Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.9.008
Shikha Sharma, Mukesh Gupta, Muskan Gupta, J. Sahu
Fused heterocyclic derivatives have become an important scaffold nowadays, which could be used as a template in drug development and medicinal chemistry. Benzimidazole moiety is an imperious aromatic heterocycle which is frequently present in naturally occurring products such as purines, vitamin B 12 and histidine as well as synthesized bioactive compounds, indomethacin and albendazole, for example. This study comprises widespread and comprehensive literature analysis on chemical reactivity and biological properties associated with Benzimidazole containing molecules. Benzimidazole ring structure possesses an extensive variety of pharmacological activities in several medications of therapeutic interest against a variety of diseases such as hypertension, malaria, cancer, microbial diseases, inflammatory disorders, etc. Furthermore, this fused heterocycle benzimidazole core might interact with various anions and cations in addition to biomolecules over different reactions in the human body, therefore exhibiting wide-ranging biological activities such as antineoplastic, antibacterial and antifungal, anti-inflammatory and analgesic, antihypertensive, antiviral and antidepressant. In this review, we are focusing on the chemistry and recent biological activities, designing approaches, and SAR (structure-activity relationship) data of different benzimidazole-based analogues during the past years.
{"title":"Significance of Benzimidazole analogues for the creation of novel molecules in drug discovery","authors":"Shikha Sharma, Mukesh Gupta, Muskan Gupta, J. Sahu","doi":"10.5267/j.ccl.2022.9.008","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.9.008","url":null,"abstract":"Fused heterocyclic derivatives have become an important scaffold nowadays, which could be used as a template in drug development and medicinal chemistry. Benzimidazole moiety is an imperious aromatic heterocycle which is frequently present in naturally occurring products such as purines, vitamin B 12 and histidine as well as synthesized bioactive compounds, indomethacin and albendazole, for example. This study comprises widespread and comprehensive literature analysis on chemical reactivity and biological properties associated with Benzimidazole containing molecules. Benzimidazole ring structure possesses an extensive variety of pharmacological activities in several medications of therapeutic interest against a variety of diseases such as hypertension, malaria, cancer, microbial diseases, inflammatory disorders, etc. Furthermore, this fused heterocycle benzimidazole core might interact with various anions and cations in addition to biomolecules over different reactions in the human body, therefore exhibiting wide-ranging biological activities such as antineoplastic, antibacterial and antifungal, anti-inflammatory and analgesic, antihypertensive, antiviral and antidepressant. In this review, we are focusing on the chemistry and recent biological activities, designing approaches, and SAR (structure-activity relationship) data of different benzimidazole-based analogues during the past years.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90291710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.9.004
G. Pandey, P. Sharma, Deepika Geedkar, Ashok Kumar
The present paper elicits the zinc oxide nanoparticles-assisted synthesis of a new series of seven-membered 1,4-diazepine heterocyclic compounds as potent lead scaffolds. Structures of synthesized compounds were corroborated using spectroanalytical techniques viz, FT-IR, 1H, 13C NMR, Mass, and elemental analysis. Also, Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), Energy dispersive x-ray analysis (EDAX), powder X-ray diffraction (PXRD), and Fourier transform infrared spectroscopy (FT-IR) were used to establish the structure and morphology of the synthesized nanocatalyst. The clean workup procedure, high to excellent yields, relatively short reaction times, and high atom economy are the incredible advantages associated with the protocol.
{"title":"One-pot strategy to synthesize seven–membered 1,4-diazepine heterocyclic scaffolds assisted by zinc oxide nanoparticles as heterogeneous catalytic support system","authors":"G. Pandey, P. Sharma, Deepika Geedkar, Ashok Kumar","doi":"10.5267/j.ccl.2022.9.004","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.9.004","url":null,"abstract":"The present paper elicits the zinc oxide nanoparticles-assisted synthesis of a new series of seven-membered 1,4-diazepine heterocyclic compounds as potent lead scaffolds. Structures of synthesized compounds were corroborated using spectroanalytical techniques viz, FT-IR, 1H, 13C NMR, Mass, and elemental analysis. Also, Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), Energy dispersive x-ray analysis (EDAX), powder X-ray diffraction (PXRD), and Fourier transform infrared spectroscopy (FT-IR) were used to establish the structure and morphology of the synthesized nanocatalyst. The clean workup procedure, high to excellent yields, relatively short reaction times, and high atom economy are the incredible advantages associated with the protocol.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"234 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85133136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.6.004
K. L. Jyothi, M. Hema, K. Kumara, N. K. Lokanath
Single crystal X-ray diffraction is the only experimental technique available to elucidate the complete three-dimensional structure of the samples at molecular and atomic levels. But this technique demands defect-free single crystals. Growing good quality single crystals which are suitable to collect X-ray intensity data is an art rather than science. Among the various crystal growth methods, the most effective and commonly used is the slow evaporation method. Using this method, defect-free single crystals of the ground mixture of gallic acid (GA) and butyramide (BU) taken in a 1:1 molar ratio are obtained. The compound was subjected to experimental characterizations like; PXRD, FTIR, SCXRD, and TGA. Further, these results were utilized in the computational characterizations namely, Hirshfeld surface analysis, interaction energy calculations, DFT studies, and docking studies. Structural characterization revealed that the GA-BU compound was crystallized as a cocrystal hydrate with 2:1:1 stoichiometry in a monoclinic crystal system and P21/n space group. Structural studies exposed the presence of various inter and intramolecular hydrogen bond interactions, ring synthons, DDAA environment of the water molecule, and π ... π stacking interactions. The contribution of the several close contacts to the crystal structure, the influence of different interaction energies in the packing, the HOMO-LUMO energy gap, and the location of reactive sites were realized through computational studies. Further, a molecular docking study has been performed to check the antiviral activity of the title compound against COVID-19.
{"title":"Gallic acid-butyramide monohydrate cocrystal: Crystal growth, Structural insights, Theoretical calculations and Molecular docking studies against COVID-19 main protease","authors":"K. L. Jyothi, M. Hema, K. Kumara, N. K. Lokanath","doi":"10.5267/j.ccl.2022.6.004","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.6.004","url":null,"abstract":"Single crystal X-ray diffraction is the only experimental technique available to elucidate the complete three-dimensional structure of the samples at molecular and atomic levels. But this technique demands defect-free single crystals. Growing good quality single crystals which are suitable to collect X-ray intensity data is an art rather than science. Among the various crystal growth methods, the most effective and commonly used is the slow evaporation method. Using this method, defect-free single crystals of the ground mixture of gallic acid (GA) and butyramide (BU) taken in a 1:1 molar ratio are obtained. The compound was subjected to experimental characterizations like; PXRD, FTIR, SCXRD, and TGA. Further, these results were utilized in the computational characterizations namely, Hirshfeld surface analysis, interaction energy calculations, DFT studies, and docking studies. Structural characterization revealed that the GA-BU compound was crystallized as a cocrystal hydrate with 2:1:1 stoichiometry in a monoclinic crystal system and P21/n space group. Structural studies exposed the presence of various inter and intramolecular hydrogen bond interactions, ring synthons, DDAA environment of the water molecule, and π ... π stacking interactions. The contribution of the several close contacts to the crystal structure, the influence of different interaction energies in the packing, the HOMO-LUMO energy gap, and the location of reactive sites were realized through computational studies. Further, a molecular docking study has been performed to check the antiviral activity of the title compound against COVID-19.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"18 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86564354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.3.006
A. Drar, S. A. Abdel-Raheem, A. Moustafa, Bahgat R. M. Hussein
This work includes the synthesis of ten heterocyclic compounds (3a-i and 4) containing pyrimidine moiety incorporated in their structures. Structure characterizations of these compounds were performed by using elemental and spectroscopic analyses. Their toxicity as potential insecticidal agents against the adults and nymphs of cowpea Aphid, Aphis craccivora Koch was evaluated. The results of this toxicological activity test revealed that a reasonable number of these compounds possess excellent toxicological activity against cowpea aphids such as compounds (3d), (3c), and (3b) with LC50 values 0.0125, 0.0134, and 0.0383 ppm, respectively. The toxicological activities of the rest of the tested compounds ranged from good to moderate against the same insects.
{"title":"Studying the toxicity and structure-activity relationships of some synthesized polyfunctionalized pyrimidine compounds as potential insecticide","authors":"A. Drar, S. A. Abdel-Raheem, A. Moustafa, Bahgat R. M. Hussein","doi":"10.5267/j.ccl.2023.3.006","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.3.006","url":null,"abstract":"This work includes the synthesis of ten heterocyclic compounds (3a-i and 4) containing pyrimidine moiety incorporated in their structures. Structure characterizations of these compounds were performed by using elemental and spectroscopic analyses. Their toxicity as potential insecticidal agents against the adults and nymphs of cowpea Aphid, Aphis craccivora Koch was evaluated. The results of this toxicological activity test revealed that a reasonable number of these compounds possess excellent toxicological activity against cowpea aphids such as compounds (3d), (3c), and (3b) with LC50 values 0.0125, 0.0134, and 0.0383 ppm, respectively. The toxicological activities of the rest of the tested compounds ranged from good to moderate against the same insects.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86154262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.5.005
S. A. Abdel-Raheem, A. Drar, Bahgat R. M. Hussein, A. Moustafa
This manuscript reports the preparation and toxicological efficacy testing of nine oxoimidazolidine and cyanoguanidine compounds (3a, 3b, 3c, 3d, 3e, 3f, 3g 4a, and 4b) against cowpea aphid, Aphis craccivora Koch. Bioefficacy data revealed that the tested compounds exhibited a range of toxicological activities against these insects, with compound 3b being the most toxic and compound 4a being the least effective. The LC50 value of compound 3b was 1.72 ppm for adults and 0.02 ppm against nymphs of the cowpea aphid, while the LC50 value of compound 4a was 72.51 ppm for adults and 18.02 ppm against nymphs. The manuscript also presents the structure-activity relationships of these compounds. These results provide valuable insights into the development of effective pest control agents for the management of such insects.
{"title":"Some oxoimidazolidine and cyanoguanidine compounds: Toxicological efficacy and structure-activity relationships studies","authors":"S. A. Abdel-Raheem, A. Drar, Bahgat R. M. Hussein, A. Moustafa","doi":"10.5267/j.ccl.2023.5.005","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.5.005","url":null,"abstract":"This manuscript reports the preparation and toxicological efficacy testing of nine oxoimidazolidine and cyanoguanidine compounds (3a, 3b, 3c, 3d, 3e, 3f, 3g 4a, and 4b) against cowpea aphid, Aphis craccivora Koch. Bioefficacy data revealed that the tested compounds exhibited a range of toxicological activities against these insects, with compound 3b being the most toxic and compound 4a being the least effective. The LC50 value of compound 3b was 1.72 ppm for adults and 0.02 ppm against nymphs of the cowpea aphid, while the LC50 value of compound 4a was 72.51 ppm for adults and 18.02 ppm against nymphs. The manuscript also presents the structure-activity relationships of these compounds. These results provide valuable insights into the development of effective pest control agents for the management of such insects.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80396171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.8.010
Ranjit C. Dabhi, Unnati Patel, Vaibhavi B. Rathod, Siddharth Shah, Jayesh J. Maru
Proficient routes were devised for coupling different aromatic/aliphatic acids with amines to form amide linkage using various catalysts. Under the optimized reaction conditions, highest conversion was possible without formation of any by-products. All synthesized compounds were purified using column chromatography and characterized by mass spectrometry, nuclear magnetic resonance spectrometry and liquid chromatography-mass spectrometric analysis.
{"title":"Process optimization for acid-amine coupling: a catalytic approach","authors":"Ranjit C. Dabhi, Unnati Patel, Vaibhavi B. Rathod, Siddharth Shah, Jayesh J. Maru","doi":"10.5267/j.ccl.2022.8.010","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.8.010","url":null,"abstract":"Proficient routes were devised for coupling different aromatic/aliphatic acids with amines to form amide linkage using various catalysts. Under the optimized reaction conditions, highest conversion was possible without formation of any by-products. All synthesized compounds were purified using column chromatography and characterized by mass spectrometry, nuclear magnetic resonance spectrometry and liquid chromatography-mass spectrometric analysis.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78280259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.4.005
H. Maruthesh, Manjunatha S. Katagi, B.P. Nandeshwarappa
A series of (E)-1-methyl-3-((substituted phenylimino)methyl)quinolin-2(1H)-one schiff bases (3a-j) bearing quinoline moiety synthesized successfully in ethanol by condensation of starting material 1-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde (1) with various substituted anilines (2a-j). The structure of the newly synthesized compounds was confirmed by proton (1H) and carbon (13C) nuclear magnetic resonance spectroscopy, Fourier transformation infrared (FT-IR), Mass spectroscopic study and elemental analysis. The in-vitro antimicrobial activity of the synthesized compounds was undertaken by agar well diffusion method against gram positive bacteria (Bacillus licheniformis and Bacillus cereus) gram negative bacteria (Escherichia coli and Acetobactor sp.) and antifungal activity against (Aspergillus Flavus and Pichnanomala). Further the compounds which shows good activity (3b, 3c, 3d, 3f, 3g and 3j) are screened for in-vitro antitubercular activity by Micro-plate alamar blue assay (MABA) method against mycobacterium tuberculosis H37Rv strain provided important information about activity against these strains. The structure activities of the synthesized compounds were also discussed. Compounds 3a, 3c, 3d, 3f and 3g show good argument with the different substituent attached to the phenyl ring.
以1-甲基-2-氧-1,2-二氢喹啉-3-甲醛(1)为原料，与不同取代苯胺(2a-j)在乙醇中缩合，成功合成了一系列(E)-1-甲基-3-(取代苯基)甲基喹啉-2(1H)- 1希夫碱(3a-j)喹啉基团。通过质子(1H)和碳(13C)核磁共振谱、傅里叶变换红外(FT-IR)、质谱研究和元素分析证实了新合成化合物的结构。采用琼脂孔扩散法对革兰氏阳性菌(地衣芽孢杆菌和蜡样芽孢杆菌)、革兰氏阴性菌(大肠杆菌和醋酸杆菌)和黄曲霉和黄曲霉进行了体外抑菌试验。利用微板alamar blue assay (MABA)法对结核分枝杆菌H37Rv菌株进行体外抗结核活性筛选，筛选出具有较好抗结核活性的化合物(3b、3c、3d、3f、3g和3j)，提供了抗结核活性的重要信息。并对合成的化合物的结构活性进行了讨论。化合物3a、3c、3d、3f和3g与不同取代基连接在苯基环上表现出良好的适应性。
{"title":"A convenient synthesis, characterization and biological evaluation of novel schiff base heterocycles as potential antimicrobial, antitubercular agents and their structural activity relationship","authors":"H. Maruthesh, Manjunatha S. Katagi, B.P. Nandeshwarappa","doi":"10.5267/j.ccl.2023.4.005","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.4.005","url":null,"abstract":"A series of (E)-1-methyl-3-((substituted phenylimino)methyl)quinolin-2(1H)-one schiff bases (3a-j) bearing quinoline moiety synthesized successfully in ethanol by condensation of starting material 1-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde (1) with various substituted anilines (2a-j). The structure of the newly synthesized compounds was confirmed by proton (1H) and carbon (13C) nuclear magnetic resonance spectroscopy, Fourier transformation infrared (FT-IR), Mass spectroscopic study and elemental analysis. The in-vitro antimicrobial activity of the synthesized compounds was undertaken by agar well diffusion method against gram positive bacteria (Bacillus licheniformis and Bacillus cereus) gram negative bacteria (Escherichia coli and Acetobactor sp.) and antifungal activity against (Aspergillus Flavus and Pichnanomala). Further the compounds which shows good activity (3b, 3c, 3d, 3f, 3g and 3j) are screened for in-vitro antitubercular activity by Micro-plate alamar blue assay (MABA) method against mycobacterium tuberculosis H37Rv strain provided important information about activity against these strains. The structure activities of the synthesized compounds were also discussed. Compounds 3a, 3c, 3d, 3f and 3g show good argument with the different substituent attached to the phenyl ring.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135686189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.12.007
S. Emama, S. Abouel‐Enein, Sanaa A. Othman, Eman M. El-Mahdey
The interaction of nicotinic acid and thiourea with the chloride salts of Ca(II), Mg(II), Co(II), Ni(II), Cu(II), and Fe(III) ions led to the synthesis of a unique series of metal chelates. All formed metal complexes were clarified using a variety of analytical and spectral techniques, besides magnetic moment and thermal tests. The electronic and magnetic measurements indicated that the paramagnetic chelates (3) and (4), as well as the diamagnetic complexes (1) and (2), were responsible for the tetrahedral geometrical structure. The outcomes also led to the production of square-planar, and high-spin octahedral structures for chelates (5) and (6). Thermodynamic studies using activation energy values revealed that complex (1) is more thermally stable than complex (2) and complex (3) is more stable than complex (4). Fe(III) complex exhibits higher antibacterial and antifungal activities than other metal complexes. Chelate (6) exhibits the highest rate of germination in wheat.
{"title":"Novel metal chelates with thiourea and nicotinic acid: Synthesis, structural characterization, and biological properties","authors":"S. Emama, S. Abouel‐Enein, Sanaa A. Othman, Eman M. El-Mahdey","doi":"10.5267/j.ccl.2022.12.007","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.12.007","url":null,"abstract":"The interaction of nicotinic acid and thiourea with the chloride salts of Ca(II), Mg(II), Co(II), Ni(II), Cu(II), and Fe(III) ions led to the synthesis of a unique series of metal chelates. All formed metal complexes were clarified using a variety of analytical and spectral techniques, besides magnetic moment and thermal tests. The electronic and magnetic measurements indicated that the paramagnetic chelates (3) and (4), as well as the diamagnetic complexes (1) and (2), were responsible for the tetrahedral geometrical structure. The outcomes also led to the production of square-planar, and high-spin octahedral structures for chelates (5) and (6). Thermodynamic studies using activation energy values revealed that complex (1) is more thermally stable than complex (2) and complex (3) is more stable than complex (4). Fe(III) complex exhibits higher antibacterial and antifungal activities than other metal complexes. Chelate (6) exhibits the highest rate of germination in wheat.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85851481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.3.007
Nguyen Huy Loi, P. M. Hung, D. Chinh, Pham Hong Phuong
We conducted an initial evaluation of the effectiveness of the application of the model of capacity building for early diagnosis and treatment with PCI in STEMI patients in Nghe An to contribute to solving the problems and to be able to replicate the model. STEMI patients received PCI from 7/2018 - 8/2020 at Nghe An General Hospital. Retrospective and prospective cross-sectional study, intervention with comparison before and after intervention included 280 patients, mean age 71.9 ± 14.59 (years); men accounted for 69.3%. After implementing the model, the number of patients increased by 135%, the time of the door - the ball decreased (71.3 ± 71.8 compared to 152.29 ± 167.3 minutes), the length of hospital stays, and the mortality rate decreased significantly.
{"title":"Effective assessment model for improving capacity of diagnosis and early treatment of st-advanced miscellaneous immediate patients: The case in Vietnam","authors":"Nguyen Huy Loi, P. M. Hung, D. Chinh, Pham Hong Phuong","doi":"10.5267/j.ccl.2023.3.007","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.3.007","url":null,"abstract":"We conducted an initial evaluation of the effectiveness of the application of the model of capacity building for early diagnosis and treatment with PCI in STEMI patients in Nghe An to contribute to solving the problems and to be able to replicate the model. STEMI patients received PCI from 7/2018 - 8/2020 at Nghe An General Hospital. Retrospective and prospective cross-sectional study, intervention with comparison before and after intervention included 280 patients, mean age 71.9 ± 14.59 (years); men accounted for 69.3%. After implementing the model, the number of patients increased by 135%, the time of the door - the ball decreased (71.3 ± 71.8 compared to 152.29 ± 167.3 minutes), the length of hospital stays, and the mortality rate decreased significantly.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90866148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.12.001
Mohamed R. Fouad, M. Badawy, A. F. El-Aswad, M. Aly
The dissipation and side-effect of metribuzin (MBZ) were studied with various factors; two soil types (clay loam and sandy loam), soil amendment (wheat straw and without amendment), two temperature levels (25 and 50°C), sterilization (sterilized and unsterilized soil) and time of incubation (15 and 30 days) and designed by Windows version of MINITAB software package to reduce the time and the cost as well as increased the precision. Determination of MBZ by HPLC with recoveries ranged from 50.85 to 108.09%. The MBZ residues were detected in all samples up to 60 days of storage, respectively with decline in their concentrations with the time of incubation. The clay loam soil showed higher dissipation than the sandy loam soil. The different factors in the present study confirmed that the wheat straw amendment, non-sterilization and incubation at 50°C caused higher dissipation of MBZ than without wheat straw, sterilization and incubation at 25°C. The dissipation was described mathematically by a first order equation with t0.5 was ranged from 9.62 to 16.82 days in clay loam soil and from 10.01 to 16.04 days in sandy loam soil. The side-effect of MBZ was tested on soil dehydrogenase activity that can be considered as an indicator of the biological activity and microbial degradation. The result proved that the enzyme activity was significantly decreased in all treatments compared with the controls at 1 and 3 days of incubation then it was gradually increased at 7, 10, 15 and 30 days of incubation. Treatments of wheat straw, non-sterilized and incubated at 25°C or 50°C showed the lowest enzyme inhibition among all treatments.
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