Pub Date : 2021-07-08DOI: 10.24092/crps.2021.110201
Anjali Chourasiya, Narendra Gehalot, S. Mahajan
NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. Novel drug delivery system have been developed to overcome the limitation of conventional drug delivery systems, such as of gastric retention by decreasing fluctuations in the concentration of the drug in blood,resulting in the reduction in unwanted toxicity and poor efficiency. As compared to traditional dosage forms bilayer tablets are more efficient for sequential release of two drugs that can be different or identical. Bilayer tablet is also capable of separating two incompatible substances and also for sustained release. Gastro retentive drug delivery system retains the period of dosage forms in the stomach or upper gastro intes-tinal tract ,as to improve bioavailability and the therapeutic efficacy of the drugs. Mainly the bilayer drug delivery system is suitable for drugs whose therapethic windows are narrow in the gastrointestinal tract (GIT) and also they have low elimination half life: 3-4 h. The purpose of this review is to disclose the challenges faced during the formulation of bilayer tablets. Finally, the whole article is firmly analyzed in a concluding paragraph. KEYWORDS: Conventional drug delivery systems, Bilayer tablet, Gastro retentive, Bioavailability
{"title":"A REVIEW ON AN EMERGIN TREND BILAYER FLOATING DRUG DELIVERY SYSTEM","authors":"Anjali Chourasiya, Narendra Gehalot, S. Mahajan","doi":"10.24092/crps.2021.110201","DOIUrl":"https://doi.org/10.24092/crps.2021.110201","url":null,"abstract":"NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. Novel drug delivery system have been developed to overcome the limitation of conventional drug delivery systems, such as of gastric retention by decreasing fluctuations in the concentration of the drug in blood,resulting in the reduction in unwanted toxicity and poor efficiency. As compared to traditional dosage forms bilayer tablets are more efficient for sequential release of two drugs that can be different or identical. Bilayer tablet is also capable of separating two incompatible substances and also for sustained release. Gastro retentive drug delivery system retains the period of dosage forms in the stomach or upper gastro intes-tinal tract ,as to improve bioavailability and the therapeutic efficacy of the drugs. Mainly the bilayer drug delivery system is suitable for drugs whose therapethic windows are narrow in the gastrointestinal tract (GIT) and also they have low elimination half life: 3-4 h. The purpose of this review is to disclose the challenges faced during the formulation of bilayer tablets. Finally, the whole article is firmly analyzed in a concluding paragraph. KEYWORDS: Conventional drug delivery systems, Bilayer tablet, Gastro retentive, Bioavailability","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86465917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.24092/CRPS.2021.110103
Gurdeep Singh, N. Jain, K. Sahu
Due to this increasing predicament of antibiotic confrontation, the lot of distinct antibiotics available is dwindling and there are only smatterings of new antibiotics in the drug development channel. Therefore, an intense necessitate for new antimicrobial drugs. In current study, substituted 1,2,4-triazolo-5-thione derivatives were synthesized from substituted aromatic aldehydes, succinic acids and the structure of synthesized compounds were established by physicochemical (Melting Point, Rf value) and spectral analysis (IR, NMR & Mass). The title compounds were then evaluated for their antimicrobial activity against ciprofloxacin as a standard drug using agar plate method. Among all synthesized derivatives A5 and A6 found were found to possess very promising antimicrobial activity. Keywords: 1,2,4-triazolo-5-thione, anti-microbial, antibiotic, thione, Ciprofloxacin.
{"title":"Synthesis, Characterization and Antimicrobial Evaluation of some 1,2,4-Triazolo-5-Thione Derivatives","authors":"Gurdeep Singh, N. Jain, K. Sahu","doi":"10.24092/CRPS.2021.110103","DOIUrl":"https://doi.org/10.24092/CRPS.2021.110103","url":null,"abstract":"Due to this increasing predicament of antibiotic confrontation, the lot of distinct antibiotics available is dwindling and there are only smatterings of new antibiotics in the drug development channel. Therefore, an intense necessitate for new antimicrobial drugs. In current study, substituted 1,2,4-triazolo-5-thione derivatives were synthesized from substituted aromatic aldehydes, succinic acids and the structure of synthesized compounds were established by physicochemical (Melting Point, Rf value) and spectral analysis (IR, NMR & Mass). The title compounds were then evaluated for their antimicrobial activity against ciprofloxacin as a standard drug using agar plate method. Among all synthesized derivatives A5 and A6 found were found to possess very promising antimicrobial activity. Keywords: 1,2,4-triazolo-5-thione, anti-microbial, antibiotic, thione, Ciprofloxacin.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"130 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74608805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-10DOI: 10.24092/CRPS.2021.110104
J. Kumari, Lovely Chaurasia
The present work aimed to produce Curcumin based nanoliposomes that nanoliposome can target the site via the brain in a controlled manner. Nanoliposomes are important in controlling the carriage; Curcumin which is an active constituent of curcuminoids thus also provides an effective treatment for the central nervous system and plays a crucial role. The interaction of the drug was ruled out by FT-IR studies and no incompatibility and lipids and surfactant. To optimize the formulation, factors affecting the physical appearance of Nanoliposomes were investigated. Curcumin-loaded Nanoliposomes were formulated using cholesterol by physical dispersion method and characterized for particle size, drug content, stability, production yield. Prepared nanoliposomes gave the better physical, morphological concerning the concentration of the lipids, surfactant, and ratio of lipid and surfactant. Six different formulations of Nanoliposomes F1-F6 were formulated to obtain the optimized formulation. The TEM (Transmission Electron Microscopy) of Nanoliposomes showed that they were rounded in shape and porous in texture. In-vitro drug release of formulation indicates that formulation F6 was selected as an optimized formulation for incorporation into the nanoliposomes among all the six formulations and liposome showed drug release in a controlled manner at the end of 10 hours. Keywords: Curcumin, Nanoliposomes, Physical Dispersion Method, Brain Targeting, Blood-Brain Barrier, Cholesterol, Bioavailability, In vitro Release.
{"title":"Formulation and Evaluation of Curcumin Loaded Nanoliposome on Brain Targeted","authors":"J. Kumari, Lovely Chaurasia","doi":"10.24092/CRPS.2021.110104","DOIUrl":"https://doi.org/10.24092/CRPS.2021.110104","url":null,"abstract":"The present work aimed to produce Curcumin based nanoliposomes that nanoliposome can target the site via the brain in a controlled manner. Nanoliposomes are important in controlling the carriage; Curcumin which is an active constituent of curcuminoids thus also provides an effective treatment for the central nervous system and plays a crucial role. The interaction of the drug was ruled out by FT-IR studies and no incompatibility and lipids and surfactant. To optimize the formulation, factors affecting the physical appearance of Nanoliposomes were investigated. Curcumin-loaded Nanoliposomes were formulated using cholesterol by physical dispersion method and characterized for particle size, drug content, stability, production yield. Prepared nanoliposomes gave the better physical, morphological concerning the concentration of the lipids, surfactant, and ratio of lipid and surfactant. Six different formulations of Nanoliposomes F1-F6 were formulated to obtain the optimized formulation. The TEM (Transmission Electron Microscopy) of Nanoliposomes showed that they were rounded in shape and porous in texture. In-vitro drug release of formulation indicates that formulation F6 was selected as an optimized formulation for incorporation into the nanoliposomes among all the six formulations and liposome showed drug release in a controlled manner at the end of 10 hours. Keywords: Curcumin, Nanoliposomes, Physical Dispersion Method, Brain Targeting, Blood-Brain Barrier, Cholesterol, Bioavailability, In vitro Release.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90744695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-08DOI: 10.24092/CRPS.2021.110102
Himanshu, Pradumn Kumar Maddheshiya, Mukesh Kumar
In today era cancer is a dangerous and terrible disease which cause due to rapid increment of unusual cells within the body. Cancer is the second influential cause of death in the world. It has become very difficult overcome cancerous disease. 10 million people died per year from cancer. The major cause of cancer is sudden change in DNA within the cells. As a result normal cells convert into cancerous cells which enhance the process of metastasis. There are some treatments of this dangerous disease but cancer treatments are so expensive not everyone and the common man can get. So, it’s our responsibility to spread awareness and convince people about such a disease. Its simple purpose is that after reading people should know more about it. And whatever, things are follow in our daily life to avoid cancer disease. Keywords: Neoplasm, Carcinoma, Leukemia, Chemotherapy, Radiation therapy.
{"title":"A brief Overview of a Fatal Disease Namely Cancer","authors":"Himanshu, Pradumn Kumar Maddheshiya, Mukesh Kumar","doi":"10.24092/CRPS.2021.110102","DOIUrl":"https://doi.org/10.24092/CRPS.2021.110102","url":null,"abstract":"In today era cancer is a dangerous and terrible disease which cause due to rapid increment of unusual cells within the body. Cancer is the second influential cause of death in the world. It has become very difficult overcome cancerous disease. 10 million people died per year from cancer. The major cause of cancer is sudden change in DNA within the cells. As a result normal cells convert into cancerous cells which enhance the process of metastasis. There are some treatments of this dangerous disease but cancer treatments are so expensive not everyone and the common man can get. So, it’s our responsibility to spread awareness and convince people about such a disease. Its simple purpose is that after reading people should know more about it. And whatever, things are follow in our daily life to avoid cancer disease. Keywords: Neoplasm, Carcinoma, Leukemia, Chemotherapy, Radiation therapy.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87750314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.24092/crps.2020.100402
Nida Musheer, Vikrant Gupta
In the present study, gliclazide-loaded niosomes are formulated and evaluated for their in vitro as well as in vivo characteristic in an attempt to improve the oral bioavailability of the drug. Formulation of niosomes was optimized for highest percentage of drug entrapment. Microscopic observation confirmed that all particles were uniform in size and shape. The entrapment efficiency was determined by separating the unentrapped drug using dialysis. The in vitro release studies of drug from niosomes exhibited a prolonged drug release as observed over a period of 24 h. The positive values of zeta potential indicated that the gliclazide niosomes were stabilized by electrostatic repulsive forces. Results from stability study have shown that the drug leakage from the vesicles was least at 4ºC followed by 25 and 37ºC. The niosomes showing maximum entrapment and suitable release rate were selected for in vivo evaluation. In conclusion, the niosomal formulation could be a promising delivery system for gliclazide with improved bioavailability and prolonged drug release profile. KEYWORDS: Heme Oxygenase Inhibitor, HO-1, 2D QSAR, 3D QSAR, kNN-MFA
在本研究中，为了提高药物的口服生物利用度，我们制定了格列齐特负载niosomes，并对其体外和体内特性进行了评估。以药物包封率最高为目标，优化了乳质体的配方。显微镜观察证实，所有的颗粒在大小和形状上都是均匀的。通过透析分离未包裹的药物来确定包裹效率。体外药物释放研究显示，在24小时的时间内，药物释放时间较长。zeta电位的阳性表明，格列齐特乳小体在静电斥力的作用下是稳定的。稳定性研究结果表明，药物在4℃时渗漏最少，其次是25℃和37℃。选择具有最大包裹度和合适释放率的乳质体进行体内评价。综上所述，niosomal制剂具有提高格列齐特生物利用度和延长药物释放时间的优点，是一种很有前景的给药系统。关键词:血红素加氧酶抑制剂，HO-1, 2D QSAR, 3D QSAR, kNN-MFA
{"title":"FORMULATION, DEVELOPMENT AND CHARACTERIZATION OF EFFECTIVE NIOSOMAL DRUG DELIVERY SYSTEM FOR THE TREATMENT OF DIABETES MELLITUS","authors":"Nida Musheer, Vikrant Gupta","doi":"10.24092/crps.2020.100402","DOIUrl":"https://doi.org/10.24092/crps.2020.100402","url":null,"abstract":"In the present study, gliclazide-loaded niosomes are formulated and evaluated for their in vitro as well as in vivo characteristic in an attempt to improve the oral bioavailability of the drug. Formulation of niosomes was optimized for highest percentage of drug entrapment. Microscopic observation confirmed that all particles were uniform in size and shape. The entrapment efficiency was determined by separating the unentrapped drug using dialysis. The in vitro release studies of drug from niosomes exhibited a prolonged drug release as observed over a period of 24 h. The positive values of zeta potential indicated that the gliclazide niosomes were stabilized by electrostatic repulsive forces. Results from stability study have shown that the drug leakage from the vesicles was least at 4ºC followed by 25 and 37ºC. The niosomes showing maximum entrapment and suitable release rate were selected for in vivo evaluation. In conclusion, the niosomal formulation could be a promising delivery system for gliclazide with improved bioavailability and prolonged drug release profile. KEYWORDS: Heme Oxygenase Inhibitor, HO-1, 2D QSAR, 3D QSAR, kNN-MFA","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88544283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.24092/crps.2020.100403
Priyanka Jartolia, S. Kondalkar, A. Kondalkar, Muraree Lal
Bilayer floating tablet of amoxicillin was formulated successfully and evaluated under suitable parameters. All the batches of tablet produced were found to exhibit short floating lag times. The tablet of batch F2 exhibited a longer floating lag time of 23 minutes. Relationship between the dependent and independent variables was further elucidated using contour and response surface plots. Dissolution profiles that the tablets of batch F3, F7, and F12 exhibits initial burst phase during the first hour of dissolution. The burst phase was followed by a limited drug release for the rest of the period. Also it was observed during the dissolution studies that tablets of all three batches eroded quickly with increased effervescence. Time required for 50 % drug to get released (T50%) and %CR10hrs were found to be in the range of 0.7 to 8.6 hours and 57.35 ± 3.89 to 99.93 ± 0.07 respectively, value of “Prob > F” less than 0. 05. Response surface plots and Contour plot indicated that at a fixed level of B (35 mg) and low level of A (amount of HPMC), % CR10hrs increases from 68.11 to 90.00 % and T50% decrease from 6.86 to 1.66 as the amount of citric acid (C) increases from 0 to 10 mg. Stability study was performed for optimized formulation and it was found that formulation was stable for 6 week at 25 °C/ 60% RH. KEYWORDS: Bilayer floating tablet, amoxicillin, Evaluated, Multi-layered tablet, Stability
{"title":"FORMULATION AND DEVELOPMENT OF BILAYER FLOATING TABLET OF AMOXICILLIN","authors":"Priyanka Jartolia, S. Kondalkar, A. Kondalkar, Muraree Lal","doi":"10.24092/crps.2020.100403","DOIUrl":"https://doi.org/10.24092/crps.2020.100403","url":null,"abstract":"Bilayer floating tablet of amoxicillin was formulated successfully and evaluated under suitable parameters. All the batches of tablet produced were found to exhibit short floating lag times. The tablet of batch F2 exhibited a longer floating lag time of 23 minutes. Relationship between the dependent and independent variables was further elucidated using contour and response surface plots. Dissolution profiles that the tablets of batch F3, F7, and F12 exhibits initial burst phase during the first hour of dissolution. The burst phase was followed by a limited drug release for the rest of the period. Also it was observed during the dissolution studies that tablets of all three batches eroded quickly with increased effervescence. Time required for 50 % drug to get released (T50%) and %CR10hrs were found to be in the range of 0.7 to 8.6 hours and 57.35 ± 3.89 to 99.93 ± 0.07 respectively, value of “Prob > F” less than 0. 05. Response surface plots and Contour plot indicated that at a fixed level of B (35 mg) and low level of A (amount of HPMC), % CR10hrs increases from 68.11 to 90.00 % and T50% decrease from 6.86 to 1.66 as the amount of citric acid (C) increases from 0 to 10 mg. Stability study was performed for optimized formulation and it was found that formulation was stable for 6 week at 25 °C/ 60% RH. KEYWORDS: Bilayer floating tablet, amoxicillin, Evaluated, Multi-layered tablet, Stability","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88400688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-08DOI: 10.24092/crps.2020.100301
Ramila Prajapati, Sanjeev Kumar
Nutraceuticals are products used as medicines in addition to nutrition. Nutraceuticals can be defined as substances that have physiological benefits or provide protection against chronic disease. Nutraceuticals can be used to improve health, slow down the aging process, prevent chronic diseases, increase life expectancy or support body structure or function. Nutraceuticals are getting a lot of attention these days because of their potential nutritional, safety and therapeutic benefits. Recent studies have shown that these compounds have promising results in various complications. In this review, we have made a great effort in proposing new concepts for nutraceuticals based on disease indications. Highlights herbal remedies that are effective for harsh therapeutic conditions associated with oxidative stress, including allergies, Alzheimer's disease, cardiovascular disease, cancer, diabetes, eye, immunity, inflammation, and Parkinson's disease and obesity. These nutraceuticals are used in various diseases, their application, and current market demand. Examples of fish oil preparations, prebiotics and probiotics reviewed. KEYWORDS: Nutraceutical, Dietary supplements, Antioxidants, Probiotics, Health benefits
{"title":"THE ROLE, SCOPE, HEALTH BENEFITS AND MARKET GROWTH OF NUTRACEUTICALS: AN OVERVIEW","authors":"Ramila Prajapati, Sanjeev Kumar","doi":"10.24092/crps.2020.100301","DOIUrl":"https://doi.org/10.24092/crps.2020.100301","url":null,"abstract":"Nutraceuticals are products used as medicines in addition to nutrition. Nutraceuticals can be defined as substances that have physiological benefits or provide protection against chronic disease. Nutraceuticals can be used to improve health, slow down the aging process, prevent chronic diseases, increase life expectancy or support body structure or function. Nutraceuticals are getting a lot of attention these days because of their potential nutritional, safety and therapeutic benefits. Recent studies have shown that these compounds have promising results in various complications. In this review, we have made a great effort in proposing new concepts for nutraceuticals based on disease indications. Highlights herbal remedies that are effective for harsh therapeutic conditions associated with oxidative stress, including allergies, Alzheimer's disease, cardiovascular disease, cancer, diabetes, eye, immunity, inflammation, and Parkinson's disease and obesity. These nutraceuticals are used in various diseases, their application, and current market demand. Examples of fish oil preparations, prebiotics and probiotics reviewed. KEYWORDS: Nutraceutical, Dietary supplements, Antioxidants, Probiotics, Health benefits","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84924313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-08DOI: 10.24092/crps.2020.100302
A. Jain
Methanolic extracts from roots of Bauhinia variegata linn were investigated for their anthelmintic activity by using three concentrations (10, 25, & 50mg/ml) as test worms. Results were expressed in terms of time of paralysis and time of death of worms and the activity was compared with albendazole as reference standard & Normal saline served as control. Dose dependent decreased paralyzing time and death time was observed. The results of present study indicated that crude methanolic root extract significantly demonstrated paralysis and also caused death of worms especially at higher concentration of (50 mg/ml), Bauhinia variegata showed the best anthelmintic activity. The use of the roots as anthelmintic has been established and further studies are recommended to isolate the active principles answerable for the activity. KEYWORDS: Anthelmintic activity, Pheretima Posthuma, Bauhinia variegata linn
{"title":"EVALUATION OF ANTHELMINTIC ACTIVITY OF BAUHINIA VARIEGATA LINN METHANOLIC ROOT EXTRACT ON PHERETIMA POSTHUMA","authors":"A. Jain","doi":"10.24092/crps.2020.100302","DOIUrl":"https://doi.org/10.24092/crps.2020.100302","url":null,"abstract":"Methanolic extracts from roots of Bauhinia variegata linn were investigated for their anthelmintic activity by using three concentrations (10, 25, & 50mg/ml) as test worms. Results were expressed in terms of time of paralysis and time of death of worms and the activity was compared with albendazole as reference standard & Normal saline served as control. Dose dependent decreased paralyzing time and death time was observed. The results of present study indicated that crude methanolic root extract significantly demonstrated paralysis and also caused death of worms especially at higher concentration of (50 mg/ml), Bauhinia variegata showed the best anthelmintic activity. The use of the roots as anthelmintic has been established and further studies are recommended to isolate the active principles answerable for the activity. KEYWORDS: Anthelmintic activity, Pheretima Posthuma, Bauhinia variegata linn","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74214120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-08DOI: 10.24092/crps.2020.100102
Munesh Kumar, M. Rani, B. Meher
Nowadays obesity is the major health problem due to food habit and life style of people. Nature and natural compounds possess lots of health benefits. To explore the therapeutic benefit of Cyperus rotundus in this work, we have evaluated the anti-obesity potential on Monosodium glutamate (MSG) induced obese rats. Methanolic extract of tubers of Cyperus rotundus was administered at the dose of 250 and 500 mg/kg/oral after 45 d of treatment and a significant improvement in body weight, organs and lipid profile was observed as compared with MSG induced obese rats. Nowadays obesity is a common metabolic disorder in developed and developing countries. It was observed that Cyperus rotundus tuber possesses anti-obesity potential and protective action on heart and liver.
{"title":"PHARMACOLOGICAL INVESTIGATIONS OF CYPERUS ROTUNDUS TUBER EXTRACT IN MONOSODIUM GLUTAMATE INDUCED EXPERIMENTAL ANIMAL","authors":"Munesh Kumar, M. Rani, B. Meher","doi":"10.24092/crps.2020.100102","DOIUrl":"https://doi.org/10.24092/crps.2020.100102","url":null,"abstract":"Nowadays obesity is the major health problem due to food habit and life style of people. Nature and natural compounds possess lots of health benefits. To explore the therapeutic benefit of Cyperus rotundus in this work, we have evaluated the anti-obesity potential on Monosodium glutamate (MSG) induced obese rats. Methanolic extract of tubers of Cyperus rotundus was administered at the dose of 250 and 500 mg/kg/oral after 45 d of treatment and a significant improvement in body weight, organs and lipid profile was observed as compared with MSG induced obese rats. Nowadays obesity is a common metabolic disorder in developed and developing countries. It was observed that Cyperus rotundus tuber possesses anti-obesity potential and protective action on heart and liver.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"212 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75758822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-08DOI: 10.24092/crps.2020.100101
Mukesh Kumar, Priya, Anoop Kumar, Shobhit Kumar
Nanoengineered drug delivery system is generally used to solubilize the hydrophobic drugs. They also carry the drug to the target site and release the drug according to need of patient. These are very effective drug carriers which minimize and resolve the problems of drug toxicity and poor bioavailability as they can load both hydrophilic and hydrophobic drugs. Nanosponges are tiny in size with three dimensional networks. These are highly porous in nature and entrap active moieties and provide an advantage of programmable release. These are prepared by cross linking using many type of cyclodextrin with carbonyl and dicarboxylate compound like cross linker. Nanosponges are used for enhancing the bioavailability of drug and delivery of drug via oral, topical and parenteral routes. These are also used as a carrier for release of enzyme, protein, vaccines and antibiotics.
{"title":"NANOSPONGES: A PROMISING NANOCARRIER SYSTEMS FOR DRUG DELIVERY","authors":"Mukesh Kumar, Priya, Anoop Kumar, Shobhit Kumar","doi":"10.24092/crps.2020.100101","DOIUrl":"https://doi.org/10.24092/crps.2020.100101","url":null,"abstract":"Nanoengineered drug delivery system is generally used to solubilize the hydrophobic drugs. They also carry the drug to the target site and release the drug according to need of patient. These are very effective drug carriers which minimize and resolve the problems of drug toxicity and poor bioavailability as they can load both hydrophilic and hydrophobic drugs. Nanosponges are tiny in size with three dimensional networks. These are highly porous in nature and entrap active moieties and provide an advantage of programmable release. These are prepared by cross linking using many type of cyclodextrin with carbonyl and dicarboxylate compound like cross linker. Nanosponges are used for enhancing the bioavailability of drug and delivery of drug via oral, topical and parenteral routes. These are also used as a carrier for release of enzyme, protein, vaccines and antibiotics.","PeriodicalId":11053,"journal":{"name":"Current Research in Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88242712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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