Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100973
Emi Kimoto, David Tess, Matthew Cerny, Sumathy Mathialagan, Sangwoo Ryu, Manoli Vourvahis, A. David Rodrigues, Manthena V. Varma
{"title":"Challenges associated with the biomarker-informed PBPK modeling of renal transporter-mediated drug interactions","authors":"Emi Kimoto, David Tess, Matthew Cerny, Sumathy Mathialagan, Sangwoo Ryu, Manoli Vourvahis, A. David Rodrigues, Manthena V. Varma","doi":"10.1016/j.dmpk.2023.100973","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100973","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"65 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Harnessing the power of IVIVE-PBPK to explore potential discordance between local gut vs systemic bioequivalence in health and disease: the case of budesonide in crohn’s disease","authors":"Chunyan Han, Siri Kalyan Chirumamilla, Tiancheng Sun, Mandy Xu, Frederic Bois, Amin Rostami-Hodjegan","doi":"10.1016/j.dmpk.2023.100970","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100970","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"163 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100988
Sabin Shin, Sangyoung Lee, Chae Bin Lee, Seong Jun Jo, Soon Uk Chae, Da Hyun Kim, Duk Yeon Kim, Ui Min Jerng, Soo Kyung Bae
{"title":"The effect of traditional herbal medicine on the permeability of clarithromycin and loxoprofen in CACO-2 cell model","authors":"Sabin Shin, Sangyoung Lee, Chae Bin Lee, Seong Jun Jo, Soon Uk Chae, Da Hyun Kim, Duk Yeon Kim, Ui Min Jerng, Soo Kyung Bae","doi":"10.1016/j.dmpk.2023.100988","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100988","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"2 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of quantitative translational model of neutropenia using nonclinical animal data and physiological parameters","authors":"Naomi Wakayama, Yosuke Nakatani, Yukiko Miyajima, Yuko Nagayama, Yoko Nishino, Etsuko Ohta","doi":"10.1016/j.dmpk.2023.100960","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100960","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"92 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100938
Ruisong Pei, Bridget Becker, Rebecca Hansen, Robert Greene, Joe Marini, Dan Albaugh
{"title":"A workflow for oligonucleotide metabolite identification studies","authors":"Ruisong Pei, Bridget Becker, Rebecca Hansen, Robert Greene, Joe Marini, Dan Albaugh","doi":"10.1016/j.dmpk.2023.100938","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100938","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"123 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100962
Duk Yeon Kim, Soo Kyung Bae, Seong Jun Jo, Chae Bin Lee, Soon Uk Chae, Sabin Shin, Da Hyun Kim
{"title":"Development of physiologically-based pharmacokinetic models to predict food effects and co-administration of proton pump inhibitors on the pharmacokinetics of sonidegib and vismodegib","authors":"Duk Yeon Kim, Soo Kyung Bae, Seong Jun Jo, Chae Bin Lee, Soon Uk Chae, Sabin Shin, Da Hyun Kim","doi":"10.1016/j.dmpk.2023.100962","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100962","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"85 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100957
Dapeng Chen, Haojing Rong, Michele Mayo, Alice McDonald, Veronica Campbell, Xiaozhang Zheng, Sagar Agarwal, Matt Weiss, Anthony Slavin
{"title":"Prediction of pharmacokinetics and pharmacodynamics in human for IRAK4 targeted protein degrader","authors":"Dapeng Chen, Haojing Rong, Michele Mayo, Alice McDonald, Veronica Campbell, Xiaozhang Zheng, Sagar Agarwal, Matt Weiss, Anthony Slavin","doi":"10.1016/j.dmpk.2023.100957","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100957","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"203 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100953
Nihan Izat, J. Brian Houston, Jill Barber, Aleksandra Galetin, Daniel Scotcher
{"title":"Bringing totality-of-evidence into PBPK predictions: fraction metabolised by aldehyde oxidase","authors":"Nihan Izat, J. Brian Houston, Jill Barber, Aleksandra Galetin, Daniel Scotcher","doi":"10.1016/j.dmpk.2023.100953","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100953","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"17 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100990
Acilegna Rodriguez, Megan Graves, Yewei Du, Roberta Kaufman, Jian-Lu Chen, Makenzie Sacca, Mark Warren
{"title":"Monocarboxylate transporter 10: substrate-dependent mode of transport","authors":"Acilegna Rodriguez, Megan Graves, Yewei Du, Roberta Kaufman, Jian-Lu Chen, Makenzie Sacca, Mark Warren","doi":"10.1016/j.dmpk.2023.100990","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100990","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":"19 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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