Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101095
Katsuhisa Inoue
{"title":"Role of intracellular SLC46A3 in the cytosolic exposure and pharmacological effect of the payload of trastuzumab emtansine (ADC)","authors":"Katsuhisa Inoue","doi":"10.1016/j.dmpk.2025.101095","DOIUrl":"10.1016/j.dmpk.2025.101095","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101095"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101090
Wenyi Wang
{"title":"Driving compound optimization in early discovery by implementing mechanistic pharmacokinetic and machine learning models","authors":"Wenyi Wang","doi":"10.1016/j.dmpk.2025.101090","DOIUrl":"10.1016/j.dmpk.2025.101090","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101090"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101151
Tony Kiang, Ala’a Al-Dajani
{"title":"Effects of mefenamic acid on the conjugative metabolism of indole and p-cresol in relation to cellular necrosis in a metabolically competent human hepatoma cell line","authors":"Tony Kiang, Ala’a Al-Dajani","doi":"10.1016/j.dmpk.2025.101151","DOIUrl":"10.1016/j.dmpk.2025.101151","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101151"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101117
Ryan Vandrey
{"title":"Challenges and breakthroughs in the conduct of clinical cannabis studies","authors":"Ryan Vandrey","doi":"10.1016/j.dmpk.2025.101117","DOIUrl":"10.1016/j.dmpk.2025.101117","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101117"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101140
Kozo Tagawa , Akiko Kiriyama , San Yuet Lin , Sota Fukunaga
{"title":"Development of dissolution evaluation system for drug absorption (V): Additional intestinal absorption module of in vitro 3D gastric emptying mmodel for orally disintegrating tablet","authors":"Kozo Tagawa , Akiko Kiriyama , San Yuet Lin , Sota Fukunaga","doi":"10.1016/j.dmpk.2025.101140","DOIUrl":"10.1016/j.dmpk.2025.101140","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101140"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101079
Akihiro Ishiguro
{"title":"Review of finalized ICH M12 guideline on drug interaction studies","authors":"Akihiro Ishiguro","doi":"10.1016/j.dmpk.2025.101079","DOIUrl":"10.1016/j.dmpk.2025.101079","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101079"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of a strategy to prevent cisplatin-induced kidney injury by targeting mate-type transporters","authors":"Masaya Kanda , Mitsuhiro Goda , Kei Kawada , Takashi Bando , Shunsuke Ishida , Shuto Itokazu , Takahiro Niimura , Fuka Aizawa , Kenta Yagi , Yuki Izawa-Ishizawa , Keisuke Ishizawa","doi":"10.1016/j.dmpk.2025.101129","DOIUrl":"10.1016/j.dmpk.2025.101129","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101129"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101067
Xinxin Ding
{"title":"In vivo models for assessing the toxicity of reactive metabolites","authors":"Xinxin Ding","doi":"10.1016/j.dmpk.2025.101067","DOIUrl":"10.1016/j.dmpk.2025.101067","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101067"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rapid production of rabbit monoclonal anti-idiotype antibody for antibody drugs by ecobody technology","authors":"Shin Kawano, Tomoe Yamauchi, Tomiko Yamada, Risumi Isogai, Satoko Yamamoto, Shoji Ohuchi","doi":"10.1016/j.dmpk.2025.101133","DOIUrl":"10.1016/j.dmpk.2025.101133","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101133"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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