccl.2022.9.005","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.9.005","url":null,"abstract":"A series of piperazine-based phthalimide derivatives 5 (a-l) were synthesized and extensively characterized using a variety of spectrum methods, including LC-MS, 1H-NMR, 13C-NMR, and FT-IR. All the derivatives were examined for their physicochemical, pharmacokinetic, bio-activity score, and PASS analysis. The 5e piperazine-based phthalimide derivative demonstrated promising antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) in the in vitro antibacterial studies. In comparison to streptomycin and bacitracin (10 µg/mL), the minimum inhibitory concentration of 5e against MRSA was discovered to be 45±0.15 micro g/ml. The anti-MRSA activity was validated with membrane damage studies by using SEM, and in silico docking studies were against 3VMT and 6FTB proteins of MRSA. In the toxicity study, 5e derivatives were evaluated against L6 cell lines. The results of the studies show the synthesized 2-(2-(4-((4-chlorophenyl) sulfonyl) piperazin-1-yl) ethyl) isoindoline-1,3-dione (5e) can be used for the development of anti-MRSA drugs.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74165863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.5.003
K. Kumar, S. Murugesan, T. Muneeswaran, C. M. Ramakritinan
Some new hydrazine complexes of trivalent lanthanide 3,3’-thiodipropanoates of empirical formulae [M(N2H5)(tdp)2] and [Pr(N2H5)(tdp)2·H2O], where M = La, Ce, Sm and Nd, H2tdp = 3,3’-thiodipropanoic acid, have been prepared and characterized by elemental analysis, mass, FTIR, Raman and electronic spectral, powder X-ray diffraction, scanning electron microscopy (SEM) and simultaneous TG–DTA techniques. The presence of bidentate carboxylate anion and coordinated N2H5 in these complexes are confirmed by IR spectra. TGA/DTA results confirmed that all the rare earth metal complexes give the corresponding metal carbonate (heating up to 1000 °C) through a metal oxalate intermediate. SEM images of Pr2O3 residue obtained from its complex show nano-sized clusters, thus the complex may be used as a precursor for nano-Pr2O3 preparation. The synthesized complexes show good antimicrobial activity against six bacteria (Bacillus cereus, Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, and Serratia species) and four fungi (Candida albicans, Aspergillus niger, Aspergillus fumigatus, and Penicillium variance) as assessed by in vitro biological activity.
{"title":"Synthesis, characterization, and biological activities of five new trivalent lanthanide complexes of hydrazine and 3,3’-thiodipropanoic acid","authors":"K. Kumar, S. Murugesan, T. Muneeswaran, C. M. Ramakritinan","doi":"10.5267/j.ccl.2023.5.003","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.5.003","url":null,"abstract":"Some new hydrazine complexes of trivalent lanthanide 3,3’-thiodipropanoates of empirical formulae [M(N2H5)(tdp)2] and [Pr(N2H5)(tdp)2·H2O], where M = La, Ce, Sm and Nd, H2tdp = 3,3’-thiodipropanoic acid, have been prepared and characterized by elemental analysis, mass, FTIR, Raman and electronic spectral, powder X-ray diffraction, scanning electron microscopy (SEM) and simultaneous TG–DTA techniques. The presence of bidentate carboxylate anion and coordinated N2H5 in these complexes are confirmed by IR spectra. TGA/DTA results confirmed that all the rare earth metal complexes give the corresponding metal carbonate (heating up to 1000 °C) through a metal oxalate intermediate. SEM images of Pr2O3 residue obtained from its complex show nano-sized clusters, thus the complex may be used as a precursor for nano-Pr2O3 preparation. The synthesized complexes show good antimicrobial activity against six bacteria (Bacillus cereus, Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, and Serratia species) and four fungi (Candida albicans, Aspergillus niger, Aspergillus fumigatus, and Penicillium variance) as assessed by in vitro biological activity.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74313227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.1.007
Akshay Thakor, V. Sharma, Suryajitsinji L. Rathod, P. Shrivastav, R. Shah
The construction of a λ-shaped three side substituted alkoxy based molecular system (E1-E8) with azo-ester group was carried out and studied for liquid crystalline applications. The mesogenic behaviour and thermal stability of synthesized derivatives were checked and analyzed by POM, DSC and TGA analysis. These azo-ester based compounds show smectic C and nematic type mesomorphic properties. The observed texture patterns of the synthesized compounds are fan, broken fan, schlieren and threaded types. All derivatives shows broad temperature range of mesophase and further stabilized upto the room temperature. The structure-property relationship has been further studied to understand the effect of variable side-chain on liquid crystalline properties.
{"title":"Synthesis and characterization of λ-shaped azo liquid crystals: The effect of terminal alkoxy group","authors":"Akshay Thakor, V. Sharma, Suryajitsinji L. Rathod, P. Shrivastav, R. Shah","doi":"10.5267/j.ccl.2023.1.007","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.1.007","url":null,"abstract":"The construction of a λ-shaped three side substituted alkoxy based molecular system (E1-E8) with azo-ester group was carried out and studied for liquid crystalline applications. The mesogenic behaviour and thermal stability of synthesized derivatives were checked and analyzed by POM, DSC and TGA analysis. These azo-ester based compounds show smectic C and nematic type mesomorphic properties. The observed texture patterns of the synthesized compounds are fan, broken fan, schlieren and threaded types. All derivatives shows broad temperature range of mesophase and further stabilized upto the room temperature. The structure-property relationship has been further studied to understand the effect of variable side-chain on liquid crystalline properties.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75797737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.4.001
I. Myrko, T. Chaban, Y. Horak, olodymyr Ogurtsov, I. Drapak, I. Chaban, V. Matiychuk
In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity.
本文报道了几种新型3- r -6-(5-芳基呋喃-2-基-[1,2,4]三唑[3,4-b][1,3,4]噻二唑的高效合成及其抗癌活性评价。我们已经证明，所提出的合成方案提供了设计具有相当化学新颖性的三唑噻唑多样性的可能性。通过1H NMR谱、质谱和元素分析等手段对目标物质的结构进行了确证。合成的化合物经美国国家癌症研究所发育治疗项目筛选，用于体外细胞系筛选。在所有被测物质中，有三种化合物表现出显著的细胞毒活性。
{"title":"Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles","authors":"I. Myrko, T. Chaban, Y. Horak, olodymyr Ogurtsov, I. Drapak, I. Chaban, V. Matiychuk","doi":"10.5267/j.ccl.2023.4.001","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.4.001","url":null,"abstract":"In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"276 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80054912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.12.003
D. Udhayakumari
Condensation product of o-aminophenol and pyrrole-2-carboxylaldehyde behaves as a fluorescent sensor for Fe3+ and Sn2+ ions in aqueous medium over the other metal ions like Na+, K+, Mg2+, Zn2+, Cd2+, Hg2+, Mn2+ and Cr3+. In aqueous solution, Fe3+ and Sn2+ ions coordinate to the receptor through a NON binding site which induces a strong fluorescence enhancement. Receptor can be applied as fluorescence enhanced probes for transition metal ions due to the inhibition of photo induced electron transfer (PET) mechanism.
{"title":"Pyrrole Based Schiff Base as a Highly Sensitive Fluorescent Sensor for Fe3+ and Sn2+ Ions","authors":"D. Udhayakumari","doi":"10.5267/j.ccl.2022.12.003","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.12.003","url":null,"abstract":"Condensation product of o-aminophenol and pyrrole-2-carboxylaldehyde behaves as a fluorescent sensor for Fe3+ and Sn2+ ions in aqueous medium over the other metal ions like Na+, K+, Mg2+, Zn2+, Cd2+, Hg2+, Mn2+ and Cr3+. In aqueous solution, Fe3+ and Sn2+ ions coordinate to the receptor through a NON binding site which induces a strong fluorescence enhancement. Receptor can be applied as fluorescence enhanced probes for transition metal ions due to the inhibition of photo induced electron transfer (PET) mechanism.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91033421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.5.002
Waseem Ahmad, Poonam Negi
The present study evaluates the photochemical behavior of a nitroimidazole derivative drug metronidazole in presence of N,N dimethylaniline and ZnO nanoparticles. The photochemical behavior was examined in a photochemical reactor by irradiating with a light of 254 and 310 nm. After completion of reaction one photoproduct was obtained. The photoproduct was isolated by using column chromatography and the structure of the isolated photoproduct was established by different spectroscopic techniques. This study provides the probable mechanism of the photochemical transformation of metronidazole in presence of an electron donor and in presence of ZnO NPs. During the photochemical transformation the nitro group of metronidazole was reduced in the amine group by a series of electron transfer processes. The ZnO nanoparticles are very efficient catalysts, and they degrade almost 90% metronidazole in the 60 min of UV irradiation. The photocatalytic mechanism of the ZnO nanoparticles is also discussed.
{"title":"N,N-Dimethylaniline and Zno nanoparticles mediated photochemical transformation of metronidazole","authors":"Waseem Ahmad, Poonam Negi","doi":"10.5267/j.ccl.2023.5.002","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.5.002","url":null,"abstract":"The present study evaluates the photochemical behavior of a nitroimidazole derivative drug metronidazole in presence of N,N dimethylaniline and ZnO nanoparticles. The photochemical behavior was examined in a photochemical reactor by irradiating with a light of 254 and 310 nm. After completion of reaction one photoproduct was obtained. The photoproduct was isolated by using column chromatography and the structure of the isolated photoproduct was established by different spectroscopic techniques. This study provides the probable mechanism of the photochemical transformation of metronidazole in presence of an electron donor and in presence of ZnO NPs. During the photochemical transformation the nitro group of metronidazole was reduced in the amine group by a series of electron transfer processes. The ZnO nanoparticles are very efficient catalysts, and they degrade almost 90% metronidazole in the 60 min of UV irradiation. The photocatalytic mechanism of the ZnO nanoparticles is also discussed.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135686287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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