Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100936
Eshani Nandita, Rahul Baghla
{"title":"Automated workflow to study microsomal clearance and analysis of metabolites using collision-induced dissociation and electron-activated dissociation MS/MS data","authors":"Eshani Nandita, Rahul Baghla","doi":"10.1016/j.dmpk.2023.100936","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100936","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100980
Baron Bechtold, Katherine Lynch, Victoria Oyanna, Michael Ridge Call, John Clarke
{"title":"Rifampin- and silymarin-mediated pharmcokinetic interactions of pitavastatin, pravastatin, coproporphyrin I, and coproporphyrin III in a transgenic OATP1B mouse model","authors":"Baron Bechtold, Katherine Lynch, Victoria Oyanna, Michael Ridge Call, John Clarke","doi":"10.1016/j.dmpk.2023.100980","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100980","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Functional characterization of ENT2/SLC29A2 as a uric acid transporter","authors":"Isamu Matake, Takahiro Yamashiro, Tomoya Yasujima, Hiroaki Yuasa","doi":"10.1016/j.dmpk.2023.100984","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100984","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100931
Joe Lim, Julia Cui, Curtis Klaassen
{"title":"Deciphering the cell and zonal distribution of drug metabolizing enzymes and transporters in humans by single cell transcriptomics","authors":"Joe Lim, Julia Cui, Curtis Klaassen","doi":"10.1016/j.dmpk.2023.100931","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100931","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141062585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100940
Shantanu Roychowdhury, Kevin Thomas, Allison Liverar, Michell Martineau, Libby Bell, Lucus Albrecht
{"title":"De-risking idiosyncratic adverse drug reactions and toxicities in drug discovery utilizing a qualitative in-vitro high-throughput reactive metabolite trapping method","authors":"Shantanu Roychowdhury, Kevin Thomas, Allison Liverar, Michell Martineau, Libby Bell, Lucus Albrecht","doi":"10.1016/j.dmpk.2023.100940","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100940","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediction and validation of human hepatobiliary clearances and hepatic concentrations of transported drugs using the relative expression factor (REF) and PET imaging approaches","authors":"Mengyue (Melody) Yin, Ankit Balhara, Solène Marie, Nicolas Tournier, Jashvant Unadkat","doi":"10.1016/j.dmpk.2023.100992","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100992","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100919
Leslie Z. Benet, Jasleen K. Sodhi
{"title":"For hepatically cleared drugs, liver to blood KPUU at steady-state is always equal to FH , which exposes the deficiency of the present extended clearance concept equation","authors":"Leslie Z. Benet, Jasleen K. Sodhi","doi":"10.1016/j.dmpk.2023.100919","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100919","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1016/j.dmpk.2023.100951
Nathan Delvaux, Morgan Knapp, Michael Schicker, Tyler Wittkopp, Mitchell Lavarias
{"title":"Use of human liver microsomes to assess flavin-containing monooxygenase (FMO) metabolism in vitro","authors":"Nathan Delvaux, Morgan Knapp, Michael Schicker, Tyler Wittkopp, Mitchell Lavarias","doi":"10.1016/j.dmpk.2023.100951","DOIUrl":"https://doi.org/10.1016/j.dmpk.2023.100951","url":null,"abstract":"","PeriodicalId":11298,"journal":{"name":"Drug Metabolism and Pharmacokinetics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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