In the current research, DNA/RNA of gum cancer cells—anti–cancer Nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments are investigated. However, it has been demonstrated by us and others that the choice of DNA/RNA of gum cancer cells—anti–cancer Nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments can greatly influence tissue classification results. In addition to developing best–practice techniques for spectral preprocessing, care must be taken when developing classification DNA/RNA of gum cancer cells—anti–cancer Nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments for diagnostic evaluation. Validation studies need to be performed to confirm that DNA/RNA of gum cancer cells—anti–cancer Nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments developed on ex vivo specimens are applicable to in vivo tissues. Machine learning DNA/RNA of gum cancer cells—anti–cancer Nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments hold the promise of automating the identification and diagnosis of gum cancer. Deep learning training, using large numbers of spectra, may also identify molecular patterns among gum cancer types, aid in margin detection, and become predictors of the aggressiveness of the gum cancer.
{"title":"DNA/RNA of gum cancer cells-anti–cancer nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments","authors":"A. Heidari, R. Gobato","doi":"10.15761/DOMR.1000366","DOIUrl":"https://doi.org/10.15761/DOMR.1000366","url":null,"abstract":"In the current research, DNA/RNA of gum cancer cells—anti–cancer Nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments are investigated. However, it has been demonstrated by us and others that the choice of DNA/RNA of gum cancer cells—anti–cancer Nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments can greatly influence tissue classification results. In addition to developing best–practice techniques for spectral preprocessing, care must be taken when developing classification DNA/RNA of gum cancer cells—anti–cancer Nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments for diagnostic evaluation. Validation studies need to be performed to confirm that DNA/RNA of gum cancer cells—anti–cancer Nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments developed on ex vivo specimens are applicable to in vivo tissues. Machine learning DNA/RNA of gum cancer cells—anti–cancer Nano drugs ligands structure determination with the two–dimensional NMR molecular line shape analysis of single, multiple, zero and double quantum correlation experiments hold the promise of automating the identification and diagnosis of gum cancer. Deep learning training, using large numbers of spectra, may also identify molecular patterns among gum cancer types, aid in margin detection, and become predictors of the aggressiveness of the gum cancer.","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85746947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Gobato, Ibtihal Kadhim Kareem Dosh, A. Heidari, A. Mitra, Marcia Regina Risso Gobato
The work characterizes the Raman spectrum of the new nano-molecule C 13 H 20 BeLi 2 SeSi / C 13 H 19 BeLi 2 SeSi, nano-molecule Kurumi. Calculations obtained in the methods Restrict Hartree-Fock of the first principles (ab initio), on the set of basis used indicate that the simulated molecule C 13 H 20 BeLi 2 SeSi / C 13 H 19 BeLi 2 SeSi features the structure polar-apolar-polar predominant. The set of basis used that have been correlation-consistent polarized Triple-zeta (CC-pVTZ) and Pople’s basis sets six gaussian functions in the shell, three double zeta Gaussian functions, Slater type orbitals with polarization function (6-311G** (3df, 3pd)). In the CC-pVTZ base set,
研究了新型纳米分子c13h20 BeLi 2 SeSi / c13h19 BeLi 2 SeSi，纳米分子Kurumi的拉曼光谱特征。用第一原理(从头算)的约束Hartree-Fock方法计算得到的结果表明，模拟分子c13h20 BeLi 2 SeSi / c13h19 BeLi 2 SeSi具有极-极-极优势结构。所使用的基集是相关一致极化的Triple-zeta (CC-pVTZ)和people的基集，在壳层中有6个高斯函数，3个双zeta高斯函数，Slater型轨道具有极化函数(6-311G** (3df, 3pd))。在CC-pVTZ基集中，
{"title":"A novel and exquisite approach to single layer bioinorganic membranes","authors":"R. Gobato, Ibtihal Kadhim Kareem Dosh, A. Heidari, A. Mitra, Marcia Regina Risso Gobato","doi":"10.15761/DOMR.1000354","DOIUrl":"https://doi.org/10.15761/DOMR.1000354","url":null,"abstract":"The work characterizes the Raman spectrum of the new nano-molecule C 13 H 20 BeLi 2 SeSi / C 13 H 19 BeLi 2 SeSi, nano-molecule Kurumi. Calculations obtained in the methods Restrict Hartree-Fock of the first principles (ab initio), on the set of basis used indicate that the simulated molecule C 13 H 20 BeLi 2 SeSi / C 13 H 19 BeLi 2 SeSi features the structure polar-apolar-polar predominant. The set of basis used that have been correlation-consistent polarized Triple-zeta (CC-pVTZ) and Pople’s basis sets six gaussian functions in the shell, three double zeta Gaussian functions, Slater type orbitals with polarization function (6-311G** (3df, 3pd)). In the CC-pVTZ base set,","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81351673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the current study, thermoplasmonic characteristics of Seaborgium nanoparticles with spherical, core-shell and rod shapes are investigated. In order to investigate these characteristics, interaction of synchrotron radiation emission as a function of the beam energy and Seaborgium nanoparticles were simulated using 3D finite element method. Firstly, absorption and extinction cross sections were calculated. Then, increases in temperature due to synchrotron radiation emission as a function of the beam energy absorption were calculated in Seaborgium nanoparticles by solving heat equation. The obtained results show that Seaborgium nanorods are more appropriate option for using in optothermal human cancer cells, tissues and tumors treatment method.
{"title":"Liénard-wiechert field study of interaction of synchrotron radiation emission as a function of the beam energy and seaborgium nanoparticles using 3d finite element method (FEM) as an optothermal human cancer cells, tissues and tumors treatment","authors":"A. Heidari, K. Schmitt, M. Henderson, E. Besana","doi":"10.15761/domr.1000339","DOIUrl":"https://doi.org/10.15761/domr.1000339","url":null,"abstract":"In the current study, thermoplasmonic characteristics of Seaborgium nanoparticles with spherical, core-shell and rod shapes are investigated. In order to investigate these characteristics, interaction of synchrotron radiation emission as a function of the beam energy and Seaborgium nanoparticles were simulated using 3D finite element method. Firstly, absorption and extinction cross sections were calculated. Then, increases in temperature due to synchrotron radiation emission as a function of the beam energy absorption were calculated in Seaborgium nanoparticles by solving heat equation. The obtained results show that Seaborgium nanorods are more appropriate option for using in optothermal human cancer cells, tissues and tumors treatment method.","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81681040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the current study, thermoplasmonic characteristics of Americium nanoparticles with spherical, core-shell and rod shapes are investigated. In order, to investigate these characteristics, interaction of synchrotron radiation emission as a function of the beam energy and Americium nanoparticles were simulated using 3D finite element method. Firstly, absorption and extinction cross sections were calculated. Then, increases in temperature due to synchrotron radiation emission as a function of the beam energy absorption were calculated in Americium nanoparticles by solving heat equation. The obtained results show that Americium nanorods are more appropriate option for using in optothermal human cancer cells, tissues and tumors treatment method.
{"title":"Nanomedicines based americium nanoparticles drug delivery systems for anti-cancer targeting and treatment under synchrotron radiation","authors":"A. Heidari, K. Schmitt, M. Henderson, E. Besana","doi":"10.15761/DOMR.1000343","DOIUrl":"https://doi.org/10.15761/DOMR.1000343","url":null,"abstract":"In the current study, thermoplasmonic characteristics of Americium nanoparticles with spherical, core-shell and rod shapes are investigated. In order, to investigate these characteristics, interaction of synchrotron radiation emission as a function of the beam energy and Americium nanoparticles were simulated using 3D finite element method. Firstly, absorption and extinction cross sections were calculated. Then, increases in temperature due to synchrotron radiation emission as a function of the beam energy absorption were calculated in Americium nanoparticles by solving heat equation. The obtained results show that Americium nanorods are more appropriate option for using in optothermal human cancer cells, tissues and tumors treatment method.","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83242882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Primary Sjögren Syndrome (PSS), also known as autoimmune epithelitis, it is an autoimmune disease with a large clinical features spectrum, from local exocrinopathy to multiple systemic manifestations. The main symptoms are xerostomia and xerophthalmia, often accompanied by systemic changes those affects parenchymal organs. The frequently associated clinical signs of PSS in the oral cavity are: loss of brightness, dryness, pale and thin appearance of oral mucosa, fissures and lobulations in the lingual dorsum, angular cheilitis and filiform papillae atrophy. And the clinical symptoms are: glossodynia (mouth burning), dysgeusia (distortion or decreased taste), speech and swallowing the bolus difficulties, dry cough, difficulty in fixing dental prostheses. It is known that genetic, hormonal and environmental factors seem to be related to the development PSS, which is associated with increasedHLA-B8 / DR3 halotype frequency. The inflammatory target in the disease is primarily the epithelium of the lacrimal and salivary glands and, therefore, some authors named the destruction of the glandular parenchyma in PSS, whose initial mechanisms may be related to the breakdown of homeostasis in glandular architecture (cell-cell and cellextracellular matrix structures) as autoimmune epithelitis. One of the main characteristics of this disease is the destruction of the salivary glands parenchyma, consequently decreasing salivary flow and xerostomia. The dentist plays an important role within the multidisciplinary team, with meticulous instructions on oral hygiene, non-cariogenic diet advice, prescription lubricating agents and constant evaluation of dental restorations to give the patients a better health wellbeing. *Correspondence to: Ricardo Hsieh, DDS, PhD, Avenida Doutor Enéas de Carvalho Aguiar, NO. 500, Prédio II, 2o Andar, São Paulo, SP, Brazil – CEP: 05403-000, Tel: +551130617064/+5511966369564; E-mail: r.hsieh@usp.br
原发性Sjögren综合征(Primary Sjögren Syndrome, PSS)，又称自身免疫性上皮炎，是一种具有广泛临床特征的自身免疫性疾病，从局部外源性病变到多系统表现。主要症状为口干和干眼症，常伴有影响实质器官的全身改变。口腔PSS的常见相关临床表现为:口腔黏膜亮度下降、干燥、苍白、薄，舌背裂开、小叶状，角状唇炎和丝状乳头萎缩。临床表现为舌痛(口腔灼烧)、发音困难(味觉扭曲或减退)、言语和吞咽困难、干咳、固定义齿困难。众所周知，遗传、激素和环境因素似乎与PSS的发展有关，PSS与hla - b8 / DR3 haltype频率增加有关。该疾病的炎症靶点主要是泪腺和唾液腺的上皮，因此，一些作者将PSS中腺体实质的破坏命名为自身免疫性上皮炎，其初始机制可能与腺体结构(细胞-细胞和细胞-细胞基质结构)的稳态破坏有关。这种疾病的主要特征之一是唾液腺实质的破坏，从而减少唾液流量和口干症。牙医在多学科团队中扮演着重要的角色，他们在口腔卫生、非龋齿饮食建议、处方润滑剂和持续评估牙齿修复方面提供细致的指导，以使患者更好地健康。*通讯:Ricardo Hsieh, DDS, PhD, Avenida Doutor en de Carvalho Aguiar, NO。500, pracimdio II, 20 Andar, s o Paulo, SP - CEP: 05403-000，电话:+551130617064/+5511966369564;电子邮件:r.hsieh@usp.br
{"title":"Primary Sjögren Syndrome: A review for health professionals","authors":"R. Hsieh, S. Lourenço","doi":"10.15761/DOMR.1000362","DOIUrl":"https://doi.org/10.15761/DOMR.1000362","url":null,"abstract":"Primary Sjögren Syndrome (PSS), also known as autoimmune epithelitis, it is an autoimmune disease with a large clinical features spectrum, from local exocrinopathy to multiple systemic manifestations. The main symptoms are xerostomia and xerophthalmia, often accompanied by systemic changes those affects parenchymal organs. The frequently associated clinical signs of PSS in the oral cavity are: loss of brightness, dryness, pale and thin appearance of oral mucosa, fissures and lobulations in the lingual dorsum, angular cheilitis and filiform papillae atrophy. And the clinical symptoms are: glossodynia (mouth burning), dysgeusia (distortion or decreased taste), speech and swallowing the bolus difficulties, dry cough, difficulty in fixing dental prostheses. It is known that genetic, hormonal and environmental factors seem to be related to the development PSS, which is associated with increasedHLA-B8 / DR3 halotype frequency. The inflammatory target in the disease is primarily the epithelium of the lacrimal and salivary glands and, therefore, some authors named the destruction of the glandular parenchyma in PSS, whose initial mechanisms may be related to the breakdown of homeostasis in glandular architecture (cell-cell and cellextracellular matrix structures) as autoimmune epithelitis. One of the main characteristics of this disease is the destruction of the salivary glands parenchyma, consequently decreasing salivary flow and xerostomia. The dentist plays an important role within the multidisciplinary team, with meticulous instructions on oral hygiene, non-cariogenic diet advice, prescription lubricating agents and constant evaluation of dental restorations to give the patients a better health wellbeing. *Correspondence to: Ricardo Hsieh, DDS, PhD, Avenida Doutor Enéas de Carvalho Aguiar, NO. 500, Prédio II, 2o Andar, São Paulo, SP, Brazil – CEP: 05403-000, Tel: +551130617064/+5511966369564; E-mail: r.hsieh@usp.br","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85987969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Modem medicine defines epilepsy as a chronic neurologic disorder characterized by frequently recurrent seizures. A seizure is a sign of a disease, which manifests as an episodic disturbance of movement, feeling, or consciousness caused by sudden synchronous, inappropriate and excessive electrical discharges that interfere with the normal functioning of the brain site of location of seizures the disease occurs independent of race, age and gender ]. However, epilepsy has been occur more frequently in men than in women. Oral manifestations are soft tissue lacerations of tongue or buccal mucosa, avulsion, luxation and fractures of teeth and jaws are more common and also subluxation of the temporo mandibular joint.due to drug therapy gingival hyperplasia, recurrent apthous like ulceration and anomalous dental development like small teeth and delayed eruption.reduce stress on the patients with psychobehavioral preparations, sedation etc. Diazepam is the drug of choice because it has anticonvilsant properties.The use of conscious sedation and general anesthesia is not contraindicated in patients’ epilepsy. In some situations nitrous oxide or intravenous sedation may be necessary to safely and effectively provide dental care. Avoid IV local anesthetics. Appointments should be short, importance of tooth brushing procedures and regular review, if appliances are indicated for tooth movement and tooth replacement, fixed type are preferred. This article discuss about etiology, clinical features and dental management of children with epilepsy.
{"title":"Dental concerns and management of children with Epilepsy: An overview","authors":"Nirmala Svsg, S. Degala","doi":"10.15761/DOMR.1000356","DOIUrl":"https://doi.org/10.15761/DOMR.1000356","url":null,"abstract":"Modem medicine defines epilepsy as a chronic neurologic disorder characterized by frequently recurrent seizures. A seizure is a sign of a disease, which manifests as an episodic disturbance of movement, feeling, or consciousness caused by sudden synchronous, inappropriate and excessive electrical discharges that interfere with the normal functioning of the brain site of location of seizures the disease occurs independent of race, age and gender ]. However, epilepsy has been occur more frequently in men than in women. Oral manifestations are soft tissue lacerations of tongue or buccal mucosa, avulsion, luxation and fractures of teeth and jaws are more common and also subluxation of the temporo mandibular joint.due to drug therapy gingival hyperplasia, recurrent apthous like ulceration and anomalous dental development like small teeth and delayed eruption.reduce stress on the patients with psychobehavioral preparations, sedation etc. Diazepam is the drug of choice because it has anticonvilsant properties.The use of conscious sedation and general anesthesia is not contraindicated in patients’ epilepsy. In some situations nitrous oxide or intravenous sedation may be necessary to safely and effectively provide dental care. Avoid IV local anesthetics. Appointments should be short, importance of tooth brushing procedures and regular review, if appliances are indicated for tooth movement and tooth replacement, fixed type are preferred. This article discuss about etiology, clinical features and dental management of children with epilepsy.","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87483161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This case report is to present two cases of young boys with β thalassemia, have skeletal class II convex profile, protrusion of the maxilla and mandible, protrusion of the upper incisors and smaller incisor widths. Cephalometric x-ray shows overgrowth of the maxilla bone, with presence of bone voids and hiatuses. The treatment of patients with β thalassemia is usually controversy, require good diagnosis, investigations and treatment plan.
{"title":"Thalassemia patients with malocclusion","authors":"Mohamad Azhar Ibrahim Kharsa","doi":"10.15761/DOMR.1000350","DOIUrl":"https://doi.org/10.15761/DOMR.1000350","url":null,"abstract":"This case report is to present two cases of young boys with β thalassemia, have skeletal class II convex profile, protrusion of the maxilla and mandible, protrusion of the upper incisors and smaller incisor widths. Cephalometric x-ray shows overgrowth of the maxilla bone, with presence of bone voids and hiatuses. The treatment of patients with β thalassemia is usually controversy, require good diagnosis, investigations and treatment plan.","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78740367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the current study, thermoplasmonic characteristics of Meitnerium nanoparticles with spherical, core-shell and rod shapes are investigated. In order to investigate these characteristics, interaction of synchrotron radiation emission as a function of the beam energy and Meitnerium nanoparticles were simulated using 3D finite element method. Firstly, absorption and extinction cross sections were calculated. Then, increases in temperature due to synchrotron radiation emission as a function of the beam energy absorption were calculated in Meitnerium nanoparticles by solving heat equation. The obtained results show that Meitnerium nanorods are more appropriate option for using in optothermal human cancer cells, tissues and tumors treatment method.
{"title":"The dynamics and quantum mechanics of an interaction of synchrotron radiation emission as a function of the beam energy and meitnerium nanoparticles using 3d finite element method (FEM) as an optothermal human cancer cells, tissues and tumors treatment","authors":"A. Heidari, J. Esposito, Angela Caissutti","doi":"10.15761/domr.1000342","DOIUrl":"https://doi.org/10.15761/domr.1000342","url":null,"abstract":"In the current study, thermoplasmonic characteristics of Meitnerium nanoparticles with spherical, core-shell and rod shapes are investigated. In order to investigate these characteristics, interaction of synchrotron radiation emission as a function of the beam energy and Meitnerium nanoparticles were simulated using 3D finite element method. Firstly, absorption and extinction cross sections were calculated. Then, increases in temperature due to synchrotron radiation emission as a function of the beam energy absorption were calculated in Meitnerium nanoparticles by solving heat equation. The obtained results show that Meitnerium nanorods are more appropriate option for using in optothermal human cancer cells, tissues and tumors treatment method.","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77960374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the current work, the anti–cancer Nano drug delivery 13C–edited/13C–filtered transferred dynamic 15N{1H} NOE measurements for studying DNA/RNA interactions with short non–linear motifs as a modern tool for studying DNA/RNA dynamics in gum cancer cells are studied. While improvements in screening have enabled the early diagnoses of many gum cancers, the significant number of diagnoses that eventually lead to death (~20% at 15 years) provide the primary impetus for advances in surgical intervention.
{"title":"The anti–cancer nano drug delivery 13C–edited/13C–filtered transferred dynamic 15N{1H} NOE measurements for studying DNA/RNA interactions with short non–linear motifs: A modern tool for studying DNA/RNA dynamics in gum cancer cells","authors":"A. Heidari, R. Gobato","doi":"10.15761/DOMR.1000365","DOIUrl":"https://doi.org/10.15761/DOMR.1000365","url":null,"abstract":"In the current work, the anti–cancer Nano drug delivery 13C–edited/13C–filtered transferred dynamic 15N{1H} NOE measurements for studying DNA/RNA interactions with short non–linear motifs as a modern tool for studying DNA/RNA dynamics in gum cancer cells are studied. While improvements in screening have enabled the early diagnoses of many gum cancers, the significant number of diagnoses that eventually lead to death (~20% at 15 years) provide the primary impetus for advances in surgical intervention.","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89559506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : Degree of monomer conversion during processing of acrylic resin denture base materials is very critical in determination of monomer release and mechanical properties of acrylic resin in service. Objectives : The purpose of this research project was to investigate the effect of aluminum oxide powder reinforcement on the degree of monomer conversion, residual monomer, deflection at fracture and flexural strength after processing of heat-cured acrylic resin denture base materials. Also, the correlation between these properties was statistically tested. Materials and methods : The materials used were conventional heat-cured and aluminum oxide powder-reinforced acrylic resin denture base materials (2.5 % and 5% aluminum powder). Samples were prepared according to the manufacturer’s instructions, ADA Specifications no. 12 and the International Organization for Standardization Recommendation. Acrylic resin samples of specific dimensions were prepared from unreinforced and reinforced acrylic resin materials using stainless steel plates. The degree of conversion was determined using FTIR Spectrometer. The concentrations of released methyl methacrylate monomer was measured using isocratic high-performance liquid chromatography. Flexural strength was tested using three point-bending test with a universal testing machine. Results : Aluminum oxide powder reinforcement showed slight increased degree of conversion than that of the unreinforced denture base resins. The released monomer in deionized water from the reinforced acrylic resins was significantly lower than that of the unreinforced specimens. The deflection at fracture of the reinforced specimens was significantly lower than that of the unreinforced acrylic resin. The flexural strength was significantly increased by addition of 2.5 % and 5 % aluminum oxide powder when compared to the unreinforced group. There was high positive correlation between the degree of conversion and flexural strength. On the other hand, there was negative correlation between degree of conversion and monomer release. Conclusions : Aluminum oxide powder reinforcement was slightly increased the degree of conversion of the heat-cured acrylic resin. Aluminum oxide powder reinforcement was significantly reduced the amount of monomer released and the deflection at fracture heat-cured specimens. The reinforced specimens showed significantly increased flexural strength than that of the unreinforced specimens. There was high positive correlation between the degree of conversion and flexural strength. There was negative correlation between degree of conversion and monomer release.
{"title":"Heat-cured acrylic resin reinforcement with aluminum oxide: Degree of conversion, monomer release and flexural strength","authors":"I. M. Hamouda, Alaa Makke","doi":"10.15761/DOMR.1000359","DOIUrl":"https://doi.org/10.15761/DOMR.1000359","url":null,"abstract":"Background : Degree of monomer conversion during processing of acrylic resin denture base materials is very critical in determination of monomer release and mechanical properties of acrylic resin in service. Objectives : The purpose of this research project was to investigate the effect of aluminum oxide powder reinforcement on the degree of monomer conversion, residual monomer, deflection at fracture and flexural strength after processing of heat-cured acrylic resin denture base materials. Also, the correlation between these properties was statistically tested. Materials and methods : The materials used were conventional heat-cured and aluminum oxide powder-reinforced acrylic resin denture base materials (2.5 % and 5% aluminum powder). Samples were prepared according to the manufacturer’s instructions, ADA Specifications no. 12 and the International Organization for Standardization Recommendation. Acrylic resin samples of specific dimensions were prepared from unreinforced and reinforced acrylic resin materials using stainless steel plates. The degree of conversion was determined using FTIR Spectrometer. The concentrations of released methyl methacrylate monomer was measured using isocratic high-performance liquid chromatography. Flexural strength was tested using three point-bending test with a universal testing machine. Results : Aluminum oxide powder reinforcement showed slight increased degree of conversion than that of the unreinforced denture base resins. The released monomer in deionized water from the reinforced acrylic resins was significantly lower than that of the unreinforced specimens. The deflection at fracture of the reinforced specimens was significantly lower than that of the unreinforced acrylic resin. The flexural strength was significantly increased by addition of 2.5 % and 5 % aluminum oxide powder when compared to the unreinforced group. There was high positive correlation between the degree of conversion and flexural strength. On the other hand, there was negative correlation between degree of conversion and monomer release. Conclusions : Aluminum oxide powder reinforcement was slightly increased the degree of conversion of the heat-cured acrylic resin. Aluminum oxide powder reinforcement was significantly reduced the amount of monomer released and the deflection at fracture heat-cured specimens. The reinforced specimens showed significantly increased flexural strength than that of the unreinforced specimens. There was high positive correlation between the degree of conversion and flexural strength. There was negative correlation between degree of conversion and monomer release.","PeriodicalId":10996,"journal":{"name":"Dental, Oral and Maxillofacial Research","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87871612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：