Pub Date : 2022-10-01DOI: 10.4103/1027-8117.359342
Yu-Hsun Wei, Sheng-Hsiang Ma, Yung-Ting Chang, Cheng-Yuan Li
{"title":"Zinc-responsive seronegative necrolytic acral erythema: A case report and literature review","authors":"Yu-Hsun Wei, Sheng-Hsiang Ma, Yung-Ting Chang, Cheng-Yuan Li","doi":"10.4103/1027-8117.359342","DOIUrl":"https://doi.org/10.4103/1027-8117.359342","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76006746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/1027-8117.359340
Chia-Lun Li, Ding-Dar Lee
{"title":"Periungual xanthomas in a case of hepatocellular carcinoma and dyslipidemia","authors":"Chia-Lun Li, Ding-Dar Lee","doi":"10.4103/1027-8117.359340","DOIUrl":"https://doi.org/10.4103/1027-8117.359340","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90065231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jinyan Yang, Mingfeng Zhan, Zhaohui Chen, Lihua Li, Juan Lu, Min Yang, Xuewen Gao
Background: Psoriasis is a common skin inflammatory disease. Dysregulated growth and differentiation of keratinocytes are the main characteristics of psoriasis. Diosmetin is a naturally occurring flavonoid with antioxidant, anti-inflammatory, and antibacterial properties. However, the anti-psoriatic role and mechanism of diosmetin remain unclear. Objectives: To investigate anti-psoriatic role and mechanism of diosmetin. Methods: Human immortalized epidermal cells (HaCaT) were treated with tumor necrosis factor-alpha (TNF-α) to establish the cell model of psoriasis. Mice were treated with imiquimod (IMQ) to establish the animal model of psoriasis. Cell viability and apoptosis were detected by methyl thiazolyl tetrazolium and flow cytometry, respectively. Reverse transcription-quantitative polymerase chain reaction and ELISA assays were performed to detect the expression of interleukin (IL)-6 and IL-8. Hematoxylin and eosin staining was used to detect the skin lesion. Results: Diosmetin reduced cell viability and promoted the apoptosis of TNF-α-induced HaCaT. Protein expression of Bax in TNF-α-induced HaCaT was up-regulated, while Bcl-2 was down-regulated by diosmetin. Diosmetin attenuated TNF-α-induced increase in IL-6 and IL-8 in HaCaT. The enhanced protein expression of toll-like receptor 4 (TLR 4) (toll-like receptor 4), p65 and IκBα phosphorylation, as well as reduced IκBα in TNF-α-induced HaCaT were restored by diosmetin. Diosmetin improved IMQ-induced skin lesion and attenuated inflammatory response in psoriasis-like mouse model. Conclusion: Diosmetin exerted anti-inflammatory and pro-apoptotic effects on TNF-α-induced HaCaT and IMQ-induced mice through inactivation of TLR4/nuclear factor kappa B pathway.
背景:银屑病是一种常见的皮肤炎症性疾病。角化细胞生长和分化失调是银屑病的主要特征。薯蓣皂苷是一种天然存在的类黄酮，具有抗氧化、抗炎和抗菌的特性。然而，薯蓣皂苷的抗银屑病作用及其机制尚不清楚。目的:探讨薯蓣皂苷的抗银屑病作用及其机制。方法:用肿瘤坏死因子α (TNF-α)处理人永生化表皮细胞(HaCaT)，建立银屑病细胞模型。用咪喹莫特(IMQ)治疗小鼠，建立牛皮癣动物模型。分别用甲基噻唑四氮唑和流式细胞术检测细胞活力和凋亡。采用逆转录-定量聚合酶链反应和ELISA法检测白细胞介素(IL)-6和IL-8的表达。采用苏木精和伊红染色检测皮肤病变。结果:薯蓣皂苷降低肿瘤坏死因子-α-诱导的HaCaT细胞活力，促进细胞凋亡。在TNF-α-诱导的HaCaT中，Bax蛋白表达上调，薯蓣皂苷下调Bcl-2蛋白表达。薯蓣皂苷可减弱TNF-α-诱导的HaCaT中IL-6和IL-8的升高。在TNF-α-诱导的HaCaT中，黄芪皂苷恢复了toll样受体4 (toll-like receptor 4)、p65和i - κ b α磷酸化水平的升高，以及i - κ b α水平的降低。薯蓣皂苷改善imq诱导的银屑病样小鼠模型皮肤损伤，减轻炎症反应。结论:薯薯素通过使TLR4/核因子κ B通路失活，对TNF-α-诱导的HaCaT和imq诱导小鼠具有抗炎和促凋亡作用。
{"title":"Diosmetin ameliorates imiquimod-induced psoriasis by regulating apoptosis and inflammation via toll-like receptor 4/nuclear factor kappa B pathway","authors":"Jinyan Yang, Mingfeng Zhan, Zhaohui Chen, Lihua Li, Juan Lu, Min Yang, Xuewen Gao","doi":"10.4103/ds.ds_31_22","DOIUrl":"https://doi.org/10.4103/ds.ds_31_22","url":null,"abstract":"Background: Psoriasis is a common skin inflammatory disease. Dysregulated growth and differentiation of keratinocytes are the main characteristics of psoriasis. Diosmetin is a naturally occurring flavonoid with antioxidant, anti-inflammatory, and antibacterial properties. However, the anti-psoriatic role and mechanism of diosmetin remain unclear. Objectives: To investigate anti-psoriatic role and mechanism of diosmetin. Methods: Human immortalized epidermal cells (HaCaT) were treated with tumor necrosis factor-alpha (TNF-α) to establish the cell model of psoriasis. Mice were treated with imiquimod (IMQ) to establish the animal model of psoriasis. Cell viability and apoptosis were detected by methyl thiazolyl tetrazolium and flow cytometry, respectively. Reverse transcription-quantitative polymerase chain reaction and ELISA assays were performed to detect the expression of interleukin (IL)-6 and IL-8. Hematoxylin and eosin staining was used to detect the skin lesion. Results: Diosmetin reduced cell viability and promoted the apoptosis of TNF-α-induced HaCaT. Protein expression of Bax in TNF-α-induced HaCaT was up-regulated, while Bcl-2 was down-regulated by diosmetin. Diosmetin attenuated TNF-α-induced increase in IL-6 and IL-8 in HaCaT. The enhanced protein expression of toll-like receptor 4 (TLR 4) (toll-like receptor 4), p65 and IκBα phosphorylation, as well as reduced IκBα in TNF-α-induced HaCaT were restored by diosmetin. Diosmetin improved IMQ-induced skin lesion and attenuated inflammatory response in psoriasis-like mouse model. Conclusion: Diosmetin exerted anti-inflammatory and pro-apoptotic effects on TNF-α-induced HaCaT and IMQ-induced mice through inactivation of TLR4/nuclear factor kappa B pathway.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82066879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/1027-8117.362992
Liang-Tseng Kuo, S. Shao, C. Chi
In recent decades, the volume of health publications has increased. A well-conducted systematic review (SR), with or without a meta-analysis, is considered the best reference for health care professionals to catch up with the best evidence. With the rapid increase in the number of published SRs, their study quality varies despite well established reporting guidelines and references. Understanding the process of producing SRs is critical to the execution and is not trivial due to the obstacles researchers may encounter. The aim of this article was to provide a step-by-step approach to help researchers (mostly novices) keep their SR up to standard. The steps presented here are a quick tutorial with reference to known and accepted international guidances and our expertise.
{"title":"Ten essential steps for performing a systematic review: A quick tutorial","authors":"Liang-Tseng Kuo, S. Shao, C. Chi","doi":"10.4103/1027-8117.362992","DOIUrl":"https://doi.org/10.4103/1027-8117.362992","url":null,"abstract":"In recent decades, the volume of health publications has increased. A well-conducted systematic review (SR), with or without a meta-analysis, is considered the best reference for health care professionals to catch up with the best evidence. With the rapid increase in the number of published SRs, their study quality varies despite well established reporting guidelines and references. Understanding the process of producing SRs is critical to the execution and is not trivial due to the obstacles researchers may encounter. The aim of this article was to provide a step-by-step approach to help researchers (mostly novices) keep their SR up to standard. The steps presented here are a quick tutorial with reference to known and accepted international guidances and our expertise.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73717580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/1027-8117.358116
Yi-Wei Huang, Wei-Hsin Wu
{"title":"Treatment of recalcitrant pemphigoid vegetans in an elderly patient with rituximab","authors":"Yi-Wei Huang, Wei-Hsin Wu","doi":"10.4103/1027-8117.358116","DOIUrl":"https://doi.org/10.4103/1027-8117.358116","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83565324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4103/1027-8117.360448
Chang-Ming Huang, T. Tsai
Background: Diphenylcyclopropenone (DPCP) is a topical contact allergen used for contact immunotherapy in alopecia areata (AA). Objectives: We aimed to evaluate the treatment effectiveness and prognostic factors in Taiwanese patients with AA treated with topical DPCP. Methods: We performed a retrospective study of all consecutive patients with AA affecting more than 10% of scalp area treated with topical DPCP for more than 90 days. Results: Eighty-six patients were assessed in the study. The greatest hair regrowth percentages of 0%, 1%–25%, 26%–50%, 51%–75%, and 76%–100% were 26.7% (23/86), 7.0% (6/86), 2.3% (2/86), 10.5% (9/86), and 53.5% (46/86) of patients, respectively. 32.6% (28/86) of patients achieved near-complete remission (with or without maintenance DPCP therapy), defined as more than 90% sustainable hair regrowth. Positive prognostic factors include older age of onset, shorter duration of AA before DPCP treatment, less severity of hair loss, and no nonscalp hair loss. Multivariate logistic regression analysis showed that more than a 2-year duration of AA before DPCP treatment (P = 0.015) and more than 90% of hair loss (P = 0.032) had a poorer treatment outcome. Factors including eczematous sensitization reaction, history of atopy, adverse reactions, or concentrations of DPCP do not predict treatment effectiveness. Pigmentary change may cause cosmetic concerns in Chinese ethnicity. Conclusion: Topical DPCP is effective for AA. Various factors were associated with the clinical outcomes. Monitoring the possible adverse events is warranted.
{"title":"Topical diphenylcyclopropenone in the treatment of alopecia areata: A 10-year follow-up of 86 cases in a single center","authors":"Chang-Ming Huang, T. Tsai","doi":"10.4103/1027-8117.360448","DOIUrl":"https://doi.org/10.4103/1027-8117.360448","url":null,"abstract":"Background: Diphenylcyclopropenone (DPCP) is a topical contact allergen used for contact immunotherapy in alopecia areata (AA). Objectives: We aimed to evaluate the treatment effectiveness and prognostic factors in Taiwanese patients with AA treated with topical DPCP. Methods: We performed a retrospective study of all consecutive patients with AA affecting more than 10% of scalp area treated with topical DPCP for more than 90 days. Results: Eighty-six patients were assessed in the study. The greatest hair regrowth percentages of 0%, 1%–25%, 26%–50%, 51%–75%, and 76%–100% were 26.7% (23/86), 7.0% (6/86), 2.3% (2/86), 10.5% (9/86), and 53.5% (46/86) of patients, respectively. 32.6% (28/86) of patients achieved near-complete remission (with or without maintenance DPCP therapy), defined as more than 90% sustainable hair regrowth. Positive prognostic factors include older age of onset, shorter duration of AA before DPCP treatment, less severity of hair loss, and no nonscalp hair loss. Multivariate logistic regression analysis showed that more than a 2-year duration of AA before DPCP treatment (P = 0.015) and more than 90% of hair loss (P = 0.032) had a poorer treatment outcome. Factors including eczematous sensitization reaction, history of atopy, adverse reactions, or concentrations of DPCP do not predict treatment effectiveness. Pigmentary change may cause cosmetic concerns in Chinese ethnicity. Conclusion: Topical DPCP is effective for AA. Various factors were associated with the clinical outcomes. Monitoring the possible adverse events is warranted.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89700313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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