Pub Date : 2024-01-05DOI: 10.31631/2073-3046-2023-22-6-33-43
A. I. Blokh, N. A. Pen`evskaya, N. Rudakov, O. F. Egorova, Kh. A. Manokhina, L. V. Abdrashitova, D. Saveliev
Relevance. The Altai Krai (AK) is among the least prosperous subjects of the Russian Federation in terms of the incidence of acute respiratory infections (ARI).Aim: to analyze the causes and conditions for the formation of a high incidence of ARI among the population of the Altai Krai based on an assessment of the long-term and intra-annual dynamics of the epidemic process in 2011–2021.Materials and methods. In the course of a retrospective epidemiological study according to the annual forms No. 2 of the state statistical observation (SOS) for 2011-2021 a comparative analysis of the incidence of ARI and community-acquired pneumonia (CAP) in various groups of the population of the AK, the Siberian federal district (SFD) and the population of the Russian Federation as a whole was carried out. Data for 2020–2021 («covid» period) was analyzed separately in comparison with the precovid period of 2011–2019. The intra-annual dynamics of the incidence of ARI and CAP in the AK were studied using the method of trend-seasonal decomposition according to the monthly forms No. 2 of the SOS.Results and discussion. It is established that in 2011–2021. the epidemic process of ARI in the AK was characterized by a higher level and rate of increase in the incidence of all population groups (adults and children, urban and rural) compared to the all-Russian and average for the Siberian Federal District; a higher proportion of children in the overall structure of ARI cases, despite the fact that the proportion of the child population did not exceed (or was even less) than in other regions; no decrease in the incidence of ARI in children in the period 2020–2021; the presence of a trend towards an increase in the incidence of ARI in both urban and rural residents in the pre-covid period; higher incidence in the rural population in 2011–2019 compared to the whole of the Russian Federation or the Siberian Federal District. A less pronounced role of the seasonal component in the registration of CAP was revealed, in comparison with ARI. In some years, an increase in the registration of CAP was observed in the spring-summer period. For 2020-2021 there was a close coincidence of the curves of the intra-annual dynamics of the registered incidence of ARI and COVID-19 among the general population, CAP and COVID-19.Conclusion. The obtained results indicate the need to study the possible impact of environmental factors, as well as the shortcomings of the etiological interpretation and differential diagnosis of some natural focal and zoonotic infections that occur with fever and respiratory symptoms on the formation of a high incidence of ARI in the Altai Territory.
相关性。目的：在评估 2011-2021 年阿勒泰边疆区人口急性呼吸道感染（ARI）发病率的长期和年内动态的基础上，分析阿勒泰边疆区人口急性呼吸道感染高发的原因和条件。在根据 2011-2021 年国家统计观察（SOS）第 2 号年表进行流行病学回顾性研究的过程中，对阿勒泰边疆区、西伯利亚联邦区（SFD）和整个俄罗斯联邦不同人群的急性呼吸道感染（ARI）和社区获得性肺炎（CAP）发病率进行了比较分析。对2020-2021年（"covid "时期）的数据与2011-2019年 "precovid "时期的数据进行了对比分析。根据 SOS 第 2 号月度表格，采用趋势-季节分解法研究了 AK 地区 ARI 和 CAP 发病率的年内动态。结果表明，2011-2021 年与全俄罗斯和西伯利亚联邦区的平均水平相比，阿卡普尔科地区所有人群（成人和儿童、城市和农村）的急性呼吸道感染发病率和增长率都较高；尽管儿童人口比例没有超过（甚至低于）其他地区，但儿童在整个急性呼吸道感染病例结构中的比例较高；2020-2021 年期间，儿童急性呼吸道感染发病率没有下降；在前伏特时期，城市和农村居民的急性呼吸道感染发病率呈上升趋势；2011-2019 年期间，农村居民的发病率高于整个俄罗斯联邦或西伯利亚联邦区。与急性呼吸道感染相比，季节性因素在CAP登记中的作用并不明显。在某些年份，春夏季节的 CAP 登记量有所增加。2020-2021 年，普通人群中 ARI 和 COVID-19 登记发病率、CAP 和 COVID-19 登记发病率的年内动态曲线非常吻合。研究结果表明，有必要研究环境因素可能造成的影响，以及对阿尔泰边疆区 ARI 高发病率形成的一些伴有发热和呼吸道症状的自然病灶和人畜共患感染的病因解释和鉴别诊断的缺陷。
{"title":"Analysis of the Causes and Conditions for the Formation of a High Incidence of Acute Respiratory Infections (ARI) in the Population of the Altai Krai (Part 1. Features of Long-Term and Intra-Annual Dynamics of ARI Incidence in 2011–2021)","authors":"A. I. Blokh, N. A. Pen`evskaya, N. Rudakov, O. F. Egorova, Kh. A. Manokhina, L. V. Abdrashitova, D. Saveliev","doi":"10.31631/2073-3046-2023-22-6-33-43","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-6-33-43","url":null,"abstract":"Relevance. The Altai Krai (AK) is among the least prosperous subjects of the Russian Federation in terms of the incidence of acute respiratory infections (ARI).Aim: to analyze the causes and conditions for the formation of a high incidence of ARI among the population of the Altai Krai based on an assessment of the long-term and intra-annual dynamics of the epidemic process in 2011–2021.Materials and methods. In the course of a retrospective epidemiological study according to the annual forms No. 2 of the state statistical observation (SOS) for 2011-2021 a comparative analysis of the incidence of ARI and community-acquired pneumonia (CAP) in various groups of the population of the AK, the Siberian federal district (SFD) and the population of the Russian Federation as a whole was carried out. Data for 2020–2021 («covid» period) was analyzed separately in comparison with the precovid period of 2011–2019. The intra-annual dynamics of the incidence of ARI and CAP in the AK were studied using the method of trend-seasonal decomposition according to the monthly forms No. 2 of the SOS.Results and discussion. It is established that in 2011–2021. the epidemic process of ARI in the AK was characterized by a higher level and rate of increase in the incidence of all population groups (adults and children, urban and rural) compared to the all-Russian and average for the Siberian Federal District; a higher proportion of children in the overall structure of ARI cases, despite the fact that the proportion of the child population did not exceed (or was even less) than in other regions; no decrease in the incidence of ARI in children in the period 2020–2021; the presence of a trend towards an increase in the incidence of ARI in both urban and rural residents in the pre-covid period; higher incidence in the rural population in 2011–2019 compared to the whole of the Russian Federation or the Siberian Federal District. A less pronounced role of the seasonal component in the registration of CAP was revealed, in comparison with ARI. In some years, an increase in the registration of CAP was observed in the spring-summer period. For 2020-2021 there was a close coincidence of the curves of the intra-annual dynamics of the registered incidence of ARI and COVID-19 among the general population, CAP and COVID-19.Conclusion. The obtained results indicate the need to study the possible impact of environmental factors, as well as the shortcomings of the etiological interpretation and differential diagnosis of some natural focal and zoonotic infections that occur with fever and respiratory symptoms on the formation of a high incidence of ARI in the Altai Territory.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139449845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-04DOI: 10.31631/2073-3046-2023-22-6-19-32
T. Platonova, A. .. Golubkova, M. S. Sklyar, E. Karbovnichaya, K. Varchenko, A. Ivanova, A. Komissarov, D. Lioznov
Relevance. One of the most affected by the new coronavirus infection (COVID-19) groups of the population were medical workers who have high risks of infection in the performance of professional dutiesAim. Analysis the clinical manifestations of COVID–19 in different periods of the pandemic in medical organizations, taking into account the genetic variability of circulating strains of SARSCoV- 2 and vaccination status.Materials and methods. To study the clinical manifestations of coronavirus infection, an online survey of medical workers in a large industrial region was conducted in March 2022 using a specially designed anonymous questionnaire. The total number of respondents was 3,078. Clinical manifestations were analyzed during five epidemic rises in the incidence of COVID-19 from March 2020 to March 2022. To assess the SARS-CoV-2 virus strains circulating in the region, data from the GISAID database (the first and second waves of the pandemic, n = 298) and the results of PCR studies in the laboratory of UMMC-Health LLC (third - fifth waves, n = 349) were used.Results and discussion. In the first and second epidemic rises of morbidity associated with SARS-CoV-2 strains B.1. and B.1.1, the structure of clinical forms did not significantly differ: 3.6% and 3.9% were asymptomatic forms, 61.3% – variants of acute respiratory infection (AR I) and 35.1% and 34.8% - pneumonia, accordingly. In the third epidemic upsurge caused by the Delta variant (V.1.617.2), the structure of clinical forms did not undergo significant changes. In the fourth epidemic rise in morbidity, also associated with the spread of the Delta variant, the share of ARI in the structure of clinical forms increased to 77.0%, and pneumonia decreased to 21.3%.In the fifth wave of the pandemic caused by the Omicron gene variant (B.1.1.529), there was an increase to 91.3% of the proportion of mild clinical forms and a decrease to 7.1% of forms with lung damage. The frequency of detection of general infectious symptoms, upper respiratory tract lesions and neurological manifestations of COVID-19 had statistically significant differences in different periods of the pandemic. Whereas the frequency of gastrointestinal disorders did not significantly differ. The high clinical efficacy of vaccination has been shown – in ter ms of a 3.6-fold reduction in the chances of developing moderate and severe forms of the disease.Conclusion. Based on the results of the study, new data were obtained on the features of the clinical manifestations of COVID-19 in different periods of the pandemic with the change of genetic variants of the pathogen and the role of vaccination in preventing the development of moderate and severe clinical forms of infection was shown.
{"title":"Clinical Manifestations of COVID-19 in Different Periods of the Pandemic in Persons from Occupational Risk Groups of Infection","authors":"T. Platonova, A. .. Golubkova, M. S. Sklyar, E. Karbovnichaya, K. Varchenko, A. Ivanova, A. Komissarov, D. Lioznov","doi":"10.31631/2073-3046-2023-22-6-19-32","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-6-19-32","url":null,"abstract":"Relevance. One of the most affected by the new coronavirus infection (COVID-19) groups of the population were medical workers who have high risks of infection in the performance of professional dutiesAim. Analysis the clinical manifestations of COVID–19 in different periods of the pandemic in medical organizations, taking into account the genetic variability of circulating strains of SARSCoV- 2 and vaccination status.Materials and methods. To study the clinical manifestations of coronavirus infection, an online survey of medical workers in a large industrial region was conducted in March 2022 using a specially designed anonymous questionnaire. The total number of respondents was 3,078. Clinical manifestations were analyzed during five epidemic rises in the incidence of COVID-19 from March 2020 to March 2022. To assess the SARS-CoV-2 virus strains circulating in the region, data from the GISAID database (the first and second waves of the pandemic, n = 298) and the results of PCR studies in the laboratory of UMMC-Health LLC (third - fifth waves, n = 349) were used.Results and discussion. In the first and second epidemic rises of morbidity associated with SARS-CoV-2 strains B.1. and B.1.1, the structure of clinical forms did not significantly differ: 3.6% and 3.9% were asymptomatic forms, 61.3% – variants of acute respiratory infection (AR I) and 35.1% and 34.8% - pneumonia, accordingly. In the third epidemic upsurge caused by the Delta variant (V.1.617.2), the structure of clinical forms did not undergo significant changes. In the fourth epidemic rise in morbidity, also associated with the spread of the Delta variant, the share of ARI in the structure of clinical forms increased to 77.0%, and pneumonia decreased to 21.3%.In the fifth wave of the pandemic caused by the Omicron gene variant (B.1.1.529), there was an increase to 91.3% of the proportion of mild clinical forms and a decrease to 7.1% of forms with lung damage. The frequency of detection of general infectious symptoms, upper respiratory tract lesions and neurological manifestations of COVID-19 had statistically significant differences in different periods of the pandemic. Whereas the frequency of gastrointestinal disorders did not significantly differ. The high clinical efficacy of vaccination has been shown – in ter ms of a 3.6-fold reduction in the chances of developing moderate and severe forms of the disease.Conclusion. Based on the results of the study, new data were obtained on the features of the clinical manifestations of COVID-19 in different periods of the pandemic with the change of genetic variants of the pathogen and the role of vaccination in preventing the development of moderate and severe clinical forms of infection was shown.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139450611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-04DOI: 10.31631/2073-3046-2023-22-6-4-18
L. Karpova, M. Y. Pelikh, K. Volik, N. M. Popovtseva, T. P. Stolyarova, D. Lioznov
Relevance. During the COVID-19 pandemic, an early determination of the start of the influenza epidemic by the incidence of influenza and SARS in total is impossible, due to the similarity of the clinical picture of SARS and lung cases of COVID-19.Aim. The goal is to calculate and test new criteria for early detection of the start of influenza epidemics and their intensity for each of the cities–reference bases (61) of the 2 WHO National Influenza Centers based on the incidence of clinically diagnosed influenza.Tasks. To evaluate the effectiveness of baseline influenza incidence and epidemic intensity thresholds for the general population and age groups of each city in the epidemic of 2022–2023. To give a retrospective assessment of the effectiveness of influenza baselines for cities, compared with the baselines of the corresponding Federal Districts, for the seasons from 2009 to 2022. To estimate the intensity of epidemics by influenza incidence over the previous epidemies of the pandemic cycle of influenza A/California/H1N1/ virus.Materials and methods. By the 2022–2023 season. baseline lines and thresholds of influenza incidence intensity were calculated using the method of moving epidemics according to clinical diagnostic data not only for federal districts, but also for each of the observed cities (61). The calculation of the baselines was carried out according to the data of the computer database of the Influenza Research Institute on the incidence of influenza by age groups in each city over the previous 5 years in the season from 2016–2017 to 2021–2022.Results. In the 2022-23 season application of new criteria for the start of epidemics (prev.- and post-epidemic baseline influenza incidence) and their intensity revealed: early onset of the influenza epidemic (07–13.11 2022); simultaneous onset in all children's age groups; geographical spread of the epidemic in federal districts; intensity of the epidemic in the general population and age groups. The thresholds for the intensity of influenza morbidity made it possible to clarify the intensity levels of influenza epidemics from 2009 to 2023 and to show that the pandemic cycle of the influenza A(H1N1) virus continues. A comparison of the effectiveness of urban baselines with federal ones in the epidemic of 2022–2023 showed that urban baseline flu incidence lines revealed the start of epidemics 1–3 weeks earlier: among the general population in 12 cities, persons over 15 years old – in 9, children 3–6 years old – in 6 and 7–14 years old – in 5. A retrospective assessment of the effectiveness of city and federal influenza baselines (from 2009 to 2022) showed their effectiveness both in the seasons from 2009 to 2016 (before the baseline calculation period) and after. The effectiveness of urban baselines for early detection of the start of epidemics depended on the etiology of the epidemic – more with influenza A(H3N2) than with influenza A(H1N1), the level of intensity of influenza diseases and
{"title":"Evaluating the Effectiveness of New Criteria for Early Detection of the Start and Intensity of Influenza Epidemics in Russian Federation","authors":"L. Karpova, M. Y. Pelikh, K. Volik, N. M. Popovtseva, T. P. Stolyarova, D. Lioznov","doi":"10.31631/2073-3046-2023-22-6-4-18","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-6-4-18","url":null,"abstract":"Relevance. During the COVID-19 pandemic, an early determination of the start of the influenza epidemic by the incidence of influenza and SARS in total is impossible, due to the similarity of the clinical picture of SARS and lung cases of COVID-19.Aim. The goal is to calculate and test new criteria for early detection of the start of influenza epidemics and their intensity for each of the cities–reference bases (61) of the 2 WHO National Influenza Centers based on the incidence of clinically diagnosed influenza.Tasks. To evaluate the effectiveness of baseline influenza incidence and epidemic intensity thresholds for the general population and age groups of each city in the epidemic of 2022–2023. To give a retrospective assessment of the effectiveness of influenza baselines for cities, compared with the baselines of the corresponding Federal Districts, for the seasons from 2009 to 2022. To estimate the intensity of epidemics by influenza incidence over the previous epidemies of the pandemic cycle of influenza A/California/H1N1/ virus.Materials and methods. By the 2022–2023 season. baseline lines and thresholds of influenza incidence intensity were calculated using the method of moving epidemics according to clinical diagnostic data not only for federal districts, but also for each of the observed cities (61). The calculation of the baselines was carried out according to the data of the computer database of the Influenza Research Institute on the incidence of influenza by age groups in each city over the previous 5 years in the season from 2016–2017 to 2021–2022.Results. In the 2022-23 season application of new criteria for the start of epidemics (prev.- and post-epidemic baseline influenza incidence) and their intensity revealed: early onset of the influenza epidemic (07–13.11 2022); simultaneous onset in all children's age groups; geographical spread of the epidemic in federal districts; intensity of the epidemic in the general population and age groups. The thresholds for the intensity of influenza morbidity made it possible to clarify the intensity levels of influenza epidemics from 2009 to 2023 and to show that the pandemic cycle of the influenza A(H1N1) virus continues. A comparison of the effectiveness of urban baselines with federal ones in the epidemic of 2022–2023 showed that urban baseline flu incidence lines revealed the start of epidemics 1–3 weeks earlier: among the general population in 12 cities, persons over 15 years old – in 9, children 3–6 years old – in 6 and 7–14 years old – in 5. A retrospective assessment of the effectiveness of city and federal influenza baselines (from 2009 to 2022) showed their effectiveness both in the seasons from 2009 to 2016 (before the baseline calculation period) and after. The effectiveness of urban baselines for early detection of the start of epidemics depended on the etiology of the epidemic – more with influenza A(H3N2) than with influenza A(H1N1), the level of intensity of influenza diseases and","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139450733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-02DOI: 10.31631/2073-3046-2023-22-3-85-92
E. Shmeleva, A. V. Melekhova, A. Saphronova
Relevance. It is known that antitoxic immunity saves from diphtheria, but does not prevent the carriage of Cd (tox+). Asymptomatic carriers of Cd (tox+) play a major role in maintaining the epidemiological process of diphtheria infection.Aims. Characteristics of the population composition and specifics of the kinetic reactions of Cd (tox-) and Cd (tox+) simultaneously functioning among people.Results. The functional features of the specific kinetic reactions of individual populations play an important role in the existence of microbial populations in human biotopes. The introduction of the corinephage tox+ gene into the symbiotic individual Cd (tox-) promoted the synthesis of the toxin and the adaptive stability of the Cd (tox-) population in the environment. Metabolites Cd (tox-) - autostabilizers of microbial growth form microecological symbiotic systems of human biotopes.Conclusions. The use of the metabiotic drug Kodivac from symbiotic Cd (tox-) allows: to treat long-term carriers of Cd (tox+); reduce circulation of Cd (tox+) in the population; together with small doses of diphtheria toxoid to create protection against diphtheria; form symbiogenesis in human biotopes, suppressing dysbiotic inflammatory reactions.
{"title":"Population and Epidemiological Aspects of Carriage of Toxigenic (Cd tox+) and Non-toxigenic (Cd tox-) Diphtheria corynebacteria","authors":"E. Shmeleva, A. V. Melekhova, A. Saphronova","doi":"10.31631/2073-3046-2023-22-3-85-92","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-3-85-92","url":null,"abstract":"Relevance. It is known that antitoxic immunity saves from diphtheria, but does not prevent the carriage of Cd (tox+). Asymptomatic carriers of Cd (tox+) play a major role in maintaining the epidemiological process of diphtheria infection.Aims. Characteristics of the population composition and specifics of the kinetic reactions of Cd (tox-) and Cd (tox+) simultaneously functioning among people.Results. The functional features of the specific kinetic reactions of individual populations play an important role in the existence of microbial populations in human biotopes. The introduction of the corinephage tox+ gene into the symbiotic individual Cd (tox-) promoted the synthesis of the toxin and the adaptive stability of the Cd (tox-) population in the environment. Metabolites Cd (tox-) - autostabilizers of microbial growth form microecological symbiotic systems of human biotopes.Conclusions. The use of the metabiotic drug Kodivac from symbiotic Cd (tox-) allows: to treat long-term carriers of Cd (tox+); reduce circulation of Cd (tox+) in the population; together with small doses of diphtheria toxoid to create protection against diphtheria; form symbiogenesis in human biotopes, suppressing dysbiotic inflammatory reactions.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89598512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-02DOI: 10.31631/2073-3046-2023-22-3-70-77
V. N. Borisova, R. Y. Maksvitis, R. Ivanov, T. A. Semenenko
Relevance. Currently, there is no registered vaccine against the hepatitis B virus (HBV) mutant G145R worldwide, which justifies the need to develop a new generation of vaccines due to large-scale immunization against hepatitis B and the accumulation of escape mutants of the virus.The aim of the study was a comparative assessment of the immunogenicity, reactogenicity and safety of Bubo®-Unigep (trivalent hepatitis B recombinant yeast vaccine) and the drug Hepatitis B recombinant yeast vaccine.Materials and methods. To assess the main characteristics of the new trivalent vaccine Bubo®-Unigep (CJSC NPC «COMBIOTECH»), a doubleblind, comparative, randomized, multicenter clinical trial was conducted in two parallel groups in previously unvaccinated individuals in an adult healthy population (n = 166) according to a protocol developed by the contract research organization «R&D Pharma».Results. The assessment of hematological and biochemical parameters during screening and the administration of vaccine preparations showed that in the individuals included in the study, the studied indicators were within the boundaries of the normal range. According to the criteria for assessing safety and efficacy, both drugs had low reactogenicity, no serious adverse events were registered. The results of a comparative analysis of the concentrations of antibodies to HBsAg determined after a full course of immunization with Bubo®-Unigep vaccine or recombinant yeast Hepatitis B vaccine showed that both drugs effectively induced a humoral immune response (anti-HBs) with seroprotection rates of 96.3% and 92.6%.Conclusion. The inclusion of the relevant HBV serotypes (ay and ad) and the mutant antigen G145R in the composition of the new polyvalent vaccine Bubo®-Unigep contributes to the expansion of the spectrum of specificity of the immune response, and, consequently, more effective vaccination of hepatitis B.
{"title":"New Russian Trivalent Hepatitis B Vaccine (Bubo®-Unigep): Clinical Study Results","authors":"V. N. Borisova, R. Y. Maksvitis, R. Ivanov, T. A. Semenenko","doi":"10.31631/2073-3046-2023-22-3-70-77","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-3-70-77","url":null,"abstract":"Relevance. Currently, there is no registered vaccine against the hepatitis B virus (HBV) mutant G145R worldwide, which justifies the need to develop a new generation of vaccines due to large-scale immunization against hepatitis B and the accumulation of escape mutants of the virus.The aim of the study was a comparative assessment of the immunogenicity, reactogenicity and safety of Bubo®-Unigep (trivalent hepatitis B recombinant yeast vaccine) and the drug Hepatitis B recombinant yeast vaccine.Materials and methods. To assess the main characteristics of the new trivalent vaccine Bubo®-Unigep (CJSC NPC «COMBIOTECH»), a doubleblind, comparative, randomized, multicenter clinical trial was conducted in two parallel groups in previously unvaccinated individuals in an adult healthy population (n = 166) according to a protocol developed by the contract research organization «R&D Pharma».Results. The assessment of hematological and biochemical parameters during screening and the administration of vaccine preparations showed that in the individuals included in the study, the studied indicators were within the boundaries of the normal range. According to the criteria for assessing safety and efficacy, both drugs had low reactogenicity, no serious adverse events were registered. The results of a comparative analysis of the concentrations of antibodies to HBsAg determined after a full course of immunization with Bubo®-Unigep vaccine or recombinant yeast Hepatitis B vaccine showed that both drugs effectively induced a humoral immune response (anti-HBs) with seroprotection rates of 96.3% and 92.6%.Conclusion. The inclusion of the relevant HBV serotypes (ay and ad) and the mutant antigen G145R in the composition of the new polyvalent vaccine Bubo®-Unigep contributes to the expansion of the spectrum of specificity of the immune response, and, consequently, more effective vaccination of hepatitis B.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80034166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-02DOI: 10.31631/2073-3046-2023-22-3-78-84
V. Akimkin, Z. G. Tagirova, A. Muzyka, N. M. Zulpukarova, N. S. Karnaeva, S. Shabalina
Relevance. Over the past two decades, due to the effectiveness of anti-epidemic measures, the incidence of infectious diseases in the Republic of Dagestan (RD) has been declining. However for some nosologies it is considerably higher than the Russian Federation average.Objective. To analyze the incidence of infectious diseases in RD in 2019–2022 in order to identify areas for preventive and anti-epidemic measures to be strengthened.Material and methods. The data on morbidity taken from federal statistical observation form No. 2 «Information on infectious and parasitic diseases», State reports on sanitary and epidemiological well-being of the population for 2019, 2020, 2021, 2022, prepared by Rospotrebnadzor and the Department of Rospotrebnadzor for Dagestan Republic were analyzed. A descriptive epidemiological method was used, which does not require statistical data processing.Results and discussion. In 2022, in the Republic of Dagestan, the infectious disease incidence was 7492.2 per 100 thousand of the population, which is 22.2% lower than in 2021, but higher than the long-term average (6149.4). In 2022, compared to 2021, there was a decrease in the incidence of 10 nosoforms of infectious diseases in the RD and 6 in the Russian Federation. Along with a decrease in morbidity, there is an increase in morbidity, in particular Sonne dysentery by 5.1 times, аcute intestinal infections (established etiology) by 39.3%. chronic hepatitis B by 97.9%, chronic hepatitis C by 2.14 times, whooping cough by 5.1 times, chicken pox by 18.6%, mumps by 2.2 times, brucellosis by 24.4%, HIV-infection by 36.3%, influenza 43.4 times. In the structure of infectious and parasitic diseases in 2022, as in previous years, acute infections of the upper respiratory tract and аcute intestinal infections prevailed.Conclusions. Despite the ongoing systematic work aimed at reducing the incidence of infectious diseases and the progress made in improving the situation with a number of infections, more measures are needed to combat acute intestinal infections, hepatitis B and C, HIV-infection, brucellosis.
{"title":"Analysis of Infectious Incidence in the Republic of Dagestan for 2019–2021","authors":"V. Akimkin, Z. G. Tagirova, A. Muzyka, N. M. Zulpukarova, N. S. Karnaeva, S. Shabalina","doi":"10.31631/2073-3046-2023-22-3-78-84","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-3-78-84","url":null,"abstract":"Relevance. Over the past two decades, due to the effectiveness of anti-epidemic measures, the incidence of infectious diseases in the Republic of Dagestan (RD) has been declining. However for some nosologies it is considerably higher than the Russian Federation average.Objective. To analyze the incidence of infectious diseases in RD in 2019–2022 in order to identify areas for preventive and anti-epidemic measures to be strengthened.Material and methods. The data on morbidity taken from federal statistical observation form No. 2 «Information on infectious and parasitic diseases», State reports on sanitary and epidemiological well-being of the population for 2019, 2020, 2021, 2022, prepared by Rospotrebnadzor and the Department of Rospotrebnadzor for Dagestan Republic were analyzed. A descriptive epidemiological method was used, which does not require statistical data processing.Results and discussion. In 2022, in the Republic of Dagestan, the infectious disease incidence was 7492.2 per 100 thousand of the population, which is 22.2% lower than in 2021, but higher than the long-term average (6149.4). In 2022, compared to 2021, there was a decrease in the incidence of 10 nosoforms of infectious diseases in the RD and 6 in the Russian Federation. Along with a decrease in morbidity, there is an increase in morbidity, in particular Sonne dysentery by 5.1 times, аcute intestinal infections (established etiology) by 39.3%. chronic hepatitis B by 97.9%, chronic hepatitis C by 2.14 times, whooping cough by 5.1 times, chicken pox by 18.6%, mumps by 2.2 times, brucellosis by 24.4%, HIV-infection by 36.3%, influenza 43.4 times. In the structure of infectious and parasitic diseases in 2022, as in previous years, acute infections of the upper respiratory tract and аcute intestinal infections prevailed.Conclusions. Despite the ongoing systematic work aimed at reducing the incidence of infectious diseases and the progress made in improving the situation with a number of infections, more measures are needed to combat acute intestinal infections, hepatitis B and C, HIV-infection, brucellosis.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80980944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-02DOI: 10.31631/2073-3046-2023-22-3-93-99
A. Kostinov, A. A. Tarasova, K. Mashilov
Relevance. Community-acquired pneumonia and chronic obstructive pulmonary disease (COPD) remain a serious public health problem in all respects today.Aims. To summarize the studies of domestic authors on the study of the effect of pneumococcal polysaccharide vaccine on various parts of the immune system and their relationship with the clinical course of the disease in patients with COPD and community-acquired pneumonia. We also consider it necessary to discuss the possible mechanisms of therapeutic effects after the introduction of a monovaccine against S. pneumoniae, as well as when it is combined with vaccines against Haemophilus influenzae type b infection, and the effectiveness of various vaccination regimens, including complex ones.Conclusions. Convincing arguments are presented proving that the introduction of vaccines against respiratory infections can have not only a reventive value, but also a therapeutic effect, accompanied by a transient restoration of the immune system parameters, as well as a reduction in the contamination or elimination of S. pneumoniae in patients with chronic pathology of the bronchopulmonary system.
{"title":"Pneumococcal Vaccine in Adults with Bronchopulmonary Pathology: from Prevention to Treatment","authors":"A. Kostinov, A. A. Tarasova, K. Mashilov","doi":"10.31631/2073-3046-2023-22-3-93-99","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-3-93-99","url":null,"abstract":"Relevance. Community-acquired pneumonia and chronic obstructive pulmonary disease (COPD) remain a serious public health problem in all respects today.Aims. To summarize the studies of domestic authors on the study of the effect of pneumococcal polysaccharide vaccine on various parts of the immune system and their relationship with the clinical course of the disease in patients with COPD and community-acquired pneumonia. We also consider it necessary to discuss the possible mechanisms of therapeutic effects after the introduction of a monovaccine against S. pneumoniae, as well as when it is combined with vaccines against Haemophilus influenzae type b infection, and the effectiveness of various vaccination regimens, including complex ones.Conclusions. Convincing arguments are presented proving that the introduction of vaccines against respiratory infections can have not only a reventive value, but also a therapeutic effect, accompanied by a transient restoration of the immune system parameters, as well as a reduction in the contamination or elimination of S. pneumoniae in patients with chronic pathology of the bronchopulmonary system.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74500605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.31631/2073-3046-2023-22-3-64-69
M. Makarova, Yulia Mikhajlova, E. Khachaturiants, V. Litvinov
Relevance. M. kansasii are one of the main nontuberculous bacteria pathogens causing mycobacterial infections in most European countries (including Russia). An important problem in the treatment of mycobacteriosis is the resistance of their pathogens to antibacterial drugs (ABDs). Bedaquiline (Bdq) is one of the new ABDs, the effectiveness of which is shown, in particular, in the most common mycobacteriosis – tuberculosis.Aim. To characterize the features of drug sensitivity of M. kansasii isolated from respiratory material at the Moscow Scientific and Practical Center for Tuberculosis Control (MNPC BT).Materials and methods. A total of 76 M. kansasii cultures have been studied. The MIC spectrum of Bdq was determined for M. kansasii, MIC50, MIC90 (the concentrations of Bdq providing inhibition of the growth of 50% and 90% mycobacterial strains, respectively) and ECOFF (epidemiological cut-off value) – the MIC value characterizing the upper limit for the «wild» population type, which was determined using the ECOFFinder statistical calculator – EUCAST. The drug sensitivity of M. kansasii to the main ABDs used in general practice for the treatment of the corresponding mycobacterioses was also evaluated.Results. It was found that the MIC of Bdq in relation to M. kansasii were distributed in the range of 0.003-2.0 (mcg/ml), the growth of most strains (73.7%) was be inhibited by the concentration of Bdq0.015 mcg/ml. Among all studied strains of M. kansasii, the number of isolates resistant to Bdq were 2 (2.6%). The data obtained are generally consistent with the data of other authors and show that Bdq can currently be an effective drug for the treatment of mycobacterial infections caused by M. kansasii.Conclusion. The results of the study, as well as literature data, indicate that M. kansasii is currently usually sensitive to Bdq. However, in some cases, resistance to this drug is already developing.
{"title":"Drug Sensitivity to Bedaquiline of M. kansasii Strains Isolated in Antituberculous Institutions of the City of Moscow","authors":"M. Makarova, Yulia Mikhajlova, E. Khachaturiants, V. Litvinov","doi":"10.31631/2073-3046-2023-22-3-64-69","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-3-64-69","url":null,"abstract":"Relevance. M. kansasii are one of the main nontuberculous bacteria pathogens causing mycobacterial infections in most European countries (including Russia). An important problem in the treatment of mycobacteriosis is the resistance of their pathogens to antibacterial drugs (ABDs). Bedaquiline (Bdq) is one of the new ABDs, the effectiveness of which is shown, in particular, in the most common mycobacteriosis – tuberculosis.Aim. To characterize the features of drug sensitivity of M. kansasii isolated from respiratory material at the Moscow Scientific and Practical Center for Tuberculosis Control (MNPC BT).Materials and methods. A total of 76 M. kansasii cultures have been studied. The MIC spectrum of Bdq was determined for M. kansasii, MIC50, MIC90 (the concentrations of Bdq providing inhibition of the growth of 50% and 90% mycobacterial strains, respectively) and ECOFF (epidemiological cut-off value) – the MIC value characterizing the upper limit for the «wild» population type, which was determined using the ECOFFinder statistical calculator – EUCAST. The drug sensitivity of M. kansasii to the main ABDs used in general practice for the treatment of the corresponding mycobacterioses was also evaluated.Results. It was found that the MIC of Bdq in relation to M. kansasii were distributed in the range of 0.003-2.0 (mcg/ml), the growth of most strains (73.7%) was be inhibited by the concentration of Bdq0.015 mcg/ml. Among all studied strains of M. kansasii, the number of isolates resistant to Bdq were 2 (2.6%). The data obtained are generally consistent with the data of other authors and show that Bdq can currently be an effective drug for the treatment of mycobacterial infections caused by M. kansasii.Conclusion. The results of the study, as well as literature data, indicate that M. kansasii is currently usually sensitive to Bdq. However, in some cases, resistance to this drug is already developing.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75726695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.31631/2073-3046-2023-22-3-26-35
G. G. Isaeva, L. Bayazitova, A. Z. Zaripova, O. Tupkina, T. A. Chazova, R. Khusainova, Yury A Tyurin, V. B. Ziatdinov
Relevance. Vaccination of the child population against pneumococcal infection (PI) has been carried out in the Republic of Tatarstan according to the national calendar of preventive vaccinations since 2014. The vaccination scheme includes vaccination with PCV-13 conjugated pneumococcal vaccine.Aim. Study of the the frequency of bacterial transmission and the serotype landscape of S. pneumoniae isolated from healthy children- bacterial carriers of preschool age in the Republic of Tatarstan (RT).Materials and methods. During the period from 2016 to 2022, 1,426 children from Kazan and the districts of the Republic of Tatarstan were examined. Examination of nasopharyngeal smears was carried out by the classical bacteriological method. Serotyping was performed using molecular genetic methods (PCR).Results. The detection rate of S. pneumoniae among healthy preschool children varied in different years from 29.5 to 63%, averaging 38.5%. In urban children, the incidence of pneumococcal transmission was significantly higher than in rural children (p<0.01). Also, when analyzing the serotype landscape, mixed colonization by several serotypes was observed. As of January 1, 2021, the immune layer to the pathogen PI among preschool children was 81.7%. Monitoring of the serotype landscape of S.pneumoniae strains circulating in the RT showed the dominance of vaccine serotypes (67.2%), of which 44.4% are PCV13 serotypes. The proportion of non–vaccinated serotypes is 26%, untyped - 6.8%. Unvaccinated serotypes 35B (21.3%) and 23A (13.6%) dominated in vaccinated children, as well as serotypes not included in the PKV-13 vaccine cocktail, but included in the PPSV-23 polysaccharide vaccine not used for vaccination of children, namely 11AD (15.3%) 9LN (9.6%). In unvaccinated children, on the contrary, vaccine serotypes included in PCV-13 prevailed: 6ABCD (17.3%), 19F (20.9%), and unvaccinated serotypes 11AD, 9LN, 35B, 23A were detected with lower frequency 11,8%, 10,0%, 4,2%, 7,3% accordingly.Conclusion. Data on the regional features of the pneumococcal serotype landscape can be the basis for expanding the vaccine cocktail due to the dominant serotypes: 9LN,11 AD, 35B, 23A.
{"title":"Regional Features of the Serotype Composition of Streptococcus pneumoniae isolated from Bacterial Carriers of Preschool Age in the Republic of Tatarstan","authors":"G. G. Isaeva, L. Bayazitova, A. Z. Zaripova, O. Tupkina, T. A. Chazova, R. Khusainova, Yury A Tyurin, V. B. Ziatdinov","doi":"10.31631/2073-3046-2023-22-3-26-35","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-3-26-35","url":null,"abstract":"Relevance. Vaccination of the child population against pneumococcal infection (PI) has been carried out in the Republic of Tatarstan according to the national calendar of preventive vaccinations since 2014. The vaccination scheme includes vaccination with PCV-13 conjugated pneumococcal vaccine.Aim. Study of the the frequency of bacterial transmission and the serotype landscape of S. pneumoniae isolated from healthy children- bacterial carriers of preschool age in the Republic of Tatarstan (RT).Materials and methods. During the period from 2016 to 2022, 1,426 children from Kazan and the districts of the Republic of Tatarstan were examined. Examination of nasopharyngeal smears was carried out by the classical bacteriological method. Serotyping was performed using molecular genetic methods (PCR).Results. The detection rate of S. pneumoniae among healthy preschool children varied in different years from 29.5 to 63%, averaging 38.5%. In urban children, the incidence of pneumococcal transmission was significantly higher than in rural children (p<0.01). Also, when analyzing the serotype landscape, mixed colonization by several serotypes was observed. As of January 1, 2021, the immune layer to the pathogen PI among preschool children was 81.7%. Monitoring of the serotype landscape of S.pneumoniae strains circulating in the RT showed the dominance of vaccine serotypes (67.2%), of which 44.4% are PCV13 serotypes. The proportion of non–vaccinated serotypes is 26%, untyped - 6.8%. Unvaccinated serotypes 35B (21.3%) and 23A (13.6%) dominated in vaccinated children, as well as serotypes not included in the PKV-13 vaccine cocktail, but included in the PPSV-23 polysaccharide vaccine not used for vaccination of children, namely 11AD (15.3%) 9LN (9.6%). In unvaccinated children, on the contrary, vaccine serotypes included in PCV-13 prevailed: 6ABCD (17.3%), 19F (20.9%), and unvaccinated serotypes 11AD, 9LN, 35B, 23A were detected with lower frequency 11,8%, 10,0%, 4,2%, 7,3% accordingly.Conclusion. Data on the regional features of the pneumococcal serotype landscape can be the basis for expanding the vaccine cocktail due to the dominant serotypes: 9LN,11 AD, 35B, 23A.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81903859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.31631/2073-3046-2023-22-3-4-13
P. Khvalyuk
Relevance. MN (malignant neoplasms) of the lungs ranked first in the world in the structure of mortality from all MN among both sexes in 2020. Despite the significant contribution to the development of MN (including MN of the trachea, bronchi, lungs (ICD-10 – C33, С34)) of production factors, their influence is underestimated.Aim. To analyze the morbidity and mortality rates from the trachea, bronchi, lungs MN in men in the age range from 40 to 65 years in 2010–2020.Materials and methods. Data on the number of tracheal, bronchial, and lung MN detected for the first time in life among men in the age range from 40 to 65 years, as well as the number of deaths, were obtained from the Cancer Registry of the P. A. Herzen medical Institutebranch of the Federal state budgetary institution «NMIC of radiology» of the Ministry of health of Russia. The method of descriptive cross-sectional epidemiological study was used. A division was carried out by quartiles of standardized (world standard) indicators of the incidence of tracheal, bronchial, lung MN per 100 thousand male population in the subjects of the Russian Federation in 2020. Statistical processing – MS Office Excel 2019, Statistica 10.Results. Irkutsk, Orenburg, Rostov region, Moscow,federal districts of the Russian Federation were selected for the study (based on the quartile division). Long-term analysis (10-year period) of morbidity and mortality from MN of the trachea, bronchi, lungs in men aged 40 to 65 years in the Federal District, selected subjects and the Russian Federation as a whole, showed a moderately pronounced downward trend. Despite this, the indicators remain at a high level.Conclusion. The influence of harmful production factors on the development of MN is recognized in the Russian Federation in a very small number of cases, and therefore the true incidence rate is higher than the registered one. It is necessary to significantly improve the quality of detection of occupational diseases, as well as to optimize preventive measures aimed at preventing the harmful effects of production factors on the health of workers. Further detailed study of the role of individual factors of harmful industries on the development of tracheal, bronchial and lung diseases is required.
{"title":"Analysis of Morbidity and Mortality Rates from Malignant Neoplasms of Trachea, Bronchi, Lungs of Professional Genesis in Men aged 40 to 65 Years Old in the Russian Federation","authors":"P. Khvalyuk","doi":"10.31631/2073-3046-2023-22-3-4-13","DOIUrl":"https://doi.org/10.31631/2073-3046-2023-22-3-4-13","url":null,"abstract":"Relevance. MN (malignant neoplasms) of the lungs ranked first in the world in the structure of mortality from all MN among both sexes in 2020. Despite the significant contribution to the development of MN (including MN of the trachea, bronchi, lungs (ICD-10 – C33, С34)) of production factors, their influence is underestimated.Aim. To analyze the morbidity and mortality rates from the trachea, bronchi, lungs MN in men in the age range from 40 to 65 years in 2010–2020.Materials and methods. Data on the number of tracheal, bronchial, and lung MN detected for the first time in life among men in the age range from 40 to 65 years, as well as the number of deaths, were obtained from the Cancer Registry of the P. A. Herzen medical Institutebranch of the Federal state budgetary institution «NMIC of radiology» of the Ministry of health of Russia. The method of descriptive cross-sectional epidemiological study was used. A division was carried out by quartiles of standardized (world standard) indicators of the incidence of tracheal, bronchial, lung MN per 100 thousand male population in the subjects of the Russian Federation in 2020. Statistical processing – MS Office Excel 2019, Statistica 10.Results. Irkutsk, Orenburg, Rostov region, Moscow,federal districts of the Russian Federation were selected for the study (based on the quartile division). Long-term analysis (10-year period) of morbidity and mortality from MN of the trachea, bronchi, lungs in men aged 40 to 65 years in the Federal District, selected subjects and the Russian Federation as a whole, showed a moderately pronounced downward trend. Despite this, the indicators remain at a high level.Conclusion. The influence of harmful production factors on the development of MN is recognized in the Russian Federation in a very small number of cases, and therefore the true incidence rate is higher than the registered one. It is necessary to significantly improve the quality of detection of occupational diseases, as well as to optimize preventive measures aimed at preventing the harmful effects of production factors on the health of workers. Further detailed study of the role of individual factors of harmful industries on the development of tracheal, bronchial and lung diseases is required.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79141155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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