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Research on Big Data Risk Control Model of Venture Capital 风险投资大数据风险控制模型研究
Boao Cui
The two main characteristics of venture capital are high risk and participation in management. Risk identification and risk evaluation before investing, risk supervise and control are important process that affect the success of venture investment. First of all, a risk evaluation index system is constructed. Partial correlation analysis is used to explore the indicators that can significantly affect the success of a company's investment, and to provide suggestions for the types of risks that start-ups should focus on controlling during the startup period. Then the principal component analysis method and the Logistic regression analysis method are combined to predict the success rate of investment, which can make up for the deficiency of the Logistic model and improve the prediction accuracy rate. Then use the test set data to calculate the accuracy of the model, and conduct an Omnibus test of the model coefficients to verify the significance of the equation. Then the SE-DEA model is constructed to calculate and compare the efficiency values of enterprises that accept different levels of post-investment services, and test the robustness of the SE-DEA model by adjusting the input and output indicators. Then through the Mann-Whitney U test and analysis, it is concluded that if the post-investment service is to have a good effect, how VC should choose the degree of intervention according to the state of the enterprise. That is to say, which indicators of the enterprise can be optimized by VC intervention in management. Finally, the models are evaluated and future research prospects in related fields are proposed.
风险投资的两个主要特征是高风险和参与管理。投资前的风险识别与风险评估、风险监督与控制是影响风险投资成功与否的重要环节。首先,构建了风险评价指标体系。通过偏相关分析,探索对企业投资成功有显著影响的指标,为创业公司在创业阶段应重点控制的风险类型提供建议。然后将主成分分析方法与Logistic回归分析方法相结合进行投资成功率预测,弥补了Logistic模型的不足,提高了预测准确率。然后利用测试集数据计算模型的精度,并对模型系数进行综合检验,验证方程的显著性。然后构建SE-DEA模型,计算并比较接受不同投资后服务水平的企业的效率值,并通过调整投入产出指标来检验SE-DEA模型的稳健性。然后通过Mann-Whitney U检验和分析,得出如果要使投后服务产生良好的效果,VC应该如何根据企业的状态选择干预程度。也就是说,企业的哪些指标可以通过VC干预管理来优化。最后,对模型进行了评价,并对未来相关领域的研究进行了展望。
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引用次数: 0
The application and influence of big data in medicine 大数据在医学领域的应用与影响
Jinghe Zhao
At present, with the gradual expansion of the application scope of big data technology, its application frequency in medicine is becoming more and more frequent. The purpose of using medical data for different projects is mainly to reduce the pressure of patients and improve the accuracy. However, the use of medical data has also caused some adverse effects, so this paper will study it from three aspects: source, application and impact.
目前,随着大数据技术应用范围的逐步扩大,其在医学领域的应用频率也越来越频繁。在不同的项目中使用医疗数据的目的主要是为了减轻患者的压力,提高准确性。然而,医疗数据的使用也造成了一些不良影响,因此本文将从来源、应用和影响三个方面进行研究。
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引用次数: 1
Analysis on Site Distribution in Yunnan and Guizhou Plateau from Neolithic to the Bronze Age Based on GIS 基于GIS的新石器时代至青铜时代云贵高原遗址分布分析
Song-Tao Hu
In this study, we apply GIS to observe the spatiotemporal distribution pattern of settlement in Yunnan and Guizhou plateau from Neolithic to Bronze Age. Based on the published archaeological materials, and combined with the information of natural geographical elements and soil sedimentary in the region, we preliminarily established a database of site distribution patterns in Yunnan-Guizhou area. As can be seen from the spatial distribution pattern of settlements in Yunnan-Guizhou area, from Neolithic to Bronze Age, settlements tended to expand eastward. On one hand, it is the consequence of population increase. On the other hand, it is also the result of culture impulsion, in this area, the Dian culture and Yelang culture have been expanding eastward due to the continuous expansion of western Dian culture. As a result, the eastwards of the settlement is under the effect both from internal and external. Meanwhile, the classification of the area and the transition over time show that the spatial distribution of the settlement is relatively scattered and equal, mainly consist of small-scale settlements, and the scale of settlements began to gradually expand in the Bronze Age. Besides, soil type is also a pivotal factor in terms of the site choice strategies for ancient people, high soil fertility, such as artificial soil, luvisols always related to the cluster of settlement distribution. It indicates that ancient people in Yunnan and Guizhou area had their site choice strategies out of certain considerations, which were profoundly influenced by the natural environment.
本研究利用GIS技术对新石器时代至青铜时代云贵高原聚落的时空分布格局进行了研究。根据已发表的考古资料,结合该地区自然地理要素和土壤沉积信息,初步建立了云贵地区遗址分布格局数据库。从云贵地区聚落的空间分布格局可以看出,从新石器时代到青铜时代,聚落有向东扩张的趋势。一方面,这是人口增长的结果。另一方面,这也是文化冲动的结果,在这一地区,由于西滇文化的不断扩张,滇文化和夜郎文化也在不断向东扩张。因此,定居点的东部受到内外两方面的影响。同时,区域分类和时间变迁表明,聚落空间分布较为分散、均匀,以小规模聚落为主,在青铜时代聚落规模开始逐渐扩大。此外,土壤类型也是古人选址策略的关键因素,高肥力的土壤,如人工土壤、草甘醇总是与聚落分布的集群有关。这说明云南和贵州地区的古代人是出于一定的考虑而做出选址策略的,这种策略深受自然环境的影响。
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引用次数: 0
Application of case teaching method and Microteaching Method in experimental teaching based on wechat platform 案例教学法和微格教学法在微信平台实验教学中的应用
Bo Song, Yan Sun, Junjie Guo, Dan Zhao, Jiayin Tan
Case teaching method emphasizes taking students as the main body, guiding students to think with questions, strengthening the understanding and mastery of the knowledge, and has achieved good teaching effect in medical education. The Microteaching Method records the students' practice process through video equipment to improve the students' learning effect. Conventional case teaching method and Microteaching Method need face-to-face communication between teachers and students, which has the limitations of time and space. As a mobile learning platform, wechat can break through the limitation of teaching time and space, and realize the diversification of teaching methods. Through the beneficial complementation of wechat platform with case teaching method and Microteaching Method, it is found that in the application of laboratory teaching, it not only stimulates students' interest in learning, mobilizes students' learning enthusiasm, but also improves students' autonomous learning ability, comprehensive analysis ability and clinical thinking ability, which is worthy of promotion and application in laboratory practice teaching.
案例教学法强调以学生为主体,引导学生用问题思考,加强对知识的理解和掌握,在医学教育中取得了良好的教学效果。微格教学法通过视频设备记录学生的练习过程,提高学生的学习效果。传统的案例教学法和微格教学法需要师生面对面交流,有时间和空间的限制。微信作为一个移动学习平台,可以突破教学时间和空间的限制,实现教学方式的多样化。通过微信平台与案例教学法、微教学法的有益互补,发现在实验教学的应用中,不仅激发了学生的学习兴趣,调动了学生的学习热情,而且提高了学生的自主学习能力、综合分析能力和临床思维能力,值得在实验室实践教学中推广应用。
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引用次数: 4
Risk Prediction in E-commerce Mobile Payment Based on PSO-SVM 基于PSO-SVM的电子商务移动支付风险预测
Xin Guan, Shufang Xie, Feng Liu, Haibo Zhao, Zhongyuan Liang
The security of e-commerce mobile payment is a key issue that needs to be paid attention to when using mobile payment. Improvement of the security performance of e-commerce mobile payment will help promote its use. In order to avoid the risks of e-commerce mobile payment and provide timely warnings, a modeling method using support vector machines and particle swarm algorithm to model and analyze e-commerce mobile payment risks is proposed in this paper. On the basis of ensuring the safety of communication and completing secure wireless transactions, PSO-SVM is used to establis-h a sophisticated risk prediction mechanism to promote the further expansion of the application scope of e-commerce mo-bile payment technology.
电子商务移动支付的安全性是使用移动支付时需要注意的关键问题。提高电子商务移动支付的安全性能有助于促进其使用。为了规避电子商务移动支付风险,及时预警,本文提出了一种利用支持向量机和粒子群算法对电子商务移动支付风险进行建模分析的建模方法。在保证通信安全、完成安全无线交易的基础上,利用PSO-SVM建立完善的风险预测机制,促进电子商务移动支付技术应用范围的进一步扩大。
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引用次数: 0
Application of Data Encryption Technology in Computer Network Security 数据加密技术在计算机网络安全中的应用
Guo Fang
At present, as an important tool to change people's production and life, computers have been widely used in all walks of life, showing broad application prospects. However, at the same time facing severe computer network security issues, the system is often damaged by accidental or malicious factors, and security issues such as data leakage occur, causing serious economic losses and negative social effects. Therefore, in order to create a safe computer network environment and effectively solve network security problems, the article aims to ensure computer network security through research and discussion on data encryption technology, and to further develop computer application security for reference.
目前,计算机作为改变人们生产和生活的重要工具,已广泛应用于各行各业,显示出广阔的应用前景。然而,在面临严峻的计算机网络安全问题的同时,系统经常受到意外或恶意因素的破坏,发生数据泄露等安全问题,造成严重的经济损失和负面的社会影响。因此,为了创造一个安全的计算机网络环境,有效解决网络安全问题,本文旨在通过对数据加密技术的研究和讨论,确保计算机网络安全,并为进一步发展计算机应用安全提供参考。
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引用次数: 4
The Inhibition of ZN Finger Transcription Factors ZN手指转录因子的抑制作用
Tianlai Chen, Zihong Chen
Zinc fingers are among the most abundant protein motifs and play a pivotal role in cell proliferation, migration, and differentiation. Emerging studies have focused on the zinc finger transcription factors role in related diseases and discovered they are involved in activating oncogenic transcription, HIV reverse transcription, and bacterium infection. Hence, it is important to investigate and understand how zinc finger transcription factors can be selectively inhibited. The aim of this minireview is to describe how Zn Finger inhibition occurs within both a chemical and biological framework. Complexes Synthesis, inhibition mechanism, and selectivity are comprehensively reviewed. Cells utilize phosphorylation and acetylation to self-inhibit the zinc finger transcription factors by adjusting spatial structure and chemical properties. Also, we propose potential regulation sites of post transcription modification, therapeutic treatments and concerns over animal trials.
锌指是最丰富的蛋白基序之一,在细胞增殖、迁移和分化中起着关键作用。新兴的研究集中在锌指转录因子在相关疾病中的作用,发现它们参与激活致癌转录,HIV逆转录和细菌感染。因此,研究和了解锌指转录因子如何被选择性抑制是很重要的。这篇综述的目的是描述锌指抑制是如何在化学和生物学框架内发生的。综述了配合物的合成、抑制机制和选择性。细胞利用磷酸化和乙酰化作用,通过调节锌指转录因子的空间结构和化学性质来自我抑制锌指转录因子。此外,我们还提出了转录后修饰的潜在调控位点、治疗方法和对动物试验的关注。
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引用次数: 0
Comparison of Picard Versions for Analyzing functional Magnetic Resonance Imaging Data Picard版本分析功能磁共振成像数据的比较
Yulong Xiong, Qin Yu, Shuang He, Haitong Tang, Kaiyue Liu, Ni-zhuan Wang
Independent Component Analysis (ICA) is a popular method that uses statistical principles to separate the mixture into statistically independent non-Gaussian sources. It has been well used in functional Magnetic Resonance Imaging (fMRI) data. However, real fMRI data can rarely be accurately modeled as mixtures of independent components, the convergence of ICA may be impaired. This paper is based on the idea of preconditioned ICA for real data (Picard), which involves a preprocessing L-BFGS strategy based on orthogonal matrix sets. In this study, we designed an experiment to validate the idea that Picard can improve ICA algorithms such as Infomax, Extended-Infomax, and FastICA, respectively named Picard 1, Picard 2, and Picard 3, for fMRI data analysis. Three Picard versions were performed on the simulated and noisy fMRI mixtures to verify the ability to separate independent sources. Experimental results showed that Picard 3 outperformed Picard 1 and Picard 2 on both noiseless and noisy simulated fMRI data, which implied the priority of Picard 3 in fMRI data analysis.
独立分量分析(ICA)是一种常用的方法,它利用统计原理将混合数据分离成统计独立的非高斯源。它在功能磁共振成像(fMRI)数据中得到了很好的应用。然而,真实的fMRI数据很少能被准确地建模为独立成分的混合物,ICA的收敛性可能会受到损害。本文以实际数据预处理ICA (Picard)思想为基础,提出了一种基于正交矩阵集的预处理L-BFGS策略。在本研究中,我们设计了一个实验来验证Picard可以改进用于fMRI数据分析的ICA算法,如Infomax、Extended-Infomax和FastICA,分别命名为Picard 1、Picard 2和Picard 3。在模拟和噪声fMRI混合物上执行了三个Picard版本,以验证分离独立源的能力。实验结果表明,在无噪声和有噪声的模拟fMRI数据上,Picard 3都优于Picard 1和Picard 2,这表明Picard 3在fMRI数据分析中具有优先性。
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引用次数: 1
Analysis method of Tissue-specific gene set weight 组织特异性基因集重量分析方法
Tian Tian, Huakun Wang
Gene set testing is one of the indispensable analysis methods for analyzing high-dimensional genome data. Although the expression and function of many genes are tissue-specific, gene set testing is performed in a way that does not distinguish between tissue types. In order to cope with this challenge, this article uses the tissue-specific gene activity information in the human protein atlas to calculate the tissue-specific gene weights, and uses the filtered gene set in the molecular signature database to generate the tissue-specific gene set weights. In order to prove the validity of these weights, this article use the weights to perform gene set tests on the gene expression data of the three diseases, and use the p-values generated by the tests to weight. Through the weighted FDR analysis, this research can conclude the proposed tissue-specific gene set weights significantly improve the statistical power of gene set testing, and more accurately identified the biological gene set association information of high-dimensional genome data.
基因集检测是分析高维基因组数据不可缺少的分析方法之一。虽然许多基因的表达和功能是组织特异性的,但基因集检测的方式并不区分组织类型。为了应对这一挑战,本文利用人类蛋白质图谱中的组织特异性基因活性信息计算组织特异性基因权重,并利用分子特征数据库中过滤后的基因集生成组织特异性基因集权重。为了证明这些权重的有效性,本文使用这些权重对三种疾病的基因表达数据进行基因集测试,并使用测试产生的p值进行加权。通过加权FDR分析,本研究得出提出的组织特异性基因集权重显著提高了基因集检测的统计能力,更准确地识别出高维基因组数据的生物基因集关联信息。
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引用次数: 0
Multi-layer skull modeling and importance for tDCS simulation 多层颅骨建模及其在tDCS仿真中的重要性
Weiqian Sun, Heng Wang, Jianxu Zhang, Tianyi Yan, Guangying Pei
Transcranial direct current stimulation (tDCS) is a popular method for non-invasive modulation of brain activity and a potential treatment for neuropsychiatric disorders. Currently the finite element head model has widely used to study tDCS. However, the typical head model ignored some extra-brain tissues, which may have a large influence on simulating the effect of tDCS. This study established a detailed head model including spongy bone to calculate the cortical electric field in tDCS. The spongy bone was extracted from the MR images and then a 6-layer head model was established. After the thickness of the skull and spongy bone was measured, the cortical electric field distributions on the detailed model and the typical model were simulated and compared. The result showed that the distribution and amplitude of electric field were different in two models, especially the distribution. The six-layer model will get a larger range of stimulus. Based on the simulation results and the real physiological structure, we conclude that it is very important to distinguish the skull into the compact bone and spongy bone for the accurate simulation of tDCS.
经颅直流电刺激(tDCS)是一种流行的无创脑活动调节方法,也是神经精神疾病的潜在治疗方法。目前,有限元水头模型已被广泛应用于tDCS的研究。然而,典型的头部模型忽略了一些脑外组织,这可能对模拟tDCS的效果有很大的影响。本研究建立了包括海绵骨在内的详细头部模型,计算tDCS的皮质电场。从MR图像中提取海绵骨,建立6层头部模型。在测量颅骨和海绵骨厚度后,模拟并比较了精细模型和典型模型上的皮层电场分布。结果表明,两种模型中电场的分布和振幅不同,特别是电场的分布。六层模型将得到更大范围的刺激。根据模拟结果和真实的生理结构,我们认为区分颅骨致密骨和海绵骨对于准确模拟tDCS非常重要。
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引用次数: 4
期刊
Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing
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