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Osteochondroma of the third metatarsal bone associated with severe intra-articular cartilage lesions in a Warmblood horse 温血马第三跖骨骨软骨瘤伴严重关节内软骨病变
IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2025-03-03 DOI: 10.1111/eve.14133
T. Willems, S. S. Matamalas, L. De Lange, M. Rohel, T. de Beauregard

This case report describes the unusual presentation of an intra-articular solitary osteochondroma in a 7-year-old Warmblood horse associated with fetlock distention and lameness. The osteochondroma was situated at the level of the distal physis of the plantar surface of the third metatarsal (MTIII) bone within the metatarsophalangeal joint and was successfully removed by arthroscopy. The owner reported a good clinical outcome 6 months after surgery, with no visible lameness at walk and trot. To the authors' knowledge, this case report has documented for the first time an intra-articular solitary osteochondroma at the level of the distal physis of the plantar surface of the MTIII bone.

本病例报告描述了一匹7岁温血马关节内孤立性骨软骨瘤的不寻常表现,并伴有足部肿胀和跛行。骨软骨瘤位于跖趾关节内第三跖骨(MTIII)足底远端物理面水平,通过关节镜成功切除。主人报告术后6个月临床结果良好,行走和小跑无明显跛行。据作者所知,本病例报告首次记录了MTIII骨足底远端物理水平的关节内孤立性骨软骨瘤。
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引用次数: 0
A pain in the neck: Discospondylitis and septic thrombophlebitis 颈部疼痛:脊柱炎和脓毒性血栓性静脉炎
IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2025-02-24 DOI: 10.1111/eve.14131
A. C. Migliorisi, Y. S. Nout-Lomas

The case report in this issue by Payette and colleagues highlights a few interesting topics and gives us the opportunity to discuss clinical signs associated with neck pain and strategies to prevent septic and nonseptic venous thrombosis in equine patients. The case illustrates the devastating consequences that septic thrombophlebitis can have on distant body systems, and in this commentary, we have highlighted several techniques that coupled with the selection of the appropriate intravenous catheter (IVC) and strategies aimed at reducing bacterial contamination of an IVC, can lead to a dramatic decrease in events of thrombosis and thrombophlebitis and a longer lifespan of the IVC. Furthermore, advances in diagnostic and management strategies for horses with neck disorders continue to provide clinicians with options for complicated cases that previously may have been unthinkable.

Payette及其同事在本期的病例报告中强调了一些有趣的话题,并使我们有机会讨论与颈部疼痛相关的临床症状以及预防马患者脓毒性和非脓毒性静脉血栓形成的策略。该病例说明了化脓性血栓性静脉炎对远端身体系统的破坏性后果,在这篇评论中,我们强调了几种技术,结合选择适当的静脉导管(IVC)和旨在减少IVC细菌污染的策略,可以显著减少血栓形成和血栓性静脉炎的事件,延长IVC的使用寿命。此外,马颈部疾病的诊断和管理策略的进步继续为临床医生提供以前可能难以想象的复杂病例的选择。
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引用次数: 0
Atypical coronary band keratoma as a cause of right forelimb lameness in a Warmblood gelding 温血骟马右前肢跛行的不典型冠状带角瘤
IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2025-02-24 DOI: 10.1111/eve.14120
K. A. Labbe, M. F. Barrett, E. C. dos Santos, J. B. Stanton, R. B. Eggleston

A 16-year-old Warmblood gelding had historically been evaluated for a chronic right forelimb lameness, localised with a palmar digital nerve block. The lameness was recurrent despite medication of the right fore distal interphalangeal joint. Magnetic resonance imaging (MRI) showed proliferative intermediate-to-low signal tissue in the location of the dorsal recess of the distal interphalangeal joint, with an overlying defect in the common digital extensor tendon. Given persistent right forelimb lameness over the following 24 months, with no improvement to the medication of the distal interphalangeal joint, a palmar digital neurectomy was performed. Three months following the neurectomy, the patient presented for a grade 4/5 right forelimb lameness. There was a firm, expanding swelling around the coronary band. Repeat diagnostic analgesia showed resolution of the lameness with local infiltration of anaesthetic around the firm swelling. At surgery, a soft tissue mass was surgically resected en bloc. The mass was histologically identified as a keratoma. To the authors' knowledge, there are no published reports of keratoma proximal to the coronary band that does not involve the hoof wall structure or underlying middle phalanx. Surgical removal of the keratoma resulted in significant improvement in right forelimb lameness at the 11-week post-op recheck and resolution of the right forelimb lameness 15 weeks post-operatively.

一匹16岁的温血马因右前肢慢性跛行而被评估,局部伴有掌指神经阻滞。尽管对右前远端指间关节进行了药物治疗,但跛行仍复发。磁共振成像(MRI)显示远端指间关节背隐窝位置增生的中至低信号组织,并在指总伸肌腱上覆盖缺损。由于右前肢在接下来的24个月里持续跛行,远端指间关节的药物治疗没有改善,我们进行了掌指神经切除术。神经切除术后3个月,患者出现4/5级右前肢跛行。冠状动脉带周围有一个坚固的、不断扩大的肿胀。重复诊断性镇痛显示跛行消退,并在硬肿周围局部浸润麻醉剂。在手术中,一个软组织团块被手术切除。该肿块经组织学鉴定为角质瘤。据作者所知,目前还没有发表的冠状动脉带近端角化瘤不涉及蹄壁结构或下伏的中指骨的报道。术后11周复查时,角质瘤切除导致右侧前肢跛行显著改善,术后15周右前肢跛行消退。
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引用次数: 0
Transverse navicular bone fracture in a hindlimb of a young Warmblood mare 一匹年轻温血母马后肢横舟骨骨折
IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2025-02-24 DOI: 10.1111/eve.14129
P. Tóth, A. Nagy

A 2.5-year-old Warmblood filly presented with an acute onset of severe right hindlimb lameness and pastern region swelling of 2 weeks' duration. Radiographic examination revealed a transverse (horizontal) displaced fracture of the navicular bone and subluxation of the distal interphalangeal (DIP) joint. Computed tomographic (CT) examination, including DIP joint contrast arthrography, identified a further fragment in the plantar pouch of the DIP joint and revealed no communication between the DIP joint and the navicular bursa. Six months later the horse showed only mild lameness at trot. Computed tomographic examination revealed a partial osseous union between the large proximal and distal fragments. Ten months following the injury the mare was pasture sound and in foal.

一只2.5岁的温血母马表现为急性发作的严重右后肢跛行和骹骨区域肿胀,持续2周。x线检查显示舟骨横向(水平)移位骨折和远端指间关节半脱位。计算机断层扫描(CT)检查,包括DIP关节造影术,在DIP关节的足底囊中发现了进一步的碎片,并显示DIP关节和舟状囊之间没有通信。六个月后,这匹马在小跑时只表现出轻微的跛行。计算机断层扫描显示大的近端和远端碎片之间部分骨愈合。受伤十个月后,这匹母马已经长得很健康,而且已经有了小马驹。
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引用次数: 0
Unusual penetrating foot injury with complete perforation of the distal phalanx by a metal object 不寻常的穿透性足部损伤,远端指骨被金属物体完全穿孔
IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2025-02-20 DOI: 10.1111/eve.14123
M. De Schryver, M. Gruyaert, E. Raes, M. Oosterlinck

A 12-year-old Warmblood gelding was presented with acute, nonweightbearing left hindlimb lameness. A foreign object was detected in the toe area of the solar surface. Radiographic examination confirmed foot penetration by a metal object, perforating the distal phalanx and dorsally reaching the lamellar dermis. Standing surgical exploration was performed. After manual removal of the object, a small circular opening in the dorsal hoof wall was created to facilitate debridement and flushing of the complete tract. Radiographically, the distal phalanx presented an irregular circular defect (35 × 33 mm) at the dorsal half of the sole just medial to the sagittal plane, without other lesions. The horse received broad-spectrum antimicrobial and nonsteroidal anti-inflammatory treatment. Lameness decreased gradually and the lesion presented progressive granulation and epithelisation. After 4 weeks, the horse was discharged from the hospital. A final cast change was performed during an ambulatory check-up at the hospital 2 weeks later. At that stage, epithelisation was complete, and first signs of keratinisation were observed. Further follow-up was performed by the referring veterinarian. The horse resumed its previous level of exercise in a riding school. Six-month follow-up did not reveal lameness; radiographically, the circular defect in the distal phalanx remained visible yet without other abnormalities.

一匹12岁的温血骟马表现为急性,非负重左后肢跛行。在太阳表面的脚趾区域发现了一个异物。x线检查证实足部被金属物体穿透,穿过远端指骨并向背侧到达板层真皮。站立手术探查。人工取出异物后,在蹄背壁上开一个小的圆形开口,以方便清创和冲洗整个尿路。x线片显示,远端指骨在矢状面内侧的足底背侧呈不规则圆形缺损(35 × 33 mm),无其他病变。马接受了广谱抗菌和非甾体抗炎治疗。跛行逐渐减轻,病变呈进行性肉芽和上皮化。4周后,马出院了。2周后,在医院的一次门诊检查中进行了最后一次更换石膏。在这个阶段,上皮已经完全形成,并观察到角化的最初迹象。进一步的随访由转诊兽医进行。这匹马在骑术学校恢复了以前的锻炼水平。6个月的随访未发现跛足;x线摄影显示,远端指骨的圆形缺损仍然可见,但没有其他异常。
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引用次数: 0
Surgical management of a perineal hernia in a 24-year-old mare 24岁母马会阴疝的外科治疗
IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2025-02-20 DOI: 10.1111/eve.14122
A. Spadari, F. Meistro, G. Saragoni, R. Rinnovati, M. V. Ralletti

A rare case of bilateral perineal hernia was reported in a 24-year-old Italian Trotter mare. The mare presented a history of chronic weight loss and bilateral perineal swelling. The right-sided swelling displayed signs of being chronic, while the left side experienced a singular episode of acute perineal swelling, coinciding with signs of colic. Due to concerns regarding potential recurrent colic episodes and the risk of bowel entrapment, the mare was hospitalised to perform a complete clinical and diagnostic assessments, and to establish an appropriate treatment. Based on history, clinical manifestations, results of palpation and ultrasonography, it was determined that the swelling was indicative of bilateral perineal hernia. An initial attempt at surgical correction through appositional herniorrhaphy proved unsuccessful. Subsequently, a novel technique involving the transposition of the semimembranosus muscle was employed as a secondary intervention. This alternative surgical method effectively addressed the issue without any short- or long-term recurrence or complications. In conclusion, perineal hernias should be included in differential diagnoses for perineal swelling in equids. Furthermore, when appositional herniorrhaphy proves ineffective, transposition of the semimembranosus muscle may be considered as a surgical option.

本文报告了一例罕见的双侧会阴疝,发生在一只24岁的意大利特等母马身上。母马表现出慢性体重减轻和双侧会阴肿胀的病史。右侧肿胀表现为慢性的迹象,而左侧经历了急性会阴肿胀的单一发作,与绞痛的迹象相一致。由于担心潜在的反复绞痛发作和肠夹的风险,母马住院进行完整的临床和诊断评估,并确定适当的治疗方法。结合病史、临床表现、触诊及超声检查结果,确定为双侧会阴疝。最初尝试通过侧疝修补术进行手术矫正是不成功的。随后,一项涉及半膜肌转位的新技术被用作次要干预。这种替代的手术方法有效地解决了这个问题,没有任何短期或长期的复发或并发症。综上所述,马科动物会阴疝应列入会阴肿胀的鉴别诊断。此外,当位置疝修补术被证明无效时,半膜肌转位可以考虑作为一种手术选择。
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引用次数: 0
Sino-nasal lymphoma Sino-nasal淋巴瘤
IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2025-02-17 DOI: 10.1111/eve.14127
A. R. Hollis

Sino-nasal neoplasia is rare in horses, and most reports are limited to small numbers of cases, making it challenging to draw firm conclusions from the available literature. Exploring data from other species often assists the equine practitioner to better understand rare diseases in horses, but there are limited data about sino-nasal lymphoma in other species. The association with human herpes virus 4 (Epstein–Barr virus) in all reported cases of sino-nasal T-cell lymphoma in humans is especially interesting, but the rarity of this tumour in horses makes such an association with equine herpes virus extremely challenging to investigate.

鼻甲状瘤变在马中很少见,大多数报道仅限于少数病例,因此很难从现有文献中得出确切的结论。探索其他物种的数据通常有助于马从业者更好地了解马的罕见疾病,但其他物种的鼻鼻淋巴瘤数据有限。在所有报告的人类鼻鼻t细胞淋巴瘤病例中,与人类疱疹病毒4(爱泼斯坦-巴尔病毒)的关联特别有趣,但这种肿瘤在马身上的罕见性使得这种与马疱疹病毒的关联极具挑战性。
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引用次数: 0
Outcome of horses with chronic gastric dilatation and delayed gastric emptying treated with oral metoclopramide 口服甲氧氯普胺治疗慢性胃扩张和胃排空延迟的疗效
IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2025-02-14 DOI: 10.1111/eve.14124
F. Bätjer, V. Bäuerlein, I. Vervuert, M. Venner

Background

Chronic gastric dilatation and delayed emptying in horses are rarely diagnosed diseases with a supposedly poor prognosis and no promising treatment options.

Objectives

To describe the clinical presentation of horses diagnosed with chronic gastric dilatation and delayed emptying, and evaluate the effects of oral metoclopramide on the clinical signs of included horses.

Study design

Retrospective observational case series.

Methods

Forty-two affected horses were included. Data was collected from clinical records between January 2011 and April 2023. A survey sent to the owners evaluated presenting complaints, percentage improvement of clinical signs associated with metoclopramide treatment and observed side effects of the treatment.

Results

The most common presenting complaints were recurrent signs of colic (51.7%, of which 66.7% postprandially), followed by poor performance (41.4%). The mean age at initial diagnosis was 13.2 years (min: 0.5; max: 30). Horses were treated with a mean dose of 0.15 ± 0.03 mg/kg bwt p.o. q.12 h of metoclopramide (min: 0.1; max: 0.22). The mean therapy duration at the time of data collection was 31.9 months (min: 3; max: 108). Twenty-nine owners replied to the survey: 73% of the cases showed a clinical improvement of ≥50%, 50% an improvement of ≥75%. One horse developed colic signs after the initiation of metoclopramide treatment. The treatment was not associated with a decreased size of the stomach in 33.3% of patients reevaluated at sonography (p = 0.2). Eight horses were euthanised because of the chronic gastric dilatation. The median survival time of the euthanised horses was 22 months (min: 12; max: 108).

Main limitations

Retrospective character, owner-answered survey, no control group.

Conclusion

The clinical improvement by oral metoclopramide treatment with only a few side effects shown by this report suggests that this could be a treatment option for horses with chronic gastric dilatation and delayed emptying.

马的慢性胃扩张和排空延迟很少被诊断为预后不良和没有希望的治疗选择的疾病。目的描述诊断为慢性胃扩张和排空延迟的马的临床表现,并评价口服甲氧氯普胺对马临床症状的影响。研究设计回顾性观察病例系列。方法选取42匹病马。数据收集自2011年1月至2023年4月的临床记录。一项发给车主的调查评估了出现的投诉、与甲氧氯普胺治疗相关的临床症状改善百分比以及观察到的治疗副作用。结果最常见的主诉是反复出现绞痛症状(51.7%,其中餐后66.7%),其次是表现不佳(41.4%)。初诊时平均年龄为13.2岁(最小0.5岁,最大30岁)。马的甲氧氯普胺平均剂量为0.15±0.03 mg/kg体重,每小时12 h(最小0.1,最大0.22)。数据收集时的平均治疗时间为31.9个月(最小3个月,最大108个月)。29名业主回答了调查:73%的病例临床改善≥50%,50%的病例改善≥75%。在甲氧氯普胺治疗开始后,一匹马出现绞痛迹象。在33.3%的超声重新评估患者中,治疗与胃大小减小无关(p = 0.2)。8匹马因慢性胃扩张而被安乐死。被安乐死的马的平均生存时间为22个月(最短12个月,最长108个月)。主要局限性:回顾性调查,业主自答调查,无对照组。结论口服甲氧氯普胺治疗马慢性胃扩张和排空延迟的临床疗效较好,副作用少。
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引用次数: 0
Uraemic syndrome following acute renal failure in horses 马急性肾衰竭后的尿毒综合征
IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2025-02-12 DOI: 10.1111/eve.14125
G. van Galen
<p>This clinical commentary accompanies the case report from Fernandes and Robin (<span>2025</span>) that describes an interesting case with multiple metabolic problems including acute renal failure (ARF), metabolic encephalopathy, uraemic syndrome and hyperammonaemia. The aim of this commentary is to review the definition and extrarenal effects of the uraemic syndrome in acute kidney injury (AKI) and ARF. As little data are available on horses, a descriptive comparison is made across species.</p><p><i>Azotaemia</i> is a pure biochemical abnormality, that is defined as the elevation or buildup of nitrogenous products and other secondary waste products within the body because of reduced renal function (Tyagi & Aeddula, <span>2025</span>). When the severity of azotaemia increases, and it becomes manifested with clinical signs, this is called <i>uraemia</i> (Tyagi & Aeddula, <span>2025</span>). Uraemia literally means ‘urine in the blood’. The increasing concentration of waste metabolites can lead to toxic levels (these are then called uraemic toxins - UTs), which can have widespread effects throughout the body because of their deleterious effects on cell metabolism and function (Schott, <span>2010b</span>). <i>Uraemic syndrome</i> describes the combination of clinical signs that develop consequently (Schott, <span>2010b</span>; Tyagi & Aeddula, <span>2025</span>).</p><p><i>Acute kidney injury (AKI)</i> means that the kidney has sustained acute damage leading to a sudden decrease in the kidney's excretory function. AKI covers the whole spectrum ranging from mild non-azotaemic kidney injury to advanced renal failure with severe uraemia (Segev et al., <span>2024</span>; van Galen et al., <span>2024</span>).</p><p>On a cellular level UTs cause endoplasmic reticulum and mitochondrial stress and reduced mitochondrial respiration (Andre et al., <span>2023</span>). They also cause activation of the aryl hydrocarbon receptor and nuclear factor kappa B (NF-κB), reactive oxygen species production and the mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and transforming growth factor β (TGF-β) signalling pathways. These effects lead to a pro-inflammatory state, cellular dysfunction and apoptosis (Andre et al., <span>2023</span>).</p><p>Some 150 molecules are considered to be <i>UTs</i> and are believed to contribute to the uraemic syndrome when their concentrations increase following a decline in renal function (Andre et al., <span>2023</span>). The most well-known UTs are blood urea nitrogen (BUN), serum creatinine, ammonia, uric acid, phenol, guanidino compounds and products of intestinal metabolism (secondary methylamines, polyamines and tryptophan breakdown products such as indole, skatole, indoleacetic acid; Lee & Downing, <span>1981</span>; Schott, <span>2010b</span>). Although some UTs are inversely correlated with renal function (glomerular filtration rate or serum creatinine concentrations; Ebrahimi
这篇临床评论伴随着Fernandes和Robin(2025)的病例报告,该报告描述了一个有趣的病例,该病例具有多种代谢问题,包括急性肾功能衰竭(ARF)、代谢性脑病、尿毒综合征和高氨血症。本文的目的是回顾急性肾损伤(AKI)和ARF中尿毒症综合征的定义和外肾效应。由于关于马的数据很少,因此进行了跨物种的描述性比较。氮血症是一种纯粹的生化异常,它被定义为由于肾功能下降而导致体内含氮产物和其他二次废物的升高或积聚(Tyagi &amp;Aeddula, 2025)。当氮血症的严重程度增加,并表现出临床症状时,称为尿毒症(Tyagi &amp;Aeddula, 2025)。尿毒症的字面意思是“血液中的尿液”。废物代谢物浓度的增加可导致毒性水平(这些被称为尿毒症毒素- ut),由于其对细胞代谢和功能的有害影响,可在整个身体中产生广泛影响(Schott, 2010b)。尿毒综合征描述了由此产生的临床症状的组合(Schott, 2010b;Tyagi,Aeddula, 2025)。急性肾损伤(AKI)是指肾脏受到持续的急性损伤,导致肾脏排泄功能突然下降。AKI涵盖了从轻度非氮化肾损伤到晚期肾功能衰竭合并严重尿毒症的整个范围(Segev et al., 2024;van Galen et al., 2024)。在细胞水平上,ut引起内质网和线粒体应激,并减少线粒体呼吸(Andre et al, 2023)。它们还会激活芳烃受体和核因子κB (NF-κB)、活性氧的产生和丝裂原活化蛋白激酶(MAPK)、细胞外信号调节激酶(ERK)和转化生长因子β (TGF-β)信号通路。这些作用导致促炎状态、细胞功能障碍和细胞凋亡(Andre et al., 2023)。大约有150种分子被认为是ut,当它们的浓度随着肾功能下降而增加时,被认为是导致尿毒症综合征的原因(Andre et al., 2023)。最著名的ut是血尿素氮(BUN)、血清肌酐、氨、尿酸、苯酚、胍类化合物和肠道代谢产物(次级甲胺、多胺和色氨酸分解产物,如吲哚、苯甲醇、吲哚乙酸;李,唐宁,1981;Schott, 2010 b)。尽管一些ut与肾功能呈负相关(肾小球滤过率或血清肌酐浓度;Ebrahimi et al., 2025),有些则不然(Andre et al., 2023;Veldeman et al., 2019)。然而,更多的分子变化正在循环中发生。众所周知,肾功能下降也会导致电解质和酸碱失衡。此外,微量矿物质的异常可能导致铝中毒和锌缺乏(Schott, 2010a, 2010b)。代谢异常、组织不敏感、激素的清除和产生也伴随着肾功能的下降,导致继发性甲状腺功能亢进(分泌过多以重建体内平衡)和胰岛素不敏感等激素问题(Schott, 2010a, 2010b)。最近,人体研究和动物模型表明,受损的肾脏会释放大量炎症介质和细胞碎片进入循环系统(Faubel &amp;埃德尔斯坦,2016)。所有这些积聚或释放到血液循环中的分子,不仅仅是ut,会对远处器官产生影响,并导致尿毒症综合征。因此,术语尿毒症综合征用于描述与尿毒症相关的临床症状,然而,不一定只是由ut引起的。氮血症、尿毒症和尿毒症综合征可伴发急性和慢性肾脏疾病。尿毒症和尿毒症综合征通常与肾功能衰竭(急性肾损伤(AKI)或慢性肾病(CKD)谱系中较严重的一端)一起发展;van Galen et al., 2024),因为氮血症需要严重到足以产生临床症状。尿毒综合征在患有慢性肾衰竭(CRF)的马中很常见(Schott, 2010b)。这种疾病的慢性导致组织长期暴露于ut和其他上述介质,并且随着时间的推移,随着它们的进一步积累,许多临床症状逐渐变得明显。急性对慢性事件可引起临床综合征的急性加重。在ARF中也可以看到尿毒症综合征。由于嗜睡和食欲下降等典型临床症状是非特异性的,通常也与诱发或潜在疾病过程有关,因此该综合征往往更难识别。 目前关于ARF马的尿毒综合征的数据有限,然而,有一些病例报告,如Fernandes和Robin(2025)和Bouchard等人(1994)的报告,轶事证据和来自人类医学的有力证据(Andre等人,2023;Caillard et al., 2022;Veldeman等人,2019;Wang等人,2019)。此外,根据我的个人经验,这种综合征可以在患有ARF的马身上看到。较轻且不明显的临床症状可能是由于AKI患者血浆中ut浓度大多低于CKD患者(Caillard et al., 2022;陈,刘,2024;Veldeman等人,2019;Wang et al., 2019),在所有ARF患者中,有些ut并没有增加,有些只是短暂的增加(Andre et al., 2023;Veldeman等人,2019;Wang等人,2019)。这些动力学在马身上可能是相似的。然而,饮食会显著影响人体内UT的浓度(Czaja-Stolc等人,2025),因此马的饮食非常不同,可能会引发不同的UT模式,从而导致临床症状。在一些肾功能急剧下降的ARF马匹中,该综合征可以变得更容易识别。根据我的经验,这可能与急性和严重的尿毒症临床症状、暴发性疾病进展和预后不良有关。在一些马身上观察到的这种快速发作与在暴露30分钟- 1小时后已经在人类细胞中观察到ut的有害影响的发现相一致(Andre et al., 2023)。在人、小动物和马中,无尿毒症的非氮血症或轻度氮血症AKI(1级或2级AKI)也可出现临床症状和并发症,尽管通常非常微妙或亚临床。因此,结论是它们发生在AKI的整个谱系中,从非氮化到严重的尿毒症衰竭,而不仅仅是在尿毒症发生时。某些ut和其他上述介质在血清肌酐和/或BUN浓度高于参考范围之前,在真正可以谈论尿毒症之前,即可以增加(Mulders等,2025)。由于临床症状不仅仅是由ut引起的,而仅仅与尿毒症有关,并且临床症状可能因为ut而没有尿毒症而发生,因此使用“尿毒症综合征”一词可能导致混淆和误解,其使用通常仅限于最严重的情况。为了避免过度简化和误解,并涵盖整个范围,作者建议简单地谈论与肾脏疾病相关的临床症状。在过去的20年里,一些涉及远端器官的并发症开始在AKI患者中得到重视,以及长期公认的并发症,如电解质紊乱、液体超载和尿毒性出血(Faubel &amp;埃德尔斯坦,2016)。事实上,AKI基本上影响到身体的每一个器官,有可能导致多器官损伤和功能障碍(MODS),最终导致多器官功能衰竭(MOF)和对身体基本功能的稳态控制丧失。事实上,在大多数人类患者中,ARF都伴有肾外器官衰竭(Mehta et al., 2004)。因此,AKI应被视为一种全身性疾病。这些并发症部分是由ut的直接毒性作用引起的,但也有炎症介质和受损肾脏释放的细胞碎片,以及液体、电解质和酸碱紊乱对远处器官造成严重的有害影响(Chan &amp;刘,2024;Faubel,埃德尔斯坦,2016)。此外,受影响的器官反过来又会对其他器官造成损害。虽然远端器官损伤和功能障碍的病理生理学目前尚未完全了解,但它被认为是多因素的(Caillard et al., 2022;陈,
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引用次数: 0
Surgical management of a bilateral mandibular fracture in a foal using LCPs as external fixator 使用lcp作为外固定架治疗马驹双侧下颌骨骨折的手术治疗
IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2025-02-10 DOI: 10.1111/eve.14111
A. B. M. Dias, K. Gustafsson, P. J. Kieffer

This report describes the use of locking compression plates (LCP) as external skeletal fixators (ESF-LCP) in the surgical repair of a bilateral open mandibular fracture in a foal. A 3-week-old 90-kg Swedish Warmblood colt presented with reluctance to nurse, bilateral mandibular swelling and haemorrhagic discharge from the mouth. Clinical examination and radiographs revealed a fracture of both mandibles, with complete fracture anatomy defined by computed tomography (CT). The right mandible had a complete, displaced, open fracture between the deciduous premolars Triadan 806 and 807. The left mandible had a minimally displaced, comminuted fracture in the caudal aspect of the interdental diastema (705–706). Both mandibles were surgically repaired using narrow 4.5 mm LCP plates as external skeletal fixators (ESF-LCP) under general anaesthesia. The ESF-LCPs were removed 36 days post-operatively after radiographic healing was observed. Three months post-operatively repeat radiographs were performed showing no abnormalities of the mandibular or dental function. At 3 years of age, a routine dental examination was performed that showed normal occlusion and function of the mandible with only a mild external callus. The use of LCP plates as ESF-LCP in a bilateral mandibular fracture in a neonatal foal resulted in an excellent outcome and complete fracture healing with minimal complications.

本报告描述了使用锁定加压钢板(LCP)作为骨外固定物(ESF-LCP)手术修复马驹双侧开放性下颌骨骨折。一匹3周大、体重90公斤的瑞典温血小马表现出不愿喂奶、双侧下颌肿胀和口腔出血。临床检查和x线片显示双下颌骨骨折,计算机断层扫描(CT)确定了完整的骨折解剖结构。右下颌骨在Triadan 806和807乳牙之间有一个完整的,移位的,开放的骨折。左侧下颌骨牙间间隙尾侧有轻度移位粉碎性骨折(705-706)。在全身麻醉下,采用4.5 mm狭窄LCP板作为骨外固定架(ESF-LCP)对双侧下颌骨进行手术修复。术后36天,观察x线片愈合后取出esf - lcp。术后3个月重复x线片显示下颌或牙功能无异常。3岁时,进行常规牙科检查,显示下颌咬合和功能正常,只有轻微的外骨痂。使用LCP钢板作为ESF-LCP治疗新生儿马驹双侧下颌骨骨折,结果良好,骨折完全愈合,并发症最少。
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引用次数: 0
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Equine Veterinary Education
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