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Review on taxonomical and pharmacological status of Dolichos lablab 石菖蒲属植物的分类和药理研究进展
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2020-07-29 DOI: 10.5530/ctbp.2020.2.23
Vishwajeet Singh, R. Kudesia
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引用次数: 2
Utility of trnS-trnG intergenic spacer in the molecular authentication of K. pinnatum trnS-trnG基因间间隔物在凤尾莲分子鉴定中的应用
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2020-07-29 DOI: 10.5530/ctbp.2020.2.21
.A RanganadhaReddy, B SrividyaSrividya, Nair Rr, P VijethaVijetha, S KrupanidhiKrupanidhi, Venkateswarulu Tc, K AbrahamPeele, A VenkatanarayanaVenkatanarayana, P SudhakarSudhakar
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引用次数: 0
Production of bio-diesel from non-edible dried fruits of Lagerstroemia speciosa 利用大叶紫薇非食用干果生产生物柴油
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2020-07-29 DOI: 10.5530/ctbp.2020.2.14
S WilliamJosephKamal, S. Ps, F. Xavier, E. Venkatanagaraju
Rapid urbanization and increase in population have evoked tremendous attention for biofuelsproduction to combatshortage of fuels, environmental concerns, foreign exchange savingsand socioeconomic issues.In recent years biodiesel production from agro-industrial feedstocks such as waste vegetable oil, animal fat, grease, non-edible fruit oils etc.,acquired prominent place to fulfil the gap between production and demand. The present investigation has been undertaken to explore a noveland environmentally friendly process for developing biodiesel production technology by subjecting dried fruits of Lagerstroemia speciosa to mild ultrasonication at 33KHz for 20 min at 35±2oCfor obtaining high lipid yield, precursor for the production of biodiesel by transesterification.The biodiesel compounds 2,4di-tert-butylphenol, hexadecanoic acid methyl ester, 9,12-octadecadienoic acid (Z, Z) methyl ester, 9-octadecenoic acid methyl ester, methyl stearate, cis-11,14-eicosadienoic acid methyl ester, 18-methylnonadecanoate were recognized as the main compounds in GC-MS analysis.
快速的城市化和人口的增加引起了人们对生物燃料生产的极大关注,以解决燃料短缺、环境问题、外汇储蓄和社会经济问题。近年来,利用废弃植物油、动物脂肪、油脂、非食用水果油等农产工业原料生产生物柴油,在填补供需缺口方面占据了突出地位。本研究旨在探索一种开发生物柴油生产技术的新的环保工艺,将紫薇干果在33KHz、35±2℃下进行20分钟的温和超声处理,以获得高的油脂产率,这是通过酯交换生产生物柴油的前体。在GC-MS分析中,生物柴油化合物2,4-二叔丁基苯酚、十六烷酸甲酯、9,12-十八碳二烯酸(Z,Z)甲酯、9-十八碳烯酸甲酯、硬脂酸甲酯、顺式-11,14-二十碳二烯酸甲酯、18-甲基九癸酸被认为是主要化合物。
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引用次数: 0
Plackett-Burman design for screening of fermentation process parameters and their effects on L-methionine production 发酵工艺参数筛选的Plackett-Burman设计及其对L-蛋氨酸生产的影响
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2020-07-29 DOI: 10.5530/ctbp.2020.2.19
A. Venkatanarayana, Venkateswarulu Tc, .A RanganadhaReddy, A RangaRao, K AbrahamPeele, D JohnBabu, S AshaAsha, B SumalathaSumalatha, P SudhakarSudhakar
Plackett-Burman design for L-methionine production Abstract In the present study, economical fermentation medium process was developed to achieve the maximum production of L-methionine by Corynebacterium glutamicum through screening of different nutritional and physical parameters by Plackett-Burman design. A total of eleven process variables such as plantain as carbon source, groundnut as nitrogen source, CaCO3, K2HPO4, KH2PO4, biotin, MgSO4.7H2O, inoculum size, agitation speed, volume ratio of medium/fermenter and pH were used for screening experiments. The PBD model results suggested that seven variables namely plantain as carbon source, groundnut as nitrogen source, CaCO3, MgSO4.7H2O and KH2PO4 had shown a significant effect on L-methionine production, while remaining six variables didn’t show a much effect on Lmethionine production. The R2 value (0.99) of analysis of variance (ANOVA) recommended that the model used for response prediction is significant (p<0.05). In comparison with the unoptimized medium, 24% higher L-methionine production was obtained from the optimized medium and L-methionine production was found to be 5.6 g/l.
摘要本研究通过Plackett-Burman设计筛选不同营养和物性参数,开发出经济型发酵培养基工艺,使谷氨酸棒状杆菌最大限度地生产l -蛋氨酸。以车前草为碳源、花生为氮源、CaCO3、K2HPO4、KH2PO4、生物素、MgSO4.7H2O、接种量、搅拌速度、培养基/发酵罐体积比、pH等11个工艺变量进行筛选实验。PBD模型结果表明,车前草为碳源、花生为氮源、CaCO3、MgSO4.7H2O和KH2PO4这7个变量对l -蛋氨酸产量有显著影响,其余6个变量对l -蛋氨酸产量影响不大。方差分析(ANOVA)的R2值(0.99)提示用于反应预测的模型具有显著性(p<0.05)。与未优化培养基相比,优化培养基的l -蛋氨酸产量提高了24%,l -蛋氨酸产量为5.6 g/l。
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引用次数: 1
Angiotensin-converting enzyme gene polymorphism may be a risk factor for COVID-19 clinical outcome 血管紧张素转换酶基因多态性可能是COVID-19临床结局的危险因素
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2020-04-01 DOI: 10.5530/ctbp.2020.2.24
K. Panati, E. Reddy, V. Narala
Angiotensin-converting enzyme 1(ACE1) and ACE2 play a major role in regulation of blood pressure and electrolytic balance. They are known to express in epithelial cells of various tissues. SARS-CoV2 uses ACE2 as one of the receptors to enter into the host cells. Coronavirus infection-associated decrease in the expression of ACE2 is known to associate with vasoconstriction, hypertension and other cardiovascular problems. Patients who are on ACE1 inhibitors show increased ACE2 expression, which is known to protect the lung from acute lung injury. ACE1 and ACE2 polymorphisms might be associated with the infectivity, severity and recovery from the COVID-19. Association studies of ACE gene polymorphisms in affected population may suggest the clinical outcome of the COVID-19.
血管紧张素转换酶1(ACE1)和ACE2在调节血压和电解质平衡中起重要作用。已知它们在各种组织的上皮细胞中表达。SARS-CoV2使用ACE2作为受体之一进入宿主细胞。已知冠状病毒感染相关的ACE2表达下降与血管收缩、高血压和其他心血管问题有关。服用ACE1抑制剂的患者表现出ACE2表达增加,这被认为可以保护肺免受急性肺损伤。ACE1和ACE2多态性可能与COVID-19的传染性、严重程度和恢复有关。感染人群中ACE基因多态性的关联研究可能提示COVID-19的临床结局。
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引用次数: 1
First week of social lockdown versus medical care against COVID-19 - with special reference to India 新冠肺炎社会封锁与医疗保健的第一周——特别是印度
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2020-04-01 DOI: 10.5530/ctbp.2020.2.20
Kabita Das, B. Paital
The disease caused by Coronavirus (CoV) is called as Coronavirus Disease (COVID-19). It became pandemic in 210 countries and rolling data indicate that 2,606,635individuals are infected with the deadly pandemic disease and 713,812 have recovered, while, 182,114 have lost their lives. Although, few drugs namely Chloroquine, Hydr oxychl or oqui ne and Azi t hr omyci n, Tocilizumab, Lopinavir; Ritonavir and Tocilizumab are recommended on contextual basis for the treatment of COVID-19, the world is still waiting to come up with a specific vaccine or medicine to combat the disease. Without a specific medicine, countries such as Italy, USA, Spain and France, withthe most advanced health care systems are unsuccessful to control both the infection and death rate under COVID-19 infection. India being the world’s 2 ndlargest populous country, where, the health care system is under developed, with major portion of people live less-hygienic life, has contracted the disease at a slower rate as compared to the above countries. India has achieved this through employing social distancing by following a strict lockdown. This article is focused on social distancing of India and the kind of social interaction that can be adapted by people during lockdown.
由冠状病毒(CoV)引起的疾病称为冠状病毒病(COVID-19)。它在210个国家成为大流行病,滚动数据表明,有2,606,635人感染了这种致命的大流行病,713,812人已经康复,而182,114人丧生。虽然,很少有药物,即氯喹、羟氧基或奥喹、阿齐、托珠单抗、洛匹那韦;利托那韦和托珠单抗被推荐用于治疗COVID-19,世界仍在等待找到一种特定的疫苗或药物来对抗这种疾病。意大利、美国、西班牙和法国等拥有最先进卫生保健系统的国家在没有特定药物的情况下,无法控制COVID-19感染下的感染率和死亡率。印度是世界上人口第二大的国家,医疗保健系统不发达,大部分人的生活不太卫生,与上述国家相比,印度感染这种疾病的速度较慢。印度通过实施严格的封锁措施,保持社交距离,实现了这一目标。这篇文章的重点是印度的社交距离以及人们在封锁期间可以适应的社交互动。
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引用次数: 22
Academic Output in Smart Agriculture with Conservation of Natural Resources : Indian vs. Global Scenario 智能农业与自然资源保护的学术产出:印度vs.全球情景
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2020-02-22 DOI: 10.5530/CTBP.2021.1.11
N. P. Kumari, Jayasomu Rs Jayasomu, M. Verma
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引用次数: 0
Anti-Angiogenic Effect of Ethanolic Extract and its Phenolic Rich Fraction of Acacia auriculiformis Bark in the Chick Embryo Chorioallantoic Membrane Model 金合欢树皮乙醇提取物及其富酚组分在鸡胚绒毛尿囊膜模型中的抗血管生成作用
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2020-02-22 DOI: 10.5530/CTBP.2020.4S.17
Chong Wei Chean, S. Chinnappan, R MoganaMogana, B. Ashokkumar
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引用次数: 0
Knowledge, Attitude and Practice of General Public Towards Counterfeit and Adulterated Medicines: A Cross-sectional Study in Malaysia 公众对假冒伪劣药品的认识、态度和做法:马来西亚的一项横断面研究
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2020-02-22 DOI: 10.5530/CTBP.2020.4S.9
C. Por, F. Keshavarzi, C. S. Yap, Yee Chang Soh
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引用次数: 2
Assessment of Eco-genotoxic Effects of Pesticide Mixtures on Freshwater Fish, Catla catla 混合农药对淡水鱼的生态遗传毒性评价
Q3 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2020-02-22 DOI: 10.5530/CTBP.2021.1.5
B. Bhargavi, R. K. Vellanki, Rajanikanth Akurathi, J. R. Kanala
Eco-genotoxicity was evaluated in fresh water fish, Catla catla using two commercially available pesticide mixtures, viz., Deltamethrin 1% + Triazophos 35% EC and Profenofos 40% EC + Cypermethrin 4% EC. Acute toxicity studies were conducted primarily to determine LC50 of each pesticide mixture. The fish were exposed to each pesticide mixture for 21 days at a dose value of 1/ 20th and 1/10th of LC50. The gills were isolated from the fish at the end of the exposure period, and processed for comet assay. Nucleoids were scored visually, observed significant increase of damage and categorized into various degrees of damages. Based on the results obtained from this study it is concluded that the pesticide mixtures evaluated could be potentially genotoxic to fresh water fish, Catla catla.
使用两种市售农药混合物,即1%的溴氰菊酯+35%的三唑磷EC和40%的毒死蜱+4%的氯氰菊酯EC,对淡水鱼Catla Catla的生态遗传毒性进行了评估。将鱼暴露于每种杀虫剂混合物21天,剂量值分别为LC50的1/20和1/10。在暴露期结束时,从鱼身上分离出鳃,并进行彗星分析。对核苷酸进行视觉评分,观察到损伤的显著增加,并将其分为不同程度的损伤。根据这项研究的结果,可以得出结论,所评估的杀虫剂混合物可能对淡水鱼Catla Catla具有潜在的遗传毒性。
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Current Trends in Biotechnology and Pharmacy
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