Pub Date : 2018-10-08DOI: 10.24092/CRPS.2018.080303
P. Sivakumar, A. Ahuja, T. Venkatachalam
Introduction: Tuberculosis (TB) is an infectious disease caused by Mycobacterium Tuberculosis, is the second leading infectious cause of death in world. The study was carried out in the DOTS centre in Coimbatore region.Material and Methods: It was a cross – sectional observational, descriptive epidemiological study. This study was a humble effort to throw light on sociodemographic profile, knowledge and awareness regarding TB among patients with TB. Results and Discussion: A total of 300 patients were included in the study. Majority of the cases (31.66%) belongs to the age groups of 21-40 years. Out of 300 patients, 223 (74.33%) of patients had aware on the aetiology of tuberculosis. Most of the patients 210 (70.00%) were aware of fact that Tuberculosis could be transmitted from one person to another person via coughing and close contact. About 196 (65.33%) of patients had the knowledge about the importance of BCG vaccine for Tuberculosis. Conclusion: Apart from pharmacological treatment, poor knowledge of TB among patients on TB also needs great attention.
{"title":"A Study of Sociodemographic Profile, Awareness and Knowledge about Tuberculosis in Patients of Tuberculosis at Dots Centre","authors":"P. Sivakumar, A. Ahuja, T. Venkatachalam","doi":"10.24092/CRPS.2018.080303","DOIUrl":"https://doi.org/10.24092/CRPS.2018.080303","url":null,"abstract":"Introduction: Tuberculosis (TB) is an infectious disease caused by Mycobacterium Tuberculosis, is the second leading infectious cause of death in world. The study was carried out in the DOTS centre in Coimbatore region.Material and Methods: It was a cross – sectional observational, descriptive epidemiological study. This study was a humble effort to throw light on sociodemographic profile, knowledge and awareness regarding TB among patients with TB. Results and Discussion: A total of 300 patients were included in the study. Majority of the cases (31.66%) belongs to the age groups of 21-40 years. Out of 300 patients, 223 (74.33%) of patients had aware on the aetiology of tuberculosis. Most of the patients 210 (70.00%) were aware of fact that Tuberculosis could be transmitted from one person to another person via coughing and close contact. About 196 (65.33%) of patients had the knowledge about the importance of BCG vaccine for Tuberculosis. Conclusion: Apart from pharmacological treatment, poor knowledge of TB among patients on TB also needs great attention.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87314227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-08DOI: 10.24092/crps.2018.080301
P. Pawar, G. Varsha
The aim of these research of an oral colon specific, pulsatile device to attain time and or site specific release of Mesalamine, based on chronopharmaceutical consideration. The basic design consists of an insoluble hard gelatin capsule body, filled with Eudragit microcapsules of Mesalamine and sealed with a hydrogel plug. The entire device was enteric coated, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The Mesalamine microcapsules were prepared in three batches, with Eudragit L-100 and S-100 (1:2) by changing drug to polymer ratio and evaluated for the particle size, drug content and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of pulsatile capsule. Different hydrogel polymers were used as plugs, to maintain a suitable lag period and it was found that the drug release was controlled by the proportion of polymers used. In vitro release studies of pulsatile device revealed that, increasing the hydrophilic polymer content resulted in delayed release of Mesalamine from microcapsules. Pulsatile, colon-specific release has been achieved from a capsule device over a 2–24 h period, consistent with the demands of chronotherapeutic drug delivery.
{"title":"Formulation and Evaluation of Mesalamine Loaded pH Dependent Colon Specific Pulsatile Drug Delivery System","authors":"P. Pawar, G. Varsha","doi":"10.24092/crps.2018.080301","DOIUrl":"https://doi.org/10.24092/crps.2018.080301","url":null,"abstract":"The aim of these research of an oral colon specific, pulsatile device to attain time and or site specific release of Mesalamine, based on chronopharmaceutical consideration. The basic design consists of an insoluble hard gelatin capsule body, filled with Eudragit microcapsules of Mesalamine and sealed with a hydrogel plug. The entire device was enteric coated, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The Mesalamine microcapsules were prepared in three batches, with Eudragit L-100 and S-100 (1:2) by changing drug to polymer ratio and evaluated for the particle size, drug content and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of pulsatile capsule. Different hydrogel polymers were used as plugs, to maintain a suitable lag period and it was found that the drug release was controlled by the proportion of polymers used. In vitro release studies of pulsatile device revealed that, increasing the hydrophilic polymer content resulted in delayed release of Mesalamine from microcapsules. Pulsatile, colon-specific release has been achieved from a capsule device over a 2–24 h period, consistent with the demands of chronotherapeutic drug delivery.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77591303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-08DOI: 10.24092/CRPS.2018.080302
Alok Sharma, Sneha Babele, K. Shukla, S. Mahajan
Tailas or oils are important group of formulations used by Ayurvedic physicians to treat various types of diseases. Mahanarayan massages oils formulation which is used for the treatment of arthritis, Paralysis, and other joint related disorders. It also helps to stimulate the internal functions of the body while providing nourishment to different body tissues. Oils also lubricate to skin and tissue. The Present work was conducted to standardize the selected five marketed Mahanarayan massages oils for their physicochemical parameters, i.e. color, odor, pH, specific gravity, acid value, peroxide value and saponification value. The findings of the study showed that Mahanarayan massages oils were complies the requirements for physicochemical parameters as prescribed in standard text.
{"title":"Comparative Assessment of Some Physicochemical Properties of marketed Ayurvedic Mahanarayan massage oils","authors":"Alok Sharma, Sneha Babele, K. Shukla, S. Mahajan","doi":"10.24092/CRPS.2018.080302","DOIUrl":"https://doi.org/10.24092/CRPS.2018.080302","url":null,"abstract":"Tailas or oils are important group of formulations used by Ayurvedic physicians to treat various types of diseases. Mahanarayan massages oils formulation which is used for the treatment of arthritis, Paralysis, and other joint related disorders. It also helps to stimulate the internal functions of the body while providing nourishment to different body tissues. Oils also lubricate to skin and tissue. The Present work was conducted to standardize the selected five marketed Mahanarayan massages oils for their physicochemical parameters, i.e. color, odor, pH, specific gravity, acid value, peroxide value and saponification value. The findings of the study showed that Mahanarayan massages oils were complies the requirements for physicochemical parameters as prescribed in standard text.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79192587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-08DOI: 10.24092/CRPS.2018.080203
A. Dixit, H. Sharma
The aim of investigation is to develop the effective delivery system for pain management of rheumatic disorders. The mouth dissolving tablets (MDTs) containing flurbiprofen was developed in order to accomplish enhanced solubility leading to better bioavailability profile. Different ratios, of flurbiprofen and Poly ethylene glycol 6000 i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were selected for the formulation of mouth dissolving tablets system and prepared by direct compression technique. The prepared batches of mouth dissolving tablets were characterized for thickness, hardness, weight variation, wetting time, disintegration time and drug content. The evaluation data for all batches was satisfactory out of them formulation C3 containing 6% MCC PH- 102 (Avicel) showed the best results with a value of 27.3 sec and 37.1 sec for wetting and disintegration, respectively.
{"title":"Preparation and Evaluation of Mouth Dissolving Tablets of Flurbiprofen","authors":"A. Dixit, H. Sharma","doi":"10.24092/CRPS.2018.080203","DOIUrl":"https://doi.org/10.24092/CRPS.2018.080203","url":null,"abstract":"The aim of investigation is to develop the effective delivery system for pain management of rheumatic disorders. The mouth dissolving tablets (MDTs) containing flurbiprofen was developed in order to accomplish enhanced solubility leading to better bioavailability profile. Different ratios, of flurbiprofen and Poly ethylene glycol 6000 i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were selected for the formulation of mouth dissolving tablets system and prepared by direct compression technique. The prepared batches of mouth dissolving tablets were characterized for thickness, hardness, weight variation, wetting time, disintegration time and drug content. The evaluation data for all batches was satisfactory out of them formulation C3 containing 6% MCC PH- 102 (Avicel) showed the best results with a value of 27.3 sec and 37.1 sec for wetting and disintegration, respectively.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83469537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-08DOI: 10.24092/crps.2018.080202
V. Dave, A. Mishra
Buccal films show rapid dissolution along with it also used to avoid first pass metabolism of the drug entrapped in the buccal film formulation because they get absorbed through buccal mucosa .The aim of present investigation was to explore the use of honey a plasticizers, compared with PEG400 as plasticizer. Film of Fentanyl Citrate a narcotic opoid analgesic for cancer breakthrough pain is formulated by solvent casting method using HPMC E15 as a film forming agent, Honey and PEG400 as plasticizers and Sodium Starch Glycolate as superdisintigrant. All the formulations were evaluated on the basis of Tensile strength, %Elongation, in-vitro drug release and folding endurance . Through optimization F3 and F6 proved to be best formulation through which formulation with PEG400 proved better than with honey. But honey as plasticizers gives satisfactory result and can be used further for formulating film with natural plasticizer.
{"title":"Formulation of Buccal Strips using PEG 400 and Honey as a Plasticizers","authors":"V. Dave, A. Mishra","doi":"10.24092/crps.2018.080202","DOIUrl":"https://doi.org/10.24092/crps.2018.080202","url":null,"abstract":"Buccal films show rapid dissolution along with it also used to avoid first pass metabolism of the drug entrapped in the buccal film formulation because they get absorbed through buccal mucosa .The aim of present investigation was to explore the use of honey a plasticizers, compared with PEG400 as plasticizer. Film of Fentanyl Citrate a narcotic opoid analgesic for cancer breakthrough pain is formulated by solvent casting method using HPMC E15 as a film forming agent, Honey and PEG400 as plasticizers and Sodium Starch Glycolate as superdisintigrant. All the formulations were evaluated on the basis of Tensile strength, %Elongation, in-vitro drug release and folding endurance . Through optimization F3 and F6 proved to be best formulation through which formulation with PEG400 proved better than with honey. But honey as plasticizers gives satisfactory result and can be used further for formulating film with natural plasticizer.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89277994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-08DOI: 10.24092/CRPS.2018.080201
P. Patil, V. Chatap, Mahesh P. More, Z. Khan
The present study provides a high degree of assurance that a specific process for manufacturing of Glibenclamide Tablets will consistently produce a product meeting its predetermined quality attributes and specifications. It mainly comprises the stages to be followed to evaluate and qualify the acceptability of manufacturing process of Glibenclamide 2.5 mg tablets. The process is limited to the three batches manufactured of specific batch size with specified equipments and control parameters for tablets. It involves All parameters related to the each step were evaluated by respective standard test involved in the manufacturing. Sampling, testing plan and acceptance criteria for each step were monitored. The analytical results of all stages were found to be within the acceptable limit. Other tests related to compression such as hardness, thickness, disintegration and dissolution for all three batches were found within the acceptable limit.
{"title":"Prospective Process Validation Study of Glibenclamide 2.5 mg Tablets","authors":"P. Patil, V. Chatap, Mahesh P. More, Z. Khan","doi":"10.24092/CRPS.2018.080201","DOIUrl":"https://doi.org/10.24092/CRPS.2018.080201","url":null,"abstract":"The present study provides a high degree of assurance that a specific process for manufacturing of Glibenclamide Tablets will consistently produce a product meeting its predetermined quality attributes and specifications. It mainly comprises the stages to be followed to evaluate and qualify the acceptability of manufacturing process of Glibenclamide 2.5 mg tablets. The process is limited to the three batches manufactured of specific batch size with specified equipments and control parameters for tablets. It involves All parameters related to the each step were evaluated by respective standard test involved in the manufacturing. Sampling, testing plan and acceptance criteria for each step were monitored. The analytical results of all stages were found to be within the acceptable limit. Other tests related to compression such as hardness, thickness, disintegration and dissolution for all three batches were found within the acceptable limit.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"193 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75851531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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