Pub Date : 2020-08-30DOI: 10.29235/1561-8323-2020-64-4-448-456
Y. Harmaza, A. Tamashevski, E. Slobozhanina
A comparative analysis of the molecular process of nanostructured zinc oxide of different shape (rod and spherical particle) and zinc chloride as a source of free ions on human lymphocytes was carried out. Our data indicated that ZnO nanostructures induced a decrease in the lymphocyte viability and an increase in the intracellular labile Zn 2+ pool in a concentration-dependent manner after 20 and 40 h incubation with cells. It was found that ZnO NRs have the lowest cytotoxicity, but ZnCl 2 - the highest. The Zn-mediated activation of free radical processes - ROS accumulation in the cells -is a possible mechanism of the cytotoxic action of these agents. Thus, the shape of ZnO nanomaterial and its ability “to shed” zinc ions make the main contribution to the detected molecular and membrane process on human lymphocytes in vitro .
{"title":"Molecular nature of cytotoxicity of zinc oxide nanostructures","authors":"Y. Harmaza, A. Tamashevski, E. Slobozhanina","doi":"10.29235/1561-8323-2020-64-4-448-456","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-4-448-456","url":null,"abstract":"A comparative analysis of the molecular process of nanostructured zinc oxide of different shape (rod and spherical particle) and zinc chloride as a source of free ions on human lymphocytes was carried out. Our data indicated that ZnO nanostructures induced a decrease in the lymphocyte viability and an increase in the intracellular labile Zn 2+ pool in a concentration-dependent manner after 20 and 40 h incubation with cells. It was found that ZnO NRs have the lowest cytotoxicity, but ZnCl 2 - the highest. The Zn-mediated activation of free radical processes - ROS accumulation in the cells -is a possible mechanism of the cytotoxic action of these agents. Thus, the shape of ZnO nanomaterial and its ability “to shed” zinc ions make the main contribution to the detected molecular and membrane process on human lymphocytes in vitro .","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87789413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-30DOI: 10.29235/1561-8323-2020-64-4-506-512
V. Gusakov, A. Kovalenya
During rapid economic development and emergence of new technologies, as well as the expansion of intercultural communications, improving the knowledge of foreign languages is one of the conditions for a successful adaptation of new generations in the social space and for the mastery of global scientific, technical, spiritual and cultural competencies. According to the latest data, about 70% of the world population speaks more than one language, while the bilingual people communicate to the best of their education. Nevertheless, the bilingualism problem is not removed from the agenda and is quite relevant for Belarus, which requires further scientific study.
{"title":"Belarusian-Russian bilingualism is the historically spiritual and cultural value of the people","authors":"V. Gusakov, A. Kovalenya","doi":"10.29235/1561-8323-2020-64-4-506-512","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-4-506-512","url":null,"abstract":"During rapid economic development and emergence of new technologies, as well as the expansion of intercultural communications, improving the knowledge of foreign languages is one of the conditions for a successful adaptation of new generations in the social space and for the mastery of global scientific, technical, spiritual and cultural competencies. According to the latest data, about 70% of the world population speaks more than one language, while the bilingual people communicate to the best of their education. Nevertheless, the bilingualism problem is not removed from the agenda and is quite relevant for Belarus, which requires further scientific study.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78541099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-30DOI: 10.29235/1561-8323-2020-64-4-495-505
V. A. Kot
Two new variants of approximate analytical solution of the one-phase Stefan problem with a convective boundary condition at a fixed boundary are proposed. These approaches are based on the use of new integral relations forming infinite sequences. It is shown that the most exact variant of solving the Stefan problem with a convective boundary condition is to refuse from the classical Stefan condition at the free boundary and to replace it with its integral relation. By the example of solving the test Stefan problem with a Robin boundary condition, having an exact analytical solution, it is shown that the proposed approach is much more exact and efficient compared to the known variants of the integral computational scheme, including the heat-balance integral method allowing the Stefan condition at the free boundary to be satisfied. The solutions obtained with the use of the square-law and cubic polynomials are presented. As for the test problem using the cubic polynomial, the relative error in determining the free boundary comprises hundredths and thousandths of percent. In this case, at the time instant t = 1, the relative error in determining the temperature profile is e T = 0.075 %.
{"title":"A new approach to approximate solution of the Stefan problem with a convective boundary condition (Communicated by Corresponding Member Nikolai V. Pavlyukevich)","authors":"V. A. Kot","doi":"10.29235/1561-8323-2020-64-4-495-505","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-4-495-505","url":null,"abstract":"Two new variants of approximate analytical solution of the one-phase Stefan problem with a convective boundary condition at a fixed boundary are proposed. These approaches are based on the use of new integral relations forming infinite sequences. It is shown that the most exact variant of solving the Stefan problem with a convective boundary condition is to refuse from the classical Stefan condition at the free boundary and to replace it with its integral relation. By the example of solving the test Stefan problem with a Robin boundary condition, having an exact analytical solution, it is shown that the proposed approach is much more exact and efficient compared to the known variants of the integral computational scheme, including the heat-balance integral method allowing the Stefan condition at the free boundary to be satisfied. The solutions obtained with the use of the square-law and cubic polynomials are presented. As for the test problem using the cubic polynomial, the relative error in determining the free boundary comprises hundredths and thousandths of percent. In this case, at the time instant t = 1, the relative error in determining the temperature profile is e T = 0.075 %.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79618021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-30DOI: 10.29235/1561-8323-2020-64-4-403-410
F. Komarov, I. Romanov, L. Vlasukova, I. Parkhomenko, A. A. Tsivako, N. Kovalchuk
The electrophysical properties and the resistive switching effect of the ITO/SiNx/Si memristor structure were studied. A silicon nitride film with a thickness of ~200 nm with an inhomogeneous element depth distribution was deposited by low-pressure chemical vapor deposition. Based on the Rutherford backscattering data, it was shown that the concentration of excess silicon atoms in the SiNx film increases from 9 to 44 % when approaching the Si substrate. The analysis of the current-voltage characteristics of ITO/SiNx/Si structures revealed that the conduction mechanism in the high-resistance state is determined by the nitride film properties and is described by the Poole–Frenkel model taking into account the hopping model of electron transport between traps. Switching to the low-resistance state is probably caused by the migration of indium or tin ions from the ITO contact to the SiNx layer. The conduction of the ITO/SiNx/Si structure in the low-resistance state is determined by both the mechanisms of charge-carrier injection from the contact and charge-carrier transport through the dielectric layer. Reverse polarity results in destructing the conductive channel and switching the structure to the high-resistance state. The photo-switching effect was found for the ITO/SiNx/Si structure, which opens up new possibilities of using memristors in silicon optoelectronic systems.
{"title":"Memristor structure with the effect of switching resistance based on silicon nitride thin layers","authors":"F. Komarov, I. Romanov, L. Vlasukova, I. Parkhomenko, A. A. Tsivako, N. Kovalchuk","doi":"10.29235/1561-8323-2020-64-4-403-410","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-4-403-410","url":null,"abstract":"The electrophysical properties and the resistive switching effect of the ITO/SiNx/Si memristor structure were studied. A silicon nitride film with a thickness of ~200 nm with an inhomogeneous element depth distribution was deposited by low-pressure chemical vapor deposition. Based on the Rutherford backscattering data, it was shown that the concentration of excess silicon atoms in the SiNx film increases from 9 to 44 % when approaching the Si substrate. The analysis of the current-voltage characteristics of ITO/SiNx/Si structures revealed that the conduction mechanism in the high-resistance state is determined by the nitride film properties and is described by the Poole–Frenkel model taking into account the hopping model of electron transport between traps. Switching to the low-resistance state is probably caused by the migration of indium or tin ions from the ITO contact to the SiNx layer. The conduction of the ITO/SiNx/Si structure in the low-resistance state is determined by both the mechanisms of charge-carrier injection from the contact and charge-carrier transport through the dielectric layer. Reverse polarity results in destructing the conductive channel and switching the structure to the high-resistance state. The photo-switching effect was found for the ITO/SiNx/Si structure, which opens up new possibilities of using memristors in silicon optoelectronic systems.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84233545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-30DOI: 10.29235/1561-8323-2020-64-4-477-487
A. Petrovsky, V. Y. Prushak, D. Puzanov
A study was made of the features of rock pressure manifestation and the deformation nature of development and assembly workings depending on the binding of the roof and its location relative to the longwalls mined by the chamber system for layers 2, 2-3, 3, as well as of the panels mined by the chamber system in the extraction conditions of the worked out fourth sylvinite layer of the Third potash horizon at a depth of more than 600 m. It was established that the service life of newly designed workings depends on their location on the panel, the roof binding and fastening parameters. The longest service life of workings will be noted when they are located in the mined space above the mined longwalls along the lower layers, and the shortest service life will be marked when they are carried out in the central part of the safety intercolumn pillars. Based on the studies performed, the recommendations were made on the selection of locations, roof bindings and on the protection and maintenance of development workings for the sites of the mine fields of the JSC “Belaruskali” mines extracting the worked out fourth sylvinite layer at depths over 600 m. The developed recommendations are aimed at improving the work safety and efficiency when extracting abandoned mineral reserves. Using the study results, the project was developed to conduct development workings of a new panel of the longwall 11-5 that provides the necessary stability of workings for the entire period of winning operations and, ultimately, safe extraction of potash ore in the amount of at least 2 million tons.
{"title":"Features of the development of longwalls that extract the underworked sylvinite layer in the deep horizons of the Starobin potash salt deposit","authors":"A. Petrovsky, V. Y. Prushak, D. Puzanov","doi":"10.29235/1561-8323-2020-64-4-477-487","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-4-477-487","url":null,"abstract":"A study was made of the features of rock pressure manifestation and the deformation nature of development and assembly workings depending on the binding of the roof and its location relative to the longwalls mined by the chamber system for layers 2, 2-3, 3, as well as of the panels mined by the chamber system in the extraction conditions of the worked out fourth sylvinite layer of the Third potash horizon at a depth of more than 600 m. It was established that the service life of newly designed workings depends on their location on the panel, the roof binding and fastening parameters. The longest service life of workings will be noted when they are located in the mined space above the mined longwalls along the lower layers, and the shortest service life will be marked when they are carried out in the central part of the safety intercolumn pillars. Based on the studies performed, the recommendations were made on the selection of locations, roof bindings and on the protection and maintenance of development workings for the sites of the mine fields of the JSC “Belaruskali” mines extracting the worked out fourth sylvinite layer at depths over 600 m. The developed recommendations are aimed at improving the work safety and efficiency when extracting abandoned mineral reserves. Using the study results, the project was developed to conduct development workings of a new panel of the longwall 11-5 that provides the necessary stability of workings for the entire period of winning operations and, ultimately, safe extraction of potash ore in the amount of at least 2 million tons.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89590668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-09DOI: 10.29235/1561-8323-2020-64-3-263-267
V. Bakhtin, B. Sadok
We consider a space of infinite signals composed of finite-alphabet letters. Each signal generates a sequence of empirical measures on the alphabet and a limit set corresponding to this sequence. The space of signals is partitioned into narrow basins consisting of signals with identical limit sets for the empirical measures, and the packing dimension is computed for each narrow basin.
{"title":"Packing dimensions of basins in the space of sequences","authors":"V. Bakhtin, B. Sadok","doi":"10.29235/1561-8323-2020-64-3-263-267","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-3-263-267","url":null,"abstract":"We consider a space of infinite signals composed of finite-alphabet letters. Each signal generates a sequence of empirical measures on the alphabet and a limit set corresponding to this sequence. The space of signals is partitioned into narrow basins consisting of signals with identical limit sets for the empirical measures, and the packing dimension is computed for each narrow basin.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84877531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-09DOI: 10.29235/1561-8323-2020-64-3-300-307
E. Kosandrovich, P. V. Nesteronok, L. N. Shachenkova, V. Soldatov
Polyampholytes, containing aminodiacetic functional groups, on the base of polyacrylonitrile fiber Nitron C were obtained by the amination reaction of nitrile groups with polyamines (number of repeating units from 1 to 5) and subsequent alkylation with monochloroacetic acid. The experimental results of potentiometric titration and sorption of supporting electrolyte (kCl) ions by synthesized ion exchangers were obtained, which made it possible to determine the acidity parameters of functional groups: the presence of four types of cation exchange and two types of anion exchange groups was detected in polyampholytes, the sequence of their neutralization in the titration process was established.
{"title":"Acid-base properties of fibrous polyampholytes with aminodiacetic functional groups","authors":"E. Kosandrovich, P. V. Nesteronok, L. N. Shachenkova, V. Soldatov","doi":"10.29235/1561-8323-2020-64-3-300-307","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-3-300-307","url":null,"abstract":"Polyampholytes, containing aminodiacetic functional groups, on the base of polyacrylonitrile fiber Nitron C were obtained by the amination reaction of nitrile groups with polyamines (number of repeating units from 1 to 5) and subsequent alkylation with monochloroacetic acid. The experimental results of potentiometric titration and sorption of supporting electrolyte (kCl) ions by synthesized ion exchangers were obtained, which made it possible to determine the acidity parameters of functional groups: the presence of four types of cation exchange and two types of anion exchange groups was detected in polyampholytes, the sequence of their neutralization in the titration process was established.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88240743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-09DOI: 10.29235/1561-8323-2020-64-3-293-299
E. Vorobieva
The swelling kinetics of cross-linked polyacrylamide was studied depending on the composition of the external solution. It was shown that the polymer gel swelling during the transition from water to a potassium or sodium chloride solution and vice versa sharply decreases, then gradually increases. The swelling of gel in a solution of sodium chloride is higher than that of potassium chloride. In the equilibrium swollen gel, the concentration of salts in the gel phase is higher than in the external solution and increases with the transition from potassium chloride to sodium chloride.
{"title":"Swelling of polyacrylamide-based hydrogel in aqueous solutions of low-molecular salts","authors":"E. Vorobieva","doi":"10.29235/1561-8323-2020-64-3-293-299","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-3-293-299","url":null,"abstract":"The swelling kinetics of cross-linked polyacrylamide was studied depending on the composition of the external solution. It was shown that the polymer gel swelling during the transition from water to a potassium or sodium chloride solution and vice versa sharply decreases, then gradually increases. The swelling of gel in a solution of sodium chloride is higher than that of potassium chloride. In the equilibrium swollen gel, the concentration of salts in the gel phase is higher than in the external solution and increases with the transition from potassium chloride to sodium chloride.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88926553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-09DOI: 10.29235/1561-8323-2020-64-3-268-272
A. P. Sadovskiĭ
The necessary conditions of the center at the singular point O (0, 0) for the kolmogorov system with fourth-degree homogeneous nonlinearities are found in the work of B. Ferenc, J. Dzheny, W. Liu, V. G. Romanovsky. For all these cases, with the exception of two, sufficiency is also proved. In the present article, sufficiency is proved for two cases of the center that were not proved in the above-mentioned work. In addition, the sufficiency of two other conditions of the center is proved in another way.
在B. Ferenc, J. Dzheny, W. Liu, V. G. Romanovsky的工作中，得到了四次齐次非线性kolmogorov系统在奇点O(0,0)处中心存在的必要条件。除两种情况外，所有这些情况也都证明了充分性。本文对上述工作中未证明的两种中心的充分性进行了证明。此外，用另一种方法证明了中心的另外两个条件的充分性。
{"title":"On the kolmogorov system with fourth-degree homogeneous nonlinearities","authors":"A. P. Sadovskiĭ","doi":"10.29235/1561-8323-2020-64-3-268-272","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-3-268-272","url":null,"abstract":"The necessary conditions of the center at the singular point O (0, 0) for the kolmogorov system with fourth-degree homogeneous nonlinearities are found in the work of B. Ferenc, J. Dzheny, W. Liu, V. G. Romanovsky. For all these cases, with the exception of two, sufficiency is also proved. In the present article, sufficiency is proved for two cases of the center that were not proved in the above-mentioned work. In addition, the sufficiency of two other conditions of the center is proved in another way.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85254564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-09DOI: 10.29235/1561-8323-2020-64-3-332-340
S. N. Chepelev, F. Vismont, S. V. Goubkin
Modern medicine faces the problem of the growth of cardiovascular pathology. Given the high medical and social significance of the problem of treating patients with coronary heart disease and acute myocardial infarction, the search for new effective methods to prevent or weaken ischemic myocardial damage and mechanisms for their implementation is an urgent task of modern experimental and clinical medicine. The aim of the study was to determine the significance of hyperlactatemia in the realization of the infarct-limiting effect of remote ischemic postconditioning (RIPostC) in rat myocardial ischemia-reperfusion in the experiment. The study revealed that after 15-minute RIPostC, which was performed 10 minutes after 30-minute acute myocardial ischemia followed by 120-minute reperfusion, the plasma lactate level in rats increased 1.87 times (87.7 %, p < 0.05) compared with intact animals. It was established that the introduction of L-lactate into the left common jugular vein at a dose of 10 μg/kg, which was carried out 25 minutes after the onset of reperfusion under the conditions of myocardial ischemia (30 minutes) and next reperfusion (120 minutes) and RIPostC (10 minutes after the onset of reperfusion), which was reproduced by ischemia of these limbs, have a heart attack-limiting effect. The increase of the level of blood lactate (hyperlactatemia) after RIPostC in myocardial ischemia-reperfusion is of significance in the implementation of its infarct-limiting effect.
{"title":"On the significance of hyperlactatemia in the implementation of the infarct-limiting effect of remote ischemic postconditioning in myocardial ischemia-reperfusion in the experiment","authors":"S. N. Chepelev, F. Vismont, S. V. Goubkin","doi":"10.29235/1561-8323-2020-64-3-332-340","DOIUrl":"https://doi.org/10.29235/1561-8323-2020-64-3-332-340","url":null,"abstract":"Modern medicine faces the problem of the growth of cardiovascular pathology. Given the high medical and social significance of the problem of treating patients with coronary heart disease and acute myocardial infarction, the search for new effective methods to prevent or weaken ischemic myocardial damage and mechanisms for their implementation is an urgent task of modern experimental and clinical medicine. The aim of the study was to determine the significance of hyperlactatemia in the realization of the infarct-limiting effect of remote ischemic postconditioning (RIPostC) in rat myocardial ischemia-reperfusion in the experiment. The study revealed that after 15-minute RIPostC, which was performed 10 minutes after 30-minute acute myocardial ischemia followed by 120-minute reperfusion, the plasma lactate level in rats increased 1.87 times (87.7 %, p < 0.05) compared with intact animals. It was established that the introduction of L-lactate into the left common jugular vein at a dose of 10 μg/kg, which was carried out 25 minutes after the onset of reperfusion under the conditions of myocardial ischemia (30 minutes) and next reperfusion (120 minutes) and RIPostC (10 minutes after the onset of reperfusion), which was reproduced by ischemia of these limbs, have a heart attack-limiting effect. The increase of the level of blood lactate (hyperlactatemia) after RIPostC in myocardial ischemia-reperfusion is of significance in the implementation of its infarct-limiting effect.","PeriodicalId":11283,"journal":{"name":"Doklady of the National Academy of Sciences of Belarus","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84818044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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