Pub Date : 2022-04-06DOI: 10.24092/crps.2022.120105
G. P D, S. K L, V. V, S. V, V. ., K. a, M. K, T. T
The availability of several brands of Ramipril tablets in Indian pharmacies now poses a generic replacement concern for doctors. The goal of this study was to evaluate and compare different brands of Ramipril manufactured by various Indian pharmaceutical businesses under various trade names in order to reduce health risks and ensure the safety of local residents. General quality assessments of these tablets, such as diameter, thickness, hardness, weight variation, friability, disintegration, and dissolution tests, were also carried out according to recognised protocols, with test results falling within the acceptable range. Active components were measured using an approved UV spectrophotometric technique. This type of research is useful for determining the idealness of commercial products. KEYWORDS: Ramipril, In vitro evaluation, Dissolution study, Disintegration test
{"title":"COMPARATIVE IN VITRO EVALUATION OF SOME COMMERCIAL BRANDS OF RAMIPRIL TABLETS MARKETED IN INDIA","authors":"G. P D, S. K L, V. V, S. V, V. ., K. a, M. K, T. T","doi":"10.24092/crps.2022.120105","DOIUrl":"https://doi.org/10.24092/crps.2022.120105","url":null,"abstract":"The availability of several brands of Ramipril tablets in Indian pharmacies now poses a generic replacement concern for doctors. The goal of this study was to evaluate and compare different brands of Ramipril manufactured by various Indian pharmaceutical businesses under various trade names in order to reduce health risks and ensure the safety of local residents. General quality assessments of these tablets, such as diameter, thickness, hardness, weight variation, friability, disintegration, and dissolution tests, were also carried out according to recognised protocols, with test results falling within the acceptable range. Active components were measured using an approved UV spectrophotometric technique. This type of research is useful for determining the idealness of commercial products. KEYWORDS: Ramipril, In vitro evaluation, Dissolution study, Disintegration test","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87002855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-08DOI: 10.24092/crps.2021.110405
M. Pawar, Neelakantha Khadatar
Pathadisura [PS] is an ayurvedic fermented formulation, prescribed for respiratory disorders. It contains Suramanda prepared from (Rice grains), Guda (Jaggery) and herbal drugs viz Patha Murva, Rasna, Saral, Devdaru. The scientific preparation method and quality parameters of PS are not documented yet. Thus present study is aimed to develop and validate the preparation method and to generate quality standards for PS. Preparation of Sura, Suramanda and PS was done as per standard protocols of ayurvedic pharmaceutics blended with modern techniques. All herbal drugs, Sura and PS were tested with standard analytical methods. Obtained values for herbal drugs were within limits as per API standards, signify purity of plant materials. Study result provides organoleptic, physico-chemical values and gas chromatography quality standards for Sura and Pathadisura. Standard operating procedure for preparation of Sura and Pathadisura is developed and validated by using standard methods of analysis. It could be used in further studies. KEYWORDS: Pathadi Sura, Sura, Annamanda, Fermentation, GC Analysis.
{"title":"PROCESS VALIDATION AND GC ANALYSIS OF PATHADISURA, A FERMENTED AYURVEDIC PRODUCT USED IN SHWAS VYADHI [BRONCHIAL ASTHMA]","authors":"M. Pawar, Neelakantha Khadatar","doi":"10.24092/crps.2021.110405","DOIUrl":"https://doi.org/10.24092/crps.2021.110405","url":null,"abstract":"Pathadisura [PS] is an ayurvedic fermented formulation, prescribed for respiratory disorders. It contains Suramanda prepared from (Rice grains), Guda (Jaggery) and herbal drugs viz Patha Murva, Rasna, Saral, Devdaru. The scientific preparation method and quality parameters of PS are not documented yet. Thus present study is aimed to develop and validate the preparation method and to generate quality standards for PS. Preparation of Sura, Suramanda and PS was done as per standard protocols of ayurvedic pharmaceutics blended with modern techniques. All herbal drugs, Sura and PS were tested with standard analytical methods. Obtained values for herbal drugs were within limits as per API standards, signify purity of plant materials. Study result provides organoleptic, physico-chemical values and gas chromatography quality standards for Sura and Pathadisura. Standard operating procedure for preparation of Sura and Pathadisura is developed and validated by using standard methods of analysis. It could be used in further studies. KEYWORDS: Pathadi Sura, Sura, Annamanda, Fermentation, GC Analysis.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84060874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-08DOI: 10.24092/crps.2021.110404
Lakshita Rathore, Narendra Gehalot, V. Jain
The pharmaceutical industry is pursuing the development of thin films as a novel method of drug administration. Thin films as an alternative to standard dosage forms have been described. They are a very adaptable platform capable of producing immediate, local, or systemic effects. Additionally, these systems are self-administered, which is advantageous for patients with dysphagia, elderly, pediatric, or bedridden patients and those who cannot administer with water. Thin film drug delivery methods are available for oral, buccal, sublingual, ophthalmic, and transdermal administration. This review explores oral thin films in all of their elements from a contemporary standpoint and provides insight into the world's expanding market share due to the expansion of study areas and technical advancements. Simultaneously, it presents an overview of the essential parameters that affect formulation design that affects thin films, including thin-film design, anatomical and physiological constraints, and the selection of suitable manufacturing processes, characterization methodologies, and the physicochemical properties of polymers and drugs are all covered in this section. Additionally, it provides insight onto the most recent thin-films produced by various pharmaceutical companies. KEYWORDS: Fast dissolving films, patient compliance, dysphagia, oral, buccal,sublingual.
{"title":"A SHORT REVIEW ON ADVANCEMENT IN FAST DISSOLVING ORAL THIN FILMS","authors":"Lakshita Rathore, Narendra Gehalot, V. Jain","doi":"10.24092/crps.2021.110404","DOIUrl":"https://doi.org/10.24092/crps.2021.110404","url":null,"abstract":"The pharmaceutical industry is pursuing the development of thin films as a novel method of drug administration. Thin films as an alternative to standard dosage forms have been described. They are a very adaptable platform capable of producing immediate, local, or systemic effects. Additionally, these systems are self-administered, which is advantageous for patients with dysphagia, elderly, pediatric, or bedridden patients and those who cannot administer with water. Thin film drug delivery methods are available for oral, buccal, sublingual, ophthalmic, and transdermal administration. This review explores oral thin films in all of their elements from a contemporary standpoint and provides insight into the world's expanding market share due to the expansion of study areas and technical advancements. Simultaneously, it presents an overview of the essential parameters that affect formulation design that affects thin films, including thin-film design, anatomical and physiological constraints, and the selection of suitable manufacturing processes, characterization methodologies, and the physicochemical properties of polymers and drugs are all covered in this section. Additionally, it provides insight onto the most recent thin-films produced by various pharmaceutical companies. KEYWORDS: Fast dissolving films, patient compliance, dysphagia, oral, buccal,sublingual.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88805168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-08DOI: 10.24092/crps.2021.110402
Urvashi Vyas, Narendra Gehalot, V. Jain, S. Mahajan
Ophthalmic drug delivery systems are both fascinating and problematic due to the normal physiological properties of the eyes, which restrict ocular product bioavailability. The development of novel ocular dosage forms for current drugs in order to enhance efficacy and bioavailability, as well as patient compliance and convenience, has become a major focus in the pharmaceutical business. Ocular In-situ gelling systems are a novel type of eye drug delivery systems that begin as a solution but rapidly convert into a thick gel when implanted or inserted into an ocular cavity where active pharmaceuticals are continually delivered. This sol-to-gel phase conversion is influenced by a range of variables, including variations in pH, the presence of ions, and temperature fluctuations. Post-transplantation gel is chosen for its viscosity and bio adhesive qualities, which prolongs the gel's presence in the ocular area and also ensures that the medicine is released slowly and continuously, in contrast to typical eye drops and ointments. This article provides an overview of situ gels, their numerous techniques of gelling, the many types of polymers utilized in situ gels, their gel-based methodologies, and the polymeric testing of situ gels. KEYWORDS: Ophthalmic, In situ gel, bioavailability, polymers, novel, sol-to-gel phase
{"title":"A REVIEW ON IN SITU GELLING SYSTEM FOR OPHTHALMIC DRUG DELIVERY","authors":"Urvashi Vyas, Narendra Gehalot, V. Jain, S. Mahajan","doi":"10.24092/crps.2021.110402","DOIUrl":"https://doi.org/10.24092/crps.2021.110402","url":null,"abstract":"Ophthalmic drug delivery systems are both fascinating and problematic due to the normal physiological properties of the eyes, which restrict ocular product bioavailability. The development of novel ocular dosage forms for current drugs in order to enhance efficacy and bioavailability, as well as patient compliance and convenience, has become a major focus in the pharmaceutical business. Ocular In-situ gelling systems are a novel type of eye drug delivery systems that begin as a solution but rapidly convert into a thick gel when implanted or inserted into an ocular cavity where active pharmaceuticals are continually delivered. This sol-to-gel phase conversion is influenced by a range of variables, including variations in pH, the presence of ions, and temperature fluctuations. Post-transplantation gel is chosen for its viscosity and bio adhesive qualities, which prolongs the gel's presence in the ocular area and also ensures that the medicine is released slowly and continuously, in contrast to typical eye drops and ointments. This article provides an overview of situ gels, their numerous techniques of gelling, the many types of polymers utilized in situ gels, their gel-based methodologies, and the polymeric testing of situ gels. KEYWORDS: Ophthalmic, In situ gel, bioavailability, polymers, novel, sol-to-gel phase","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79958089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-08DOI: 10.24092/crps.2021.110403
Vishnu P. Tripathi, M. K. Aneebuddin, C. Alex, Keshav Moharir
"Liquid biopsy" concentrates on the identification of ‘Circulating Tumor Cells (CTC) as well as ‘Cell-free Tumor DNA’ (ctDNA) in the systemic circulation of individuals suffering from cancer, has received a lot of interest due to its evident clinical implications for individualized therapy. CTC and ctDNA studies have created fresh diagnostic approaches and are now the foundations of liquid biopsy. The existing study concentrates on cancer diagnoses, prognosis prediction in people having treatable diseases, observing systemic therapy, and patient categorization depending on the identification of aimed therapeutics or resistance mechanisms. Although the use of CTCs and ctDNA for initial cancer diagnosis is gaining popularity, existing techniques experience major challenges in terms of particularity and sensitivity. Prognosis projection in people with the treatable disease so far realized in some cancer entities, especially in breast cancer. Sequential assessments of CTCs or ctDNA can also be used to monitor the progress or non-success of systemic medicines (such as hormone and chemotherapy as well as various targeted therapies).To integrate liquid diagnostic tests into personalized medicine, interventional studies on therapy stratification based on CTC and ctDNA analyses are required. KEYWORDS: Tumor cells, DNA, Circulating cells, Chemotherapy, Liquid biopsy
{"title":"VALUATING CLINICAL APPLICATIONS OF LIQUID BIOPSY BY COMBINING CIRCULATING TUMOR DNA AND TUMOR CELLS","authors":"Vishnu P. Tripathi, M. K. Aneebuddin, C. Alex, Keshav Moharir","doi":"10.24092/crps.2021.110403","DOIUrl":"https://doi.org/10.24092/crps.2021.110403","url":null,"abstract":"\"Liquid biopsy\" concentrates on the identification of ‘Circulating Tumor Cells (CTC) as well as ‘Cell-free Tumor DNA’ (ctDNA) in the systemic circulation of individuals suffering from cancer, has received a lot of interest due to its evident clinical implications for individualized therapy. CTC and ctDNA studies have created fresh diagnostic approaches and are now the foundations of liquid biopsy. The existing study concentrates on cancer diagnoses, prognosis prediction in people having treatable diseases, observing systemic therapy, and patient categorization depending on the identification of aimed therapeutics or resistance mechanisms. Although the use of CTCs and ctDNA for initial cancer diagnosis is gaining popularity, existing techniques experience major challenges in terms of particularity and sensitivity. Prognosis projection in people with the treatable disease so far realized in some cancer entities, especially in breast cancer. Sequential assessments of CTCs or ctDNA can also be used to monitor the progress or non-success of systemic medicines (such as hormone and chemotherapy as well as various targeted therapies).To integrate liquid diagnostic tests into personalized medicine, interventional studies on therapy stratification based on CTC and ctDNA analyses are required. KEYWORDS: Tumor cells, DNA, Circulating cells, Chemotherapy, Liquid biopsy","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78232672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-08DOI: 10.24092/crps.2021.110401
Farida Nizami, Yogendra Malviya
Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermined release of two drugs in combination, separating two incompatible substances, and sustained-release tablets with one layer serving as the loading dose and the second layer serving as the maintenance dose. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. However, bilayer tablet technology is resource-intensive. A thorough selection of excipients and manufacturing conditions for each technical stage is also required. The purpose of this paper is to summarize the state of art in bilayer tablet technology and to highlight the difficulties encountered during bilayer tablet manufacture, as well as the possible solutions for these obstacles. KEYWORDS: Bilayer tablet, Conventional release, Controlled release, Sustained release, Maintenance dose
{"title":"RECENT ADVANCEMENT AND CHALLENGES IN BILAYER TABLET TECHNOLOGY: AN OVERVIEW","authors":"Farida Nizami, Yogendra Malviya","doi":"10.24092/crps.2021.110401","DOIUrl":"https://doi.org/10.24092/crps.2021.110401","url":null,"abstract":"Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermined release of two drugs in combination, separating two incompatible substances, and sustained-release tablets with one layer serving as the loading dose and the second layer serving as the maintenance dose. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. However, bilayer tablet technology is resource-intensive. A thorough selection of excipients and manufacturing conditions for each technical stage is also required. The purpose of this paper is to summarize the state of art in bilayer tablet technology and to highlight the difficulties encountered during bilayer tablet manufacture, as well as the possible solutions for these obstacles. KEYWORDS: Bilayer tablet, Conventional release, Controlled release, Sustained release, Maintenance dose","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88180196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-08DOI: 10.24092/crps.2021.110301
Prabhakar Maurya, M. Naim, R. K. Singh, J. Bashar, Radhe Shyam
Tulsi, the famous "unmatched" plant of India, is one of the most popular and beneficial of the numerous therapeutic and health-promoting herbs. Ayurvedic and Unani systems Medicinal natural products are increasingly being investigated in clinical trials for superior pharmacological responses and lack of side effects compared to symptomatic agents. Ocimum sanctum, often referred to as "Holy Basil" or "Tulsi," is known in the traditional Ayurvedic literature for its use in the treatment of many illnesses. The active ingredients obtained from plants, and their biological function in disease prevention have stimulated people's curiosity. This overview includes the nomenclature of plant vesicles, their components, and their use in the treatment of diseases. KEYWORDS: Illness, Ayurveda, Diseases, Treat, Tulsi, Natural product, Plant
{"title":"TULSI: A MIRACLE HERB USED IN THE TREATMENT OF MANY ILLNESSES: A REVIEW","authors":"Prabhakar Maurya, M. Naim, R. K. Singh, J. Bashar, Radhe Shyam","doi":"10.24092/crps.2021.110301","DOIUrl":"https://doi.org/10.24092/crps.2021.110301","url":null,"abstract":"Tulsi, the famous \"unmatched\" plant of India, is one of the most popular and beneficial of the numerous therapeutic and health-promoting herbs. Ayurvedic and Unani systems Medicinal natural products are increasingly being investigated in clinical trials for superior pharmacological responses and lack of side effects compared to symptomatic agents. Ocimum sanctum, often referred to as \"Holy Basil\" or \"Tulsi,\" is known in the traditional Ayurvedic literature for its use in the treatment of many illnesses. The active ingredients obtained from plants, and their biological function in disease prevention have stimulated people's curiosity. This overview includes the nomenclature of plant vesicles, their components, and their use in the treatment of diseases. KEYWORDS: Illness, Ayurveda, Diseases, Treat, Tulsi, Natural product, Plant","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90918860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-08DOI: 10.24092/crps.2021.110302
Mohit Gupta, R. Shekhar, J. Sahu
Central nervous system (CNS) stimulants are drugs, which produce a response that could be used to alleviate a particular medical condition. These are the agents, which speed up to treat conditions characterized by lack of adrenergic stimulation, including narcolepsy and neonatal apnea. The majority of CNS stimulants is chemically similar to the neurohormone norepinephrine and simulates the traditional "fight or flight" syndrome associated with sympathetic nervous system arousal. A small figure of added members of the CNS stimulant class do not fall into definite chemical groups. The review on central nervous system stimulants gives detail study of CNS stimulant drugs, their mechanism of action and in vivo models of CNS stimulants. The brain is a delicate tissue, and advancement built very effective methods to guard it. Unfortunately, the same mechanisms that protect it against intrusive chemicals can also upset therapeutic interventions. Many current medications are rendered unsuccessful in the treatment of cerebral maladies due to our incapability to efficiently deliver and sustain them within the brain. KEYWORDS: CNS Stimulants, Blood brain barrier (BBB), Drug toxicity, Drug Safety
{"title":"ROLE OF DRUG DISCOVERY IN CENTRAL NERVOUS SYSTEM DISORDERS: AN OVERVIEW","authors":"Mohit Gupta, R. Shekhar, J. Sahu","doi":"10.24092/crps.2021.110302","DOIUrl":"https://doi.org/10.24092/crps.2021.110302","url":null,"abstract":"Central nervous system (CNS) stimulants are drugs, which produce a response that could be used to alleviate a particular medical condition. These are the agents, which speed up to treat conditions characterized by lack of adrenergic stimulation, including narcolepsy and neonatal apnea. The majority of CNS stimulants is chemically similar to the neurohormone norepinephrine and simulates the traditional \"fight or flight\" syndrome associated with sympathetic nervous system arousal. A small figure of added members of the CNS stimulant class do not fall into definite chemical groups. The review on central nervous system stimulants gives detail study of CNS stimulant drugs, their mechanism of action and in vivo models of CNS stimulants. The brain is a delicate tissue, and advancement built very effective methods to guard it. Unfortunately, the same mechanisms that protect it against intrusive chemicals can also upset therapeutic interventions. Many current medications are rendered unsuccessful in the treatment of cerebral maladies due to our incapability to efficiently deliver and sustain them within the brain. KEYWORDS: CNS Stimulants, Blood brain barrier (BBB), Drug toxicity, Drug Safety","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82069536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-08DOI: 10.24092/crps.2021.110203
Arti Choursiya, D. Pandit
The present study was focused on preparation and evaluation of Lanzoprazole fast dissolving tablets. Lansoprazole (LAN) is a proton pump inhibitor drug and used for the treatment of gastric ulcer. Lansoprazole is acid labile drug and to avoid the acidic pH of the stomach LAN is formulated as oral fast dissolving tablets. Lansoprazole is the class II drug of the BCS classification and has a low aqueous solubility. Hence, to improve the solubility of the drug we have prepared Lansoprazole solid dispersion with poly ethylene glycol and complex with β cyclodextrin. Fast Dissolving tablets of LAN were formulated using different superdisintegrants like Sodium Starch Glycolate, Cross Povidone, Cross Carmellose Sodium by direct compression method. The prepared fast dissolving tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug content, wetting time, in-vitro drug release and short term stability studies. Percentage weight variation, hardness, friability and drug content uniformity were found to be within the approved range for all the formulations. The in-vitro release studies showed that 99.6% of LAN within 90 sec. Overall, in the formulations prepared by the direct compression method, F3, which contains 6% CCS as super disintegrants release 99% of (LAN) in 2 min was found to be the best formulation. The results concluded that fast dissolving tablets of LAN showing enhanced dissolution might lead to improved bioavailability and effective therapy for gastric ulcer. KEYWORDS: β cyclodextrin, Cross Povidone, Fast dissolving tablets, Gastric ulcer, Lanzoprazole, Solid dispersion
{"title":"FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LANSOPRAZOLE BY SOLUBILITY ENHANCEMENT TECHNIQUE","authors":"Arti Choursiya, D. Pandit","doi":"10.24092/crps.2021.110203","DOIUrl":"https://doi.org/10.24092/crps.2021.110203","url":null,"abstract":"The present study was focused on preparation and evaluation of Lanzoprazole fast dissolving tablets. Lansoprazole (LAN) is a proton pump inhibitor drug and used for the treatment of gastric ulcer. Lansoprazole is acid labile drug and to avoid the acidic pH of the stomach LAN is formulated as oral fast dissolving tablets. Lansoprazole is the class II drug of the BCS classification and has a low aqueous solubility. Hence, to improve the solubility of the drug we have prepared Lansoprazole solid dispersion with poly ethylene glycol and complex with β cyclodextrin. Fast Dissolving tablets of LAN were formulated using different superdisintegrants like Sodium Starch Glycolate, Cross Povidone, Cross Carmellose Sodium by direct compression method. The prepared fast dissolving tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug content, wetting time, in-vitro drug release and short term stability studies. Percentage weight variation, hardness, friability and drug content uniformity were found to be within the approved range for all the formulations. The in-vitro release studies showed that 99.6% of LAN within 90 sec. Overall, in the formulations prepared by the direct compression method, F3, which contains 6% CCS as super disintegrants release 99% of (LAN) in 2 min was found to be the best formulation. The results concluded that fast dissolving tablets of LAN showing enhanced dissolution might lead to improved bioavailability and effective therapy for gastric ulcer. KEYWORDS: β cyclodextrin, Cross Povidone, Fast dissolving tablets, Gastric ulcer, Lanzoprazole, Solid dispersion","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81455625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-08DOI: 10.24092/crps.2021.110202
Prabhakar Maurya, M. Naim, N. Sharma
Using simple, precise, and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method, the synchronous of lornoxicam (LOR) and paracetamol (PCM) in the unite dosage form in the tablet has been established and confirmed. Acetonitrile: methanol: water is the mobile phase of the RP-HPLC method (pH adjusted with orthophosphoric acid), pH 3.8 (50:30:20 v/v/v), a diode array detector tuned to 290 nm was used to detect the signal. For LOR and PCM, chromatographic technique linearity was obtained in the concentration, ranges of 2-40 and 8–150 g/mL, respectively. In HPLC techniques, the recoveries were in the range of 99.85 0.0642 percent for LOR and 99.73 0.187 percent for PCM. Both approaches may be used to analyze the medicines in a pharmaceutical formulation regularly. The results of the analysis were statistically verified. KEYWORDS: linearity, validation, oxicam, N-methyl Aspartate
{"title":"SIMULTANEOUS ESTIMATION OF LORNOXICAM AND PARACETAMOL IN COMBINED TABLET DOSAGE FORM USING REVERSE PHASE HIGH- PERFORMANCE LIQUID CHROMATOGRAPHY METHOD","authors":"Prabhakar Maurya, M. Naim, N. Sharma","doi":"10.24092/crps.2021.110202","DOIUrl":"https://doi.org/10.24092/crps.2021.110202","url":null,"abstract":"Using simple, precise, and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method, the synchronous of lornoxicam (LOR) and paracetamol (PCM) in the unite dosage form in the tablet has been established and confirmed. Acetonitrile: methanol: water is the mobile phase of the RP-HPLC method (pH adjusted with orthophosphoric acid), pH 3.8 (50:30:20 v/v/v), a diode array detector tuned to 290 nm was used to detect the signal. For LOR and PCM, chromatographic technique linearity was obtained in the concentration, ranges of 2-40 and 8–150 g/mL, respectively. In HPLC techniques, the recoveries were in the range of 99.85 0.0642 percent for LOR and 99.73 0.187 percent for PCM. Both approaches may be used to analyze the medicines in a pharmaceutical formulation regularly. The results of the analysis were statistically verified. KEYWORDS: linearity, validation, oxicam, N-methyl Aspartate","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81033920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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