INTRODUCTION: Achievement of absolute sobriety, its maintenance and preservation are the main tasks of the stage of tertiary prophylaxis of narcological patients. AIM: To perform a comparative analysis of personality- and value-and-meaning-related characteristics of narcological patients with syndrome of addiction to psychoactive substances, with similar characteristics of healthy individuals without significant experience in use of alcohol and other psychoactive substances (absolute and relative abstainers). MATERIALS AND METHODS: The age, gender, level of education, experience in use of nicotine in the past and present, leading coping strategies, levels of religiosity and magic thinking have been studied. RESULTS: Two diametrically opposite images of abstainers were identified: on the one end individuals with higher level of education and lower levels of religiosity and magic thinking, and on the other individuals with lower level of education, but higher levels of religiosity and magic thinking. The group of abstainers is in general characterized by absence of the experience in nicotine use. CONCLUSION: Taking into account personality- and value-and-meaning-related characteristics helps more accurately determine the goals and directions of psychotherapeutic and rehabilitation measures, to differentiate patients according to rehabilitation programs, increases the level of motivation and adherence to treatment, which in turn leads to a longer and stable remission.
{"title":"Comparative Analysis of Personality-Related and Value-and-Meaning-Related Characteristics of Narcological Patients and Healthy Individuals (Abstainers) in Terms of Tertiary Prevention","authors":"V. V. Korduban, O. Buzik, T. Agibalova","doi":"10.17816/pavlovj109308","DOIUrl":"https://doi.org/10.17816/pavlovj109308","url":null,"abstract":"INTRODUCTION: Achievement of absolute sobriety, its maintenance and preservation are the main tasks of the stage of tertiary prophylaxis of narcological patients. \u0000AIM: To perform a comparative analysis of personality- and value-and-meaning-related characteristics of narcological patients with syndrome of addiction to psychoactive substances, with similar characteristics of healthy individuals without significant experience in use of alcohol and other psychoactive substances (absolute and relative abstainers). \u0000MATERIALS AND METHODS: The age, gender, level of education, experience in use of nicotine in the past and present, leading coping strategies, levels of religiosity and magic thinking have been studied. \u0000RESULTS: Two diametrically opposite images of abstainers were identified: on the one end individuals with higher level of education and lower levels of religiosity and magic thinking, and on the other individuals with lower level of education, but higher levels of religiosity and magic thinking. The group of abstainers is in general characterized by absence of the experience in nicotine use. \u0000CONCLUSION: Taking into account personality- and value-and-meaning-related characteristics helps more accurately determine the goals and directions of psychotherapeutic and rehabilitation measures, to differentiate patients according to rehabilitation programs, increases the level of motivation and adherence to treatment, which in turn leads to a longer and stable remission.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130258052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Bolobonkina, Aleksey A. Dement’yev, N. Minaeva, Mihail M. Lapkin, P. A. Kulagin
INTRODUCTION: In conditions of spread of the new coronavirus infection SARS-CoV-2 (COVID-19), the work regimen and working conditions of the mobile emergency medical teams have changed, the range of occupational hazards has expanded, which led to unfavorable alterations in the functional state of the nervous system of workers. AIM: To study the influence of the professional activity on the functional state of an organism of medical workers of mobile emergency medical teams in conditions of COVID-19 pandemic. MATERIALS AND METHODS: Parameters of the functional state of an organism of medical workers of mobile emergency medical teams were studied before, after the work and between shifts in the period from May to October 2021. The extent of centralization of the heart rhythm control was evaluated by use of strain index (SI) of regulatory systems. The sample included 67 workers of mobile teams (21 men and 46 women), 16 doctors and 51 paramedics. The average age of workers participating in the study was 36.28 2.82 years. RESULTS: By the end of shift, in more than half the medical workers of mobile EMT, SI grew by 74.75 units (p = 0,021). The age (2 = 6.467; р = 0.040) and length of service (2 = 6.069; р = 0.049) influenced the distribution of workers with different SI dynamics on the basis of the results of the work shift. By the beginning of the next shift, in 60.71% of workers included into the study, a significant increase in SI was recorded on average by 74.02 (р = 0.001) compared to the beginning of the previous shift. The influence of length of service on the distribution of workers with different dynamics of SI in the successive shifts into groups was recorded (2 = 7.313; р = 0.026). CONCLUSIONS: The dynamics of the growth of the strain index of regulatory systems indicates low effectiveness of recovery of the functional state of an organism of workers in the period of scheduled rest. The greatest influence on the growth of parameters was exerted by length of service, which indicates the negative impact of working conditions on the functional state of an organism of workers.
{"title":"Intra-shift and Inter-shift Dynamics of Stress Index of Regulatory Systems in Medical Personnel of Mobile Emergency Medical Teams in Modern Conditions","authors":"T. Bolobonkina, Aleksey A. Dement’yev, N. Minaeva, Mihail M. Lapkin, P. A. Kulagin","doi":"10.17816/pavlovj106170","DOIUrl":"https://doi.org/10.17816/pavlovj106170","url":null,"abstract":"INTRODUCTION: In conditions of spread of the new coronavirus infection SARS-CoV-2 (COVID-19), the work regimen and working conditions of the mobile emergency medical teams have changed, the range of occupational hazards has expanded, which led to unfavorable alterations in the functional state of the nervous system of workers. \u0000AIM: To study the influence of the professional activity on the functional state of an organism of medical workers of mobile emergency medical teams in conditions of COVID-19 pandemic. \u0000MATERIALS AND METHODS: Parameters of the functional state of an organism of medical workers of mobile emergency medical teams were studied before, after the work and between shifts in the period from May to October 2021. The extent of centralization of the heart rhythm control was evaluated by use of strain index (SI) of regulatory systems. The sample included 67 workers of mobile teams (21 men and 46 women), 16 doctors and 51 paramedics. The average age of workers participating in the study was 36.28 2.82 years. \u0000RESULTS: By the end of shift, in more than half the medical workers of mobile EMT, SI grew by 74.75 units (p = 0,021). The age (2 = 6.467; р = 0.040) and length of service (2 = 6.069; р = 0.049) influenced the distribution of workers with different SI dynamics on the basis of the results of the work shift. By the beginning of the next shift, in 60.71% of workers included into the study, a significant increase in SI was recorded on average by 74.02 (р = 0.001) compared to the beginning of the previous shift. The influence of length of service on the distribution of workers with different dynamics of SI in the successive shifts into groups was recorded (2 = 7.313; р = 0.026). \u0000CONCLUSIONS: The dynamics of the growth of the strain index of regulatory systems indicates low effectiveness of recovery of the functional state of an organism of workers in the period of scheduled rest. The greatest influence on the growth of parameters was exerted by length of service, which indicates the negative impact of working conditions on the functional state of an organism of workers.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115027942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Zvyagina, K. Shumaev, E. Belskikh, O. M. Uryasyev, Sabina R. Akhmedova, Y. Marsyanova, A. Shitikova, Ol’ga N. Suchkova
INTRODUCTION: The study of markers of oxidative stress, metabolites of nitric oxide (II) (NOx) and the balance of carnitine fractions in mitochondria of rat epididymis, permits to evaluate the protective role of L-arginine in experimental hyperhomocysteinemia. AIM: To study the influence of L-arginine on the parameters of energy metabolism, level of NO metabolites, oxidative modification of proteins and balance of carnitine fractions in mitochondria of the head and tail of rat epididymis in hyperhomocysteinemia. MATERIALS AND METHODS: In animals of group 1 (n = 8), severe hyperhomocysteinemia (HHcy) was modeled by administration of methionine suspension at a dose of 1.5 g/kg twice daily for 21 days with addition of 1% methionine in drinking water; group 2 rats (n = 8) received suspension base without methionine; animals of group 3 (n = 8) were daily administered L-arginine solution at a dose of 500 mg/kg intragastrically against the background methionine load from day 11 to day 21; group 4 animals (n = 8) were administered L-arginine solution of at a dose of 500 mg/kg for 10 days; group 5 (n = 8) served as a control for group 4 and received drinking water intragastrically. Concentrations of total homocysteine and NOx were determined in serum. In the mitochondrial fraction of the homogenate of epididymis tissues, the level of oxidatively modified proteins (OMP), the concentration of NOx, lactate and carnitine fractions, the activity of lactate dehydrogenase (LDH), superoxide dismutase (SOD), H+-ATPase, succinate dehydrogenase (SDH) were evaluated. RESULTS: HHcy was accompanied by reduction of the level of NOx in blood serum and mitochondria of epididymis head tissues. In mitochondria of tissues of head and tail of epididymis, a marked reduction of all fractions of carnitine, activity of LDH, H+-ATPase, SDH, increase in the activity of SOD and in the level of OMP were observed. With modeled HHcy, L-arginine reduced the extent of hyperhomocysteinemia, prevented reduction of NOx level in the blood serum and epididymis head and reduced the content of OMP of the epididymis mitochondria. CONCLUSION: L-arginine introduced in combination with methionine, reduces the extent of severity of hyperhomocysteinemia. The positive effect of L-arginine on increase in the concentration of NOx metabolites in blood serum and mitochondria of epididymis in conditions of methionine load was also confirmed. L-arginine exhibits antioxidant properties, reducing the severity of oxidative stress induced by hyperhomocysteinemia. Differences in the adaptive response to oxidative stress of the mitochondria of the head and tail of epididymis were demonstrated.
{"title":"Protective Effects of L-Arginine on Mitochondria of Rat Epididymis in Hyperhomocysteinemia Induced by Prolonged Methionine Load","authors":"V. Zvyagina, K. Shumaev, E. Belskikh, O. M. Uryasyev, Sabina R. Akhmedova, Y. Marsyanova, A. Shitikova, Ol’ga N. Suchkova","doi":"10.17816/pavlovj109410","DOIUrl":"https://doi.org/10.17816/pavlovj109410","url":null,"abstract":"INTRODUCTION: The study of markers of oxidative stress, metabolites of nitric oxide (II) (NOx) and the balance of carnitine fractions in mitochondria of rat epididymis, permits to evaluate the protective role of L-arginine in experimental hyperhomocysteinemia. \u0000AIM: To study the influence of L-arginine on the parameters of energy metabolism, level of NO metabolites, oxidative modification of proteins and balance of carnitine fractions in mitochondria of the head and tail of rat epididymis in hyperhomocysteinemia. \u0000MATERIALS AND METHODS: In animals of group 1 (n = 8), severe hyperhomocysteinemia (HHcy) was modeled by administration of methionine suspension at a dose of 1.5 g/kg twice daily for 21 days with addition of 1% methionine in drinking water; group 2 rats (n = 8) received suspension base without methionine; animals of group 3 (n = 8) were daily administered L-arginine solution at a dose of 500 mg/kg intragastrically against the background methionine load from day 11 to day 21; group 4 animals (n = 8) were administered L-arginine solution of at a dose of 500 mg/kg for 10 days; group 5 (n = 8) served as a control for group 4 and received drinking water intragastrically. Concentrations of total homocysteine and NOx were determined in serum. In the mitochondrial fraction of the homogenate of epididymis tissues, the level of oxidatively modified proteins (OMP), the concentration of NOx, lactate and carnitine fractions, the activity of lactate dehydrogenase (LDH), superoxide dismutase (SOD), H+-ATPase, succinate dehydrogenase (SDH) were evaluated. \u0000RESULTS: HHcy was accompanied by reduction of the level of NOx in blood serum and mitochondria of epididymis head tissues. In mitochondria of tissues of head and tail of epididymis, a marked reduction of all fractions of carnitine, activity of LDH, H+-ATPase, SDH, increase in the activity of SOD and in the level of OMP were observed. With modeled HHcy, L-arginine reduced the extent of hyperhomocysteinemia, prevented reduction of NOx level in the blood serum and epididymis head and reduced the content of OMP of the epididymis mitochondria. \u0000CONCLUSION: L-arginine introduced in combination with methionine, reduces the extent of severity of hyperhomocysteinemia. The positive effect of L-arginine on increase in the concentration of NOx metabolites in blood serum and mitochondria of epididymis in conditions of methionine load was also confirmed. L-arginine exhibits antioxidant properties, reducing the severity of oxidative stress induced by hyperhomocysteinemia. Differences in the adaptive response to oxidative stress of the mitochondria of the head and tail of epididymis were demonstrated.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126937868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atypical hemolytic-uremic syndrome (aHUS) is an ultra-rare (orphan) disease with a progressive course, which is a systemic thrombotic microangiopathy resulting from uncontrolled activation of the alternative complement pathway. There exist the so called obstetric thombotic microangiopathies (pre-eclampsia, HELLP syndrome) which are considered as triggers causing development of aHUS in pregnancy in genetically predisposed female patients. Here, the main peculiarity of these pathologies is the improvement of the condition of the puerpera after delivery. In case of non-obstetric thombotic microangiopathies, delivery does not lead to regress of symptoms, on the contrary, microangiopathic process progresses with rapid development of multiorgan failure. The development of thrombotic thrombocytopenic purpura and aHUS in pregnancy may induce physiological changes in the organism of a pregnant woman. There occurs a build-up of the activity of von Willebrand factor with a parallel reduction of the activity of ADAMTS 13 enzyme (metalloprotease that cleaves its super-large multimers). This is probably a physiological adaptation of the body to minimize blood loss during childbirth. As a result of the imbalance, the risk of developing thrombotic microangiopathy increases by the end of II beginning of III trimester. The concept of chronic uncontrolled activation of the alternative complement pathway implies a genetic defect of regulatory proteins with increased formation of C5 convertase, increased release of C5a a strong chemoattractant, and of membraneattacking complex C5bC9, which leads to damage to endothelial cells, exposure of the subendothelial layer and thrombosis. The currently used drug eculizumab is a recombinant humanized monoclonal antibody that binds to the complement C5 protein and suppresses the activation of complement-mediated cell lysis. The article presents a clinical case of the development of aHUS in a patient during pregnancy, the main stages of diagnostic search are considered, routing is determined and the therapy used is justified.
{"title":"Case Report of Development of Atypical Hemolytic-Uremic Syndrome in Pregnancy","authors":"E. Smirnova, Ol'ga V. Kurtikova","doi":"10.17816/pavlovj106407","DOIUrl":"https://doi.org/10.17816/pavlovj106407","url":null,"abstract":"Atypical hemolytic-uremic syndrome (aHUS) is an ultra-rare (orphan) disease with a progressive course, which is a systemic thrombotic microangiopathy resulting from uncontrolled activation of the alternative complement pathway. There exist the so called obstetric thombotic microangiopathies (pre-eclampsia, HELLP syndrome) which are considered as triggers causing development of aHUS in pregnancy in genetically predisposed female patients. Here, the main peculiarity of these pathologies is the improvement of the condition of the puerpera after delivery. In case of non-obstetric thombotic microangiopathies, delivery does not lead to regress of symptoms, on the contrary, microangiopathic process progresses with rapid development of multiorgan failure. The development of thrombotic thrombocytopenic purpura and aHUS in pregnancy may induce physiological changes in the organism of a pregnant woman. There occurs a build-up of the activity of von Willebrand factor with a parallel reduction of the activity of ADAMTS 13 enzyme (metalloprotease that cleaves its super-large multimers). This is probably a physiological adaptation of the body to minimize blood loss during childbirth. As a result of the imbalance, the risk of developing thrombotic microangiopathy increases by the end of II beginning of III trimester. The concept of chronic uncontrolled activation of the alternative complement pathway implies a genetic defect of regulatory proteins with increased formation of C5 convertase, increased release of C5a a strong chemoattractant, and of membraneattacking complex C5bC9, which leads to damage to endothelial cells, exposure of the subendothelial layer and thrombosis. The currently used drug eculizumab is a recombinant humanized monoclonal antibody that binds to the complement C5 protein and suppresses the activation of complement-mediated cell lysis. The article presents a clinical case of the development of aHUS in a patient during pregnancy, the main stages of diagnostic search are considered, routing is determined and the therapy used is justified.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"57 10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123316906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
INTRODUCTION: The information about the variants of the structure and topography of the moderator band (MB) that connects the interventricular septum with the anterior papillary muscle and the anterior wall of the right ventricle in the heart of a fetus and a newborn, is of great importance for cardiac surgery. AIM: To establish the prevalence of the MB and describe the variants of its shape, structure and position in the right ventricle of the normal human heart in the early antenatal period of development. MATERIALS AND METHODS: Using Olympus SZX2-ZB10 stereomicroscope with 4.725X to 15X magnification, formalin-fixed hearts of fetuses and stillborns of 1728 weeks were studied. The results are presented in the form of median, 25th and 75th percentiles, extreme values. Correlation analysis was performed. Significance of the difference of proportions was evaluated by one-sided t-test. The results are presented in the form of median (Me), 25th and 75th percentiles (Q25%Q75%). RESULTS: MB was found in 73 of 90 preparations (81.1%), in 48 cases (66%) it was bridge-like, and in 24 of 72 (33.3%) ― parietal. MB had flattened (crest-like) or cylindrical shape (62.5% vs 33%; p = 0.0002). The most common was flattened bridge-like variant. The length of MB was 2.2 (1.753.0) mm, width 1.35 (0.91.75) mm, thickness 1.0 (0.651.5) mm. The band mainly originated from the interventricular septum between the middle and apical thirds of the longitudinal axis, and the anterior and middle thirds of the transverse axis of the interventricular septum. It typically terminated with the attachment to the anterior papillary muscle (47.7%), or to the anterior wall of the right ventricle immediately in front of this muscle (38.5%). In 22.2% of cases, the MB had papillary muscles on it, and in 37.5%, the secondary trabeculae extended from it to the apex of the ventricle. CONCLUSION: MB is a normal, but not obligatory structure of the heart in the antenatal period, its normal anatomy is variable and is manifested by typical and rare variants of the form, position, beginning and end, which in many cases can impede diagnostics and treatment of the pathology of the right ventricle.
{"title":"Variant Anatomy of the Right Ventricular Moderator Band in Human Heart in Early Antenatal Period of Development","authors":"A. Yakimov","doi":"10.17816/pavlovj106689","DOIUrl":"https://doi.org/10.17816/pavlovj106689","url":null,"abstract":"INTRODUCTION: The information about the variants of the structure and topography of the moderator band (MB) that connects the interventricular septum with the anterior papillary muscle and the anterior wall of the right ventricle in the heart of a fetus and a newborn, is of great importance for cardiac surgery. \u0000AIM: To establish the prevalence of the MB and describe the variants of its shape, structure and position in the right ventricle of the normal human heart in the early antenatal period of development. \u0000MATERIALS AND METHODS: Using Olympus SZX2-ZB10 stereomicroscope with 4.725X to 15X magnification, formalin-fixed hearts of fetuses and stillborns of 1728 weeks were studied. The results are presented in the form of median, 25th and 75th percentiles, extreme values. Correlation analysis was performed. Significance of the difference of proportions was evaluated by one-sided t-test. The results are presented in the form of median (Me), 25th and 75th percentiles (Q25%Q75%). \u0000RESULTS: MB was found in 73 of 90 preparations (81.1%), in 48 cases (66%) it was bridge-like, and in 24 of 72 (33.3%) ― parietal. MB had flattened (crest-like) or cylindrical shape (62.5% vs 33%; p = 0.0002). The most common was flattened bridge-like variant. The length of MB was 2.2 (1.753.0) mm, width 1.35 (0.91.75) mm, thickness 1.0 (0.651.5) mm. The band mainly originated from the interventricular septum between the middle and apical thirds of the longitudinal axis, and the anterior and middle thirds of the transverse axis of the interventricular septum. It typically terminated with the attachment to the anterior papillary muscle (47.7%), or to the anterior wall of the right ventricle immediately in front of this muscle (38.5%). In 22.2% of cases, the MB had papillary muscles on it, and in 37.5%, the secondary trabeculae extended from it to the apex of the ventricle. \u0000CONCLUSION: MB is a normal, but not obligatory structure of the heart in the antenatal period, its normal anatomy is variable and is manifested by typical and rare variants of the form, position, beginning and end, which in many cases can impede diagnostics and treatment of the pathology of the right ventricle.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132645329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. N. Poplevchenkov, T. Agibalova, O. Buzik, Denis A. Mischenko
INTRODUCTION: According to official statistics, there is an annual increase in the production and consumption of various psychostimulants, and as a result, an increase in the number of patients with addiction of psychostimulants. At the same time, there are no effective methods of treating such disorders within the framework of a modern personalized approach to therapy. AIM: To study peculiarities of the temperament and character of patients with combined dependence on psychostimulants and other psychoactive substances (PASs) and with comorbid psychiatric pathology to increase the effectiveness of psychotherapeutic methods in personalized therapeutic approach. MATERIALS AND METHODS: The study included 325 patients (ethnic Russian men and women aged from 18 to 50 years) with the diagnosis: dependence on psychostimulants and dependence on psychostimulants in combination with comorbid psychiatric pathology, who signed the informed consent. R. Cloninger method of assessment of the temperament and character (Temperament and Character Inventory, TCI-125) was used. RESULTS: Patients were divided to groups depending on PASs used by them and the existence of comorbid psychiatric pathology. Of temperament dimensions, the novelty seeking predominated in all the groups (up to 15 points; р 0.002) in comparison with harm avoidance (up to 10 points; р 0.112), reward dependence (up to 9 points; р 0.442) and persistence (up to 3 points; р 0.226). This combination of temperament dimensions corresponds to antisocial personality disorder. High cooperativeness (17 points; p 0.005) was observed in patients with a full course of rehabilitation and remissions up to 12 months. The maximal self-transcendence (10 points; p 0.02) corresponded to psychiatric pathology. CONCLUSION: On the basis of the results obtained, personality profiles of patients were determined. Patients of the first profile with dependence only on psychostimulants with minimal novelty seeking dimension of the temperament along with high cooperativeness character trait were more communicative, adapted to the treatment and rehabilitation program, and had longer remission periods. Patients of the second profile with a combined dependence on psychostimulants and other PASs with maximal novelty seeking dimension in the temperament along with minimal values on the character scales required the maximal effort of the specialists to keep them in the treatment and rehabilitation program. Patients of the third profile with dependence on psychostimulants and comorbid psychiatric pathology with maximal novelty seeking dimension in the temperament together with maximal self-transcendence were characterized by suspiciousness and required a special gradual establishment of psychotherapeutic contact to involve them in the treatment and rehabilitation process.
导言:根据官方统计，各种精神兴奋剂的生产和消费每年都在增加，因此，精神兴奋剂成瘾的患者人数也在增加。与此同时，在现代个性化治疗方法的框架内，没有有效的方法来治疗这些疾病。目的:研究精神兴奋剂及其他精神活性物质联合依赖(PASs)患者的气质及性格特点，以提高心理治疗方法在个性化治疗中的有效性。材料和方法:研究纳入325例诊断为精神兴奋剂依赖和精神兴奋剂依赖合并共病精神病理的患者(俄罗斯族，男女，年龄18 - 50岁)，并签署知情同意书。采用R. Cloninger气质与性格评定法(temperament and character Inventory, TCI-125)。结果:根据患者使用的PASs及是否存在精神病理合并症将患者分组。气质维度上，追求新奇在所有组中占主导地位(高达15分;与避免伤害相比(高达10分;0.112)，奖励依赖性(最高9分;0.442)和持久性(高达3分;р0.226)。这种气质维度的组合对应于反社会人格障碍。合作度高(17分;P 0.005)，在整个康复过程和缓解达12个月的患者中观察到。最大自我超越(10分;P < 0.02)符合精神病理。结论:在所得结果的基础上，确定了患者的性格特征。第一种类型的患者仅对精神兴奋剂依赖，且气质中寻求新奇的维度最小，同时具有较高的合作性性格特征，其沟通能力更强，适应治疗和康复计划，缓解期更长。第二种类型的患者同时依赖精神兴奋剂和其他PASs在气质上具有最大的新奇追求维度以及在性格量表上的最小值需要专家付出最大的努力来保持他们在治疗和康复计划中。第三种类型的患者具有精神兴奋剂依赖和精神病理共病，在气质上具有最大的新奇追求维度和最大的自我超越，以怀疑为特征，需要特殊的逐步建立心理治疗接触，使其参与治疗和康复过程。
{"title":"Peculiarities of Temperament and Character of Patients with Comorbid Psychiatric Pathology and Combined Dependence on Psychostimulants and Other Psychoactive Substances","authors":"K. N. Poplevchenkov, T. Agibalova, O. Buzik, Denis A. Mischenko","doi":"10.17816/pavlovj105870","DOIUrl":"https://doi.org/10.17816/pavlovj105870","url":null,"abstract":"INTRODUCTION: According to official statistics, there is an annual increase in the production and consumption of various psychostimulants, and as a result, an increase in the number of patients with addiction of psychostimulants. At the same time, there are no effective methods of treating such disorders within the framework of a modern personalized approach to therapy. \u0000AIM: To study peculiarities of the temperament and character of patients with combined dependence on psychostimulants and other psychoactive substances (PASs) and with comorbid psychiatric pathology to increase the effectiveness of psychotherapeutic methods in personalized therapeutic approach. \u0000MATERIALS AND METHODS: The study included 325 patients (ethnic Russian men and women aged from 18 to 50 years) with the diagnosis: dependence on psychostimulants and dependence on psychostimulants in combination with comorbid psychiatric pathology, who signed the informed consent. R. Cloninger method of assessment of the temperament and character (Temperament and Character Inventory, TCI-125) was used. \u0000RESULTS: Patients were divided to groups depending on PASs used by them and the existence of comorbid psychiatric pathology. Of temperament dimensions, the novelty seeking predominated in all the groups (up to 15 points; р 0.002) in comparison with harm avoidance (up to 10 points; р 0.112), reward dependence (up to 9 points; р 0.442) and persistence (up to 3 points; р 0.226). This combination of temperament dimensions corresponds to antisocial personality disorder. High cooperativeness (17 points; p 0.005) was observed in patients with a full course of rehabilitation and remissions up to 12 months. The maximal self-transcendence (10 points; p 0.02) corresponded to psychiatric pathology. \u0000CONCLUSION: On the basis of the results obtained, personality profiles of patients were determined. Patients of the first profile with dependence only on psychostimulants with minimal novelty seeking dimension of the temperament along with high cooperativeness character trait were more communicative, adapted to the treatment and rehabilitation program, and had longer remission periods. Patients of the second profile with a combined dependence on psychostimulants and other PASs with maximal novelty seeking dimension in the temperament along with minimal values on the character scales required the maximal effort of the specialists to keep them in the treatment and rehabilitation program. Patients of the third profile with dependence on psychostimulants and comorbid psychiatric pathology with maximal novelty seeking dimension in the temperament together with maximal self-transcendence were characterized by suspiciousness and required a special gradual establishment of psychotherapeutic contact to involve them in the treatment and rehabilitation process.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131819043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sergey G. Bolotin, Mariya S. Zenina, A. V. Solov’yeva, A. Pristupa
INTRODUCTION: Multiple myeloma (MM) is a disease whose substrate is plasma cells; it is characterized by the production of monoclonal immunoglobulin. Epidemiology of MM in Russia is insufficiently studied. Of interest is a study of dynamics of the main epidemiological parameters of multiple myeloma in the context of a poor epidemiological prognosis for oncological diseases in the Russian Federation and in the world in general. AIM: To analyze the main epidemiological parameters of symptomatic MM in the Ryazan region for 10 years (20102019). MATERIALS AND METHODS: A total of 343 medical records of patients with symptomatic MM were analyzed, of them 146 men (age median 65 years), 197 women (age median 64 years). The patients underwent inpatient treatment in the hematology and chemotherapy department of Ryazan Regional Clinical Hospital from 2010 to 2019. The epidemiological analysis consisted in evaluation of the parameters of the registered morbidity, prevalence and hospital mortality. The criterion for inclusion in the study was the existence of symptomatic MM in the patient. For statistical processing, Microsoft information and analytical system, Office package was used. RESULTS: The highest amount of new cases of MM were identified in 2018 (4.19 per 100,000 population), the lowest in 2012 (1.83 per 100,000 population). In the analyzed period, the number of cases of newly diagnosed MM per year increased by 30.3%. Most patients at the time of diagnosis were in the age group of 6069 years. Morbidity with MM in the age group of 3049 years was comparable in men and women, however, among the patients 50 years women predominated. Over 10 years, the index of MM prevalence in the Ryazan region increased 1.43 times: from 6.71 to 9.6 per 100,000 population, index of hospital mortality from 1.4% to 3.3%. CONCLUSION: The growth of the registered mortality and prevalence of MM in the Ryazan region in 20102019 was identified, which corresponds to the dynamics in other regions of the Russian Federation. Also, during the analyzed period, an increase in hospital mortality of patients with MM was observed in the region.
{"title":"Analysis of Recorded Morbidity, Prevalence and Hospital Mortality of Patients with Symptomatic Multiple Myeloma in the Ryazan Region for 10 Years","authors":"Sergey G. Bolotin, Mariya S. Zenina, A. V. Solov’yeva, A. Pristupa","doi":"10.17816/pavlovj108985","DOIUrl":"https://doi.org/10.17816/pavlovj108985","url":null,"abstract":"INTRODUCTION: Multiple myeloma (MM) is a disease whose substrate is plasma cells; it is characterized by the production of monoclonal immunoglobulin. Epidemiology of MM in Russia is insufficiently studied. Of interest is a study of dynamics of the main epidemiological parameters of multiple myeloma in the context of a poor epidemiological prognosis for oncological diseases in the Russian Federation and in the world in general. \u0000AIM: To analyze the main epidemiological parameters of symptomatic MM in the Ryazan region for 10 years (20102019). \u0000MATERIALS AND METHODS: A total of 343 medical records of patients with symptomatic MM were analyzed, of them 146 men (age median 65 years), 197 women (age median 64 years). The patients underwent inpatient treatment in the hematology and chemotherapy department of Ryazan Regional Clinical Hospital from 2010 to 2019. The epidemiological analysis consisted in evaluation of the parameters of the registered morbidity, prevalence and hospital mortality. The criterion for inclusion in the study was the existence of symptomatic MM in the patient. For statistical processing, Microsoft information and analytical system, Office package was used. \u0000RESULTS: The highest amount of new cases of MM were identified in 2018 (4.19 per 100,000 population), the lowest in 2012 (1.83 per 100,000 population). In the analyzed period, the number of cases of newly diagnosed MM per year increased by 30.3%. Most patients at the time of diagnosis were in the age group of 6069 years. Morbidity with MM in the age group of 3049 years was comparable in men and women, however, among the patients 50 years women predominated. Over 10 years, the index of MM prevalence in the Ryazan region increased 1.43 times: from 6.71 to 9.6 per 100,000 population, index of hospital mortality from 1.4% to 3.3%. \u0000CONCLUSION: The growth of the registered mortality and prevalence of MM in the Ryazan region in 20102019 was identified, which corresponds to the dynamics in other regions of the Russian Federation. Also, during the analyzed period, an increase in hospital mortality of patients with MM was observed in the region.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124212949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Artur V. Kondaraki, A. V. Chupin, B. Alekyan, V. A. Kul’bak
Vertebrobasilar insufficiency (VBI) remains an important problem in the modern medicine since approximately every fourth cerebral infarction occurs in the posterior circulation of the brain. These strokes are accompanied by severe consequences and a high risk of repeated events. The article presents the current concepts for surgical treatment of lesions of the subclavian (ScA) and vertebral (VA) arteries responsible for the development of VBI. In the open surgical treatment of symptomatic lesion of the ScA, primarily of occlusion one, extrathoracic interventions prevail in the form of carotid-subclavian bypass and carotid-subclavian transposition. According to our analysis, the results of carotid-subclavian transposition prove to be more preferable. In the endovascular intervention on the ScA, balloon angioplasty is used with possible stenting. In the analysis, we found no differences in the long-term patency between angioplasty and stenting, although the extent of technical success was higher in the group of stenting. In case of stenosis of the ScA, the world medicine gives priority to endovascular methods. To date, there are no sharply defined criteria permitting to choose between the open and endovascular interventions for treatment of the ScA occlusion, although a probable technical failure of endovascular revascularization and higher long-term patency give priority to open surgery. As for symptomatic stenosis of VA, to date there is no evidence of the advantage of stenting over conservative therapy. Thus, surgical intervention should rather be used in case the drug treatment is ineffective. The same can be said about the open reconstruction of the VA, except for the cases of contraindications for stenting of the VA, for example, its tortuosity.
{"title":"Achievements and Prospects for Vascular Surgery in Treatment of Vertebrobasilar Insufficiency","authors":"Artur V. Kondaraki, A. V. Chupin, B. Alekyan, V. A. Kul’bak","doi":"10.17816/pavlovj109601","DOIUrl":"https://doi.org/10.17816/pavlovj109601","url":null,"abstract":"Vertebrobasilar insufficiency (VBI) remains an important problem in the modern medicine since approximately every fourth cerebral infarction occurs in the posterior circulation of the brain. These strokes are accompanied by severe consequences and a high risk of repeated events. The article presents the current concepts for surgical treatment of lesions of the subclavian (ScA) and vertebral (VA) arteries responsible for the development of VBI. In the open surgical treatment of symptomatic lesion of the ScA, primarily of occlusion one, extrathoracic interventions prevail in the form of carotid-subclavian bypass and carotid-subclavian transposition. According to our analysis, the results of carotid-subclavian transposition prove to be more preferable. In the endovascular intervention on the ScA, balloon angioplasty is used with possible stenting. In the analysis, we found no differences in the long-term patency between angioplasty and stenting, although the extent of technical success was higher in the group of stenting. In case of stenosis of the ScA, the world medicine gives priority to endovascular methods. To date, there are no sharply defined criteria permitting to choose between the open and endovascular interventions for treatment of the ScA occlusion, although a probable technical failure of endovascular revascularization and higher long-term patency give priority to open surgery. As for symptomatic stenosis of VA, to date there is no evidence of the advantage of stenting over conservative therapy. Thus, surgical intervention should rather be used in case the drug treatment is ineffective. The same can be said about the open reconstruction of the VA, except for the cases of contraindications for stenting of the VA, for example, its tortuosity.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123580222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Rozov, V. Trezubov, V. D. Vagner, A. Urakov, Aleksey P. Reshetnikov
INTRODUCTION: The range of antiseptic agents used in clinical practice, is rather wide. However, only single studies are devoted to comparative characteristics of their effectiveness in the conditions of the oral cavity. AIM: To choose the optimal antiseptic dental cleaner by experimental study. MATERIALS AND METHODS: An aqueous solution of Furacilin (0.02%), chlorhexidine bigluconate (0.05%), Miramistin (0.01%), cetylpyridinium chloride (0.05%), hydrogen peroxide (3%), Iodinol, Rotokan, distilled water were used as washing liquids for elimination of dental plaque. The model of the dentition was created from quartz plates with an imitation of fresh plaque. Biomaterial imitating dental plaque included two solutions: 1) a strong fresh infusion of black tea leaves, cooled to +25C; 2) oatmeal jelly with temperature from +60C to +65C. The authors method of screening dental cleaners was used, based on comparing the transparency of the laboratory model of the dentition before and after exposure to the test solution by determination with an amperemeter of strength of the electric current in the photosensor device from the oxyhemograph sensor after white light emitted by a mini-emitter passed through biological material and plates and fell on it. RESULTS: The cleaning capacity of distilled water is the lowest (p 0.050.001). Rotokan, Furacilin and Iodinol have a low cleaning capacity, and Iodinol can cause a burn of the gingival cuff in case of high reaction to it, and allergic reactions. Hydrogen peroxide has an average degree of efficiency, but it dries the oral mucosa. Chlorhexidine bigluconate has the highest cleaning effect, Miramistin and cetylpyridinium chloride are slightly inferior to it (p 0.05). By the cleaning capacity, chlorhexidine bigluconate solution is significantly superior to hydrogen peroxide (p 0.05), Iodinol (p 0.02), Furacilin (p 0.02), Rotokan (p 0.01). CONCLUSION: The described method received the patent for invention of the Russian Federation No. 2019121293. Experimental studies have shown the best cleaning effect of 0.05% solution of chlorhexidine bigluconate.
{"title":"Experimentally Justified Choice of Optimal Antiseptic Solution for Hygienic Care of Oral Cavity and Dentures","authors":"R. Rozov, V. Trezubov, V. D. Vagner, A. Urakov, Aleksey P. Reshetnikov","doi":"10.17816/pavlovj108653","DOIUrl":"https://doi.org/10.17816/pavlovj108653","url":null,"abstract":"INTRODUCTION: The range of antiseptic agents used in clinical practice, is rather wide. However, only single studies are devoted to comparative characteristics of their effectiveness in the conditions of the oral cavity. \u0000AIM: To choose the optimal antiseptic dental cleaner by experimental study. \u0000MATERIALS AND METHODS: An aqueous solution of Furacilin (0.02%), chlorhexidine bigluconate (0.05%), Miramistin (0.01%), cetylpyridinium chloride (0.05%), hydrogen peroxide (3%), Iodinol, Rotokan, distilled water were used as washing liquids for elimination of dental plaque. The model of the dentition was created from quartz plates with an imitation of fresh plaque. Biomaterial imitating dental plaque included two solutions: 1) a strong fresh infusion of black tea leaves, cooled to +25C; 2) oatmeal jelly with temperature from +60C to +65C. The authors method of screening dental cleaners was used, based on comparing the transparency of the laboratory model of the dentition before and after exposure to the test solution by determination with an amperemeter of strength of the electric current in the photosensor device from the oxyhemograph sensor after white light emitted by a mini-emitter passed through biological material and plates and fell on it. \u0000RESULTS: The cleaning capacity of distilled water is the lowest (p 0.050.001). Rotokan, Furacilin and Iodinol have a low cleaning capacity, and Iodinol can cause a burn of the gingival cuff in case of high reaction to it, and allergic reactions. Hydrogen peroxide has an average degree of efficiency, but it dries the oral mucosa. Chlorhexidine bigluconate has the highest cleaning effect, Miramistin and cetylpyridinium chloride are slightly inferior to it (p 0.05). By the cleaning capacity, chlorhexidine bigluconate solution is significantly superior to hydrogen peroxide (p 0.05), Iodinol (p 0.02), Furacilin (p 0.02), Rotokan (p 0.01). \u0000CONCLUSION: The described method received the patent for invention of the Russian Federation No. 2019121293. Experimental studies have shown the best cleaning effect of 0.05% solution of chlorhexidine bigluconate.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124162945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. S. Martyusheva, A. Subbotina, A. Abramova, Irina V. Alekseeva, S. Pertsov
INTRODUCTION: Currently, biomedical specialists give special attention to studying the influence of stressogenic factors on an organism of a pregnant woman, the embryonic development of the fetus and the subsequent development of offspring in the early and late ontogenesis. It has been found in a number of studies that prenatal stress can lead to reduction of physical activity and hormonal disorders. The factors leading to disorders in regulation of immune and metabolic homeostasis have been identified. Despite considerable interest in the study of the consequences of prenatal stress, its impact on changes in metabolic intensity in different periods of postnatal ontogenesis in animals of different genders has not been sufficiently studied. AIM: To study parameters of metabolism intensity in different age periods of postnatal ontogenesis in rats offspring of both genders after intrauterine stress load. MATERIALS AND METHODS: Stress load was modeled in daily forced swimming of pregnant rats at 1012C for 5 min. Oxygen consumption, carbon dioxide excretion (ml/h/kg), and heat exchange (kcal/h/kg) in male and female rats were determined using a Phenomaster automated modular unit (TSE Systems GmbH, Germany) on the 21st, 30th and 60th day of the ontogenesis. Statistical significance of differences between the studied parameters was assessed using Mann-Whitney U-test for independent groups. RESULTS: The study parameters of intact animals practically did not differ in the suckling (the 21st day) and infantile period (the 30th day), but significantly decreased in the juvenile period of development (the 60th day). It was found that the intrauterine stress did not lead to statistically significant changes in the absolute values of metabolic parameters as compared to the control, but affected the period of appearance of age-related variations of these parameters in male rats. In these animals, the volumes of oxygen consumption, carbon dioxide excretion, and the level of heat radiation reduced as early as in the infantile period (as compared to 21-day-old rats) and reached the minimum level by the 60th day of the postnatal ontogenesis. In female rats subjected to intrauterine stress, changes in the study parameters in different periods of life were similar to those of intact animals. CONCLUSION: Therefore, prenatal stress modeled by swimming of female parents in cold water, has a modulating effect on age-related dynamics of metabolic parameters of male rats, which was manifested by the decrease in these parameters in the earlier period of development.
导读:目前，生物医学专家特别关注研究应激因素对孕妇机体、胎儿胚胎发育和后代在个体发生早期和晚期的后续发育的影响。许多研究发现，产前压力会导致身体活动减少和荷尔蒙紊乱。导致免疫和代谢稳态调节失调的因素已经确定。尽管对产前应激后果的研究有相当大的兴趣，但其对不同性别动物出生后个体发生不同时期代谢强度变化的影响尚未得到充分研究。目的:研究子宫内应激负荷对雌雄大鼠子代出生后不同年龄阶段机体代谢强度的影响。材料与方法:模拟妊娠大鼠在1012C下每天强迫游泳5分钟的应激负荷。在个体发生的第21、30和60天，使用Phenomaster自动化模块化装置(TSE Systems GmbH, Germany)测定雄性和雌性大鼠的耗氧量、二氧化碳排泄量(ml/h/kg)和热交换量(kcal/h/kg)。采用Mann-Whitney u检验对独立组进行研究参数间差异的统计学显著性评估。结果:完整动物的研究参数在哺乳期(第21天)和婴儿期(第30天)几乎没有差异，但在幼年发育期(第60天)显著降低。研究发现，与对照组相比，宫内应激没有导致代谢参数绝对值发生统计学意义上的显著变化，但影响了雄性大鼠这些参数出现年龄相关变化的时间。在这些动物中，氧气消耗量、二氧化碳排泄量和热辐射水平早在婴儿期就减少了(与21日龄大鼠相比)，并在出生后第60天达到最低水平。在宫内应激的雌性大鼠中，不同生命时期的研究参数变化与完整动物相似。结论:由此可见，雌性亲本在冷水中游泳模拟的产前应激对雄性大鼠代谢参数的年龄相关动态具有调节作用，表现为发育早期代谢参数的降低。
{"title":"Changes in Metabolic Parameters of Rats in Different Age Periods After Prenatal Stress","authors":"A. S. Martyusheva, A. Subbotina, A. Abramova, Irina V. Alekseeva, S. Pertsov","doi":"10.17816/pavlovj106532","DOIUrl":"https://doi.org/10.17816/pavlovj106532","url":null,"abstract":"INTRODUCTION: Currently, biomedical specialists give special attention to studying the influence of stressogenic factors on an organism of a pregnant woman, the embryonic development of the fetus and the subsequent development of offspring in the early and late ontogenesis. It has been found in a number of studies that prenatal stress can lead to reduction of physical activity and hormonal disorders. The factors leading to disorders in regulation of immune and metabolic homeostasis have been identified. Despite considerable interest in the study of the consequences of prenatal stress, its impact on changes in metabolic intensity in different periods of postnatal ontogenesis in animals of different genders has not been sufficiently studied. \u0000AIM: To study parameters of metabolism intensity in different age periods of postnatal ontogenesis in rats offspring of both genders after intrauterine stress load. \u0000MATERIALS AND METHODS: Stress load was modeled in daily forced swimming of pregnant rats at 1012C for 5 min. Oxygen consumption, carbon dioxide excretion (ml/h/kg), and heat exchange (kcal/h/kg) in male and female rats were determined using a Phenomaster automated modular unit (TSE Systems GmbH, Germany) on the 21st, 30th and 60th day of the ontogenesis. Statistical significance of differences between the studied parameters was assessed using Mann-Whitney U-test for independent groups. \u0000RESULTS: The study parameters of intact animals practically did not differ in the suckling (the 21st day) and infantile period (the 30th day), but significantly decreased in the juvenile period of development (the 60th day). It was found that the intrauterine stress did not lead to statistically significant changes in the absolute values of metabolic parameters as compared to the control, but affected the period of appearance of age-related variations of these parameters in male rats. In these animals, the volumes of oxygen consumption, carbon dioxide excretion, and the level of heat radiation reduced as early as in the infantile period (as compared to 21-day-old rats) and reached the minimum level by the 60th day of the postnatal ontogenesis. In female rats subjected to intrauterine stress, changes in the study parameters in different periods of life were similar to those of intact animals. \u0000CONCLUSION: Therefore, prenatal stress modeled by swimming of female parents in cold water, has a modulating effect on age-related dynamics of metabolic parameters of male rats, which was manifested by the decrease in these parameters in the earlier period of development.","PeriodicalId":113364,"journal":{"name":"I.P. Pavlov Russian Medical Biological Herald","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124164510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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