Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.6.001
Esraa Rasool Radhi, K. Ali, Fatima Hydar Abdul Hussein
The objective of the present work is to develop batch and merging-zone flow injection methods for sensitive and accurate spectrophotometric determination of tetracycline hydrochloride. The methods depend on the oxidation of the studied drug with potassium permanganate in an alkaline medium, and the absorbance of the green oxidation product was measured at 610 nm. The calibration graphs in both procedures were linear in the concentration ranges of 0.5 – 25 and 1 – 25 μg mL−1 using the spectrophotometric and merging-zone flow injection methods, respectively. Specific and molar absorption coefficients, limits of detection and quantification, and Sandell’s sensitivity were calculated. The suggested procedures were further applied to the quantitative determination of tetracycline in pharmaceutical formulations.
{"title":"Batch and merging-zone flow injection methods for determination of tetracycline hydrochloride","authors":"Esraa Rasool Radhi, K. Ali, Fatima Hydar Abdul Hussein","doi":"10.5267/j.ccl.2023.6.001","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.6.001","url":null,"abstract":"The objective of the present work is to develop batch and merging-zone flow injection methods for sensitive and accurate spectrophotometric determination of tetracycline hydrochloride. The methods depend on the oxidation of the studied drug with potassium permanganate in an alkaline medium, and the absorbance of the green oxidation product was measured at 610 nm. The calibration graphs in both procedures were linear in the concentration ranges of 0.5 – 25 and 1 – 25 μg mL−1 using the spectrophotometric and merging-zone flow injection methods, respectively. Specific and molar absorption coefficients, limits of detection and quantification, and Sandell’s sensitivity were calculated. The suggested procedures were further applied to the quantitative determination of tetracycline in pharmaceutical formulations.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75146286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.12.004
N. Virk, J. Iqbal, A. Aziz-ur-Rehman, M. Abbasi, S. Z. Siddiqui, S. Rasool, Mehr-un-Nisa Mehr-un-Nisa, M. Abid, H. Khalid, Fatiqa Zafar, Huraiza Javaid
The 1,3,4-Oxadiazole is an aromatic heterocyclic moiety recognized in drug research for its low lipophilicity. The multiple functionalities, heterocyclic azinane, sulfonamide, 1,3,4-oxadiazole and acetamide, are combined collectively to enhance the bioactivity potential of synthesized molecules. All the compounds were acquired by following microwave assisted and conventional techniques in a comparative way. The synthesized derivatives were screened for their antibacterial and enzyme inhibition potential. Furthermore, BSA binding analysis was executed to infer about the interaction with serum albumin. The spectral data of IR, EI-MS, 1H-NMR and 13C-NMR were used to elucidate the final structures of compounds. The synthesized compounds had a modest antibacterial potential. Compound 8f bearing 2-methyl-4,5-dinitrophenyl group was the most active one against all the bacterial strains taken into account and α-glucosidase enzyme. Compound 8d bearing 4-nitrophenyl group was the best acetyl cholinesterase inhibitor and 8i bearing phenylethyl group was the best urease inhibitor.
{"title":"In vitro biological assessment of 1,3,4-oxadiazole sandwiched by azinane and acetamides supported by molecular docking and BSA binding studies","authors":"N. Virk, J. Iqbal, A. Aziz-ur-Rehman, M. Abbasi, S. Z. Siddiqui, S. Rasool, Mehr-un-Nisa Mehr-un-Nisa, M. Abid, H. Khalid, Fatiqa Zafar, Huraiza Javaid","doi":"10.5267/j.ccl.2022.12.004","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.12.004","url":null,"abstract":"The 1,3,4-Oxadiazole is an aromatic heterocyclic moiety recognized in drug research for its low lipophilicity. The multiple functionalities, heterocyclic azinane, sulfonamide, 1,3,4-oxadiazole and acetamide, are combined collectively to enhance the bioactivity potential of synthesized molecules. All the compounds were acquired by following microwave assisted and conventional techniques in a comparative way. The synthesized derivatives were screened for their antibacterial and enzyme inhibition potential. Furthermore, BSA binding analysis was executed to infer about the interaction with serum albumin. The spectral data of IR, EI-MS, 1H-NMR and 13C-NMR were used to elucidate the final structures of compounds. The synthesized compounds had a modest antibacterial potential. Compound 8f bearing 2-methyl-4,5-dinitrophenyl group was the most active one against all the bacterial strains taken into account and α-glucosidase enzyme. Compound 8d bearing 4-nitrophenyl group was the best acetyl cholinesterase inhibitor and 8i bearing phenylethyl group was the best urease inhibitor.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"181 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72541166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.3.009
Bimal Boro, Sanjay Basumatary, B. Das
Metals play a crucial role in the metabolic pathways during the growth of vegetable plants. The presence of heavy metals or trace metals also takes a vital role in the nutrient quality of a vegetable. The vegetables are an inevitable part of the human diet and provide essential nutrients to maintain the normal functioning of human health and growth. The application of fertilizers and pesticides facilitates the accumulation of heavy metals by the vegetables grown in the fields. Consumption of heavy metals beyond the permissible limit along with vegetables may impact human health. Moreover, the production of nutritious food and its safety is an important aspect of the measure of any nation’s economy. Considering all these points, the present work was undertaken to analyze the heavy metal contents in the six mostly produced and consumed vegetables grown in Bodoland Territorial Region (BTR), a tribal-dominated region of the state Assam, India. The vegetables analyzed were fern leaves (Diplazium esculentum), jute leaves (Corchorus olitorius), green arum leaves (Colocasia esculenta), pointed gourd (Trichosanthes dioica), yard long bean (Vigna unguiculata ssp. Sesquipedalis) and spiny gourd (Momordica dioica). The metals analyzed were Cu, Fe, Ni, and Zn. The presence of heavy metals was detected in all the vegetable samples.
{"title":"Metal contents of some selected vegetables grown in Bodoland territorial region of Assam, India","authors":"Bimal Boro, Sanjay Basumatary, B. Das","doi":"10.5267/j.ccl.2023.3.009","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.3.009","url":null,"abstract":"Metals play a crucial role in the metabolic pathways during the growth of vegetable plants. The presence of heavy metals or trace metals also takes a vital role in the nutrient quality of a vegetable. The vegetables are an inevitable part of the human diet and provide essential nutrients to maintain the normal functioning of human health and growth. The application of fertilizers and pesticides facilitates the accumulation of heavy metals by the vegetables grown in the fields. Consumption of heavy metals beyond the permissible limit along with vegetables may impact human health. Moreover, the production of nutritious food and its safety is an important aspect of the measure of any nation’s economy. Considering all these points, the present work was undertaken to analyze the heavy metal contents in the six mostly produced and consumed vegetables grown in Bodoland Territorial Region (BTR), a tribal-dominated region of the state Assam, India. The vegetables analyzed were fern leaves (Diplazium esculentum), jute leaves (Corchorus olitorius), green arum leaves (Colocasia esculenta), pointed gourd (Trichosanthes dioica), yard long bean (Vigna unguiculata ssp. Sesquipedalis) and spiny gourd (Momordica dioica). The metals analyzed were Cu, Fe, Ni, and Zn. The presence of heavy metals was detected in all the vegetable samples.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85212012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.1.004
Pradeep Rameshrao Totawar, Dr. Ravi Varala, Vijay Kotra, J. Pulle
In the present work, synthesis of phthalimide and naphthalimide derived Biginelli compounds was performed. Allylation of phthalic & naphthalic anhydride, followed by ozonolysis resulted in the formation of N-phathalimido/naphpthalimido acetaldehyde (2 and 7). These aldehydes were subjected to Biginelli reaction using urea/thiourea and divergent β-keto esters in the presence of sulfated tin oxide (5 mol%) as catalyst in ethanol reflux to produce the corresponding dihydropyrimidinone compounds (5a-j and 8a-h). Additionally, both their antioxidant and anti-inflammatory functions were carried out. Compounds 5e, 5f, 5i, and 5j have shown potent to moderate potent activity for both antioxidant and anti-inflamamtory activities when compared to standard. Compounds 8c and 8g have shown potent antioxidant and anti-inflamamtory activities when compared to other compounds.
{"title":"Synthesis of phthalimide and naphthalimide derived Biginelli compounds and evaluation of their anti-inflammatory and anti-oxidant activities","authors":"Pradeep Rameshrao Totawar, Dr. Ravi Varala, Vijay Kotra, J. Pulle","doi":"10.5267/j.ccl.2023.1.004","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.1.004","url":null,"abstract":"In the present work, synthesis of phthalimide and naphthalimide derived Biginelli compounds was performed. Allylation of phthalic & naphthalic anhydride, followed by ozonolysis resulted in the formation of N-phathalimido/naphpthalimido acetaldehyde (2 and 7). These aldehydes were subjected to Biginelli reaction using urea/thiourea and divergent β-keto esters in the presence of sulfated tin oxide (5 mol%) as catalyst in ethanol reflux to produce the corresponding dihydropyrimidinone compounds (5a-j and 8a-h). Additionally, both their antioxidant and anti-inflammatory functions were carried out. Compounds 5e, 5f, 5i, and 5j have shown potent to moderate potent activity for both antioxidant and anti-inflamamtory activities when compared to standard. Compounds 8c and 8g have shown potent antioxidant and anti-inflamamtory activities when compared to other compounds.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82729796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.11.002
M. Bakry, A. Badawy, L. Mohamed
Pulvinaria tenuivalvata (Newstead) (Hemiptera: Coccidae) red soft scale insect is one of the most prevalent insect pests that attacks sugarcane plants. Insecticidal efficiency of six selected insecticides (Malatox, Sulfar, Admiral, Nomolt, Tafaban and Biover) was evaluated for their impact against nymphs and adult females of P. tenuivalvata on sugarcane leaves using leave dipping methods. This investigation was carried out for two successive seasons (July 2021-2022) at the laboratory of the Plant Protection Research Department at the El-Mattana Agricultural Research Station, Luxor Governorate, Egypt. Obtained results showed that the tested insecticides varied in efficacy on the different stages of pest (nymphs and adult females). Moreover, the nymphal stage of P.tenuivalvata was more susceptible to the tested pesticides compared to the adult stage. Admiral and nomolt were the most toxic against the nymphal and adult female stages of P. tenuivalvata on sugarcane leaves, sulfar, however, was the least successful in controlling this pest.
{"title":"Toxicity assessment of certain insecticides on the red soft scale insect, Pulvinaria tenuivalvata (Newstead) infesting sugarcane plants","authors":"M. Bakry, A. Badawy, L. Mohamed","doi":"10.5267/j.ccl.2022.11.002","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.11.002","url":null,"abstract":"Pulvinaria tenuivalvata (Newstead) (Hemiptera: Coccidae) red soft scale insect is one of the most prevalent insect pests that attacks sugarcane plants. Insecticidal efficiency of six selected insecticides (Malatox, Sulfar, Admiral, Nomolt, Tafaban and Biover) was evaluated for their impact against nymphs and adult females of P. tenuivalvata on sugarcane leaves using leave dipping methods. This investigation was carried out for two successive seasons (July 2021-2022) at the laboratory of the Plant Protection Research Department at the El-Mattana Agricultural Research Station, Luxor Governorate, Egypt. Obtained results showed that the tested insecticides varied in efficacy on the different stages of pest (nymphs and adult females). Moreover, the nymphal stage of P.tenuivalvata was more susceptible to the tested pesticides compared to the adult stage. Admiral and nomolt were the most toxic against the nymphal and adult female stages of P. tenuivalvata on sugarcane leaves, sulfar, however, was the least successful in controlling this pest.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89377118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.9.006
V. Vidya, V. Sadasivan
Metal complexes of [2-(2-hydroxynaphthalen-1-ylazo)-pyridin-3-ol] are derived from 2-amino-3-hydroxypyridine and β-naphthol was synthesized and characterized by thermal, spectral and analytical tools. The ligand was reacted with Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) in 1:2 stoichiometry. The IR spectra confirms the azo ligand coordination to metal ions via azo nitrogen and phenolic oxygen of pyridine after deprotonation. Both IR and 1HNMR spectra recorded involvement of deprotonated hydroxyl groups with proton displacement. The magnified fluorescence was shown by Mn(II) and Ni(II) complexes. None of the prepared ligands or complexes show any NLO activity with KDP as standard. The DNA cleavage and anticancerous activities done. The influence of zinc chelates on cure characteristics of rubber compounds was estimated based on rheometer measurements. The ligand and metal complexes are tested in vitro against some bacteria and fungi species. The antioxidant activities, DNA cleavage and anticancerous activities done. Ligand and its complexes catalysed cleavage of DNA.
{"title":"Synthesis, spectroscopic characterization and biological activities of some metal complexes with new heterocyclic azodye ligand 2-(2-hydroxynaphthalen-1-yl azo)-pyridin-3-ol","authors":"V. Vidya, V. Sadasivan","doi":"10.5267/j.ccl.2022.9.006","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.9.006","url":null,"abstract":"Metal complexes of [2-(2-hydroxynaphthalen-1-ylazo)-pyridin-3-ol] are derived from 2-amino-3-hydroxypyridine and β-naphthol was synthesized and characterized by thermal, spectral and analytical tools. The ligand was reacted with Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) in 1:2 stoichiometry. The IR spectra confirms the azo ligand coordination to metal ions via azo nitrogen and phenolic oxygen of pyridine after deprotonation. Both IR and 1HNMR spectra recorded involvement of deprotonated hydroxyl groups with proton displacement. The magnified fluorescence was shown by Mn(II) and Ni(II) complexes. None of the prepared ligands or complexes show any NLO activity with KDP as standard. The DNA cleavage and anticancerous activities done. The influence of zinc chelates on cure characteristics of rubber compounds was estimated based on rheometer measurements. The ligand and metal complexes are tested in vitro against some bacteria and fungi species. The antioxidant activities, DNA cleavage and anticancerous activities done. Ligand and its complexes catalysed cleavage of DNA.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85944237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.8.009
Ahmed M. K. Abouhalima, Liang Yingxia
The Nile River is an important natural and exclusive source of fresh water in Egypt. Water samples were taken monthly from twelve sites from 2015 to 2020 in El Beheira Governorate and eighteen physicochemical parameters were measured. The results show that the Rahawy drain recorded the highest values for most of the physicochemical parameters. The HPI and MI indicators in Rahawy drain were higher (70 % & 100 %) than in other sites, especially in the summer and winter seasons. The Rahawy WQI values were classified as poor quality. The IWQI results indicate that the water quality for the Rahawy was within the "severe restriction" class, with many restrictions to be used in agriculture. The water quality of the Nile River in the south of Egypt is better than that of the north and the water quality recovery takes more time and distance.
{"title":"Studies on Nile river pollution and water quality indicators in Egypt","authors":"Ahmed M. K. Abouhalima, Liang Yingxia","doi":"10.5267/j.ccl.2022.8.009","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.8.009","url":null,"abstract":"The Nile River is an important natural and exclusive source of fresh water in Egypt. Water samples were taken monthly from twelve sites from 2015 to 2020 in El Beheira Governorate and eighteen physicochemical parameters were measured. The results show that the Rahawy drain recorded the highest values for most of the physicochemical parameters. The HPI and MI indicators in Rahawy drain were higher (70 % & 100 %) than in other sites, especially in the summer and winter seasons. The Rahawy WQI values were classified as poor quality. The IWQI results indicate that the water quality for the Rahawy was within the \"severe restriction\" class, with many restrictions to be used in agriculture. The water quality of the Nile River in the south of Egypt is better than that of the north and the water quality recovery takes more time and distance.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80060008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.3.001
Mohamed R. Fouad, A. F. El-Aswad, M. Aly, Mohamed Alfateh Badawy
The behavior of bispyribac-sodium and metribuzin herbicides was investigated into alluvial soil. Effect of pH, temperature, and particle size of soil on the sorption process was studied. Sorption isotherms by bulk soil and its sand, silt, clay and humic acid (HA) fractions were quantified using the batch equilibration technique. The results showed that sorption of herbicides tested was significantly affected by temperature and was a spontaneous interfacial process into soil. Freundlich equation accurately predicted the sorption behavior of two herbicides. Thermodynamic parameters summarized that the negative values of the standard free energy changes (ΔG˚) were obtained therefore, the adsorption of tested pesticides in soil was spontaneous and small negative values indicate the sorption is physical in nature involving weak forces of attraction. The negative ΔH˚ value, indicating metribuzin and bispyribac-sodium interactions are exothermic processes and products are energetically stable with a high binding of compound to soil sites. There was an increase in the entropy of tested pesticides-soil systems as shown by positive values of ΔS˚. The highest adsorption in soil was at pH 5 for bispyribac-sodium and at pH 7 for metribuzin. The sorption of metribuzin and bispyribac-sodium were significantly greater on HA fraction followed by clay fraction than the bulk soil. The KF and Kd values increase with decreasing particle size particularly in the case of adsorption of metribuzin.
{"title":"Sorption characteristics and thermodynamic parameters of bispyribac-sodium and metribuzin on alluvial soil with difference in particle size and pH value","authors":"Mohamed R. Fouad, A. F. El-Aswad, M. Aly, Mohamed Alfateh Badawy","doi":"10.5267/j.ccl.2023.3.001","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.3.001","url":null,"abstract":"The behavior of bispyribac-sodium and metribuzin herbicides was investigated into alluvial soil. Effect of pH, temperature, and particle size of soil on the sorption process was studied. Sorption isotherms by bulk soil and its sand, silt, clay and humic acid (HA) fractions were quantified using the batch equilibration technique. The results showed that sorption of herbicides tested was significantly affected by temperature and was a spontaneous interfacial process into soil. Freundlich equation accurately predicted the sorption behavior of two herbicides. Thermodynamic parameters summarized that the negative values of the standard free energy changes (ΔG˚) were obtained therefore, the adsorption of tested pesticides in soil was spontaneous and small negative values indicate the sorption is physical in nature involving weak forces of attraction. The negative ΔH˚ value, indicating metribuzin and bispyribac-sodium interactions are exothermic processes and products are energetically stable with a high binding of compound to soil sites. There was an increase in the entropy of tested pesticides-soil systems as shown by positive values of ΔS˚. The highest adsorption in soil was at pH 5 for bispyribac-sodium and at pH 7 for metribuzin. The sorption of metribuzin and bispyribac-sodium were significantly greater on HA fraction followed by clay fraction than the bulk soil. The KF and Kd values increase with decreasing particle size particularly in the case of adsorption of metribuzin.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90432436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2023.2.001
C. Kumar, S. Manjunatha, B. Nandeshwarappa
The present includes the synthesis of pyrazoline derivatives using chalcones and phenyl hydrazine in the presence of ethanol. It also reveals that 2-pyrazoline complexes are physiologically active and may be used in a variety of therapeutic functions. FT-IR, 1H-NMR, 13C-NMR, LC-MS, and elemental analyses were used to characterise newly synthesised phenyl-pyrazoline derivatives. The antimicrobial activity of the synthesised compounds was assessed using the agar well diffusion assay and the Minimum Inhibition Concentration (MIC). Compounds 4b, 4f, and 4h have exhibited remarkable antibiotic action against bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Salmonella. Typhi, and Shigella sp. On the other hand, compound 4h had significant antifungal activity against Candida albicans and Aspergillus fusarium and was a highly promising agent when compared to standard nystatin.
{"title":"Synthesis of novel pyrazolic analogues of chalcones as potential antibacterial and antifungal agents","authors":"C. Kumar, S. Manjunatha, B. Nandeshwarappa","doi":"10.5267/j.ccl.2023.2.001","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.2.001","url":null,"abstract":"The present includes the synthesis of pyrazoline derivatives using chalcones and phenyl hydrazine in the presence of ethanol. It also reveals that 2-pyrazoline complexes are physiologically active and may be used in a variety of therapeutic functions. FT-IR, 1H-NMR, 13C-NMR, LC-MS, and elemental analyses were used to characterise newly synthesised phenyl-pyrazoline derivatives. The antimicrobial activity of the synthesised compounds was assessed using the agar well diffusion assay and the Minimum Inhibition Concentration (MIC). Compounds 4b, 4f, and 4h have exhibited remarkable antibiotic action against bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Salmonella. Typhi, and Shigella sp. On the other hand, compound 4h had significant antifungal activity against Candida albicans and Aspergillus fusarium and was a highly promising agent when compared to standard nystatin.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80199009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5267/j.ccl.2022.8.005
A. Goel, M. Rani
In the present work the synthesis of 4-phenyl-2, 6-di (thiazol-2-yl) pyridine copper chloride (abbreviated as Cu-DTPy) complex using copper (II) chloride and 2, 6-di (thiazol-2-yl) pyridine has been carried out. The complex has been specified by UV-Vis, FT-IR, CHNS and ESI-MS methods of analysis. The synthesized copper complex has been used as catalyst in the oxidation of p-aminophenol using hexacyanoferrate (III) ions as an oxidant in aqueous alkaline medium by kinetic-spectrophotometric method. This experimental work was carried out at optimum pH 11.0 and temperature 25ºC. The variation of effect of concentration of p-aminophenol (abbreviated as PAP), hexacyanoferrate (III) ions, and Cu-DTPy catalyst on reaction rate has been studied. Thermodynamic parameters such as free energy of activation, activation energy, enthalpy and frequency factor have been evaluated with the change in rate of the reaction at four disparate temperatures i.e. 25-40ᵒC. The oxidation products have been identified by FT-IR and ESI-MS spectroscopic analytical techniques. The major product of this reaction is NN’-bis-(p-hydroxyphenyl)-2-hydroxy-5-amino-1,4-benzoquinone di-imine. Thus, this method is highly efficient and environmentally safe to remove PAP from polluted water resources.
{"title":"Synthesis and catalytic activity of Cu (II) complex with 4-phenyl 2, 6-di (thiazol-2-yl) pyridine in the oxidation of para-aminophenol","authors":"A. Goel, M. Rani","doi":"10.5267/j.ccl.2022.8.005","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.8.005","url":null,"abstract":"In the present work the synthesis of 4-phenyl-2, 6-di (thiazol-2-yl) pyridine copper chloride (abbreviated as Cu-DTPy) complex using copper (II) chloride and 2, 6-di (thiazol-2-yl) pyridine has been carried out. The complex has been specified by UV-Vis, FT-IR, CHNS and ESI-MS methods of analysis. The synthesized copper complex has been used as catalyst in the oxidation of p-aminophenol using hexacyanoferrate (III) ions as an oxidant in aqueous alkaline medium by kinetic-spectrophotometric method. This experimental work was carried out at optimum pH 11.0 and temperature 25ºC. The variation of effect of concentration of p-aminophenol (abbreviated as PAP), hexacyanoferrate (III) ions, and Cu-DTPy catalyst on reaction rate has been studied. Thermodynamic parameters such as free energy of activation, activation energy, enthalpy and frequency factor have been evaluated with the change in rate of the reaction at four disparate temperatures i.e. 25-40ᵒC. The oxidation products have been identified by FT-IR and ESI-MS spectroscopic analytical techniques. The major product of this reaction is NN’-bis-(p-hydroxyphenyl)-2-hydroxy-5-amino-1,4-benzoquinone di-imine. Thus, this method is highly efficient and environmentally safe to remove PAP from polluted water resources.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83875617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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