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Exogenous Enzymes in Cheese Making: An Overview 奶酪制作中的外源酶:综述
IF 0.9 Q4 NUTRITION & DIETETICS Pub Date : 2022-02-18 DOI: 10.2174/1573401318666220218111515
E. Caputo, C. Meinardi, L. Mandrich
The flavour in mature cheese results from a complex series of biochemical events that occur in the curd during ripening. More than 500 varieties of cheese are produced in the world, and each of them possesses its typical sensory characteristics. Flavour depends on milk variety, starter bacteria used in cheese-making and ripening. Amino acids and free fatty acids (FFA) act mainly as precursors of a series of catabolic reactions, still not well understood. These reactions lead to the production of aroma compounds such as esters, fatty acids, aldehydes, alcohols, ketones, hydrocarbons, lactones, and sulphur. Enzymes involved in all these processes are derived from milk, Lactic Acid Bacteria (LAB), Non-Starter Lactic Acid Bacteria (NSLAB), rennet, or fungi. In cheese industrial production, the milk pasteurization process leads to the removal of endogenous bacteria, therefore it is necessary to add exogenous enzymes to enrich and standardize cheeses flavour. Here, we reviewed some exogenous enzymes used in industrial cheeses production, or which have interesting potential in cheese making and ripening.
成熟奶酪的风味源于成熟过程中凝乳中发生的一系列复杂的生化事件。世界上生产的奶酪有500多种,每一种都有其典型的感官特征。口味取决于牛奶的种类、奶酪制作和成熟过程中使用的发酵菌。氨基酸和游离脂肪酸(FFA)主要作为一系列分解代谢反应的前体,目前尚不清楚。这些反应会产生芳香化合物,如酯类、脂肪酸、醛类、醇类、酮类、烃类、内酯和硫。参与所有这些过程的酶来源于牛奶、乳酸菌(LAB)、非起始乳酸菌(NSLAB),凝乳酶或真菌。在干酪工业生产中,牛奶巴氏杀菌过程会去除内源性细菌,因此有必要添加外源酶来丰富和规范干酪的风味。在这里,我们综述了一些用于工业奶酪生产的外源酶,或在奶酪制作和成熟方面具有有趣潜力的外源酶。
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引用次数: 2
A Review on the Nutraceutical Anti-Metastatic Importance of Annona Muricata Crude Extract (AMCE) and its Coping Mechanism Against Breast Cancer 番荔枝粗提物(AMCE)抗乳腺癌转移作用及其机制研究进展
IF 0.9 Q4 NUTRITION & DIETETICS Pub Date : 2022-02-18 DOI: 10.2174/1573401318666220218110419
Ms. Dimple Dalal, Srujana Medithi
Annona Muricata is used as a folkloric herbal medicine as it has anticancer, antiproliferative and anti-tumorigenic properties. The extracts from various parts of the plant are considered therapeutic due to Annonaceous Acetogenin compounds which are an absolute boon to the versatility of the plant, paving the mechanistic pathways for its therapeutic potential.Google Scholar and PubMed databases were reviewed with the main focus on availing information on Annona muricata and its anticancer effect on breast cancer.- An array of clinical investigations on the dosage of extracts on cell lines, animal models, and human trials provide confirmatory insights of A. muricata as a preventive and therapeutic measure for cancer. The extract when administered at different dosages shows a high cytotoxic effect on the cancer cells, mostly accounting for an IC50 of less than 1000µg/mL which is of significance.Although high efficacy has been conclusive, assurance of the safety prior to commercialization is of significance. Investigations are required to define the origin and magnitude of side effects along with long-term safety for the enhancement of efficacy and optimum utilization of potential chemo-preventive properties of the plant for the curation of a nutraceutical intervention for cancer that surpasses the traditional medicine.
番荔枝是一种民间草药,因为它具有抗癌、抗增殖和抗肿瘤的特性。来自植物不同部位的提取物被认为具有治疗作用,因为番荔枝属的丙酮原化合物对植物的多功能性有绝对的好处,为其治疗潜力铺平了机制途径。对Google Scholar和PubMed数据库进行了审查,主要集中于获得关于番石榴及其对癌症抗癌作用的信息一系列关于细胞系、动物模型和人体试验提取物剂量的临床研究为A.muricata作为癌症的预防和治疗措施提供了验证性见解。当以不同剂量给药时,提取物显示出对癌症细胞的高细胞毒性作用,主要是IC50低于1000µg/mL,这具有重要意义。尽管高效性已经是决定性的,但在商业化之前确保安全性具有重要意义。需要进行研究,以确定副作用的来源和严重程度以及长期安全性,从而提高疗效并优化利用植物的潜在化学保护特性,从而控制癌症的营养干预,超越传统药物。
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引用次数: 0
Determination of Quality of Green Chili Sauce Served by Street Food Venders (SFVs) in Delhi (India) 印度德里街头小吃摊供应的青辣椒酱的品质测定
IF 0.9 Q4 NUTRITION & DIETETICS Pub Date : 2022-02-17 DOI: 10.2174/1573401318666220217105651
Sukhneet Suri, Arushi Jain, Meenaxi Lohia
India is enriched with local culture and street food vending practices. Street Food Joints (SFJs) cater to the demands of economical and on-the-go needs of the consumers. In view of its increasing popularity, the quality and safety aspects of street foods need continuous evaluation.There are not many studies in our country focusing on the quality determination of sauces being served as an accompaniment to street foods by local venders. Therefore, this study was undertaken to assess the quality of commonly served green chili sauce.A total of 100 samples in duplicate of green chili sauce were collected from Street Food Joints in five geographical zones of Delhi. The pH, titratable acidity and Total Soluble Solids (TSS) content on salt-free basis was assessed for all samples using standardized estimation techniques given by National regulator (Food Safety and Standards Authority of India-FSSAI).The pH of the samples was in the range of 3.1-5.1. The average titratable acidity expressed as acetic acid was 0.67± 0.25 %, which is below the limit of 1% given by FSSAI. The average TSS content (salt-free basis) was found to be 6.23 ± 3.75 % which is well below the regulatory limit of 8%. Only 25% of samples conformed to the national regulatory limits for all parameters.Stringent surveillance system which lays emphasis on the training of microentrepreneurs needs to be framed to ensure regulatory compliance amongst small-scale manufacturers of street foods such as green chili sauce.
印度丰富了当地文化和街头食品贩卖活动。街头小吃店(SFJs)迎合了消费者对经济和方便的需求。鉴于其日益普及,街头食品的质量和安全方面需要不断评估。国内对地方摊贩在街头小吃中所配酱料的质量检测研究不多。因此,本研究旨在评估常食用的青辣椒酱的品质。从德里五个地理区域的街头小吃店共收集了100份绿色辣椒酱的副本样本。使用国家监管机构(印度食品安全和标准局fssai)提供的标准化估计技术,对所有样品的pH、可滴定酸度和无盐总可溶性固形物(TSS)含量进行了评估。样品的pH值在3.1 ~ 5.1之间。以醋酸表示的平均可滴定酸度为0.67±0.25%,低于FSSAI规定的1%的限值。平均TSS含量(无盐基)为6.23±3.75%,远低于8%的规定限值。只有25%的样品符合所有参数的国家规定限值。必须建立严格的监督制度,强调培训微型企业家,以确保绿色辣椒酱等街头食品的小规模生产商遵守规章制度。
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引用次数: 0
Role of Plant Derived Products Through Exhilarating Peroxisome Proliferator Activated Receptor-γ (ppar-γ) in the Amelioration of Obesity Induced Insulin Resistance 通过激活过氧化物酶体增殖物激活受体-γ (ppar-γ)的植物源性产品在改善肥胖诱导的胰岛素抵抗中的作用
IF 0.9 Q4 NUTRITION & DIETETICS Pub Date : 2022-02-17 DOI: 10.2174/1573401318666220217111415
Devender Singh, Sachin Sharma, M. Choudhary, Prabhjeet Kaur, V. Budhwar
Insulin resistance is an elemental facet of the etiology of diabetes mellitus and the principal relating factor between obesity and diabetes. Oxidative stress, lipotoxicity, inflammation and receptor dysfunction are the underlying determinants of insulin resistance commencement in metabolic illnesses. ppar-γ is a nuclear transcription factor whose activation or inhibition directly influences insulin resistance and controls glucose and lipid homeostasis by modulating gene expression. Synthetic ligands of ppar-γ are therapeutically employed to counter the hyper-glycaemia associated with obesity and type 2 diabetes, but they possess severe side effects. In the modern era, bioactive phytochemicals have been employed in the drug development process and a considerable investigation has recently been initiated to analyze the ppar-γ activating ability of diverse phytochemicals. In this review, we outlined the role of phytochemicals in insulin resistance treatment through ppar-γ activation.
胰岛素抵抗是糖尿病病因的一个基本方面,也是肥胖和糖尿病之间的主要相关因素。氧化应激、脂毒性、炎症和受体功能障碍是代谢性疾病中胰岛素抵抗开始的潜在决定因素。ppar-γ是一种核转录因子,其激活或抑制直接影响胰岛素抵抗,并通过调节基因表达来控制糖脂稳态。ppar-γ的合成配体被用于治疗与肥胖和2型糖尿病相关的高血糖,但它们具有严重的副作用。在现代,生物活性植物化学物质已被用于药物开发过程,最近开始了大量的研究来分析各种植物化学物质的ppar-γ激活能力。在这篇综述中,我们概述了植物化学物质通过ppar-γ激活在胰岛素抵抗治疗中的作用。
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引用次数: 0
Technological, Biochemical and Microbiological Evaluation of Dehydrated Pleurotus ostreatus Powder for Nutraceutical Applications 营养保健用脱水平菇粉的工艺、生化及微生物学评价
IF 0.9 Q4 NUTRITION & DIETETICS Pub Date : 2022-02-11 DOI: 10.2174/1573401318666220211101143
Daily Arias-Ramos, Idelsy Chil-Núñez, H. Morris, Miladis Camacho-Pozo, Yamila Lebeque-Pérez, Gabriel Llauradó-Maury, P. Cos, C. Vervaet
Background: Mushroom-based products can serve as superior nutraceuticals in both preventing and alleviati human diseases. Dehydrated powder of Pleurotus ostreatus grown in Cuba has a rich nutritional composition and a large number of therapeutic properties. However, technological parameters (e.g. rheological), as well as biochemical and microbiological quality control standards for its use as a raw material in the manufacture of solid dosage forms with nutraceutical and biopharmaceutical applications have not been established yet.The study aims to determine the technological, biochemical and microbiological quality parameters of dehydrated Pleurotus ostreatus powder.Rheological ngproperties (Carr´s index, Hausner´s ratio, angle of repose and flow rate) were determined in seven batches of mushroom powder. Biochemical and microbiological analyses were performed using standard methods. Other physicochemical properties (mean particle size, pH and moisture) were also determined.Technical parameters showed a mean particle size of 224.08±7.96 µm, Carr´s compressibility index (23.08-26.58%), Hausner´s ratio (1.30-1.36), angle of repose (36.6-41.90°) and flow rate (3.69-6.93 g cm-2 s-1), typical of materials with poor flowability. Biochemical analyses indicated significant nutraceutical composition: protein (25.0-30.4%), carbohydrate (45-60%), ash (6.1-9.8%), fiber (5-9%), -D-Glucans (1.47-1.61%), iron (21-50 mg/100 g), zinc (3.8-8.0 mg/100 g), and polyphenols (123-160 mg/100 g). Moisture content was ≤3.50% and microbiological analyses were in agreement with ISO standards.Dehydrated P. ostreatus powder exhibits good nutraceutical composition and microbiological quality. Technological parameters evidenced poor flow properties, suggesting the need to include excipients to improve the rheological properties for applications as an active ingredient in solid dosage forms for health benefits.
背景:以蘑菇为基础的产品可以作为预防和减轻人类疾病的优质营养品。古巴种植的平菇脱水粉具有丰富的营养成分和大量的治疗特性。然而,技术参数(如流变学)以及作为原料用于生产具有营养和生物制药应用的固体剂型的生化和微生物质量控制标准尚未制定。本研究旨在测定脱水平菇粉的工艺、生化和微生物质量参数。测定了七批蘑菇粉的流变性能(卡尔指数、豪斯纳比、休止角和流速)。采用标准方法进行生化和微生物分析。还测定了其他物理化学性质(平均粒径、pH值和湿度)。技术参数显示,平均粒径为224.08±7.96µm,卡尔压缩指数(23.08-26.58%),豪斯纳比(1.30-1.36),休止角(36.6-41.90°)和流速(3.69-6.93 g cm-2 s-1),这是流动性差的材料的典型值。生化分析表明,营养成分显著:蛋白质(25.0-30.4%)、碳水化合物(45-60%)、灰分(6.1-9.8%)、纤维(5-9%),-D-葡聚糖(1.47-1.61%)、铁(21-50mg/100g)、锌(3.8-8.0mg/100g)和多酚(123-160mg/100g。水分含量≤3.50%,微生物分析符合ISO标准。脱水平菇粉具有良好的营养成分和微生物质量。工艺参数证明流动性较差,这表明需要包括赋形剂来改善流变性,作为固体剂型中的活性成分应用于健康益处。
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引用次数: 0
Clinical Overview of Arthritis with a Focus on Management Options and Preventive Lifestyle Measures for Its Control 关节炎的临床综述,重点关注管理选择和控制关节炎的预防性生活方式措施
IF 0.9 Q4 NUTRITION & DIETETICS Pub Date : 2022-02-04 DOI: 10.2174/1573401318666220204095629
U. Gupta, Subhas C. Gupta, S. S. Gupta
Arthritis is the spectrum of conditions that cause swelling and tenderness of one or more body joints with key symptoms of joint pain and stiffness. Its progression is closely tied to age. Although there are a number of arthritis types, such as, ankylosing, gout, joint infections, juvenile idiopathic, reactive and septic; the two most common types are osteoarthritis and rheumatoid arthritis. Osteoarthritis causes the articulating smooth cartilage that covers the ends of bones, where they form a joint, to breakdown. Rheumatoid arthritis is a disease in which the immune system attacks joints, beginning with the cartilaginous lining of the joints. The latter is considered a systemic disease, i.e. affecting many parts of the body, but the respiratory system is involved in 10 to 20 % of all mortality. Osteoarthritis is one of the leading causes of disability globally. Several preventive measures to control arthritis have been suggested, such as the use of analgesics, non-steroid anti-inflammatory drugs, moderate to vigorous physical activity and exercise, reducing sedentary hours, getting adequate sleep and maintaining a healthy body weight. Foods including, a Mediterranean diet rich in fruits and vegetables, fish oil, medicinal plants and microbiota are vital protective methods. The intake of vitamins such as A and C, minerals e.g., selenium and zinc; poly unsaturated and n-3 fatty acids is also a significant preventive measures.
关节炎是一系列导致一个或多个身体关节肿胀和压痛的疾病,主要症状是关节疼痛和僵硬。它的发展与年龄密切相关。尽管有许多关节炎类型,如强直、痛风、关节感染、幼年特发性、反应性和败血症;两种最常见的类型是骨关节炎和类风湿性关节炎。骨关节炎会导致覆盖骨骼末端的关节平滑软骨破裂,而骨骼末端是软骨形成关节的地方。类风湿性关节炎是一种免疫系统攻击关节的疾病,始于关节的软骨衬里。后者被认为是一种系统性疾病,即影响身体的许多部位,但呼吸系统占所有死亡率的10%至20%。骨关节炎是全球致残的主要原因之一。有人建议采取几种预防措施来控制关节炎,如使用止痛药、非类固醇抗炎药、适度到剧烈的体育活动和锻炼、减少久坐时间、充足的睡眠和保持健康的体重。富含水果和蔬菜的地中海饮食、鱼油、药用植物和微生物群等食物是至关重要的保护方法。维生素(如A和C)、矿物质(如硒和锌)的摄入;多不饱和和n-3脂肪酸也是一种重要的预防措施。
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引用次数: 0
Micronutrient Fortification in Foods and Soy Milk, Plant Based Milk Substitute, as a Candidate Vehicle 食品和豆浆中的微量营养素强化,植物奶替代品,作为候选载体
IF 0.9 Q4 NUTRITION & DIETETICS Pub Date : 2022-02-04 DOI: 10.2174/1573401318666220204091748
Baishakhi De, T. K. Goswami
Background: Food fortification is an effective intervention strategy to combat micronutrient malnutrition, hidden hunger, and improvement of public health and nutritional status. Choice of a cost-effective, widely consumed, compatible, and stable candidate vehicle is essential for a successful fortification.Objective: This comprehensive review discusses the aspects of food fortification along with the suitability of soy milk, plant based milk substitute as a candidate vehicle for fortification.Methods: Literature mining was done in food research journals, Pubmed, Scopus for collection of adopted fortification strategies and preferred vehicles for fortification.Results: Soy milk is a popular health beverage, globally consumed and preferred amongst lacto-vegetarians and especially those with bovine milk allergy and lactose intolerance. This plant-based milk alternative is enriched in polyunsaturated fatty acids, phytoestrogens, and isoflavones along with different macro-and micronutrients. As a candidate vehicle, soy milk offers the advantage of incorporating a wide range of fortificants, is widely consumed, stable, and is compatible with fortificants.Conclusion: Successful implementation of the fortification strategy and its global scale-up need to overcome different scientific and technological hurdles, socio-economic, ethical, and political barriers as well as legislative issues. Public-private, multi-stake holder and global partnerships, boosting of small-scale food industries, and developing tie-ups with large scale industries, promoting public awareness about the need of fortification are other necessary requisites.
背景:食物强化是对抗微量营养素营养不良、隐性饥饿以及改善公共健康和营养状况的有效干预策略。选择成本效益高、消费广泛、兼容且稳定的候选车辆对于成功防御至关重要。目的:本综述全面讨论了食品强化的各个方面,以及植物奶替代品豆奶作为强化候选载体的适用性。方法:在食品研究期刊、Pubmed、Scopus上进行文献挖掘,收集所采用的强化策略和首选的强化载体。结果:豆浆是一种受欢迎的健康饮料,在全球范围内被乳素食主义者食用,尤其是那些对牛奶过敏和乳糖不耐受的人。这种植物奶替代品富含多不饱和脂肪酸、植物雌激素和异黄酮,以及不同的宏量和微量营养素。作为一种候选载体,豆奶具有包含多种增强剂的优点,消费广泛、稳定,并且与增强剂相容。结论:防御战略的成功实施及其全球推广需要克服不同的科学和技术障碍、社会经济、伦理和政治障碍以及立法问题。公私营、多方利益相关者和全球伙伴关系、促进小规模食品工业、发展与大型工业的合作、提高公众对强化需求的认识也是其他必要条件。
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引用次数: 1
A Review: Application of Enzymes in Dairy Processing Industry 酶在乳制品加工中的应用综述
IF 0.9 Q4 NUTRITION & DIETETICS Pub Date : 2022-02-04 DOI: 10.2174/1573401318666220204093121
Akash Kumar, Aarzoo Jangra, Jhilam Pramanik
Enzymes are proteins and bio-catalyst. They are responsible for initiating a specific response to a specific outcome. In the dairy industry numerous enzymes are used; rennet and proteolytic enzymes. These enzymes are used for the coagulation and ripening of cheese. Enzymes are also used to increase the nutritional value of dairy products to alleviate the state of malnutrition. This review paper converges on
酶是蛋白质和生物催化剂。他们负责发起针对特定结果的特定响应。在乳制品工业中使用了大量的酶;凝乳酶和蛋白水解酶。这些酶用于奶酪的凝固和成熟。酶也被用来增加乳制品的营养价值,以缓解营养不良的状态。这篇综述论文集中于
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引用次数: 1
Chronic Kidney Disease, Metabolic Syndrome and Cardiovascular Risk: Insights and Associated Mechanistic Pathways 慢性肾脏疾病、代谢综合征和心血管风险:见解和相关的机制途径
IF 0.9 Q4 NUTRITION & DIETETICS Pub Date : 2022-02-03 DOI: 10.2174/1573401318666220203164619
T. R. Nogueira, Camila Santos Marreiros, Betânia de Jesus e Silva de Almendra Freitas
This study is a narrative review that aims to address the conceptual, characteristic, pathophysiological, and mechanistic aspects that define the profile of metabolic syndrome and chronic kidney disease. The objective was to investigate current knowledge and elucidate, through discussions on the topic, the main interrelated paths. This review was carried out unsystematically, from March to May 2020, by means of a survey of the literature indexed in the PubMed, Web of Science, and Scopus (Elsevier®) databases. The scientific materials collected showed that the cross-talk between the diseases in question is mainly based on the conditions of resistance to insulin action, endothelial dysfunction, activation pathways of the Renin-Angiotensin-Aldosterone system and adipokine imbalance, also emphasizing the influence of atherosclerotic events in kidney damage. Furthermore, it was reinforced the fact that inflammatory processes play an important role in the worsening and evolution of the clinical condition of patients, especially when they have underlying pathologies chronically treated for subclinical inflammation. It is expected that a greater number of original researches will propose to investigate other possible interactions, with a view to standardized treatment of these diseases or nutritional management.
本研究是一篇叙述性综述,旨在解决代谢综合征和慢性肾脏疾病的概念、特征、病理生理和机制方面的问题。其目的是调查目前的知识,并通过对该专题的讨论阐明主要的相互关联的途径。本综述是在2020年3月至5月期间通过对PubMed、Web of Science和Scopus (Elsevier®)数据库中检索的文献进行的非系统调查。收集到的科学资料表明,上述疾病之间的相互影响主要基于对胰岛素作用的抵抗、内皮功能障碍、肾素-血管紧张素-醛固酮系统的激活途径和脂肪因子失衡的情况,同时也强调动脉粥样硬化事件对肾损害的影响。此外,这一事实也加强了炎症过程在患者临床状况的恶化和演变中发挥重要作用,特别是当他们有潜在的病理长期治疗亚临床炎症时。预计将有更多的原始研究提出调查其他可能的相互作用,以期对这些疾病进行标准化治疗或营养管理。
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引用次数: 0
Zinc, Copper, Magnesium Levels in Polycystic Ovarian Syndrome Patients 多囊卵巢综合征患者的锌、铜、镁水平
IF 0.9 Q4 NUTRITION & DIETETICS Pub Date : 2022-02-01 DOI: 10.2174/1573401318666220201114704
S. Kharb, Chetna Bhatotiya, S. Gaur, Rajni Goel, Aparna Khadelwal, S. Nanda
Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases and the status of trace elements is not clear.Aim and Objectives: In the present cross-sectional study, the potential relationships between serum levels of zinc, copper, magnesium and PCOS were explored.Materials and Methods: One hundred participants with PCOS and 100 healthy controls were studied. They were in the age group (15-35 years) with the same socio-demographic characteristics. Blood samples were drawn to estimate the levels of serum zinc, copper, magnesium by autoanalyzer.Results: Serum zinc and magnesium levels were found significantly higher among the study group as compared to the control group. Serum copper levels were significantly lower in the study group. Among the PCOS women, serum copper levels were significantly correlated with age and BMI. Serum magnesium and zinc levels had a maximum area under the ROC curve and the high discriminating power of serum magnesium correlated with zinc levels for PCOS.Conclusion: These results suggest that trace elements have a role in the pathogenesis of PCOS and their possible supplementation may have a role in the management of PCOS.
背景:多囊卵巢综合征(PCOS)是最常见的内分泌疾病之一,其微量元素的状况尚不清楚。目的:在本横断面研究中,探讨血清锌、铜、镁水平与PCOS之间的潜在关系。材料与方法:对100名PCOS患者和100名健康对照者进行研究。他们属于具有相同社会人口特征的年龄组(15-35岁)。抽取血样,用自动分析仪测定血清锌、铜、镁的含量。结果:研究组的血清锌和镁水平明显高于对照组。研究组的血清铜水平明显较低。在多囊卵巢综合征妇女中,血清铜水平与年龄和BMI显著相关。血清镁、锌水平在PCOS的ROC曲线下面积最大,且血清镁与锌水平的判别能力较高。结论:微量元素与PCOS的发病机制有关,补充微量元素可能对PCOS的治疗有一定作用。
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引用次数: 0
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Current Nutrition & Food Science
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