Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101150
Sarah Glass, Isaiah Swauncy, Annie Caudle, Kevin Coe
{"title":"Confounding effects of B-glucuronidase on UDP-Glucuronosyltransferase stability: Development of a modified metabolic stability assay to enable SAR for a discovery program","authors":"Sarah Glass, Isaiah Swauncy, Annie Caudle, Kevin Coe","doi":"10.1016/j.dmpk.2025.101150","DOIUrl":"10.1016/j.dmpk.2025.101150","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101150"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101152
Yuu Miyauchi , Madoka Sawai , Hisao Kansui , Shinji Takechi , Peter I. Mackenzie , Yuji Ishii
{"title":"SDS-stable homo-oligomers of UDP-Glucuronosyltransferase 2B7: Involvement of disulfide bond formation via a specific cystein residue","authors":"Yuu Miyauchi , Madoka Sawai , Hisao Kansui , Shinji Takechi , Peter I. Mackenzie , Yuji Ishii","doi":"10.1016/j.dmpk.2025.101152","DOIUrl":"10.1016/j.dmpk.2025.101152","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101152"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101077
Yasushi Okuno
{"title":"AI platform to accelerate drug discovery","authors":"Yasushi Okuno","doi":"10.1016/j.dmpk.2025.101077","DOIUrl":"10.1016/j.dmpk.2025.101077","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101077"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101144
Chao Zhang, Huan He, Shoutao Liu, Lijuan Hou, Jacob Zhi Chen, Yi Tao, Liang Shen
{"title":"Evaluation of different tissue processing methods in Bama pig skin as an animal model for topical delivery systems","authors":"Chao Zhang, Huan He, Shoutao Liu, Lijuan Hou, Jacob Zhi Chen, Yi Tao, Liang Shen","doi":"10.1016/j.dmpk.2025.101144","DOIUrl":"10.1016/j.dmpk.2025.101144","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101144"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101078
Aleksandra Galetin
{"title":"Endogenous biomarker-informed approaches for evaluation of transporter-mediated drug-drug and drug-disease interactions","authors":"Aleksandra Galetin","doi":"10.1016/j.dmpk.2025.101078","DOIUrl":"10.1016/j.dmpk.2025.101078","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101078"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101083
Sheila Peters
{"title":"Utility of mechanistic static models for predicting CYP- and transporter-mediated DDI","authors":"Sheila Peters","doi":"10.1016/j.dmpk.2025.101083","DOIUrl":"10.1016/j.dmpk.2025.101083","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101083"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101131
Suhong Zhang, Samuel Koppara
{"title":"Quantitative analysis of antibody conjugate payload by LC MS/MS without immunocapture","authors":"Suhong Zhang, Samuel Koppara","doi":"10.1016/j.dmpk.2025.101131","DOIUrl":"10.1016/j.dmpk.2025.101131","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101131"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.dmpk.2025.101109
Hideki Hirabayashi
{"title":"Best practice of mitigating P-Glycoprotein liabilities in drug discovery - Assessment and prediction of P-GP mediated nonlinear PK, brain penetration, and interactions","authors":"Hideki Hirabayashi","doi":"10.1016/j.dmpk.2025.101109","DOIUrl":"10.1016/j.dmpk.2025.101109","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"61 ","pages":"Article 101109"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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