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A rare morphological variation of the coeliac trunk in a Sri Lankan cadaver 一具斯里兰卡尸体乳糜干的罕见形态学变异
Pub Date : 2020-10-22 DOI: 10.15406/ijcam.2020.13.00518
L. Ranaweera
The classic branches of the coeliac trunk are the left gastric, common hepatic and the splenic arteries. In a routine dissection of a 72year old male cadaver at the Faculty of Medicine, University Sri Lanka a variation of five branches originating directly from the abdominal aorta at the level of the origin of coeliac trunk was observed; left gastric artery, splenic artery, main hepatic artery, first direct hepatic branch and second direct hepatic branch. This deviation from three main classic branches of coeliac trunk to five direct branches is a very rare occurrence. Records of this type of vascular patterns are really important in planning and performing abdominal surgical and radiological procedures as well as radiological interventions.
腹腔干的典型分支是胃左动脉、肝总动脉和脾动脉。在斯里兰卡大学医学院对一名72岁男性尸体的常规解剖中,观察到在腹腔干起源水平直接起源于腹主动脉的五个分支的变化;胃左动脉、脾动脉、肝主动脉、肝第一直支、肝第二直支。从乳糜干的三个主要分支到五个直接分支的偏离是非常罕见的。这种类型的血管模式的记录在计划和实施腹部手术和放射治疗以及放射干预中非常重要。
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引用次数: 0
A network pharmacological approach to evaluate Jia-Wei-Xiao-Yao-san formula’s mechanistic pathways and its implication in the symptomatology of polycystic ovarian syndrome 用网络药理学方法评价加味消脘散方的机制通路及其对多囊卵巢综合征的证候意义
Pub Date : 2020-10-19 DOI: 10.15406/ijcam.2020.13.00517
B. Leclerc, Yu Wu, Priscilla Wu
Polycystic ovary syndrome (PCOS) is a disorder characterized mainly by a disruption of androgen secretion or endocrine feedback mechanism dysfunction occurring subtlety during adolescence and progressively impairing the ovarian folliculogenesis which affects preponderantly women of reproductively active age. Most of the reproductive active period of women is hampered by this condition, thereof reducing their fertility and causing metabolic disturbances. Traditional Chinese Medicine principles have been historically settled to develop Chinese Herbal Medicine formulas designed to treat various ailments including reproductive disorders. This study addresses the mechanisms of action of Jia-Wei-Xiao-Yao-San formula by examining the functional predicted PCOS-related targets networks first enriched by STITCH chemical interactions and then analyzed by STRING protein interactions database. Using the highest confidence interaction score as a screening binding parameter, we obtained a total of 274 PCOS-related targets interacting with 58 bioactive compounds from the formula and 22 PCOS-related drugs interacting with a total of 133 PCOS-related targets. Our analysis identified a total of 84 common PCOS-related targets shared by both the formula and the PCOS-related drugs and demonstrate the predicted PCOS-related protein-protein interaction network resulting in various KEGG pathways. These findings indicated the formula functionality role preponderantly in cholesterol metabolism, ovarian steroidogenesis, peroxisome proliferator-activated receptors, and adipocytokine signaling pathway. Numerous compounds identified here are known to have high binding interactions with PCOS-related targets. Our methodological approach demonstrates that both the drugs-PCOS-related targets network support Jia-Wei- Xiao-Yao-San formula as an appropriate Traditional Chinese Medicine to treat at least the symptoms associated with PCOS manifestations.
多囊卵巢综合征(PCOS)是一种以雄激素分泌紊乱或内分泌反馈机制功能障碍为主要特征的疾病,发生在青春期,并逐渐损害卵巢卵泡发生,主要影响生育活跃年龄的女性。大多数妇女的生殖活跃期受到这种情况的阻碍,从而降低了她们的生育能力并引起代谢紊乱。传统的中医原理已经在历史上确立了中医配方,旨在治疗包括生殖障碍在内的各种疾病。本研究首先通过STITCH化学相互作用丰富pcos相关的功能预测靶点网络,然后通过STRING蛋白相互作用数据库对其进行分析,以此来探讨jia - wei - xiaoyao - san配方的作用机制。以最高信度相互作用评分作为筛选结合参数,共获得274个pcos相关靶点与该配方中的58个生物活性化合物相互作用,22个pcos相关药物与133个pcos相关靶点相互作用。我们的分析确定了该配方和pcos相关药物共有的84个常见pcos相关靶点,并证明了预测的pcos相关蛋白-蛋白相互作用网络导致各种KEGG通路。这些发现表明,该配方的功能主要作用于胆固醇代谢、卵巢类固醇生成、过氧化物酶体增殖物激活受体和脂肪细胞因子信号通路。这里鉴定的许多化合物已知与pcos相关靶标具有高结合相互作用。我们的方法学研究表明,药物-多囊卵巢综合征相关靶点网络支持加味消药散方作为一种适合治疗多囊卵巢综合征相关症状的中药。
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引用次数: 0
Flavonoids and ferrochel in women with iron deficiency anemia of abnormal uterine bleeding: our experience in community-based private hematology/oncology and integrative medicine practice 黄酮类化合物和铁螯合铁在缺铁性贫血女性异常子宫出血中的作用:我们在社区私人血液学/肿瘤学和中西医结合实践中的经验
Pub Date : 2020-10-12 DOI: 10.15406/ijcam.2020.13.00516
Raul H Morales-Borges
Abnormal uterine bleeding (AUB), conjointly referred to as atypical and dysfunctional female internal reproductive organ bleeding, is often inflicting iron deficiency anemia.1,2 It will affect the standard of life negatively. AUB may be a common condition because it affects over seventieth of all gynecological consults (3). AUB affects two-hundredths of generative aged girls.2 The underlying causes could embrace gonad issues, fibroids, endometrial dysplasia, female internal reproductive organ polyps, underlying harm issues, aspect effects from contraception, or cancer.1–3 over one class of causes could apply in a personal case. The workup’s primary step is to rule out an abnormal abdominal or physiological state.3 The AUB’s causes are divided into nine groups: endometrial polyps, uterine fibroids, endometriosis, gynecological cancer, coagulation disorders, issues with biological process, mucosa issues, attention induced, and not nonetheless classified.3–5 Over one class of causes could apply in a personal case. Attention induced causes could embrace the aspect effects of contraception. Treatment depends on the underlying cause2,3 and includes oral contraceptive pills, gonadotropin-releasing secretion (GnRH) agonists, oral antifibrinolytics, NSAIDs, and surgery like mucosa ablation or ablation. Polyps, endometriosis, and cancer are treated with surgery. Iron supplementation is also required.
异常子宫出血(AUB),联合称为非典型和功能失调的女性内部生殖器官出血,经常造成缺铁性贫血。它会对生活水平产生负面影响。AUB可能是一种常见的情况,因为它影响了超过70%的妇科咨询(3)。AUB影响了2%的育龄女孩(2)潜在的原因可能包括性腺问题、肌瘤、子宫内膜发育不良、女性内部生殖器官息肉、潜在的伤害问题、避孕的影响或癌症。1-3类以上的原因可以适用于个人案件。检查的首要步骤是排除异常的腹部或生理状态AUB的病因分为九组:子宫内膜息肉、子宫肌瘤、子宫内膜异位症、妇科癌症、凝血功能障碍、生物过程问题、粘膜问题、注意力诱导,尽管如此,仍未分类。3-5在个人案件中可适用一种以上的原因。注意诱发的原因可能包括避孕的多方面影响。治疗取决于潜在的病因2,3,包括口服避孕药,促性腺激素释放分泌(GnRH)激动剂,口服抗纤溶药,非甾体抗炎药和手术,如粘膜消融或消融。息肉、子宫内膜异位症和癌症都可以通过手术治疗。还需要补充铁。
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引用次数: 0
Trigeminal neuralgia complicating a syndromic craniosynostosis treated with acupuncture: a case report 针灸治疗三叉神经痛合并综合征性颅缝闭塞1例
Pub Date : 2020-10-08 DOI: 10.15406/ijcam.2020.13.00515
C. Guido, V. Santarlasci, O. Gallo, R. Mediati, G. Cristofaro
Trigeminal neuralgia (TN) is the most common cranial neuralgia, defined as sudden, usually unilateral, severe, brief, stabbing, recurrent episodes of pain in the distribution of one or more branches of the trigeminal nerve; some patients experience also a degree of dull, burning, or tingling pain between attacks. TN may have a significant impact upon quality of life due to the associated depres sion and anxiety. TN’s pain is generally managed with medical therapy alone, carbamazepine being the first-line medica tion. Pfeiffer syndrome is a rare inherited disorder associated with primary craniosynostosis, midface hypoplasia and other anatomical abnormalities. Acupuncture is a valid therapeutic option for painful conditions, including neuralgias. Hereby, we describe remission from trigeminal neuralgia- related pain in a 37years old man with Pfeiffer Syndrome, after acupuncture.
三叉神经痛(TN)是最常见的颅神经痛,定义为突然的,通常是单侧的,严重的,短暂的,刺痛的,反复发作的疼痛,分布在三叉神经的一个或多个分支;有些患者在发作之间还会有一定程度的钝痛、灼痛或刺痛。由于相关的抑郁和焦虑,TN可能对生活质量产生重大影响。TN的疼痛一般仅用药物治疗,卡马西平是一线药物。Pfeiffer综合征是一种罕见的遗传性疾病,与原发性颅缝闭锁、中脸发育不全和其他解剖异常有关。针灸是治疗包括神经痛在内的疼痛的有效方法。在此,我们描述缓解三叉神经痛相关的疼痛在37岁男子与普发综合征,针灸后。
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引用次数: 1
Sadyo maraneeyam of Bhela indriya sthana - An explorative study 印度大蠊的研究:一项探索性研究
Pub Date : 2020-09-16 DOI: 10.15406/ijcam.2020.13.00514
Kshama Gupta, Prasad Mamidi
Bhela samhita is an Ayurvedic (Indian system of medicine) treatise written by ‘Maharshi Bhela’ (belongs to 1000-2000 BC). Maharshi Bhela was the student of popular preceptor ‘Acharya Punarvasu Atreya’ and colleague of ‘Agnivesha’ (author of the popular Ayurvedic text ‘Charaka samhita’). Bhela samhita consists of 8 sections and 120 chapters. ‘Indriya sthana’ is one of the eight sections of ‘Bhela samhita’ which comprises 12 chapters. ‘Bhela Indriya sthana’ deals with prognostic aspects. ‘Sadyo maraneeyam indriyam’ is the fourth chapter of ‘Bhela indriya sthana’ which contains the description of various emergency conditions with high mortality rates. The word ‘sadyo maraneeyam’ denotes an immediate death caused by various emergency conditions. Though previous works have explored ‘Charaka indriya sthana’, studies on ‘Bhela indriya sthana’ are lacking. The present work is aimed to explore the contents of ‘Sadyo maraneeyam indriyam’ of ‘Bhela indriya sthana’. Various emergency conditions such as coronary artery disease, cardiovascular disease, acute coronary syndrome, Granulomatosis with polyangiitis, increased intra-cranial pressure, abdominal compartment syndrome, cancer cachexia, increased intra-abdominal or intra-pelvic pressure due to benign or malignant tumours, prostate cancer, neurosyphilis with saddle nose and ocular manifestations, gastro-duodenal perforation or ulcer, perforation of peptic ulcer, acute abdomen, inflammatory bowel disease, ulcerative colitis, Crohn’s disease, lower gastrointestinal bleeding, upper gastrointestinal bleeding, colon cancer, proctalgia fugax, disseminated intravascular coagulation, idiopathic thrombocytopenic purpura, Henoch-Schönlein purpura, coagulation disorders, cardiac cachexia, coma, shock, pulmonary cachexia, acute respiratory distress syndrome, and chronic obstructive pulmonary disease etc are documented in this chapter by ‘Maharshi Bhela’. ‘Maharshi Bhela’ has provided a list of signs & symptoms or clinical features of emergency conditions having poor prognosis.
Bhela samhita是由Maharshi Bhela撰写的阿育吠陀(印度医学系统)论文(属于公元前1000-2000年)。Maharshi Bhela是著名导师Acharya Punarvasu Atreya的学生,也是阿育吠陀经典《Charaka samhita》的作者Agnivesha的同事。《毗罗三经》由8节120章组成。“Indriya sthana”是由12章组成的“Bhela samhita”的八个部分之一。“Bhela Indriya sthana”涉及预测方面。" Sadyo maraneeyam indriyam "是" Bhela indriya sthana "的第四章,其中描述了各种高死亡率的紧急情况。“sadyo maraneeyam”一词表示因各种紧急情况而立即死亡。虽然以前的作品已经探讨了“查拉卡·因德里亚·斯塔纳”,但对“贝拉·因德里亚·斯塔纳”的研究却很缺乏。目前的工作旨在探索“Bhela indriya sthana”的“Sadyo maraneeyam indriyam”的内容。各种紧急情况,如冠状动脉疾病、心血管疾病、急性冠状动脉综合征、多血管性肉芽肿病、颅内压升高、腹腔隔室综合征、癌症恶病质、良性或恶性肿瘤引起的腹腔或盆腔内压升高、前列腺癌、伴有鞍鼻和眼部症状的神经梅毒、胃-十二指肠穿孔或溃疡、消化性溃疡穿孔、急腹症、炎症性肠病、溃疡性结肠炎、克罗恩病、下消化道出血、上消化道出血、结肠癌、隐伏性直痛、弥散性血管内凝血、特发性血小板减少性紫癜、Henoch-Schönlein紫癜、凝血障碍、心脏恶病质、昏迷、休克、肺恶病质、急性呼吸窘迫综合征和慢性阻塞性肺病等都记录在Maharshi Bhela的这一章中。“Maharshi Bhela”提供了预后不良的紧急情况的体征和症状或临床特征清单。
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引用次数: 3
A chronicle of temperature and SARS-CoV-2 viability: a retrospective study 温度和SARS-CoV-2生存能力的编年史:一项回顾性研究
Pub Date : 2020-08-05 DOI: 10.15406/ijcam.2020.13.00511
J. Körmendy-Rácz, G. Hegyi
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引用次数: 1
A chronicle of temperature and SARS-CoV-2 viability: a retrospective study 温度和SARS-CoV-2生存能力的编年史:一项回顾性研究
Pub Date : 2020-07-29 DOI: 10.15406/ijcam.2020.13.00509
Mohd Faizan Siddiqui
The COVID-19 outbreak, which emerged in Wuhan city China, at the end of 2019, burgeoned into a pandemic in March 2020 and now has become a grievous public health issue. One of the pronounced features of this malady was its propensity of transmission in the healthcare premises, among close family and social contact. The stability of the virus at different temperature and the influence of meteorological factors on the transmission posed to be key factors for the spread of COVID-19 since the beginning. This study aimed to find the impact of temperature on the extremity of the COVID-19 outbreak on a worldwide scale and to explore the association between COVID-19 death and weather parameter. As it was earlier speculated that the transmission of COVID-19 might be dwindling or even disappeared when the temperature and UV radiation increase in the summer. So, since the climate seems to be one of the key variances between the countries with high and low COVID-19 cases, we have cross-checked temperature among the topmost 50 affected countries with COVID-19. Our perusal showed no possible association between low temperature and high temperature with increases number of daily COVID-19 cases throughout the world.
2019年底在中国武汉市爆发的新冠肺炎疫情,于2020年3月迅速发展为大流行,目前已成为一个严重的公共卫生问题。这种疾病的一个显著特征是其倾向于在医疗场所传播,在密切的家庭和社会接触中传播。从一开始,病毒在不同温度下的稳定性和气象因素对传播的影响就成为COVID-19传播的关键因素。本研究旨在发现全球范围内温度对COVID-19疫情极端程度的影响,并探讨COVID-19死亡与天气参数之间的关系。正如此前的猜测,随着夏季气温和紫外线辐射的增加,新冠病毒的传播可能会减少甚至消失。因此,由于气候似乎是COVID-19高病例和低病例国家之间的关键差异之一,我们对50个受COVID-19影响最严重的国家的温度进行了交叉核对。我们的研究显示,低温和高温与全球每日COVID-19病例数的增加之间没有可能存在关联。
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引用次数: 0
Does cognitive functional therapy improves chronic low back pain? a case report 认知功能疗法能改善慢性腰痛吗?病例报告
Pub Date : 2020-07-27 DOI: 10.15406/ijcam.2020.13.00508
D. G. D. Freitas, J. D. Neto, Gislene Gomes da Silva, T. Batista, Cláudio Cazarini Júnior
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引用次数: 0
Management of nirupastambhita vatavyadhi – a case report nirupastambhita vatavyadhi的处理-一个案例报告
Pub Date : 2020-07-02 DOI: 10.15406/ijcam.2020.13.00507
Jasminbegam B. Momin, Kulkarni Pv, Gogate Ve
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引用次数: 0
Bloom’s taxonomy and goals of traditional education system insight from Ayurveda 布鲁姆对传统教育系统的分类和目标的见解来自阿育吠陀
Pub Date : 2020-06-24 DOI: 10.15406/ijcam.2020.13.00506
Kalpana Tawalare, Kiran A. Tawalare
Bloom’s taxonomy classifies the goals of modern education system. It defines three domain of learning cognitive, affective and psychomotor domain, related with head, heart and body respectively. Ayurveda mentioned four qualities of physician in the form of chatushpada (quadruple), as to acquire knowledge, to gain practical knowledge and importance of cleanliness. Proposed review study was carried out to high light the concept of traditional education system designed by Acharya Charaka, Sushruta and Vagbhata to reflect goals of traditional education system. Classical texts (Samhita) of Ayurveda as Charaka, Sushruta, Ashtanga Sangraha and Ashtanga Hridaya were consulted as references to know the qualities of chatushpada. Literature available regarding modern Bloom’s taxonomy was also collected. These references from both streams of knowledge were compared and analyzed critically. Literature search revealed that qualities of bhishak (physician) among chatushpada, includes the three domain of Ayurvedic education system. Paryavadatatva means having excellence in theoretical knowledge, bahushodrustakarmata means having extensive practical experience, dakshya means dexterity and shouch means cleanliness of mana (mind) and sharir (body). If physician endowed with these qualities leads to elimination of disorders. As Bloom’s taxonomy classify the goals of modern education system, the four qualities of physician reflects the goals of traditional system of education in Ayurveda.
布鲁姆的分类法对现代教育体系的目标进行了分类。它定义了三个学习领域:认知领域、情感领域和精神运动领域,分别与头部、心脏和身体有关。阿育吠陀以chatushpada(四重)的形式提到了医生的四种品质,即获得知识,获得实用知识和清洁的重要性。为了突出Acharya Charaka, Sushruta和Vagbhata设计的传统教育体系的概念,以反映传统教育体系的目标,进行了拟议的审查研究。阿育吠陀的经典文本(Samhita)如Charaka, Sushruta, Ashtanga sangha和Ashtanga Hridaya被作为参考来了解chatushpada的品质。还收集了有关现代布鲁姆分类学的文献。这些来自两种知识流的参考文献进行了批判性的比较和分析。文献检索显示,恰图斯帕达的医生素质包括阿育吠陀教育体系的三个领域。Paryavadatatva意为拥有卓越的理论知识,bahushodrustakarmata意为拥有丰富的实践经验,dakshya意为灵巧,而showh意为mana(思想)和sharir(身体)的清洁。如果医生具有这些品质,就能消除疾病。布鲁姆的分类法对现代教育体系的目标进行了分类,医生的四种素质反映了阿育吠陀传统教育体系的目标。
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引用次数: 1
期刊
International Journal of Complementary and Alternative Medicine
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