Dermatosen in Beruf und Umwelt. Occupation and environment最新文献

Evaluation of our standardized test results from 1972 to 1983 indicated Vioform allergies in 1.2% of all cases and Sterosan allergies in 1.1%. Our results are within the spectrum found in the literature for Vioform between 0.3 and 5.1% and for Sterosan between 0.3 and 3.7%. In the course of those 12 years we observed a growing tendency towards Vioform and Sterosan allergies on the basis of annual percentage figures. In the last year of our observation the frequency of Vioform and Sterosan allergies amounted to 1.7% each. We conclude, therefore, that inclusion of these two substances in the standard battery is justified. According to the pertinent literature, Sterosan and Vioform allergies are, on an average, 3 to 4 times more frequent in patients suffering from leg ulcers and/or chronic venous insufficiency than amongst eczema patients.

We carried out patch testing with a chinoline block comprising 25 substances in 316 patients with a suspected allergy to chinoline derivatives in the period from February 1969 to December 1983. 110 patients reacted to 2 or more substances. The reactions were totaled and tabulated in a list indicating frequency of sensitisation as decreasing in the order of Cl-F-Br-I halogens. The most frequent reactions observed were with Chlorisept, Sterosan, Vio-form, Chinosol, Ondron, and Broxychinolin, for all of which primary sensitisations are also possible. Concomitant reactions to chinaldol, chinaldine, aminochinaldine and chinoline are considered to be group allergies since contact is hardly possible with these substances in everyday life. Due to the lack of appropriate history, reactions to Resochin and the isoquinoline compounds Papaverine and Eupaverine may also be regarded as group allergies. Accordingly, non-hydroxylized chinoline derivatives are also viewed as group allergies in cases of sensitisation to hydroxy-chinoline derivatives. The group spectrum of hydroxy-chinoline allergy seems to be more far-reaching than was assumed. Five cases of a quinine allergy identified by appropriate history and confirmed epicutaneously are presented with a group allergy to various chinoline derivatives, including two cases with quinidine.

After four years employment in a factory manufacturing flame retardants, a 29 year old man developed eczematous reactions on both hands. Patch tests performed with different agents handled by the patient solely at his place of work were positive for the flame retardant and dicyanodiamide, even in high dilutions. Upon changing jobs, the lesions healed completely. To our knowledge, this is the first recorded instance of a contact allergy due to dicyanodiamide in the pertinent literature.

An autopsy assistant developed respiratory distress at his job after four years of work on post-mortems. His symptoms commenced immediately upon entering the work rooms. Diagnosis was confirmed by positive medical history, skin tests and RAST investigations, all of which taken together gave proof of occupationally induced asthma of anaphylactic origin (Type I reaction).

Subjective (sensory) irritation was studied with lactic acid test on 74 females; 8 reacted positively with "stinging" and/or itching or burning and another 5 had mild subjective sensations. History of previous corresponding sensations from contact with cosmetic products was significantly more common in stingers than in non-stingers (p less than 0.001); other factors, such as dermatologic history, sensitivity to ultraviolet light or skin dryness had no characteristic patterns. In the objective, immediate non-immunologic contact urticaria tests with sorbic acid and benzoic acid, the stingers developed significantly more erythema to 0.5% sorbic acid (p less than 0.05) and to 1% benzoic acid (p less than 0.02). 1% sorbic acid also induced more edema in stingers (p less than 0.02). Increased reactivity to a 24 h sodium lauryl sulfate (SLS) patch test was demonstrated only with laser Doppler velocimetry (p less than 0.05). Stingers and non-stingers reacted similarly to open, cumulative SLS irritation as measured with transepidermal water loss. These studies provide clinical and biological information about subjective irritation; the data suggest a functional correlation for the what had been considered a purely subjective (sensory) phenomena.

Patients with demonstrated contact dermatitis to DNCB (dinitrochlorobenzene) were patch-tested using various dinitrophenyl (DNP) derivatives. These investigations revealed the varying sensitivities to the structural isomers DNP-L-alpha-alanine (59% positive) and DNP-beta-alanine (4% positive). These results are discussed both in connection with various sensitivity rates to other DNP compounds and published findings from the literature concerning the influence of structural factors on immune reactivity.

An outbreak of acneiform eruptions occurred in 14 workers in a polyvinyl chloride (PVC) manufacturing factory. The cause was probably a combination of heat, high humidity and irritation from PVC powder. PVC slurry, scales and powder, to which the workers were exposed, were not comedogenic on rabbit ear. Lowering the temperature and humidity by airconditioning and improving ventilation, together with reduction of dust level at the workplaces, eliminated further outbreak's.

Erythema chronicum migrans, lymphadenosis benigna cutis and acrodermatitis chronica atrophicans represent the dermatological manifestations of the multi-organ disease Lyme borreliosis. Koch's requirements of evidence for an infectious disease, demonstration of the bacterium, transfer, and culture have proven Borrelia burgdorferi to be the causative agent of the above mentioned skin diseases. This justifies a penicillin therapy, that has been administered in Europe empirically for the last 30 years. Correct and prompt diagnosis is important since delayed treatment is less effective, presumably because the spirochete becomes sequestered in immune-privileged sites. Recent observations in several laboratories that antibody titers to Borrelia burgdorferi are also elevated in several other skin diseases and that the spirochete can be detected in tissue sections of different organs may imply extension of the dermatological spectrum of Lyme disease. The significance of these findings in such heterogeneous diseases as morphea, lichen sclerosus et atrophicans, etc. however awaits final examination.

We report two cases of occupational contact dermatitis in billboard workers due to employment of a new paste additive. Clinical picture, patch test result, histological pattern of the test reaction and course of the disease indicate that the observed eczema are manifestations of contact allergy and do not represent irritant-toxic dermatitis. The glue is a hydrous solution of a heterogeneous mixture of condensation products of acetone and formaldehyde with a small part of free acetone and formaldehyde. Exact determination of the allergen and identification of the substance group failed. The allergen seems to be a strong sensitizer.

The present paper describes the microcomputer-based allergy data storage and retrieval system, realized with the relational database system INFORMIX on a Siemens MX2 computer. The main features of the kind and structure of data stored are discussed, as well as some general aspects of data storage. Additionally, the activities of the German Contact Dermatitis Group with regard to computer-based documentation are mentioned.