Pub Date : 2023-01-08DOI: 10.24092/crps.2022.120403
Pradyumna Ghosal, S. S
Quality is of principal subject to human beings in all perspective of life. When it comes to the quality of the pharmaceuticals which are consumed by humans, it is of most extreme significant as they are utilized for the prosperity of the humanity. In this study our objective was to evaluate the experimental in vitro study of the commercially obtainable Diclofenac Sodium injection brands which are available in Greater Noida. Ten different ampoules of 75mg/3ml diclofenac sodium injection products randomly collected from retail pharmacies and Govt. Hospital of targeted area in Greater Noida, Uttar Pradesh, India, twenty ampoules 75 mg/3ml have the same batch number of each brand were collected for the analysis. All the analytical methods were done in the quality control laboratories of JBJM Parenteral Pvt Ltd, Greater Noida, Uttar Pradesh, India. The study was carried out by performing various tests which is affiliated with the quality such asgeneral appearance of Diclofenac Sodium injection ampoule, Particulate matter, Average fill volume, pH and content assay through pH Meter (Spectra lab), UV-Vis Spectrophotometer (UV-1900i SHIMADZU). The assay was evaluated by UV-Vis Spectrophotometer at the wavelength of 276nm. The results show that diclofenac sodium injection following IP specification, it can be concluded that all of the 10 brands of the drug passed through UV-Vis spectroscopy method also in pH meter. The Spectroscopy method was successfully applied to evaluate of Diclofenac Sodium injection. KEYWORDS: In vitro evaluation, Diclofenac sodium injection, UV-Vis Spectroscopy, pH, Analytical method, Pharmaceutical analysis, SHIMADZU, Greater Noida, Spectroscopy, Quality evaluation
{"title":"IN VITRO EVALUATION OF SOME BRANDS OF DICLOFENAC SODIUM INJECTION MARKETED IN GREATER NOIDA, UTTAR PRADESH, INDIA USING UV-VIS SPECTROPHOTOMETRIC METHOD","authors":"Pradyumna Ghosal, S. S","doi":"10.24092/crps.2022.120403","DOIUrl":"https://doi.org/10.24092/crps.2022.120403","url":null,"abstract":"Quality is of principal subject to human beings in all perspective of life. When it comes to the quality of the pharmaceuticals which are consumed by humans, it is of most extreme significant as they are utilized for the prosperity of the humanity. In this study our objective was to evaluate the experimental in vitro study of the commercially obtainable Diclofenac Sodium injection brands which are available in Greater Noida. Ten different ampoules of 75mg/3ml diclofenac sodium injection products randomly collected from retail pharmacies and Govt. Hospital of targeted area in Greater Noida, Uttar Pradesh, India, twenty ampoules 75 mg/3ml have the same batch number of each brand were collected for the analysis. All the analytical methods were done in the quality control laboratories of JBJM Parenteral Pvt Ltd, Greater Noida, Uttar Pradesh, India. The study was carried out by performing various tests which is affiliated with the quality such asgeneral appearance of Diclofenac Sodium injection ampoule, Particulate matter, Average fill volume, pH and content assay through pH Meter (Spectra lab), UV-Vis Spectrophotometer (UV-1900i SHIMADZU). The assay was evaluated by UV-Vis Spectrophotometer at the wavelength of 276nm. The results show that diclofenac sodium injection following IP specification, it can be concluded that all of the 10 brands of the drug passed through UV-Vis spectroscopy method also in pH meter. The Spectroscopy method was successfully applied to evaluate of Diclofenac Sodium injection. KEYWORDS: In vitro evaluation, Diclofenac sodium injection, UV-Vis Spectroscopy, pH, Analytical method, Pharmaceutical analysis, SHIMADZU, Greater Noida, Spectroscopy, Quality evaluation","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87528969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-08DOI: 10.24092/crps.2022.120401
Nandini Chaudhary, B. Yadav, Rajneesh Kumar, Arti Sinoria, Amresh Gupta
Automated dispensing systems have been applied for maintaining medication safety, improving drug distribution, and reducing the risk of medication errors in different pharmacy practice. Automated dispensing machines maintain the balance of accessibility, stock control of medications, and protection which were the main features of a safe medication distribution system. It should be linked with medication review and regular patient counselling. Encourage the timely administration of drugs through expanding their access to patient care units and first-dose availability was improved in automated dispensing machines. Physicians allow treatment efficiently by providing convenient access to medications of critically ill patients for emergencies during and after pharmacy hours with automated dispensing machines. This investigation demonstrates that the nature of pharmacotherapy for patients with automated dose dispensing can be improved. This study highlights the impact of an automated dispensing system in primary healthcare, Automated Dispensing Cabinets, or, in an intensive care unit to reduce medication errors. Implementation of automated dispensing systems reduces dispensing errors and gives pharmacists more time to review patient profiles. It recommends that every patient with automatic dose dispensing ought to go through a careful medication review through prescribers and pharmacists. It concluded that the automatic drug dispensing focuses on the effect of a medication review in patients. The ideal recurrence for conducting medication reviews and follow-up will likely contrast between individual patients. Hence, it provides an insight data on medication safety based on the automated dispensing system in accordance with drug complications. KEYWORDS: Automated dose dispensing, Medication safety, Drug complication, Impact, Evaluation, Insight report on medication safety
{"title":"AN INSIGHT DATA ON MEDICATION SAFETY IN ACCORDANCE WITH DRUG COMPLICATIONS BASED ON THE AUTOMATED DISPENSING SYSTEM","authors":"Nandini Chaudhary, B. Yadav, Rajneesh Kumar, Arti Sinoria, Amresh Gupta","doi":"10.24092/crps.2022.120401","DOIUrl":"https://doi.org/10.24092/crps.2022.120401","url":null,"abstract":"Automated dispensing systems have been applied for maintaining medication safety, improving drug distribution, and reducing the risk of medication errors in different pharmacy practice. Automated dispensing machines maintain the balance of accessibility, stock control of medications, and protection which were the main features of a safe medication distribution system. It should be linked with medication review and regular patient counselling. Encourage the timely administration of drugs through expanding their access to patient care units and first-dose availability was improved in automated dispensing machines. Physicians allow treatment efficiently by providing convenient access to medications of critically ill patients for emergencies during and after pharmacy hours with automated dispensing machines. This investigation demonstrates that the nature of pharmacotherapy for patients with automated dose dispensing can be improved. This study highlights the impact of an automated dispensing system in primary healthcare, Automated Dispensing Cabinets, or, in an intensive care unit to reduce medication errors. Implementation of automated dispensing systems reduces dispensing errors and gives pharmacists more time to review patient profiles. It recommends that every patient with automatic dose dispensing ought to go through a careful medication review through prescribers and pharmacists. It concluded that the automatic drug dispensing focuses on the effect of a medication review in patients. The ideal recurrence for conducting medication reviews and follow-up will likely contrast between individual patients. Hence, it provides an insight data on medication safety based on the automated dispensing system in accordance with drug complications. KEYWORDS: Automated dose dispensing, Medication safety, Drug complication, Impact, Evaluation, Insight report on medication safety","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"508 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91521087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-08DOI: 10.24092/crps.2022.120301
Shambhvi Singh, I. Singh
Emulgels are a new drug delivery technology for hydrophobic drugs that have received popularity in recent years. This formulation is a blend of emulsion and gel, and it is an innovative type of drug delivery mechanism. The goal of this review is to gain insight into emulgel preparation and evaluation to determine how essential these dosage forms are. It will be widely utilized in the future since it is simple to use and improves patient compliance. Emulgels are readily removed, spreadable, thixotropic, greaseless, pleasant, emollient, have a long shelf life, and are clear. Gels have several advantages, but their delivery of hydrophobic agents is one of them. To solve this constraint, an emulsion-based technique is being developed. Emulgel is a unique topical medication delivery technology since it has both a gel and an emulsion release control system. When emulsions are mixed with gel as a form of administration, an emulgel with the dual release is created. Polymers with better release patterns have emerged as a consequence of this method, allowing for a controlled and extended-release. KEYWORDS: Emulgel, gelling agent, polymers, emulsions, herbal emulgel
{"title":"EVOLVING IMPLEMENTATION OF EMULGEL AS A TOPICAL DRUG DELIVERY SYSTEM: A SYSTEMATIC REVIEW","authors":"Shambhvi Singh, I. Singh","doi":"10.24092/crps.2022.120301","DOIUrl":"https://doi.org/10.24092/crps.2022.120301","url":null,"abstract":"Emulgels are a new drug delivery technology for hydrophobic drugs that have received popularity in recent years. This formulation is a blend of emulsion and gel, and it is an innovative type of drug delivery mechanism. The goal of this review is to gain insight into emulgel preparation and evaluation to determine how essential these dosage forms are. It will be widely utilized in the future since it is simple to use and improves patient compliance. Emulgels are readily removed, spreadable, thixotropic, greaseless, pleasant, emollient, have a long shelf life, and are clear. Gels have several advantages, but their delivery of hydrophobic agents is one of them. To solve this constraint, an emulsion-based technique is being developed. Emulgel is a unique topical medication delivery technology since it has both a gel and an emulsion release control system. When emulsions are mixed with gel as a form of administration, an emulgel with the dual release is created. Polymers with better release patterns have emerged as a consequence of this method, allowing for a controlled and extended-release. KEYWORDS: Emulgel, gelling agent, polymers, emulsions, herbal emulgel","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82511660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-08DOI: 10.24092/crps.2022.120302
A. Chauhan, Shikhabaghel Chauhan
Skin disease is a persistent inflammatory skin disorder that affects around 70% of teenage females throughout puberty. To counteract this problem, antibiotics are being administered more often, which has resulted in a variety of undesirable side effects. As a result, as a first-line topical therapy, it must target on the herbal formulation. In this study, medicinal plant extracts and oils with high antibacterial activity, such as Curcuma longa and Aloe barbadensis, tea tree oil, and lemongrass oil, were chosen to produce a polyherbal emulgel for the treatment of acne vulgaris. Curcuma longa, Aloe barbadensis, tea tree oil, and lemongrass oil were all extracted and reported in this study. Lemongrass oil, tea tree oil, aloe Vera extract, and turmeric extract were used in various amounts in the topical gels. After being kept at room temperature for 24 hours, the gel was prepared and evaluated. As a result of the study's findings, a prepared polyherbal emulgel containing extracts of Curcuma longa, lemon grass oil and tea tree oil at concentrations of 0.5 percent, 5 percent, 5 percent respectively, can be used to treat acne vulgaris. KEYWORDS: Polyherbal emulgel, Anti-acne formulation, Acne vulgaris, Curcuma longa, lemongrass oil, tea tree oil
{"title":"FORMULATION AND EVALUATION OF POLYHERBAL EMULGEL FOR TREATMENT OF ACNE","authors":"A. Chauhan, Shikhabaghel Chauhan","doi":"10.24092/crps.2022.120302","DOIUrl":"https://doi.org/10.24092/crps.2022.120302","url":null,"abstract":"Skin disease is a persistent inflammatory skin disorder that affects around 70% of teenage females throughout puberty. To counteract this problem, antibiotics are being administered more often, which has resulted in a variety of undesirable side effects. As a result, as a first-line topical therapy, it must target on the herbal formulation. In this study, medicinal plant extracts and oils with high antibacterial activity, such as Curcuma longa and Aloe barbadensis, tea tree oil, and lemongrass oil, were chosen to produce a polyherbal emulgel for the treatment of acne vulgaris. Curcuma longa, Aloe barbadensis, tea tree oil, and lemongrass oil were all extracted and reported in this study. Lemongrass oil, tea tree oil, aloe Vera extract, and turmeric extract were used in various amounts in the topical gels. After being kept at room temperature for 24 hours, the gel was prepared and evaluated. As a result of the study's findings, a prepared polyherbal emulgel containing extracts of Curcuma longa, lemon grass oil and tea tree oil at concentrations of 0.5 percent, 5 percent, 5 percent respectively, can be used to treat acne vulgaris. KEYWORDS: Polyherbal emulgel, Anti-acne formulation, Acne vulgaris, Curcuma longa, lemongrass oil, tea tree oil","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91026425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-08DOI: 10.24092/crps.2022.120204
Guman Singh Rana, D. Basedia, B. Dubey, Sandra
The present investigation was carried out with an objective to evaluate and establish the anti epileptic action of ethanolic extract of Thuja occidentalis leaf. The ethanolic extraction was carried out using soxhlet apparatus and the yield of extract was obtained to be 34.1 %. The findings of the phytochemical analysis suggest the presence of alkaloids, phenolics, terpenoids, sterols, and flavonoids in the ethanolic extract leaves. The total flavonoid content of the extract was determined as quercetin equivalent and was found to be 0.497 mg/100 mg quercetin equivalent. The acute toxicity study revealed a dose of 750 mg/kg body weight as maximum safe dose. The anticonvulsant action was determined using maximal electroshock induced seizure model and pilocarpine induced convulsions model. Two different dose levels (75 mg/kg and 150 mg/kg body weight) of Thuja occidentalis leaf extract were selected for evaluation of the antiepileptic action. The results indicated that the extract of Thuja occidentalis leaf was able to decrease the onset of hind limb extension significantly and also it abolished the occurrence of clonus in the test animals. Key words: Thuja occidentalis, extract, epilepsy, pilocarpine, latency.
{"title":"Evaluation of Antiepileptic Potential of Ethanolic Extract of Thuja Occidentalis Leaves in Mice","authors":"Guman Singh Rana, D. Basedia, B. Dubey, Sandra","doi":"10.24092/crps.2022.120204","DOIUrl":"https://doi.org/10.24092/crps.2022.120204","url":null,"abstract":"The present investigation was carried out with an objective to evaluate and establish the anti epileptic action of ethanolic extract of Thuja occidentalis leaf. The ethanolic extraction was carried out using soxhlet apparatus and the yield of extract was obtained to be 34.1 %. The findings of the phytochemical analysis suggest the presence of alkaloids, phenolics, terpenoids, sterols, and flavonoids in the ethanolic extract leaves. The total flavonoid content of the extract was determined as quercetin equivalent and was found to be 0.497 mg/100 mg quercetin equivalent. The acute toxicity study revealed a dose of 750 mg/kg body weight as maximum safe dose. The anticonvulsant action was determined using maximal electroshock induced seizure model and pilocarpine induced convulsions model. Two different dose levels (75 mg/kg and 150 mg/kg body weight) of Thuja occidentalis leaf extract were selected for evaluation of the antiepileptic action. The results indicated that the extract of Thuja occidentalis leaf was able to decrease the onset of hind limb extension significantly and also it abolished the occurrence of clonus in the test animals. Key words: Thuja occidentalis, extract, epilepsy, pilocarpine, latency.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74786962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-08DOI: 10.24092/crps.2022.120205
Jainul Basher, Prabhakar Maurya, Radheshyam
Plants have had an essential role in the folklore of ancient culture. In addition to the use as food and spices, plants have also been utilized as medicines for over 5000 years. Herbal products such as plant extracts, dry powder and parts of plants, fungi, and algae have been used as complementary treatments alongside conventional drugs. Cancer is a severe metabolic syndrome and is one of the leading causes of death regardless of developments in the tools of disease diagnosis, treatment and prevention measures. Cancer is one of the principal causes of mortality and morbidity around the globe and the number of cases are constantly increasing estimated to be 21 million by 2030. Several medicinal plant species and their phytochemicals inhibit the progression and development of cancer. In the present work In vitro anti cancer activity of gamma oryzanol was performed using SRB assay. Result shown that gamma oryzanol has anti cancer activity for SKMEL-2 cancerous cell line. On the basis of this result further study plan can be designed. Key words: Cancer, Gamma oryzanol, Phytochemicals.
{"title":"In Vitro Anticancer Activity of Gamma Oryzanol in Skin Cancer","authors":"Jainul Basher, Prabhakar Maurya, Radheshyam","doi":"10.24092/crps.2022.120205","DOIUrl":"https://doi.org/10.24092/crps.2022.120205","url":null,"abstract":"Plants have had an essential role in the folklore of ancient culture. In addition to the use as food and spices, plants have also been utilized as medicines for over 5000 years. Herbal products such as plant extracts, dry powder and parts of plants, fungi, and algae have been used as complementary treatments alongside conventional drugs. Cancer is a severe metabolic syndrome and is one of the leading causes of death regardless of developments in the tools of disease diagnosis, treatment and prevention measures. Cancer is one of the principal causes of mortality and morbidity around the globe and the number of cases are constantly increasing estimated to be 21 million by 2030. Several medicinal plant species and their phytochemicals inhibit the progression and development of cancer. In the present work In vitro anti cancer activity of gamma oryzanol was performed using SRB assay. Result shown that gamma oryzanol has anti cancer activity for SKMEL-2 cancerous cell line. On the basis of this result further study plan can be designed. Key words: Cancer, Gamma oryzanol, Phytochemicals.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87343424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-08DOI: 10.24092/crps.2022.120206
Ankush Sharma, Amit Jain
The leaves of Plumeria pudica grow whirling around the stem and have a sessile base. The leaves are light green in color and the shape of the blade is spoon like, the apex is sharp. The extraction abilities of different solvents for recovering extractable components from leaves followed the order: methanol>water>chloroform>benzene. The results suggest the presence of alkaloids, saponin glycosides, phenolics, terpenoids, sterols, proteins and flavonoids in the leaf of the plant. All the extracts were subjected to in vitro determination of their anti-inflammatory potential using inhibition of albumin denaturation as well as anti-proteinase methods. All the concentration levels of the extracts showed the inhibition of albumin denaturation. The 500 µg/mL methanolic extract had shown the greatest inhibition capacity (64.36%) whereas the lowest inhibition capacity was exhibited by 100 µg/mL of the benzene extract (1.29%). The highest anti-proteinase activity was exhibited by methanolic extract solution at 500 µg/mL concentration, inhibiting 51.37% while the 100 µg/mL methanolic solution was able to inhibit only 13.01% protease activity. The methanolic extract was found to be the most potential in exhibiting anti-inflammatory action in the in vitro assays and hence it was used for in vivo anti-inflammatory screening at two dose levels. The methanolic leaf extract of Plumeria pudica (MLEPP) was able to reduce the inflammation in a dose dependent manner. The maximum inhibition of edema by MLEPP at 100 mg/kg dose was 28.78% at the end of the 4th hour while that with 200 mg/kg dose was 50.4%. Key words: In-Vivo, Anti-Inflammtory, Plumeria Pudica,
{"title":"Evaluation of in vivo Anti-inflammatory Action of Leaf Extracts of Plumeria pudica","authors":"Ankush Sharma, Amit Jain","doi":"10.24092/crps.2022.120206","DOIUrl":"https://doi.org/10.24092/crps.2022.120206","url":null,"abstract":"The leaves of Plumeria pudica grow whirling around the stem and have a sessile base. The leaves are light green in color and the shape of the blade is spoon like, the apex is sharp. The extraction abilities of different solvents for recovering extractable components from leaves followed the order: methanol>water>chloroform>benzene. The results suggest the presence of alkaloids, saponin glycosides, phenolics, terpenoids, sterols, proteins and flavonoids in the leaf of the plant. All the extracts were subjected to in vitro determination of their anti-inflammatory potential using inhibition of albumin denaturation as well as anti-proteinase methods. All the concentration levels of the extracts showed the inhibition of albumin denaturation. The 500 µg/mL methanolic extract had shown the greatest inhibition capacity (64.36%) whereas the lowest inhibition capacity was exhibited by 100 µg/mL of the benzene extract (1.29%). The highest anti-proteinase activity was exhibited by methanolic extract solution at 500 µg/mL concentration, inhibiting 51.37% while the 100 µg/mL methanolic solution was able to inhibit only 13.01% protease activity. The methanolic extract was found to be the most potential in exhibiting anti-inflammatory action in the in vitro assays and hence it was used for in vivo anti-inflammatory screening at two dose levels. The methanolic leaf extract of Plumeria pudica (MLEPP) was able to reduce the inflammation in a dose dependent manner. The maximum inhibition of edema by MLEPP at 100 mg/kg dose was 28.78% at the end of the 4th hour while that with 200 mg/kg dose was 50.4%. Key words: In-Vivo, Anti-Inflammtory, Plumeria Pudica,","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87974183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-08DOI: 10.24092/crps.2022.120201
K. Verma, Shobhit Kumar
Peutz-Jegers Syndrome (PJS) autosomal dominant disorder characterized by melanin spots, colon polyps and increased risk of cancer, especially due to mucosal skin pigmentation of the red edges of the lips, and gastrointestinal hematogenous polyposis. PJS was first reported in 1895. PJS can caused with or without mutation. Polyps have also been seen in the ureter, airway body system, and gastrointestinal system. The most common location is jejunum. DBE is an enteroscopy technique that enables the evaluation and treatment of the small bowel. Cancers of the colon, stomach, small intestine, pancreas, breast, and other organs are more common in PJS patients. PJS has a strong link with several malignancies like adenoma malignum (ADM) and a rare ovary tumor called sex cord tumor with annular tubules (SCTATs) in female PJS patients. Key words: Peutz-Jeghers Syndrome; intraoperative enteroscopy; dual-balloon enteroscopy
{"title":"Genetic alternation in Peutz-Jeghers Syndrome (PJS) and its Diagnostic Method","authors":"K. Verma, Shobhit Kumar","doi":"10.24092/crps.2022.120201","DOIUrl":"https://doi.org/10.24092/crps.2022.120201","url":null,"abstract":"Peutz-Jegers Syndrome (PJS) autosomal dominant disorder characterized by melanin spots, colon polyps and increased risk of cancer, especially due to mucosal skin pigmentation of the red edges of the lips, and gastrointestinal hematogenous polyposis. PJS was first reported in 1895. PJS can caused with or without mutation. Polyps have also been seen in the ureter, airway body system, and gastrointestinal system. The most common location is jejunum. DBE is an enteroscopy technique that enables the evaluation and treatment of the small bowel. Cancers of the colon, stomach, small intestine, pancreas, breast, and other organs are more common in PJS patients. PJS has a strong link with several malignancies like adenoma malignum (ADM) and a rare ovary tumor called sex cord tumor with annular tubules (SCTATs) in female PJS patients. Key words: Peutz-Jeghers Syndrome; intraoperative enteroscopy; dual-balloon enteroscopy","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76358239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-08DOI: 10.24092/crps.2022.120202
A. Yakub, Ankita Mathur, S. Yahaya
Development of resistance against the frontline anti-malarial drugs has created an alarming situation, which requires intensive drug recovery to develop new, more effective, affordable and accessible anti-malarial agents. Plants as Senna occidentalis produce a wide variety of phytochemical constituents, which are secondary metabolites and are used either directly or indirectly in the pharmaceutical industry. Phytochemical screening and antiplasmodial activity of the aqueous and ethanol extracts of S. occidentalis (L.) leaves and stems were studied in this work. The preliminary screening of the leaf extracts revealed the presence of alkaloids, saponins, cardiac glycosids, quinine, protein and amino acid, phenol, flavonoids and carbohydrate and showed absence of tannins. Likewise, stem extracts which shows absence of phenols in addition to tannins in the ethanol extract. These extracts were assayed at various concentration using double serial dilution (20mg/ml, 10mg/ml, 5mg/ml, 2.5mg/ml and 1.25mg/ml) for antiplasmodial effect after 24, 48 and 72hours respectively, and the activity of the extracts were obtained as percentage activity of the extracts after 72 hours of incubation period. The result of antiplasmodial activity revealed that both aqueous and ethanol stem and leaf extracts of the plant were effective against the malaria parasite. However, the aqueous stem extract showed greater activities than the ethanol extract. At extract concentration of 20mg/ml, both ethanol and aqueous extracts produced highest parasite clearance rate after 72 hours of incubation with percentage elimination of 77%. From these observations, S. occidentalis is likely to contain promising chemical compounds which can be utilized as an effective plant-based medicine for the treatment of malaria. Key words: Malaria, phytochemicals, antiplasmodial, parasite, aqueous, ethanol
{"title":"In vitro Antiplasmodial Actitvity of Aqueous and Ethanol Stem And Leaf Extracts of Senna Occidentalis (Coffee Senna)","authors":"A. Yakub, Ankita Mathur, S. Yahaya","doi":"10.24092/crps.2022.120202","DOIUrl":"https://doi.org/10.24092/crps.2022.120202","url":null,"abstract":"Development of resistance against the frontline anti-malarial drugs has created an alarming situation, which requires intensive drug recovery to develop new, more effective, affordable and accessible anti-malarial agents. Plants as Senna occidentalis produce a wide variety of phytochemical constituents, which are secondary metabolites and are used either directly or indirectly in the pharmaceutical industry. Phytochemical screening and antiplasmodial activity of the aqueous and ethanol extracts of S. occidentalis (L.) leaves and stems were studied in this work. The preliminary screening of the leaf extracts revealed the presence of alkaloids, saponins, cardiac glycosids, quinine, protein and amino acid, phenol, flavonoids and carbohydrate and showed absence of tannins. Likewise, stem extracts which shows absence of phenols in addition to tannins in the ethanol extract. These extracts were assayed at various concentration using double serial dilution (20mg/ml, 10mg/ml, 5mg/ml, 2.5mg/ml and 1.25mg/ml) for antiplasmodial effect after 24, 48 and 72hours respectively, and the activity of the extracts were obtained as percentage activity of the extracts after 72 hours of incubation period. The result of antiplasmodial activity revealed that both aqueous and ethanol stem and leaf extracts of the plant were effective against the malaria parasite. However, the aqueous stem extract showed greater activities than the ethanol extract. At extract concentration of 20mg/ml, both ethanol and aqueous extracts produced highest parasite clearance rate after 72 hours of incubation with percentage elimination of 77%. From these observations, S. occidentalis is likely to contain promising chemical compounds which can be utilized as an effective plant-based medicine for the treatment of malaria. Key words: Malaria, phytochemicals, antiplasmodial, parasite, aqueous, ethanol","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86764159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-08DOI: 10.24092/crps.2022.120207
U. Sharma, B. Tyagi
The present investigation was undertaken with an objective to standardize and validate a self proclaimed proprietary medicine promoted online by the name of Diabex capsule (DC), available for management of diabetes. The procured capsules of DC were evaluated for texture, color, taste and odor. Total ash value of is an indication of the amount of minerals and earthy materials present in the formulations. DC exhibited 9.3 % total ash with 3.16 % acid insoluble ash and 5.08 % water soluble ash. The water soluble and alcohol soluble extractives were 1.48 % and 1.42 % respectively suggesting the formulation to be suitable for human use. The powder of DC was subjected to various chemical tests for preliminary screening of the class of phytoconstituents present in them. The spot for quercetin appeared at Rf value of 0.83 on the TLC plate. The peak at 5.048 min was found due to the presence of quercetin in DC. The quantitation of the quercetin was done from the calibration curve of peak area obtained from standard quercetin and it was found that DC contained 1.89 mg quercetin per 250 mg of DC (0.756 %). A glucose tolerance test determines the blood glucose level in fasting condition then after 2 hours of drinking a solution of glucose in specific quantity. Alloxan is considered to be the most common chemical substance to induce diabetes in experimental animals. DC was able to decrease blood sugar by 35.03% while the standard drug glibenclamide could reduce it by 42.54%. This makes it evident that the polyherbal formulation DC was almost equipotent to the standard drug. Key words: Antidiabetic, Diabex, Standardization, Physicochemical, Capsule, WHO
{"title":"Establishing the Antidiabetic Potential of Marketed Product Diabex Capsules and Standardization of its Physicochemical Parameters","authors":"U. Sharma, B. Tyagi","doi":"10.24092/crps.2022.120207","DOIUrl":"https://doi.org/10.24092/crps.2022.120207","url":null,"abstract":"The present investigation was undertaken with an objective to standardize and validate a self proclaimed proprietary medicine promoted online by the name of Diabex capsule (DC), available for management of diabetes. The procured capsules of DC were evaluated for texture, color, taste and odor. Total ash value of is an indication of the amount of minerals and earthy materials present in the formulations. DC exhibited 9.3 % total ash with 3.16 % acid insoluble ash and 5.08 % water soluble ash. The water soluble and alcohol soluble extractives were 1.48 % and 1.42 % respectively suggesting the formulation to be suitable for human use. The powder of DC was subjected to various chemical tests for preliminary screening of the class of phytoconstituents present in them. The spot for quercetin appeared at Rf value of 0.83 on the TLC plate. The peak at 5.048 min was found due to the presence of quercetin in DC. The quantitation of the quercetin was done from the calibration curve of peak area obtained from standard quercetin and it was found that DC contained 1.89 mg quercetin per 250 mg of DC (0.756 %). A glucose tolerance test determines the blood glucose level in fasting condition then after 2 hours of drinking a solution of glucose in specific quantity. Alloxan is considered to be the most common chemical substance to induce diabetes in experimental animals. DC was able to decrease blood sugar by 35.03% while the standard drug glibenclamide could reduce it by 42.54%. This makes it evident that the polyherbal formulation DC was almost equipotent to the standard drug. Key words: Antidiabetic, Diabex, Standardization, Physicochemical, Capsule, WHO","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89538105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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