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Neutrophil-to-lymphocyte ratio as a potential differential diagnostic marker for Alzheimer’s disease, major depressive disorder, and Parkinson’s disease 中性粒细胞与淋巴细胞比值作为阿尔茨海默病、重度抑郁症和帕金森病的潜在鉴别诊断指标
Pub Date : 2018-12-26 DOI: 10.5350/DAJPN2018310407
H. Baykan, Özgür Baykan, E. Esen, Ayfer Tirak, Serap Akdeniz Gorgulu, T. Karlıdere
Introduction: Major depressive disorder, Alzheimer’s, and Parkinson’s disease are among the leading causes of dementia in the elderly. These diseases are often misdiagnosed because of overlapping symptoms. This study aimed to evaluate whether neutrophil-to-lymphocyte ratio, which has been used as an indicator of systemic inflammation, can be used for the differential diagnoses of these diseases. Materials and Method: A total of 95 patients with major depressive disorder, Alzheimer’s, or Parkinson’s disease were enrolled. Blood specimens were drawn from participants and neutrophil-to-lymphocyte ratios were calculated. We compared the three groups according to mean neutrophil-to-lymphocyte ratio and mean neutrophil-to-lymphocyte ratio adjusted for age. We used the Receiver Operating Characteristics curve analysis to predict the sensitivity and specificity of this ratio for the differential diagnosis between depression and Alzheimer’s disease. Results: The mean neutrophil-to-lymphocyte ratio for the depression, Alzheimer’s, and Parkinson’s disease groups was 2.2 ± 0.7, 2.9 ± 1.2, and 2.2 ± 0.9, respectively (P = 0.005). The adjusted mean neutrophil-to-lymphocyte ratio for age for the depression, Alzheimer’s, and Parkinson’s disease groups was 2.2 ± 0.17, 2.8 ± 0.15, and 2.2 ± 0.2, respectively (P = 0.025). Receiver Operating Characteristics curve analyses predicted that the sensitivity and specificity for the differential diagnosis between depression and Alzheimer’s disease was 54.8% and 80%, respectively. Conclusion: This study suggested that a simple arithmetic calculation could help clinicians in the differential diagnosis between depression, Alzheimer’s, and Parkinson’s disease. Neutrophil-to-lymphocyte ratio can be used as a secondary line of evidence, along with the initial clinical assessment.
重度抑郁症、阿尔茨海默病和帕金森病是导致老年人痴呆的主要原因。这些疾病常因症状重叠而被误诊。本研究旨在评估中性粒细胞/淋巴细胞比率是否可用于这些疾病的鉴别诊断,中性粒细胞/淋巴细胞比率已被用作系统性炎症的指标。材料与方法:共纳入95例重度抑郁症、阿尔茨海默病或帕金森病患者。从参与者身上抽取血液标本,计算中性粒细胞与淋巴细胞的比率。我们根据中性粒细胞与淋巴细胞的平均比率和年龄调整后的中性粒细胞与淋巴细胞的平均比率对三组进行比较。我们使用受试者工作特征曲线分析来预测该比值对抑郁症和阿尔茨海默病鉴别诊断的敏感性和特异性。结果:抑郁症、阿尔茨海默病组和帕金森病组的平均中性粒细胞与淋巴细胞比值分别为2.2 ±0.7、2.9 ±1.2和2.2 ±0.9 (P = 0.005)。抑郁症、阿尔茨海默病组和帕金森病组的校正后平均中性粒细胞与淋巴细胞比值分别为2.2 ±0.17、2.8 ±0.15和2.2 ±0.2 (P = 0.025)。受试者工作特征曲线分析预测,抑郁症与阿尔茨海默病鉴别诊断的敏感性和特异性分别为54.8%和80%。结论:本研究提示一个简单的算术计算可以帮助临床医生鉴别抑郁症、阿尔茨海默病和帕金森病。中性粒细胞与淋巴细胞的比值可以作为次要的证据,与最初的临床评估一起使用。
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引用次数: 5
A psychological and social perspective on completed suicides in Western Anatolia, Turkey: a case-control psychological autopsy study 在土耳其西部安纳托利亚完成自杀的心理和社会视角:一项病例对照心理解剖研究
Pub Date : 2018-12-26 DOI: 10.5350/DAJPN2018310401
N. Oğuzhanoğlu, T. Uğurlu, Kemalettin Acar, F. Atesci
A psychological and social perspective on completed suicides in Western Anatolia, Turkey: a case-control psychological autopsy study Objective: Aim of this study was an evaluation of the completed suicide rate as well as exploring what associated psychological and social factors might have increased the risk of death from suicide. Method: The study examines all adult suicide cases in the Province of Denizli that occurred between January 2009 and December 2010. In addition to examining the judicial f iles, interviews were conducted with the suicide victims’ relatives to elaborate the cases and evaluate the risk factors for suicide. For 19 of 53 suicide victims (35.9%), no interviews were conducted; telephone interviews were carried out with relatives of 27 of the victims (50.9%), and face-to-face interviews were held with relatives of 7 of the subjects (13.2%). Healthy controls were randomly chosen from the registers of 14 Denizli primary healthcare centers. The 31 control individuals were from a similar geographic area and social backgrounds as the case group. Results: Of the cases, 13.2% (n=7) were female, while 86.8% (n=46) were male. The mean age was 41.57±15.33 years. The total mean age of the control group was 42.84±16.98 years (p=0.725). The results of this study showed that a history of psychiatric disorder, prior suicide attempts, a history of alcohol abuse, stressful life events, and lack of social support/interaction were associated with suicide. Conclusion: Clinical and psychosocial factors such as a history of psychiatric disorder, unemployment, and financial or relationship problems increase the risk of suicide.
土耳其西部安纳托利亚地区完成自杀的心理和社会视角:一项病例对照心理解剖研究目的:本研究的目的是评估完成自杀率,并探讨可能增加自杀死亡风险的相关心理和社会因素。方法:本研究调查了2009年1月至2010年12月发生在德尼兹利省的所有成人自杀病例。除了查阅司法档案外,我们还与自杀受害者的亲属进行了访谈,以详细说明案件并评估自杀的危险因素。在53名自杀受害者中,有19名(35.9%)没有进行访谈;对27名受害者的亲属进行了电话访谈(50.9%),对7名受试者的亲属进行了面对面访谈(13.2%)。从代尼兹利14个初级卫生保健中心的登记册中随机选择健康对照。31名对照个体来自与病例组相似的地理区域和社会背景。结果:女性7例,占13.2%;男性46例,占86.8%。平均年龄41.57±15.33岁。对照组患者总平均年龄为42.84±16.98岁(p=0.725)。研究结果表明,精神疾病史、自杀未遂史、酗酒史、生活压力事件以及缺乏社会支持/互动与自杀有关。结论:临床和社会心理因素,如精神病史、失业、经济或人际关系问题增加了自杀的风险。
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引用次数: 7
Staging bipolar disorder: theoretical exercise or clinical reality? 双相情感障碍分期:理论练习还是临床现实?
Pub Date : 2018-12-26 DOI: 10.5350/DAJPN20183104001
R. Kupka
Dusunen Adam The Journal of Psychiatry and Neurological Sciences, Volume 31, Number 4, December 2018 In an optimistic view, bipolar mood disorders are seen as episodic illnesses with complete remission after each episode that respond well to lithium. This clinical picture exists; however, among patients diagnosed with bipolar disorder there is a vast variety of clinical presentations, with differences in previous illness and treatment histories, treatment responses, and degrees of interepisode residual symptoms and cognitive or functional impairment. Some patients have an illness course somewhere in between schizophrenia and bipolar disorder, conveniently classified as schizo-affective disorder. Moreover, patients may or may not have a family history of mood disorders, a personal biography complicated by traumatic life events, a comorbid anxiety disorder, substance abuse disorder, or personality disorder. Still, treatment practice, treatment guidelines, and clinical trials tend to disregard this heterogeneity, lumping patients together under the shared diagnosis of bipolar disorder, only to be differentiated into large subcategories such as bipolar I or bipolar II. Although the cross-sectional clinical syndromes of mania, hypomania, and depression may have many similarities among patients, it is in the longitudinal illness course where the individual differences become apparent. Some patients continue to thrive, even after repeated and sometimes severe mood episodes, while others show a gradual decline in psychosocial and cognitive functioning. It is therefore not surprising that treatment response and outcome may differ considerably within a group of bipolar patients, be it in an outpatient treatment program or in a formal clinical trial. In an era where early intervention and personalized treatment have become issues of growing interest, clinical staging of psychiatric disorders is one approach to deal with individual differences in illness progression, complementing current classification. In general medicine, the staging of progressive disorders is well established in areas such as oncology, cardiovascular disease, and kidney disease. Staging has prognostic significance and helps the clinician to decide which treatment is the most appropriate in an individual patient. Staging systems in psychiatry have been introduced some decades ago (1) but are hampered by the fact that the pathophysiology of psychiatric illness is still largely unknown and recognition of biomarkers is currently in its infancy. Disorders are entirely defined by their Dusunen Adam The Journal of Psychiatry and Neurological Sciences 2018;31:329-330 Guest Editorial / Misafir Editoryal DOI: 10.5350/DAJPN20183104001
《精神病学与神经科学杂志》,第31卷,第4期,2018年12月乐观地认为,双相情感障碍被视为一种发作性疾病,每次发作后都能完全缓解,对锂的反应良好。这种临床表现是存在的;然而,在被诊断为双相情感障碍的患者中,有各种各样的临床表现,在既往疾病和治疗史、治疗反应、发作间残留症状和认知或功能障碍的程度上存在差异。一些患者的病程介于精神分裂症和双相情感障碍之间,被方便地归类为精神分裂情感障碍。此外,患者可能有也可能没有情绪障碍的家族史,有创伤性生活事件的个人传记,共病焦虑症,药物滥用障碍或人格障碍。然而,治疗实践、治疗指南和临床试验倾向于忽视这种异质性,将患者集中在双相情感障碍的共同诊断下,只是为了区分为双相情感障碍I或双相情感障碍II等大亚类。尽管躁狂、轻躁狂和抑郁的横截面临床症状在患者之间可能有许多相似之处,但在纵向病程中,个体差异才变得明显。有些患者即使在反复发作(有时是严重的情绪发作)后仍能保持健康,而另一些患者则表现出社会心理和认知功能的逐渐下降。因此,在一组双相患者中,无论是在门诊治疗方案中还是在正式的临床试验中,治疗反应和结果可能存在很大差异,这并不奇怪。在一个早期干预和个性化治疗日益受到关注的时代,精神疾病的临床分期是处理疾病进展中的个体差异的一种方法,补充了当前的分类。在一般医学中,进行性疾病的分期在肿瘤、心血管疾病和肾脏疾病等领域得到了很好的确立。分期具有预后意义,并有助于临床医生决定哪种治疗方法对个体患者最合适。精神病学的分期系统在几十年前就已经被引入(1),但由于精神疾病的病理生理学在很大程度上仍然是未知的,而且对生物标志物的认识目前还处于起步阶段,因此受到了阻碍。疾病完全由他们的Dusunen Adam定义精神病学和神经科学杂志2018;31:329-330客座编辑/ Misafir编辑DOI: 10.5350/DAJPN20183104001
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引用次数: 0
Acute dystonia caused by clomipramine: a case report 氯丙咪嗪致急性肌张力障碍1例
Pub Date : 2018-12-26 DOI: 10.5350/DAJPN2018310408
Sema Baykara, M. F. Tabara, S. Korkmaz, M. Atmaca
Acute dystonia caused by clomipramine: a case report Drug-induced acute dystonia is a movement disorder that occurs most often with neuroleptics, though there are many drugs in its etiology. The exact mechanism of antidepressant-associated extrapyramidal side effects (EPS) is not known. However, hypotheses including inhibition of dopaminergic function in the nigrostriatal pathway, impaired balance between dopaminergic, serotonergic, noradrenergic or cholinergic activity, and serotonergic inhibition of dopaminergic functions in the striatum leading to extrapyramidal side effects have been suggested. The number of cases with acute dystonia during clomipramine use is low. We wish to draw attention to this rare side effect of clomipramine and to contribute to the literature by presenting a case of acute dystonia on the 5th day of clomipramine treatment in a 19-year-old male patient.
氯丙咪嗪引起的急性肌张力障碍:1例药物性急性肌张力障碍是一种运动障碍,最常见于抗精神病药物,尽管其病因有许多药物。抗抑郁药相关的锥体外系副作用(EPS)的确切机制尚不清楚。然而,已经提出了一些假说,包括抑制黑质纹状体途径中的多巴胺能功能,破坏多巴胺能、血清素能、去甲肾上腺素能或胆碱能活性之间的平衡,以及血清素能抑制纹状体中的多巴胺能功能导致锥体外副作用。氯丙咪嗪使用期间出现急性肌张力障碍的病例数很低。我们希望引起人们对氯丙咪嗪这种罕见副作用的关注,并通过提出一个19岁男性患者在氯丙咪嗪治疗第5天出现急性肌张力障碍的病例,为文献做出贡献。
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引用次数: 1
Venlafaxine-induced hematuria and prostatism: a case report 文拉法辛致血尿前列腺1例
Pub Date : 2018-12-26 DOI: 10.5350/DAJPN2018310411
İbrahim Gündoğmuş, A. Karagoz, A. Algul
Venlafaxine-induced hematuria and prostatism: a case report Hematuria and prostatism are important medical conditions affecting the quality of life. They are most often seen causally related to prostate hyperplasia but may also occur as a side effect of certain medications. Although the urogenital side effects of antidepressants are common in the literature, reports that indicate antidepressant induced hematuria are rare. Venlafaxine, an antidepressant that inhibits serotonin-noradrenaline reuptake, is used in clinical practice in a number of psychiatric disorders, especially in major depressive disorder. Although it is a safe and effective antidepressant, it can cause side effects. We present a 55-year-old man with hematuria and symptoms of prostatism starting after the use of venlafaxine that resolved after the withdrawal of venlafaxine. In the literature, symptoms of prostatism have been reported related to antidepressants that are effective through the noradrenaline mechanism, such as venlafaxine, duloxetine, milnacipran, and reboxetine, but there are no reports on hematuria. As far as we know, this is the first report to present a case of venlafaxine-induced hematuria.
文拉法辛致血尿和前列腺炎1例报告血尿和前列腺炎是影响生活质量的重要疾病。它们通常与前列腺增生有因果关系,但也可能是某些药物的副作用。虽然抗抑郁药对泌尿生殖系统的副作用在文献中很常见,但报告显示抗抑郁药引起的血尿是罕见的。文拉法辛是一种抑制血清素-去甲肾上腺素再摄取的抗抑郁药,在临床实践中用于治疗许多精神疾病,特别是重度抑郁症。虽然它是一种安全有效的抗抑郁药,但它会产生副作用。我们报告了一位55岁的男性患者,在使用文拉法辛后开始出现血尿和前列腺症状,在文拉法辛停药后消退。在文献中,前列腺症状已被报道与通过去甲肾上腺素机制有效的抗抑郁药物有关,如文拉法辛、度洛西汀、米那西普兰和瑞波西汀,但没有关于血尿的报道。据我们所知,这是第一个报道文拉法辛引起血尿的病例。
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引用次数: 1
Investigating the psychometric properties of the Turkish form of the Grief and Meaning Reconstruction Inventory 土耳其式悲伤与意义重建量表的心理测量特征研究
Pub Date : 2018-12-26 DOI: 10.5350/DAJPN2018310405
Emrah Keser, S. Işıklı
Investigating the psychometric properties of the Turkish form of the Grief and Meaning Reconstruction Inventory Objective: The aim of this study is to adapt the Grief and Meaning Reconstruction Inventory (GMRI) to Turkish. Method: Three hundred and six adults who lost their spouse or one of their parents or siblings due to death in a period between 6 months and 10 years previously were included in the study. The participants were asked to complete a questionnaire set including GMRI, Beck Depression Inventory (BDI), StateTrait Anxiety Inventory (STAI), and a demographic information form that was generated by the researchers. To investigate the psychometric properties of the Turkish form of the scale, exploratory factor analyses, parallel analysis, reliability analyses (Cronbach’s alpha), correlation analyses, and regression analyses were conducted. Results: Exploratory Factor Analysis (EFA) showed that the Turkish form of the GMRI consisted of 27 items and 4 subscales. Parallel analysis also supported a four-factor structure. Cronbach’s alpha values for the Turkish form of the GMRI were found to be similar to the original scale. Correlation analyses showed that the GMRI scores were strongly negatively correlated with both depressive symptoms and anxiety symptoms. In addition, after controlling for the time elapsed since the loss, age of the bereaved, education level of the bereaved, and age of the deceased person, GMRI scores were found to be a significant negative predictor of BDI and STAI scores. Conclusion: This study showed that the Turkish version of the GMRI can be used in Turkish culture as a valid and reliable measurement tool.
目的:本研究的目的是使悲伤与意义重建量表(GMRI)适用于土耳其语。方法:306名在6个月至10年内因死亡而失去配偶或父母或兄弟姐妹之一的成年人被纳入研究。参与者被要求完成一套问卷,包括GMRI、贝克抑郁量表(BDI)、状态-特质焦虑量表(STAI)和一份由研究人员生成的人口统计信息表。为了研究土耳其式量表的心理测量特性,我们进行了探索性因素分析、平行分析、信度分析(Cronbach’s alpha)、相关分析和回归分析。结果:探索性因子分析(EFA)显示,土耳其式GMRI由27个条目和4个分量表组成。并行分析也支持四因素结构。发现土耳其式GMRI的Cronbach alpha值与原始量表相似。相关分析显示,GMRI评分与抑郁症状和焦虑症状呈显著负相关。此外,在控制了失去亲人的时间、失去亲人的年龄、失去亲人的教育程度和死者的年龄后,发现GMRI分数是BDI和STAI分数的显著负向预测因子。结论:本研究表明,土耳其语版GMRI可以作为一种有效和可靠的测量工具在土耳其文化中使用。
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引用次数: 3
Substance abuse in high school students: their self-efficacy to avoid substance abuse and related factors 高中生药物滥用:避免药物滥用的自我效能感及其相关因素
Pub Date : 2018-12-26 DOI: 10.5350/DAJPN2018310404
Sultan Uzun, M. Kelleci
Substance abuse in high school students: their self-efficacy to avoid substance abuse and related factors Objective: This study aimed at determining high school students’ self-efficacy in the prevention of substance abuse and identifying related factors, given that substance abuse, a major health problem both in Turkey and in other countries of the world, is on the increase not only among adolescents but even among primary school students. Method: The study population comprised 22,623 students (11,210 males, 11,413 females) in 37 high schools in the provincial center of Sivas. The study sample included 911 students (485 females, 426 males). The sample size was calculated using a formula for finite population sampling. The study data were collected using a Sociodemographic Characteristics Questionnaire and the Self-Efficacy for Protecting Adolescences from Substance Abuse Scale. In the data analysis, frequency distribution, variance analysis (ANOVA), Student’s t test, Chi-square test, logistic regression analysis, and correlation analysis were used. Results: Of the participating students, 38.7% reported that they or people around them used a substance. The substances used were cigarettes (32.8%), alcohol (6.8%), bonsai (2.1%), bally (1.6%), cannabis (0.7%), and ecstasy (0.4%). The mean score on the Self-Efficacy for Protecting Adolescences from Substance Abuse Scale students who either used a substance themselves or had people around them who were substance users was 97.7±19.39, while the mean score for those who neither used a substance themselves nor had substance users in their environment was 102.24±18.51 (p=0.001). The difference between the two groups was statistically significant (p=0.001). In the prevention of substance abuse, participants who were aged 17 years or older, had any illness, studied in a vocational high school, had a broken family, defined themselves as aggressive, had parents with a low education level, had a bad relationship with their family members, were not satisfied with school life, and had low academic achievement were found to have low self-efficacy (p<0.05). This was 1.46 times higher than in subjects who were not at risk of substance use among the members of the age group 17-19. Students with a history of illness were 0.53 times more likely to use drugs than healthy participants. Conclusion: It was concluded that studies should be carried out to improve self-efficacy to prevent substance abuse among high school students, particularly among those in the at-risk group.
目的:本研究旨在确定高中生在预防药物滥用方面的自我效能,并确定相关因素,因为药物滥用是土耳其和世界其他国家的一个主要健康问题,不仅在青少年中,甚至在小学生中都在增加。方法:研究对象为锡瓦斯省中心37所高中的22,623名学生(男11,210名,女11,413名)。研究样本包括911名学生(485名女生,426名男生)。使用有限总体抽样公式计算样本量。研究数据采用社会人口学特征问卷和青少年药物滥用自我保护效能量表收集。在数据分析中,采用频率分布、方差分析(ANOVA)、Student 's t检验、卡方检验、logistic回归分析和相关分析。结果:在参与调查的学生中,38.7%的人报告说他们或他们周围的人使用过某种物质。使用的物质是香烟(32.8%)、酒精(6.8%)、盆景(2.1%)、大麻(1.6%)、大麻(0.7%)和摇头丸(0.4%)。《青少年预防药物滥用自我效能感量表》中,自己使用药物或周围有药物使用者的学生平均得分为97.7±19.39,而自己不使用药物且周围环境中没有药物使用者的学生平均得分为102.24±18.51 (p=0.001)。两组间差异有统计学意义(p=0.001)。在预防药物滥用方面,年龄在17岁及以上、有疾病、在职业高中就读、家庭破裂、自我定义为攻击性、父母受教育程度低、与家庭成员关系不好、对学校生活不满意、学习成绩低的被试自我效能感较低(p<0.05)。这是17-19岁年龄组中没有药物使用风险的受试者的1.46倍。有病史的学生吸毒的可能性是健康参与者的0.53倍。结论:应开展提高自我效能感的研究,以预防高中生,特别是高危群体的药物滥用。
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引用次数: 13
A norm study of a neuropsychological test battery for evaluating cognitive functions in commercial airline pilots 商业航空公司飞行员认知功能评估的神经心理测试系统规范研究
Pub Date : 2018-12-26 DOI: 10.5350/DAJPN2018310406
Z. Arıkan, Dijan Ertemir, Cahit Keskinkiliç
A norm study of a neuropsychological test battery for evaluating cognitive functions in commercial airline pilots Objective: This study aims to establish a norm for Turkish commercial airl ine pilots with a neuropsychological test battery that has been prepared specif ically for pilots. The test battery assesses all of the attention components that are critical for piloting: working memory, information processing rate, mental flexibility, reaction time, set switching, inhibiting cognitive interference, several parameters of short/long term visual memory, and spatial comprehension. Method: The study included 147 healthy commercial airline pilots, of whom 144 were men and 3 women. The participants were divided into four age groups: 20-29 years, 30-39 years, 40-49 years, and 50 years and above. They were given the following tests: Wechsler Adult Intelligence Scale-Revised (WAIS-R) Digit Span, Rey Complex Figure Test (RCFT), Continuous Performance Test (CPT), Paced Auditory Serial Addition Test (PASAT), Reaction Time Test (RTT), d2 Test of Attention (d2TA), Stroop Test (ST), Trail Making Test (TMT), Visual Elevator Test (VET), and Judgement of Line Orientation Test (JLO). Results: There was a relation between age and military vs. civilian background, type of bachelor’s degree, and flight experience, but no relation was found between age and hand dominance. It was found that there was a signif icant difference in all test scores between age groups except for CPT scores, d2 Test percentage of errors and total number of errors, ST 1st, 2nd, 5th card self-corrections and 3rd card errors, TMT A and B Form errors, and VET switching numbers. Conclusion: It was concluded that commercial airline pilots’ neuropsychological test scores differ according to age but not by hand dominance. The importance of pilot norms and the necessity of comparing pilots according to professional norms was highlighted in the discussion.
评估商业航空公司飞行员认知功能的神经心理测试单元的规范研究目的:本研究旨在为土耳其商业航空公司飞行员建立专门为飞行员准备的神经心理测试单元的规范。测试单元评估了所有对驾驶至关重要的注意力组成部分:工作记忆、信息处理速度、心理灵活性、反应时间、设定切换、抑制认知干扰、短期/长期视觉记忆的几个参数和空间理解。方法:研究对象为147名健康的商业航空公司飞行员,其中男性144人,女性3人。参与者被分为四个年龄组:20-29岁、30-39岁、40-49岁和50岁及以上。进行韦氏成人智力量表数字广度(WAIS-R)、Rey复合图形测验(RCFT)、连续表现测验(CPT)、节奏性听觉序列加法测验(PASAT)、反应时间测验(RTT)、d2注意力测验(d2TA)、Stroop测验(ST)、轨迹制作测验(TMT)、视觉电梯测验(VET)和线向判断测验(JLO)。结果:年龄与军民背景、本科学历类型、飞行经验相关,而与手优势无关。结果发现,除CPT成绩、d2测试错误百分比和总错误数、ST第1、2、5卡自我纠正和第3卡错误、TMT a、B表错误和VET切换次数外,各测试成绩在年龄组之间存在显著差异。结论:商业航空公司飞行员的神经心理测试得分随年龄的不同而不同,但不受手型优势的影响。讨论中强调了飞行员规范的重要性和按照专业规范比较飞行员的必要性。
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引用次数: 0
Barkley Child Attention Scale validity and reliability study 巴克利儿童注意量表效度与信度研究
Pub Date : 2018-09-27 DOI: 10.5350/DAJPN2018310306
S. Fırat, G. Ü. Bolat, Hesna Gul, Muharrem Burak Baytunca, Burcu Kardaş, A. Aysev, E. Ercan
Barkley Child Attention Scale validity and reliability study Objective: The purpose of this study is to examine the psychometric properties of the Barkley Child Attention Scale (BCAS) for 6to 12-year-old children. Method: This study was conducted with 291 children (of an age of 6-12 years) with a clinically normal level of intelligence and a diagnosis of attention-deficit/hyperactivity disorder (ADHD). The structure validity of the scale was studied by exploratory and confirmatory factor analyses. In order to evaluate the measuredependent validity of the scale, Child Behavior Checklist for ages 6-18 and Swanson, Nolan and Pelham Questionnaire (SNAP-IV) parental form were used. Reliability of the scale was measured by Cronbach’s alpha coefficient. Results: As a result of the exploratory factor analysis, the scale consists of two factors called “daydreaming” and “sluggish,” as is the case in its original form. Confirmatory factor analysis indicated that the fit indices of the scale were at an acceptable level. The correlation analysis study for the criterion-related validity study of the scale revealed that Sluggish Cognitive Tempo (SCT) had a positive correlation with ADHD-IN and internalization problems, a negative correlation with attention deficit hyperactivity disorder/hyperactivityimpulsivity (ADHD-HI), and no correlation with externalization problems. Cronbach’s alpha coefficient of the BCAS is 0.86 and the scale is seen to be reliable. Conclusion: It can be said that the BCAS is a valid and reliable scale that can measure sluggish cognitive tempo symptoms of 6to 12-year-old children.
巴克利儿童注意量表效度和信度研究目的:本研究的目的是检验6 ~ 12岁儿童巴克利儿童注意量表(BCAS)的心理测量学特征。方法:研究对象为291名临床智力正常且诊断为注意力缺陷多动障碍(ADHD)的儿童(年龄6-12岁)。采用探索性因子分析和验证性因子分析对量表的结构效度进行了研究。为了评估量表的测量依赖效度,使用了6-18岁儿童行为检查表和Swanson, Nolan and Pelham问卷(SNAP-IV)家长表格。量表的信度采用Cronbach’s alpha系数来衡量。结果:探索性因子分析的结果是,量表由两个因子组成,分别是“白日梦”和“呆滞”,与最初的形式一样。验证性因子分析表明,量表的拟合指标处于可接受的水平。对量表标准效度的相关分析研究发现,迟缓认知节奏(SCT)与ADHD-IN和内化问题呈正相关,与ADHD-HI呈负相关,与外化问题无相关性。BCAS的Cronbach’s alpha系数为0.86,量表是可靠的。结论:BCAS是一种有效、可靠的6 ~ 12岁儿童认知节奏迟缓症状量表。
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引用次数: 20
Correlation of anxiety and depression levels with attitudes towards coping with illness and sociodemographic characteristics in patients with a diagnosis of breast cancer 乳腺癌患者焦虑和抑郁水平与应对疾病态度和社会人口学特征的相关性
Pub Date : 2018-09-27 DOI: 10.5350/DAJPN2018310302
Rabia Geyikci, S. Çakmak, M. Demirkol, S. Uguz
Correlation of anxiety and depression levels with attitudes towards coping with illness and sociodemographic characteristics in patients with a diagnosis of breast cancer Objective: The aim of this study was to investigate the relationship of anxiety and depression levels of breast cancer patients that had completed a year since receiving the diagnosis with their sociodemographic characteristics and attitudes towards coping with their disease. Method: This study was conducted with 94 female patients between the ages of 35 and 65 years who had been diagnosed with breast cancer and who were treated at the Oncology Department of Cukurova University’s Faculty of Medicine between June 5 and July 31, 2017. Data were collected via a personal information form prepared by the investigator, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and COPE inventory. Results: It was found that 27.7% and 16.0% of patients with breast cancer who had completed one year of treatment and had not presented or been referred to psychiatry experienced clinically relevant anxiety symptoms and depressive symptoms, respectively. A positive relationship was found between depression and anxiety in breast cancer patients (p<0.05, r=0.68). The level of anxiety was higher in patients who were not sufficiently informed about the disease (p=0.014) and who thought that the partner was behaving more distant (p=0.019). Patients between the ages of 35 and 44 years were found to be more depressive and anxious than those at age 55-65 (p=0.006 and p=0.010, respectively). It was found that primary school graduates were more likely to use “religious coping” (p=0.02) and university graduates were more likely to use “humor” (p=0.04). In addition, “positive reinterpretation” and “planning” attitudes were found to be more common in those with sufficient knowledge of the disease (p=0.045 and p=0.01, respectively). There was a negative correlation between depression and “mental disengagement” (p=0.011) and “active coping” (p=0.008). There was a positive relationship between anxiety and “use of emotional social support” (p=0.038). Conclusion: In our study, sufficient information about the disease and the partner’s behavior were found to be associated with anxiety in breast cancer patients, and coping attitudes were found to be effective regarding depression and development of anxiety. Addressing the psychological effects of breast cancer and giving importance to psychosocial interventions and coping attitudes have been considered preventive factors in the development of depression and anxiety.
乳腺癌患者焦虑、抑郁水平与疾病应对态度和社会人口学特征的相关性研究目的:本研究旨在探讨乳腺癌患者自确诊后一年的焦虑、抑郁水平与其社会人口学特征和疾病应对态度的关系。方法:本研究纳入了2017年6月5日至7月31日在库库罗娃大学医学院肿瘤科接受治疗的94名年龄在35岁至65岁之间的女性乳腺癌患者。数据通过研究者准备的个人信息表、贝克抑郁量表(BDI)、贝克焦虑量表(BAI)和COPE量表收集。结果:27.7%和16.0%的乳腺癌患者完成了一年的治疗,没有出现或转介到精神病学,分别出现临床相关的焦虑症状和抑郁症状。乳腺癌患者抑郁与焦虑呈正相关(p<0.05, r=0.68)。对疾病了解不够的患者(p=0.014)和认为伴侣行为疏远的患者(p=0.019)的焦虑水平更高。35 ~ 44岁的患者比55 ~ 65岁的患者抑郁和焦虑程度更高(p=0.006和p=0.010)。结果发现,小学毕业生更多使用“宗教应对”(p=0.02),大学毕业生更多使用“幽默应对”(p=0.04)。此外,“积极的重新解释”和“计划”态度在对疾病有充分了解的人群中更为常见(p=0.045和p=0.01)。抑郁与“精神脱离”(p=0.011)和“积极应对”(p=0.008)呈负相关。焦虑与“情感社会支持的使用”呈正相关(p=0.038)。结论:在我们的研究中,我们发现足够的疾病信息和伴侣的行为与乳腺癌患者的焦虑有关,应对态度对抑郁和焦虑的发展是有效的。解决乳腺癌的心理影响,重视社会心理干预和应对态度被认为是抑郁和焦虑发展的预防因素。
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引用次数: 16
期刊
Dusunen Adam: The Journal of Psychiatry and Neurological Sciences
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