A. Gaibov, O. Nematzoda, Dzhamshed K. Rakhmonov, R. K. Davlatov, E. Kalmykov
INTRODUCTION: The problem of treatment of patients with chronic lower limb ischemia (CLLI) remains extremely important to date. This is first of all due to increase in the number of patients with chronic obliterating diseases of peripheral arteries, which hold one of the leading positions in the structure of morbidity and disability of the population over 60 years. The progression of the disease with development of critical CLLI leads to amputation of the limb within five years in a third of patients. The first line therapy for CLLI is endovascular interventions both stand-alone and with use of hybrid approach, especially in patients with critical CLLI. In many cases of multi-level, especially multifocal lesions of arterial vessels, the choice of revascularization tactics is not yet completely defined. CONCLUSION: In recent years, there has been a trend of using endovascular revascularization technologies in continued stenosis and occlusions of the lower limb arteries. However, there is an essential need to study their long-term results, as well as to clarify the indications for stenting in critical CLLI.
{"title":"Endovascular Recanalization Methods in Treatment of Chronic Lower Limb Ischemia: Modern State of Problem","authors":"A. Gaibov, O. Nematzoda, Dzhamshed K. Rakhmonov, R. K. Davlatov, E. Kalmykov","doi":"10.17816/pavlovj107324","DOIUrl":"https://doi.org/10.17816/pavlovj107324","url":null,"abstract":"INTRODUCTION: The problem of treatment of patients with chronic lower limb ischemia (CLLI) remains extremely important to date. This is first of all due to increase in the number of patients with chronic obliterating diseases of peripheral arteries, which hold one of the leading positions in the structure of morbidity and disability of the population over 60 years. The progression of the disease with development of critical CLLI leads to amputation of the limb within five years in a third of patients. The first line therapy for CLLI is endovascular interventions both stand-alone and with use of hybrid approach, especially in patients with critical CLLI. In many cases of multi-level, especially multifocal lesions of arterial vessels, the choice of revascularization tactics is not yet completely defined. \u0000CONCLUSION: In recent years, there has been a trend of using endovascular revascularization technologies in continued stenosis and occlusions of the lower limb arteries. However, there is an essential need to study their long-term results, as well as to clarify the indications for stenting in critical CLLI.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133996716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Seleznev, S. S. Yаkushin, P. Mylnikov, Yu. S. Tranova, A. V. Shchul’kin, E. Yakusheva, N. N. Nikulina
INTRODUCTION: Despite the recently established evidence-based and systemic approach to treatment for arterial hypertension (AH), not in all cases its control can be achieved. AIM: To conduct a comparative analysis of the concentration of antihypertensive drugs (AHTDs) in blood serum of patients with controlled and uncontrolled AH. MATERIALS AND METHODS: Fifty six patients were included. Inclusion criteria: age 18 years, signing of informed consent, established diagnosis of AH, regular intake of any two of study antihypertensive drugs (lisinopril, amlodipine, valsartan) and also of indapamide at stable doses, for women adequate contraception. According to the results of daily monitoring of the arterial pressure (AP), patients were divided into two groups: the first group controlled hypertension (AP 140/90 mmHg; n = 39), the second uncontrolled hypertension (AP 140/90 mmHg; n = 17). The mean age of patients in the first group was 65.03 10.80 years, in the second 63.50 8.31 (p = 0.576). In the first group, women prevailed (64.1% vs. 35.3%, p = 0.047) and the mean body mass index was lower (26.30 1.38 kg/m2 vs. 32.20 4.15 kg/m2, p = 0.02). In patients of both groups, venous blood was taken in fasting condition in the morning and 2 hours after intake of AHTDs to assess their concentration by high-performance liquid chromatography. The analytical range for lisinopril, indapamide, amlodipine was 5500 ng/ml, for valsartan 1010,000 ng/ml. RESULTS: In the first group, equilibrium concentration of lisinopril was 2.67 times higher (p = 0.053), and concentration of indapamide in 2 hours after intake was 1.83 times higher (р = 0,084); when normalized to the dose, the differences were leveled out (p 0.05). Concentrations of amlodipine and valsartan did not differ between the groups both before and 2 hours after intake (p 0.05). In 3 of 39 (7.7%) patients with controlled hypertension and in one of 17 patients (5.9%, p = 1.0) with uncontrolled hypertension, AHTDs were detected in blood serum, which were not administered to them. CONCLUSIONS: Results of the pilot part of the study (n = 56) demonstrated the absence of difference between the mean concentrations of the study AHTDs in the blood serum of patients with controlled and uncontrolled AH, and in some cases the presence of traces of AHTDs not administered by the doctor.
{"title":"Therapeutic Drug Monitoring in Uncontrolled Arterial Hypertension: Result of the Pilot Part of Study","authors":"S. Seleznev, S. S. Yаkushin, P. Mylnikov, Yu. S. Tranova, A. V. Shchul’kin, E. Yakusheva, N. N. Nikulina","doi":"10.17816/pavlovj119880","DOIUrl":"https://doi.org/10.17816/pavlovj119880","url":null,"abstract":"INTRODUCTION: Despite the recently established evidence-based and systemic approach to treatment for arterial hypertension (AH), not in all cases its control can be achieved. \u0000AIM: To conduct a comparative analysis of the concentration of antihypertensive drugs (AHTDs) in blood serum of patients with controlled and uncontrolled AH. \u0000MATERIALS AND METHODS: Fifty six patients were included. Inclusion criteria: age 18 years, signing of informed consent, established diagnosis of AH, regular intake of any two of study antihypertensive drugs (lisinopril, amlodipine, valsartan) and also of indapamide at stable doses, for women adequate contraception. According to the results of daily monitoring of the arterial pressure (AP), patients were divided into two groups: the first group controlled hypertension (AP 140/90 mmHg; n = 39), the second uncontrolled hypertension (AP 140/90 mmHg; n = 17). The mean age of patients in the first group was 65.03 10.80 years, in the second 63.50 8.31 (p = 0.576). In the first group, women prevailed (64.1% vs. 35.3%, p = 0.047) and the mean body mass index was lower (26.30 1.38 kg/m2 vs. 32.20 4.15 kg/m2, p = 0.02). In patients of both groups, venous blood was taken in fasting condition in the morning and 2 hours after intake of AHTDs to assess their concentration by high-performance liquid chromatography. The analytical range for lisinopril, indapamide, amlodipine was 5500 ng/ml, for valsartan 1010,000 ng/ml. \u0000RESULTS: In the first group, equilibrium concentration of lisinopril was 2.67 times higher (p = 0.053), and concentration of indapamide in 2 hours after intake was 1.83 times higher (р = 0,084); when normalized to the dose, the differences were leveled out (p 0.05). Concentrations of amlodipine and valsartan did not differ between the groups both before and 2 hours after intake (p 0.05). In 3 of 39 (7.7%) patients with controlled hypertension and in one of 17 patients (5.9%, p = 1.0) with uncontrolled hypertension, AHTDs were detected in blood serum, which were not administered to them. \u0000CONCLUSIONS: Results of the pilot part of the study (n = 56) demonstrated the absence of difference between the mean concentrations of the study AHTDs in the blood serum of patients with controlled and uncontrolled AH, and in some cases the presence of traces of AHTDs not administered by the doctor.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129339183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Kalinin, I. Suchkov, Andrey B. Agapov, N. Mzhavanadze, V. Povarov, A. Nikiforov
INTRODUCTION: A new coronavirus infection (NCI) is characterized by catastrophic coagulopathy with development of thrombotic and hemorrhagic complications. The choice of an optimal anticoagulant in these patients remains an important issue. AIM: To evaluate risk factors for venous thromboembolic complications (VTEC), effectiveness and safety of different variants of anticoagulant therapy (ACT) in patients with NCI. MATERIALS AND METHODS: A prospective study was conducted that involved 370 patients with NCI: group 1 patients who received low molecular weight heparin (LMWH) 190 people, group 2 patients who received unfractionated heparin (UFH) 123 people, group 3 patients who took direct oral anticoagulants (DOAC) 57 individuals. Clinical and anamnestic data, frequency of thrombotic and hemorrhagic complications were evaluated. The study was approved by the Local Ethics Committee and was registered on ClinicalTrials.gov. platform. RESULTS: The existence of chronic venous diseases increases the risk of development of venous thromboembolism (VTE) in patients with NCI 6.433 times (95% confidence interval (CI) 2.16719.093)) (р = 0.001), use of UFH instead of LMWH or DOAC 3.542 times (95% CI 1.14910.916) (р = 0.028), use of artificial lung ventilation (ALV) 5.925 times (95% CI 2.03417.26) (р = 0.001), high D-dimer level 2.024 times (95% CI 1.2313.33) (р = 0.005). The level of C-reactive protein and ferritin decreased in all patients in the course of treatment for NCI, with the lowest levels in patients receiving LMWH (С-reactive protein 5.8 (1.715.0) mg/l, р = 0.004; ferritin 364 (324497) g/l, р = 0.001). Lower fibrinogen levels were recorded in patients of group 1 compared to groups 2 and 3 (2.43 (1.93.52) g/l versus 3.37 (2.84.92) g/l and 4.1 (2.85.25) g/l, respectively, р = 0.002). A high frequency of pulmonary embolism with unspecified source was recorded in patients receiving UFH 11.4% of cases, with this, the frequency of using ALV in the group with UFH was evaluated as high 21% of cases. CONCLUSION: Risk factors of VTEC in patients with NCI are both factors typical of VTEC in general (obesity, chronic vein diseases, elevated D-dimer level), and factors specific of NCI (ALV, hypoventilation). Effective and safe anticoagulants in this group of patients are LMWH that demonstrated low frequency of development of VTEC and of hemorrhagic complications.
一种新型冠状病毒感染(NCI)以灾难性凝血功能障碍为特征，并发血栓和出血性并发症。在这些患者中选择最佳抗凝剂仍然是一个重要的问题。目的:评价NCI患者静脉血栓栓塞并发症(VTEC)的危险因素、不同抗凝治疗(ACT)的有效性和安全性。材料与方法:对370例NCI患者进行前瞻性研究:1组接受低分子肝素(LMWH)治疗的患者190例，2组接受未分离肝素(UFH)治疗的患者123例，3组接受直接口服抗凝剂(DOAC)治疗的患者57例。临床和记忆资料，血栓和出血性并发症的频率进行评估。该研究得到了当地伦理委员会的批准，并在ClinicalTrials.gov上注册。平台。结果:慢性静脉疾病的存在使NCI患者发生静脉血栓栓塞(VTE)的风险增加6.433倍(95%可信区间(CI) 2.16719.093) (r = 0.001)，使用UFH代替低分子肝素或DOAC的风险增加3.542倍(95% CI 1.14910.916) (r = 0.028)，使用人工肺通气(ALV)的风险增加5.925倍(95% CI 2.03417.26) (r = 0.001)，高d -二聚体水平增加2.024倍(95% CI 1.2313.33) (r = 0.005)。在NCI治疗过程中，所有患者的c反应蛋白和铁蛋白水平均下降，低分子肝素治疗的患者水平最低(С-reactive蛋白5.8 (1.715.0)mg/l， χ = 0.004;铁蛋白364 (324497)g/l, r = 0.001)。1组患者纤维蛋白原水平低于2组和3组(分别为2.43 (1.93.52)g/l和3.37 (2.84.92)g/l和4.1 (2.85.25)g/l， χ 2 = 0.002)。在接受UFH治疗的患者中，有11.4%的病例记录了高频率的不明来源肺栓塞，因此，在接受UFH治疗的患者中，使用ALV的频率被评估为高达21%的病例。结论:NCI患者发生VTEC的危险因素既有VTEC的典型因素(肥胖、慢性静脉疾病、d -二聚体水平升高)，也有NCI的特异性因素(ALV、低通气)。在这组患者中，有效和安全的抗凝剂是低分子肝素，其VTEC和出血性并发症的发生频率较低。
{"title":"Analysis of Risk Factors of Venous Thromboembolic Complications and of Different Variants of Anticoagulant Therapy in Patients with New Coronavirus Infection","authors":"R. Kalinin, I. Suchkov, Andrey B. Agapov, N. Mzhavanadze, V. Povarov, A. Nikiforov","doi":"10.17816/pavlovj110956","DOIUrl":"https://doi.org/10.17816/pavlovj110956","url":null,"abstract":"INTRODUCTION: A new coronavirus infection (NCI) is characterized by catastrophic coagulopathy with development of thrombotic and hemorrhagic complications. The choice of an optimal anticoagulant in these patients remains an important issue. \u0000AIM: To evaluate risk factors for venous thromboembolic complications (VTEC), effectiveness and safety of different variants of anticoagulant therapy (ACT) in patients with NCI. \u0000MATERIALS AND METHODS: A prospective study was conducted that involved 370 patients with NCI: group 1 patients who received low molecular weight heparin (LMWH) 190 people, group 2 patients who received unfractionated heparin (UFH) 123 people, group 3 patients who took direct oral anticoagulants (DOAC) 57 individuals. Clinical and anamnestic data, frequency of thrombotic and hemorrhagic complications were evaluated. The study was approved by the Local Ethics Committee and was registered on ClinicalTrials.gov. platform. \u0000RESULTS: The existence of chronic venous diseases increases the risk of development of venous thromboembolism (VTE) in patients with NCI 6.433 times (95% confidence interval (CI) 2.16719.093)) (р = 0.001), use of UFH instead of LMWH or DOAC 3.542 times (95% CI 1.14910.916) (р = 0.028), use of artificial lung ventilation (ALV) 5.925 times (95% CI 2.03417.26) (р = 0.001), high D-dimer level 2.024 times (95% CI 1.2313.33) (р = 0.005). The level of C-reactive protein and ferritin decreased in all patients in the course of treatment for NCI, with the lowest levels in patients receiving LMWH (С-reactive protein 5.8 (1.715.0) mg/l, р = 0.004; ferritin 364 (324497) g/l, р = 0.001). Lower fibrinogen levels were recorded in patients of group 1 compared to groups 2 and 3 (2.43 (1.93.52) g/l versus 3.37 (2.84.92) g/l and 4.1 (2.85.25) g/l, respectively, р = 0.002). A high frequency of pulmonary embolism with unspecified source was recorded in patients receiving UFH 11.4% of cases, with this, the frequency of using ALV in the group with UFH was evaluated as high 21% of cases. \u0000CONCLUSION: Risk factors of VTEC in patients with NCI are both factors typical of VTEC in general (obesity, chronic vein diseases, elevated D-dimer level), and factors specific of NCI (ALV, hypoventilation). Effective and safe anticoagulants in this group of patients are LMWH that demonstrated low frequency of development of VTEC and of hemorrhagic complications.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125856835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. A. Gladchenko, S. M. Bogdanov, Lyudmila V. Roschina, A. Chelnokov
INTRODUCTION: Currently, the results of investigation of different types of spinal inhibition in isometric voluntary contraction of muscles have been published. There are separate reports devoted to the role of recurrent and presynaptic inhibition in the regulation of isometric and anisometric voluntary contractions of submaximal and maximal strength. AIM: To evaluate the effect of the type and strength of muscle contraction with and without performing Jendrassik maneuver on the manifestation of reciprocal inhibition of -motor neurons of antagonistic muscles of the lower leg. MATERIALS AND METHODS: The study involved 8 healthy men aged 2022 years. Reciprocal inhibition was evaluated by suppression of the amplitude of testing H-reflex of m. soleus in conditioning stimulation of n. peroneus profundus, and of testing stimulation of n. tibialis with 3 msec interval between stimuli. Reciprocal inhibition was recorded in concentric, eccentric and isometric contractions with 50% and 100% of maximal voluntary contraction (MVC) with and without Jendrassic maneuver. RESULTS: In performing concentric, eccentric and isometric contractions of lower leg muscles with increase in strength from 50% to 100% of MVC, the activity of reciprocal inhibition decreased. Reciprocal inhibition was most evident in concentric contraction with 50% of MVC strength, less evident in eccentric contraction and was lowest in isometric contraction. With the maximal strength, reciprocal inhibition was most expressed in isometric contraction, less expressed in concentric contraction and was weakest in eccentric contraction. With Jendrassik maneuver, reduction of reciprocal inhibition was more expressed in different types of MVCs in comparison with parameters obtained with 50% of MVC. Using Jendrassic maneuver with 50% and 100% of MVC effort, strongest reciprocal inhibition was recorded in isometric contraction, weaker inhibition in concentric contraction and weakest in eccentric contraction. The effect of Jendrassik maneuver was manifested by weakening of reciprocal inhibition in concentric and eccentric contraction of submaximal force, and by its enhancement in isometric contraction. CONCLUSION: Variability of manifestation of reciprocal inhibition of -motor neurons of antagonistic muscles of lower leg in different types of muscle contractions of submaximal and maximal strength is associated with the fact that the pool of segmental motor neurons of m. soleus is controlled not only by a wide spectrum of excitatory cortico- and reticulospinal influences, but also by other kinds of inhibition, thus providing coordinated motor actions.
{"title":"Functional Activity of Reciprocal Inhibition of α-Motor Neurons of Antagonistic Muscles in Different Types of Muscle Contractions of Submaximal and Maximal Force","authors":"D. A. Gladchenko, S. M. Bogdanov, Lyudmila V. Roschina, A. Chelnokov","doi":"10.17816/pavlovj110739","DOIUrl":"https://doi.org/10.17816/pavlovj110739","url":null,"abstract":"INTRODUCTION: Currently, the results of investigation of different types of spinal inhibition in isometric voluntary contraction of muscles have been published. There are separate reports devoted to the role of recurrent and presynaptic inhibition in the regulation of isometric and anisometric voluntary contractions of submaximal and maximal strength. \u0000AIM: To evaluate the effect of the type and strength of muscle contraction with and without performing Jendrassik maneuver on the manifestation of reciprocal inhibition of -motor neurons of antagonistic muscles of the lower leg. \u0000MATERIALS AND METHODS: The study involved 8 healthy men aged 2022 years. Reciprocal inhibition was evaluated by suppression of the amplitude of testing H-reflex of m. soleus in conditioning stimulation of n. peroneus profundus, and of testing stimulation of n. tibialis with 3 msec interval between stimuli. Reciprocal inhibition was recorded in concentric, eccentric and isometric contractions with 50% and 100% of maximal voluntary contraction (MVC) with and without Jendrassic maneuver. \u0000RESULTS: In performing concentric, eccentric and isometric contractions of lower leg muscles with increase in strength from 50% to 100% of MVC, the activity of reciprocal inhibition decreased. Reciprocal inhibition was most evident in concentric contraction with 50% of MVC strength, less evident in eccentric contraction and was lowest in isometric contraction. With the maximal strength, reciprocal inhibition was most expressed in isometric contraction, less expressed in concentric contraction and was weakest in eccentric contraction. With Jendrassik maneuver, reduction of reciprocal inhibition was more expressed in different types of MVCs in comparison with parameters obtained with 50% of MVC. Using Jendrassic maneuver with 50% and 100% of MVC effort, strongest reciprocal inhibition was recorded in isometric contraction, weaker inhibition in concentric contraction and weakest in eccentric contraction. The effect of Jendrassik maneuver was manifested by weakening of reciprocal inhibition in concentric and eccentric contraction of submaximal force, and by its enhancement in isometric contraction. \u0000CONCLUSION: Variability of manifestation of reciprocal inhibition of -motor neurons of antagonistic muscles of lower leg in different types of muscle contractions of submaximal and maximal strength is associated with the fact that the pool of segmental motor neurons of m. soleus is controlled not only by a wide spectrum of excitatory cortico- and reticulospinal influences, but also by other kinds of inhibition, thus providing coordinated motor actions.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"411 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123386226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Oleynik, V. A. Evdakov, V. Plechev, Ramil' I. Izhbul'din
INTRODUCTION: Despite the increased volume of rendered high-tech assistance and objective improvement of the condition of the majority of operated patients, the parameters of physical activity and working capacity in this category of patients remain low. AIM: To study the effect of 5-oxymethyluracil with angiogenic properties on the quality of life of patients in the early and long-term period after coronary artery bypass grafting (CABG). MATERIALS AND METHODS: The randomized prospective study included two groups of patients: the main group (n = 87) which in the perioperative period of CABG (5 days before and 14 days after surgery), in addition to standard therapy, received the drug 5-oxymethyluracil), and the control group (n = 81) which received standard therapy. The groups were comparable in gender, age, basic clinical and functional characteristics and peculiarities of surgical intervention. The quality of life of patients was determined by the Seattle Angina Questionnaire (SAQ) before CABG surgery (upon admission to the vascular surgery department) and after surgery (after 2 months and 1618 years). There were no statistically significant differences in the preoperative parameters of quality of life in the control and main groups. RESULTS: In the long-term period of surgical revascularization of the myocardium (1618 years after the operation) the severity of angina according to SAQ was: in the control group 33.30 (20.00-60.00), in the main group 60.00 (33.30-70.00; р = 0.0407). Other scales of SAQ, including physical activity, stability of anginal course, satisfaction with treatment and perception of the disease, did not demonstrate any differences between the studied groups in 2 months or 1618 years after CABG. CONCLUSION: Perioperative use of 5-oxymethyluracil influenced the improvement of only one parameter of quality of life according to the SAQ questionnaire the severity of angina, with statistically significant differences between the groups in the long-term period of CABG (1618 years after surgery). According to SAQ questionnaire, there was no effect on the remaining parameters of the quality of life with the underlying perioperative use of the studied drug in all follow-up periods.
{"title":"New Pharmacological Approach to Improvement of Quality of Life of Patients after Coronary Artery Bypass Grafting through Stimulation of Neoangiogenesis","authors":"B. Oleynik, V. A. Evdakov, V. Plechev, Ramil' I. Izhbul'din","doi":"10.17816/pavlovj111931","DOIUrl":"https://doi.org/10.17816/pavlovj111931","url":null,"abstract":"INTRODUCTION: Despite the increased volume of rendered high-tech assistance and objective improvement of the condition of the majority of operated patients, the parameters of physical activity and working capacity in this category of patients remain low. \u0000AIM: To study the effect of 5-oxymethyluracil with angiogenic properties on the quality of life of patients in the early and long-term period after coronary artery bypass grafting (CABG). \u0000MATERIALS AND METHODS: The randomized prospective study included two groups of patients: the main group (n = 87) which in the perioperative period of CABG (5 days before and 14 days after surgery), in addition to standard therapy, received the drug 5-oxymethyluracil), and the control group (n = 81) which received standard therapy. The groups were comparable in gender, age, basic clinical and functional characteristics and peculiarities of surgical intervention. The quality of life of patients was determined by the Seattle Angina Questionnaire (SAQ) before CABG surgery (upon admission to the vascular surgery department) and after surgery (after 2 months and 1618 years). There were no statistically significant differences in the preoperative parameters of quality of life in the control and main groups. \u0000RESULTS: In the long-term period of surgical revascularization of the myocardium (1618 years after the operation) the severity of angina according to SAQ was: in the control group 33.30 (20.00-60.00), in the main group 60.00 (33.30-70.00; р = 0.0407). Other scales of SAQ, including physical activity, stability of anginal course, satisfaction with treatment and perception of the disease, did not demonstrate any differences between the studied groups in 2 months or 1618 years after CABG. \u0000CONCLUSION: Perioperative use of 5-oxymethyluracil influenced the improvement of only one parameter of quality of life according to the SAQ questionnaire the severity of angina, with statistically significant differences between the groups in the long-term period of CABG (1618 years after surgery). According to SAQ questionnaire, there was no effect on the remaining parameters of the quality of life with the underlying perioperative use of the studied drug in all follow-up periods.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128477512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kabanova, Irina O. Pokhoden'ko-Chudakova, S. Kabanova
INTRODUCTION: The systemic inflammatory response syndrome (SIRS) is a progressive, pathophysiological process which may be caused by a variety of clinical precursor events including local or generalized infection, or non-infective inflammatory process. АIM: To determine the development of systemic inflammatory response syndrome (SIRS) and serum procalcitonin level in patients with odontogenic infection of the maxillofacial area. MATERIALS AND METHODS: The prospective observational study evaluated on 158 medical patients from 2015 to 2018 at the Department of maxillofacial surgery, Faculty of Stomatology, Vitebsk state medical University. The patients were divided into 3 groups: 1 group (96 people) had acute purulent odontogenic osteomyelitis of mandible complicated by the cellulitis of one space cellular spaces, group 2 (36 patients) had acute purulent odontogenic osteomyelitis of mandible complicated by the cellulitis of 24 cellular spaces, group 3 (26 people) had acute purulent odontogenic osteomyelitis of the mandible complicated by Ludwig's angina. Blood tests of all patients were performed. Based on the blood test, breath rate, heart rate and body temperature SIRS was determined. RESULTS: Acute odontogenic osteomyelitis, complicated by cellulitis, is characterized by the development of SIRS. In case of one cellular space cellulitis SIRS developed in 9.0% of patients, in case of 24 cellular spaces cellulitis in 36.0%, in case of Ludwig's angina in 80.0%. PCT blood level in healthy group was 0.009 (0.0060.018) pg/ml. All patients groups had significantly higher PCT blood level compared with the healthy group: 1 group 0.034 (0.0190.050) pg/ml, U = 23, р = 0.01; 2 group 0.11 (0.060.24) pg/ml, U =12, р = 0.003; 3 group 0.41 (0.301.15) pg/ml, U = 17, р 0.001. CONCLUSION: Odontogenic maxillofacial infection is accompanied by SIRS. The search for significant diagnostic criteria for the development of life-threatening conditions should continue.
全身性炎症反应综合征(SIRS)是一个进行性的病理生理过程，可能由多种临床前驱事件引起，包括局部或全身性感染，或非感染性炎症过程。АIM:研究颌面部牙源性感染患者全身炎症反应综合征(SIRS)的发展及血清降钙素原水平。材料与方法:前瞻性观察研究评估了维捷布斯克国立医科大学口腔医学院颌面外科2015年至2018年收治的158例患者。将患者分为3组:1组96例合并1个间隙蜂窝织炎，2组36例合并24个间隙蜂窝织炎，3组26例合并路德维希心绞痛。对所有患者进行血液检查。根据血液测试、呼吸频率、心率和体温来确定SIRS。结果:急性牙源性骨髓炎，并发蜂窝织炎，以SIRS的发展为特征。单个细胞间隙蜂窝织炎的SIRS发生率为9.0%，24个细胞间隙蜂窝织炎的SIRS发生率为36.0%，路德维希心绞痛的SIRS发生率为80.0%。健康组血PCT水平为0.009 (0.0060.018)pg/ml。各患者组PCT血药浓度均显著高于健康组:1组0.034 (0.0190.050)pg/ml, U = 23, r = 0.01;2组0.11 (0.060.24)pg/ml, U =12, r = 0.003;3组0.41 (0.301.15)pg/ml, U = 17，±0.001。结论:牙源性颌面部感染伴发SIRS。应该继续寻找危及生命的疾病发展的重要诊断标准。
{"title":"Systemic Inflammatory Response Syndrome and Serum Procalcitonin in Odontogenic Maxillofacial Infection","authors":"A. Kabanova, Irina O. Pokhoden'ko-Chudakova, S. Kabanova","doi":"10.17816/pavlovj106281","DOIUrl":"https://doi.org/10.17816/pavlovj106281","url":null,"abstract":"INTRODUCTION: The systemic inflammatory response syndrome (SIRS) is a progressive, pathophysiological process which may be caused by a variety of clinical precursor events including local or generalized infection, or non-infective inflammatory process. \u0000АIM: To determine the development of systemic inflammatory response syndrome (SIRS) and serum procalcitonin level in patients with odontogenic infection of the maxillofacial area. \u0000MATERIALS AND METHODS: The prospective observational study evaluated on 158 medical patients from 2015 to 2018 at the Department of maxillofacial surgery, Faculty of Stomatology, Vitebsk state medical University. The patients were divided into 3 groups: 1 group (96 people) had acute purulent odontogenic osteomyelitis of mandible complicated by the cellulitis of one space cellular spaces, group 2 (36 patients) had acute purulent odontogenic osteomyelitis of mandible complicated by the cellulitis of 24 cellular spaces, group 3 (26 people) had acute purulent odontogenic osteomyelitis of the mandible complicated by Ludwig's angina. Blood tests of all patients were performed. Based on the blood test, breath rate, heart rate and body temperature SIRS was determined. \u0000RESULTS: Acute odontogenic osteomyelitis, complicated by cellulitis, is characterized by the development of SIRS. In case of one cellular space cellulitis SIRS developed in 9.0% of patients, in case of 24 cellular spaces cellulitis in 36.0%, in case of Ludwig's angina in 80.0%. PCT blood level in healthy group was 0.009 (0.0060.018) pg/ml. All patients groups had significantly higher PCT blood level compared with the healthy group: 1 group 0.034 (0.0190.050) pg/ml, U = 23, р = 0.01; 2 group 0.11 (0.060.24) pg/ml, U =12, р = 0.003; 3 group 0.41 (0.301.15) pg/ml, U = 17, р 0.001. \u0000CONCLUSION: Odontogenic maxillofacial infection is accompanied by SIRS. The search for significant diagnostic criteria for the development of life-threatening conditions should continue.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124061202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lyudmila V. Tribuntseva, S. N. Avdeyev, A. Budnevskiy, G. Prozorova, S. A. Kozhevnikova
INTRODUCTION: Bronchial asthma (BA) is a serious medical and social problem due to its increasing prevalence, significant burden on healthcare and the persisting high level of disability and mortality. AIM: To study a combined effect of multimorbidity and increased body mass index (BMI) on BA control and quality of life (QL) of patients to determine the possibilities of optimization of personalized program of patient management. MATERIALS AND METHODS: Two hundred thirty seven patients with BA were divided to 3 groups: 1 with normal body weight (n = 59; 24.9%); 2 with overweight (n = 69; 29.1%); 3 with obesity (n = 109; 46.0%). The level of multimorbidity was analyzed by Charlson comorbidity Index (CCI) and the cumulative illness rating scale (CIRS); BA control by ASTTM and ACQ-5; QL by AQLQ. The average number of groups of comorbid diseases (according to CIRS) was 7.44 0.95, while 13.5% of patients had 12 groups of comorbid diseases, 33.8% 34 groups, 46.8% 5 groups. In the group of obesity, 82.6% of patients had 5 groups of diseases. The average score of CIRS index was 7.44 0.95 points, the maximum score was 19, the minimum was 2. In the first group, the average value of CIRS index was 4.68 0.31 points, in the second 5.62 0.43 points, in the third 10.1 1.9 points (p1, 2 = 0.001, p1, 3 0.0001, p2, 3 0.0001). RESULTS: Ten patients (4%) had fully controlled BA by АСТ and 33 (14%) by ACQ-5. In the group with obesity, controlled BA was not detected (2 = 34.128; p = 0.0002), (F = 41.362; p 0.001). With increase in the number of comorbid diseases, the control of BA reliably decreased; thus, in groups 2 and 3 with the existence of 5 groups of comorbid diseases, asthma had uncontrolled course with the lowest parameters in patients with obesity (р 0.05). Analysis of BA by AQLQ showed negative influence of the disease on the severity of symptoms, motor activity, general QL of patients with obesity. The data obtained are confirmed by the correlation analysis. CONCLUSION: Multimorbidity negatively influences control of BA: increase in CCI and CIRS parameters considerably impairs control of BA. Increase in BMI is a significant additional risk factor of impairment of BA control. Multimorbidity in combination with obesity significantly impairs QL of patients with BA according to AQLQ. The absence of control of BA according to АСТ and ACQ-5 influences the quality of life of patients with BA. The evaluation of multimorbidity and BMI must be included in the personalized program for management of patients with BA to take into account multivariate assessment of treatable signs of the disease.
{"title":"Combined Effect of Multimorbidity and Increased Body Mass Index on Control of Bronchial Asthma and Quality of Patients’ Life","authors":"Lyudmila V. Tribuntseva, S. N. Avdeyev, A. Budnevskiy, G. Prozorova, S. A. Kozhevnikova","doi":"10.17816/pavlovj111895","DOIUrl":"https://doi.org/10.17816/pavlovj111895","url":null,"abstract":"INTRODUCTION: Bronchial asthma (BA) is a serious medical and social problem due to its increasing prevalence, significant burden on healthcare and the persisting high level of disability and mortality. \u0000AIM: To study a combined effect of multimorbidity and increased body mass index (BMI) on BA control and quality of life (QL) of patients to determine the possibilities of optimization of personalized program of patient management. \u0000MATERIALS AND METHODS: Two hundred thirty seven patients with BA were divided to 3 groups: 1 with normal body weight (n = 59; 24.9%); 2 with overweight (n = 69; 29.1%); 3 with obesity (n = 109; 46.0%). The level of multimorbidity was analyzed by Charlson comorbidity Index (CCI) and the cumulative illness rating scale (CIRS); BA control by ASTTM and ACQ-5; QL by AQLQ. The average number of groups of comorbid diseases (according to CIRS) was 7.44 0.95, while 13.5% of patients had 12 groups of comorbid diseases, 33.8% 34 groups, 46.8% 5 groups. In the group of obesity, 82.6% of patients had 5 groups of diseases. The average score of CIRS index was 7.44 0.95 points, the maximum score was 19, the minimum was 2. In the first group, the average value of CIRS index was 4.68 0.31 points, in the second 5.62 0.43 points, in the third 10.1 1.9 points (p1, 2 = 0.001, p1, 3 0.0001, p2, 3 0.0001). \u0000RESULTS: Ten patients (4%) had fully controlled BA by АСТ and 33 (14%) by ACQ-5. In the group with obesity, controlled BA was not detected (2 = 34.128; p = 0.0002), (F = 41.362; p 0.001). With increase in the number of comorbid diseases, the control of BA reliably decreased; thus, in groups 2 and 3 with the existence of 5 groups of comorbid diseases, asthma had uncontrolled course with the lowest parameters in patients with obesity (р 0.05). Analysis of BA by AQLQ showed negative influence of the disease on the severity of symptoms, motor activity, general QL of patients with obesity. The data obtained are confirmed by the correlation analysis. \u0000CONCLUSION: Multimorbidity negatively influences control of BA: increase in CCI and CIRS parameters considerably impairs control of BA. Increase in BMI is a significant additional risk factor of impairment of BA control. Multimorbidity in combination with obesity significantly impairs QL of patients with BA according to AQLQ. The absence of control of BA according to АСТ and ACQ-5 influences the quality of life of patients with BA. The evaluation of multimorbidity and BMI must be included in the personalized program for management of patients with BA to take into account multivariate assessment of treatable signs of the disease.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125252953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Agibalova, Viktoriya N. Nobatova, O. Tuchina, E. V. Leonov, A.R. Pinegin, El'mira I. Tukhvatullina
INTRODUCTION: Achievement of a sustained remission in patients with substance dependence syndrome is the main criterion of the quality of narcological treatment and a priority treatment task. The article presents a review of factors that influence remission in patients with mental and behavioral disorders resulting from use of psychoactive substances. Studies performed in the recent 15 years, consider the main five groups of factors for development and failure of remission: biological (gender, age, genetic parameters, organic lesions of the brain, etc.), narcological (course of the disease, age at the first use of a drug), personality and pathopsychological (cognitive disorders, comorbid mental disorders, mental trauma, etc.), social (employment, family and social situation, social support, etc.) and therapeutic factors (duration and methods of treatment, therapeutic alliance, etc.).. CONCLUSION: There are basic factors of favorable prognosis of the course of narcological diseases that are confirmed from study to study: late onset of the disease, absence of a comorbid dependence syndrome and of a severe mental disorder, involvement in long-term treatment and rehabilitation programs that continue after remission.
{"title":"Review of Factors Affecting Remission in Narcological Patients","authors":"T. Agibalova, Viktoriya N. Nobatova, O. Tuchina, E. V. Leonov, A.R. Pinegin, El'mira I. Tukhvatullina","doi":"10.17816/pavlovj105809","DOIUrl":"https://doi.org/10.17816/pavlovj105809","url":null,"abstract":"INTRODUCTION: Achievement of a sustained remission in patients with substance dependence syndrome is the main criterion of the quality of narcological treatment and a priority treatment task. The article presents a review of factors that influence remission in patients with mental and behavioral disorders resulting from use of psychoactive substances. Studies performed in the recent 15 years, consider the main five groups of factors for development and failure of remission: biological (gender, age, genetic parameters, organic lesions of the brain, etc.), narcological (course of the disease, age at the first use of a drug), personality and pathopsychological (cognitive disorders, comorbid mental disorders, mental trauma, etc.), social (employment, family and social situation, social support, etc.) and therapeutic factors (duration and methods of treatment, therapeutic alliance, etc.).. \u0000CONCLUSION: There are basic factors of favorable prognosis of the course of narcological diseases that are confirmed from study to study: late onset of the disease, absence of a comorbid dependence syndrome and of a severe mental disorder, involvement in long-term treatment and rehabilitation programs that continue after remission.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117338636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
INTRODUCTION: Type 2 diabetes mellitus is an urgent problem due to its widespread prevalence and disability of patents in result of macro- and microvascular complications. Diabetic neuropathy (DN) considerably impairs the quality of life of patients. Use of alpha-lipoic acid (ALA) prevents the development of oxidative stress and improves oxidation of fatty acids. AIM: To study the influence of alpha-lipoic acid on the variability of glycemia, lipid spectrum, positive and negative neurological symptoms in patients with DM2 and DN. MATERIALS AND METHODS: The prospective study included 39 patients with DM2 and DN in the clinical stage: patients of group 1 (n = 20) were administered intravenous drip infusion of ALA 600 mg once a day for 2 weeks in hospital conditions followed by intake of 600 mg once a day per os for 2.5 months on an outpatient basis; patients of group 2 (n = 19) did not receive ALA preparations. In all the patients, parameters of lipid and carbohydrate metabolism were studied, pain, tactile, temperature, vibration sensitivity and muscle strength of lower extremities were evaluated. RESULTS: In patients of group 1, after 12 weeks of using ALA, decrease in positive symptoms in the lower legs and feet, improvement in vibration (0.6 0.5 points, p = 0.0095), tactile (0.7 0.6 points, p = 0.037), temperature sensitivity (0.2 0.4 points, p = 0.027), and also decrease in the average value of glycemia (8.7 [7.4; 9.2] mmol/l, p = 0.0078), decrease in glycated hemoglobin with the achievement of the target value (7.5 0.1%, p = 0.046) and improvement of lipid spectrum (total cholesterol 5.9 0.1 mmol/ l, p = 0.043) were recorded; low density lipoproteins 3.6 0.1 mmol/l, p = 0.0076; high density lipoproteins 1.2 0.1 mmol/l, p = 0.034). CONCLUSION: In patients with type 2 diabetes mellitus with diabetic neuropathy in the clinical stage who received preparations of alpha-lipoic acid in complex treatment, reduction of neurologic deficit, of positive neurologic symptoms was achieved in 12 weeks; with that, improvement of lipid spectrum and of glycemic control was found, which may be considered as pleiotropic effects associated with acceleration of mitochondrial biosynthesis.
{"title":"Pleiotropic Effects of Alpha-Lipoic Acid in Treatment of Diabetic Neuropathy in Patients with Type 2 Diabetes Mellitus","authors":"O. M. Uryasyev, V. V. Baranov, Polina L. Novikova","doi":"10.17816/pavlovj106658","DOIUrl":"https://doi.org/10.17816/pavlovj106658","url":null,"abstract":"INTRODUCTION: Type 2 diabetes mellitus is an urgent problem due to its widespread prevalence and disability of patents in result of macro- and microvascular complications. Diabetic neuropathy (DN) considerably impairs the quality of life of patients. Use of alpha-lipoic acid (ALA) prevents the development of oxidative stress and improves oxidation of fatty acids. \u0000AIM: To study the influence of alpha-lipoic acid on the variability of glycemia, lipid spectrum, positive and negative neurological symptoms in patients with DM2 and DN. \u0000MATERIALS AND METHODS: The prospective study included 39 patients with DM2 and DN in the clinical stage: patients of group 1 (n = 20) were administered intravenous drip infusion of ALA 600 mg once a day for 2 weeks in hospital conditions followed by intake of 600 mg once a day per os for 2.5 months on an outpatient basis; patients of group 2 (n = 19) did not receive ALA preparations. In all the patients, parameters of lipid and carbohydrate metabolism were studied, pain, tactile, temperature, vibration sensitivity and muscle strength of lower extremities were evaluated. \u0000RESULTS: In patients of group 1, after 12 weeks of using ALA, decrease in positive symptoms in the lower legs and feet, improvement in vibration (0.6 0.5 points, p = 0.0095), tactile (0.7 0.6 points, p = 0.037), temperature sensitivity (0.2 0.4 points, p = 0.027), and also decrease in the average value of glycemia (8.7 [7.4; 9.2] mmol/l, p = 0.0078), decrease in glycated hemoglobin with the achievement of the target value (7.5 0.1%, p = 0.046) and improvement of lipid spectrum (total cholesterol 5.9 0.1 mmol/ l, p = 0.043) were recorded; low density lipoproteins 3.6 0.1 mmol/l, p = 0.0076; high density lipoproteins 1.2 0.1 mmol/l, p = 0.034). \u0000CONCLUSION: In patients with type 2 diabetes mellitus with diabetic neuropathy in the clinical stage who received preparations of alpha-lipoic acid in complex treatment, reduction of neurologic deficit, of positive neurologic symptoms was achieved in 12 weeks; with that, improvement of lipid spectrum and of glycemic control was found, which may be considered as pleiotropic effects associated with acceleration of mitochondrial biosynthesis.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123690847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. A. Kiryushin, N. A. Bobotina, Mariya A. Demchenko, Tat'yana V. Motalova
INTRODUCTION: Atmospheric air pollution is the underlying factor of a great number of human diseases in both industrialized and developing countries. Studies show that exposure to atmospheric pollutions in pregnancy can be associated with an increased risk of congenital anomalies (CAs). AIM: To analyze the impact of atmospheric air pollutants in Ryazan city on the incidence of CAs in newborns. MATERIALS AND METHODS: The data of monitoring of CAs by Ryazan Regional Perinatal Center; information on atmospheric air pollution of the Federal Service for Hydrometeorology and Environmental Monitoring, of Ryazan Center for Hydrometeorology and Environmental Monitoring, of Rospotrebnadzor of the Ryazan region are presented. The statistical analysis was conducted using free R computing environment (ver. 4.1.2). RESULTS: In 2019, the prevalence of CAs in Ryazan was 24.09 per 1,000 newborns; in the period 20102021, the absolute number of recorded CAs grew by 244.57%. The most common congenital anomalies were Q21.0 Ventricular septal defects (28.5%, 95% CI: 20.836.2%) and Q62.0 Congenital hydronephrosis (7.3%, 95% CI: 2.911.7%). Correlation was recorded with such air pollutant as sulfur dioxide (SO2) in the second month of pregnancy (AOR 1.39; 95%; CI 1.051.83, p 0.05) and the third month of pregnancy (AOR 1.59; 95% CI 1.172.16, p 0.05). No statistically significant relationship was established between CAs and carbon monoxide (CO), nitrogen dioxide (NO2) and ozone (O3, p 0.05). CONCLUSION: The study confirms the association between atmospheric air pollution and frequency of CAs. In particular, SO2 has a negative effect in the second and third months of pregnancy. In this context, it is important that the authority bodies of the region and governmental regulatory agencies direct their efforts to reduction of the pollution of the environment which should help reduce the frequency of CAs in children.
导言:大气污染是工业化国家和发展中国家许多人类疾病的潜在因素。研究表明，怀孕期间接触大气污染可能与先天性异常(CAs)的风险增加有关。目的:分析梁赞市大气污染物对新生儿CAs发病率的影响。材料与方法:梁赞地区围产中心监测CAs数据;介绍了梁赞地区Rospotrebnadzor水文气象和环境监测中心水文气象和环境监测联邦局大气污染资料。统计分析是在免费的R计算环境下进行的。4.1.2)。结果:2019年梁赞县CAs患病率为24.09 / 1000例新生儿;在2010 - 2021年期间，记录在案的ca绝对数量增长了244.57%。最常见的先天性异常是Q21.0室间隔缺损(28.5%，95% CI: 20.836.2%)和Q62.0先天性肾积水(7.3%，95% CI: 2.911.7%)。妊娠第二个月与空气污染物二氧化硫(SO2)相关(AOR 1.39;95%;CI 1.051.83, p 0.05)和妊娠第3个月(AOR 1.59;95% CI 1.172.16, p 0.05)。ca与一氧化碳(CO)、二氧化氮(NO2)、臭氧(O3, p < 0.05)无统计学意义。结论:本研究证实了大气污染与CAs发生频率之间的相关性。特别是，二氧化硫在怀孕的第二和第三个月有负面影响。在这方面，重要的是该区域的主管机构和政府管理机构应将其努力用于减少对环境的污染，这应有助于减少儿童患小儿麻痹症的频率。
{"title":"Influence of Atmospheric Air Pollution on Frequency of Congenital Anomalies (on an example of a region)","authors":"V. A. Kiryushin, N. A. Bobotina, Mariya A. Demchenko, Tat'yana V. Motalova","doi":"10.17816/pavlovj109333","DOIUrl":"https://doi.org/10.17816/pavlovj109333","url":null,"abstract":"INTRODUCTION: Atmospheric air pollution is the underlying factor of a great number of human diseases in both industrialized and developing countries. Studies show that exposure to atmospheric pollutions in pregnancy can be associated with an increased risk of congenital anomalies (CAs). \u0000AIM: To analyze the impact of atmospheric air pollutants in Ryazan city on the incidence of CAs in newborns. \u0000MATERIALS AND METHODS: The data of monitoring of CAs by Ryazan Regional Perinatal Center; information on atmospheric air pollution of the Federal Service for Hydrometeorology and Environmental Monitoring, of Ryazan Center for Hydrometeorology and Environmental Monitoring, of Rospotrebnadzor of the Ryazan region are presented. The statistical analysis was conducted using free R computing environment (ver. 4.1.2). \u0000RESULTS: In 2019, the prevalence of CAs in Ryazan was 24.09 per 1,000 newborns; in the period 20102021, the absolute number of recorded CAs grew by 244.57%. The most common congenital anomalies were Q21.0 Ventricular septal defects (28.5%, 95% CI: 20.836.2%) and Q62.0 Congenital hydronephrosis (7.3%, 95% CI: 2.911.7%). Correlation was recorded with such air pollutant as sulfur dioxide (SO2) in the second month of pregnancy (AOR 1.39; 95%; CI 1.051.83, p 0.05) and the third month of pregnancy (AOR 1.59; 95% CI 1.172.16, p 0.05). No statistically significant relationship was established between CAs and carbon monoxide (CO), nitrogen dioxide (NO2) and ozone (O3, p 0.05). \u0000CONCLUSION: The study confirms the association between atmospheric air pollution and frequency of CAs. In particular, SO2 has a negative effect in the second and third months of pregnancy. In this context, it is important that the authority bodies of the region and governmental regulatory agencies direct their efforts to reduction of the pollution of the environment which should help reduce the frequency of CAs in children.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129092013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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