Paula González‐Andrés , Carlos Díez‐Poza , Laura F. Peña , Daniel Gónzalez‐Pinardo , Israel Fernández , Asunción Barbero
This work provides an in‐depth analysis of the factors governing the different reaction pathways in the acid‐catalyzed cyclization of gem‐vinylsilyl alcohols with aldehydes. The study evaluates the impact of both the ligands attached to silicon and the choice of the Lewis acid on the reaction outcome. Additionally, computational studies offer valuable insights into the mechanism that control these distinct pathways. The process enables the chemo‐ and stereocontrolled formation of a variety of structural frameworks, offering significant potential for the generation of a broad range of molecular architectures.
{"title":"Insight into the Key Factors that Influence the Reaction Pathways in the Silyl‐Prins Cyclization of gem‐Vinylsilyl Alcohols","authors":"Paula González‐Andrés , Carlos Díez‐Poza , Laura F. Peña , Daniel Gónzalez‐Pinardo , Israel Fernández , Asunción Barbero","doi":"10.1002/adsc.202401437","DOIUrl":"10.1002/adsc.202401437","url":null,"abstract":"<div><div>This work provides an in‐depth analysis of the factors governing the different reaction pathways in the acid‐catalyzed cyclization of <em>gem</em>‐vinylsilyl alcohols with aldehydes. The study evaluates the impact of both the ligands attached to silicon and the choice of the Lewis acid on the reaction outcome. Additionally, computational studies offer valuable insights into the mechanism that control these distinct pathways. The process enables the chemo‐ and stereocontrolled formation of a variety of structural frameworks, offering significant potential for the generation of a broad range of molecular architectures.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401437"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsc.202401437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wen‐Jun Han , Fang‐Long Yang , Zhiyuan Hu , Wenxia Chen , Shun Liu , Ke Guo , Xin‐Yuan Yang , Bin Cheng
A copper‐powder‐mediated tandem hydroamination cyclization–hydrocyanation of alkyne‐tethered ketoximes is described by using TMSCN as a commercially available cyanating reagent. This methodology provides an alternative strategy for the synthesis of a series of structurally important cyano‐substituted cyclic nitrones. The hydrocyanation process exhibits distinct regioselectivity depending on the substituent pattern of the alkyne moiety. Moreover, the synthesized products were shown to be capable of undergoing various derivatization reactions.
{"title":"Copper‐Powder‐Mediated Tandem Hydroamination Cyclization‐Hydrocyanation of Alkyne‐Tethered Ketoximes Toward Cyano‐Substituted Cyclic Nitrones","authors":"Wen‐Jun Han , Fang‐Long Yang , Zhiyuan Hu , Wenxia Chen , Shun Liu , Ke Guo , Xin‐Yuan Yang , Bin Cheng","doi":"10.1002/adsc.202401049","DOIUrl":"10.1002/adsc.202401049","url":null,"abstract":"<div><div>A copper‐powder‐mediated tandem hydroamination cyclization–hydrocyanation of alkyne‐tethered ketoximes is described by using TMSCN as a commercially available cyanating reagent. This methodology provides an alternative strategy for the synthesis of a series of structurally important cyano‐substituted cyclic nitrones. The hydrocyanation process exhibits distinct regioselectivity depending on the substituent pattern of the alkyne moiety. Moreover, the synthesized products were shown to be capable of undergoing various derivatization reactions.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401049"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Highly atom‐economic conversion of diaryliodonium salts represents an underdeveloped but highly desirable domain. Most reactions involving these species only utilize single aryl group of the diaryliodonium salts and produce an equivalent of aryl iodide as waste. Herein, by further transforming the side‐product aryl iodide, we report an overall new two‐step one‐pot strategy that allows photocatalytic C−I bond borylation of diaryliodonium salts and ensures effective conversion of both aryl groups of the diaryliodonium into the relevant arylboronic esters. Mechanistic investigations suggest that electron‐donor‐acceptor complex is formed between the photocatalyst phenothiazine and diaryliodonium salt substrate. Upon visible light irradiation, this complex produces aryl radical and aryl iodide. With addition of a base in the second step, the reducing ability of the photocatalyst is enhanced via proton‐coupled electron transfer process, thereby aryl iodide produced in the first step is reduced to yield aryl radical again. Both aryl radicals generated in the two steps react with B2(OR)4 to produce the corresponding monoarylation product in a quantitative yield. The strategy is also applicable for C−I bond phosphorylation of diaryliodonium salts, ensuring that both aryl moieties can be phosphorylated with high efficiency.
{"title":"Photocatalytic C−I Bond Borylation and Phosphorylation of Diaryliodonium Salts with Excellent Atom‐Economy","authors":"Tian‐Yu Ding , Xiao‐Ning Guo , Bin Chen , Chen‐Ho Tung , Li‐Zhu Wu","doi":"10.1002/adsc.202401240","DOIUrl":"10.1002/adsc.202401240","url":null,"abstract":"<div><div>Highly atom‐economic conversion of diaryliodonium salts represents an underdeveloped but highly desirable domain. Most reactions involving these species only utilize single aryl group of the diaryliodonium salts and produce an equivalent of aryl iodide as waste. Herein, by further transforming the side‐product aryl iodide, we report an overall new two‐step one‐pot strategy that allows photocatalytic C−I bond borylation of diaryliodonium salts and ensures effective conversion of both aryl groups of the diaryliodonium into the relevant arylboronic esters. Mechanistic investigations suggest that electron‐donor‐acceptor complex is formed between the photocatalyst phenothiazine and diaryliodonium salt substrate. Upon visible light irradiation, this complex produces aryl radical and aryl iodide. With addition of a base in the second step, the reducing ability of the photocatalyst is enhanced via proton‐coupled electron transfer process, thereby aryl iodide produced in the first step is reduced to yield aryl radical again. Both aryl radicals generated in the two steps react with B<sub>2</sub>(OR)<sub>4</sub> to produce the corresponding monoarylation product in a quantitative yield. The strategy is also applicable for C−I bond phosphorylation of diaryliodonium salts, ensuring that both aryl moieties can be phosphorylated with high efficiency.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401240"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142797653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shulei Hu , Yong Wang , Xiong Xie , Renwen Liang , Hong Liu , Jiang Wang
A ruthenium(II)‐catalyzed C−H acylmethylation of Trp‐containing peptides with α‐chloro ketones is reported here. This reaction features good C‐2 selectivity and chemoselectivity, making it suitable for late‐stage modification of Trp‐containing peptides. Low‐cost metal ruthenium as a catalyst enables the reaction to be conducted on a gram scale. This report also discusses the synthetic applications and presents a method to remove the pyridine directing group. In addition, a plausible mechanism of the C(2)−H acylmethylation reaction is proposed in this article.
{"title":"Ruthenium(II)‐Catalyzed Pyridyl‐Directed Tryptophan C−H Acylmethylation with α‐Chloro Ketones","authors":"Shulei Hu , Yong Wang , Xiong Xie , Renwen Liang , Hong Liu , Jiang Wang","doi":"10.1002/adsc.202400947","DOIUrl":"10.1002/adsc.202400947","url":null,"abstract":"<div><div>A ruthenium(II)‐catalyzed C−H acylmethylation of Trp‐containing peptides with <em>α</em>‐chloro ketones is reported here. This reaction features good C‐2 selectivity and chemoselectivity, making it suitable for late‐stage modification of Trp‐containing peptides. Low‐cost metal ruthenium as a catalyst enables the reaction to be conducted on a gram scale. This report also discusses the synthetic applications and presents a method to remove the pyridine directing group. In addition, a plausible mechanism of the C(2)−H acylmethylation reaction is proposed in this article.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202400947"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xueyan Lv , Shichen Li , Shuai Fang , Xiaotian Wu , Bingchuan Yang , Chen Ma
Herein, we present a protocol starting from styrene oxide reacting with o‐acylaniline and o‐alkenylaniline derivatives to obtain 3,4‐disubstituted quinoline and 2‐acylquinoline derivatives, respectively, in 32–92% yields under specific conditions. Preliminary research outcomes underscore the versatility of our approach, as exemplified by its scalability for large‐scale synthesis, downstream derivatization, and the characteristic properties manifested by the modified molecules.
{"title":"Direct Synthesis of 3,4‐Disubstituted Quinolines and 2‐Acylquinolines from Amines and Epoxides","authors":"Xueyan Lv , Shichen Li , Shuai Fang , Xiaotian Wu , Bingchuan Yang , Chen Ma","doi":"10.1002/adsc.202401055","DOIUrl":"10.1002/adsc.202401055","url":null,"abstract":"<div><div>Herein, we present a protocol starting from styrene oxide reacting with <em>o</em>‐acylaniline and <em>o</em>‐alkenylaniline derivatives to obtain 3,4‐disubstituted quinoline and 2‐acylquinoline derivatives, respectively, in 32–92% yields under specific conditions. Preliminary research outcomes underscore the versatility of our approach, as exemplified by its scalability for large‐scale synthesis, downstream derivatization, and the characteristic properties manifested by the modified molecules.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401055"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vishal Talukdar, Siddhartha Paul, Krishanu Mondal, Parthasarathi Das
An efficient copper‐catalyzed Chan–Lam type N‐arylation of various amides, sulfonamides, urea, azoles, and amines has been demonstrated using a CuF2/DMSO catalytic system with structurally diverse aryl(trimethoxy)silanes under base and ligand‐free conditions. This approach facilitates effective C‐N cross‐coupling with user‐friendly organosilicon reagents without requiring an external fluoride source. CuF2 serves a dual function as both a catalyst and a desilylating agent, facilitating the cleavage of the aryl‐silane bond. The process is compatible with a broad range of substrates, ensuring high efficiency and excellent functional group compatibility. Moreover, this protocol is proven to be valuable for late‐stage modification of amide and sulfonamide‐containing drug molecules, as well as for synthesizing agrochemicals.
{"title":"CuF2‐Catalyzed C‐N Cross‐Coupling of Aryl Silanes: Expanding the Scope of Chan‐Lam Type Reaction","authors":"Vishal Talukdar, Siddhartha Paul, Krishanu Mondal, Parthasarathi Das","doi":"10.1002/adsc.202401498","DOIUrl":"https://doi.org/10.1002/adsc.202401498","url":null,"abstract":"An efficient copper‐catalyzed Chan–Lam type N‐arylation of various amides, sulfonamides, urea, azoles, and amines has been demonstrated using a CuF2/DMSO catalytic system with structurally diverse aryl(trimethoxy)silanes under base and ligand‐free conditions. This approach facilitates effective C‐N cross‐coupling with user‐friendly organosilicon reagents without requiring an external fluoride source. CuF2 serves a dual function as both a catalyst and a desilylating agent, facilitating the cleavage of the aryl‐silane bond. The process is compatible with a broad range of substrates, ensuring high efficiency and excellent functional group compatibility. Moreover, this protocol is proven to be valuable for late‐stage modification of amide and sulfonamide‐containing drug molecules, as well as for synthesizing agrochemicals.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"64 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The combination of palladium and silver complexes has emerged as a bimetallic catalytic system in C−H activation, frequently outperforming palladium‐only systems. Beyond the conventional roles of silver (I) salts serving as oxidants, halide scavengers, and Lewis acids, Pd−Ag bimetallic synergism has been shown to facilitate C−H cleavage. In this study, we explore the incorporation of a pyrazolopyridone (PzPyOH) ligand into a Pd−Ag bimetallic catalytic system, which together promote both C−H cleavage and migratory insertion processes. This synergistic approach enables dehydrogenative C−H alkenylations at the C4 position of 2,1,3‐benzothiadiazole, 2,1,3‐benzoxadiazole, and 2,1,3‐benzotriazole with alkenes. These results demonstrate the potential of combining novel ligands with heterobimetallic systems to facilitate other elementary steps beyond C−H cleavage, suggesting their broader applicability in C−H functionalization.
{"title":"Synergistic Palladium/Silver/Ligand Catalysis for C−H Alkenylation of 2,1,3‐Benzofused Heterodiazoles","authors":"Siyeon Jeong , Chaerin Lee , Jung Min Joo","doi":"10.1002/adsc.202401139","DOIUrl":"10.1002/adsc.202401139","url":null,"abstract":"<div><div>The combination of palladium and silver complexes has emerged as a bimetallic catalytic system in C−H activation, frequently outperforming palladium‐only systems. Beyond the conventional roles of silver (I) salts serving as oxidants, halide scavengers, and Lewis acids, Pd−Ag bimetallic synergism has been shown to facilitate C−H cleavage. In this study, we explore the incorporation of a pyrazolopyridone (PzPyOH) ligand into a Pd−Ag bimetallic catalytic system, which together promote both C−H cleavage and migratory insertion processes. This synergistic approach enables dehydrogenative C−H alkenylations at the C4 position of 2,1,3‐benzothiadiazole, 2,1,3‐benzoxadiazole, and 2,1,3‐benzotriazole with alkenes. These results demonstrate the potential of combining novel ligands with heterobimetallic systems to facilitate other elementary steps beyond C−H cleavage, suggesting their broader applicability in C−H functionalization.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401139"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dilip V. Patil , Rahulkumar Patel , Shinobu Takizawa , Hun Y. Kim , Kyungsoo Oh
The visible light‐induced one‐pot tandem photolysis of areneazo‐2‐(2‐nitro)propanes was achieved to give carbazole and indole derivatives. The aryl azidation followed by an intramolecular C−H amination smoothly proceeded under visible light irradiation without any photocatalyst, demonstrating the synthetic versatility of areneazo‐2‐(2‐nitro)propanes. The in situ generation of aryl azide intermediates was executed under mild visible light photolysis conditions, showcasing the synthetic versatility of areneazo‐2‐(2‐nitro)propanes, a safe alternative of diazonium salts.
{"title":"Tandem Photocatalyst‐Free Visible Light Aryl Azidation‐Intramolecular C−H Amination: One‐Pot Access to Carbazoles and Indoles from Areneazo‐2‐(2‐nitro)propanes","authors":"Dilip V. Patil , Rahulkumar Patel , Shinobu Takizawa , Hun Y. Kim , Kyungsoo Oh","doi":"10.1002/adsc.202401333","DOIUrl":"10.1002/adsc.202401333","url":null,"abstract":"<div><div>The visible light‐induced one‐pot tandem photolysis of areneazo‐2‐(2‐nitro)propanes was achieved to give carbazole and indole derivatives. The aryl azidation followed by an intramolecular C−H amination smoothly proceeded under visible light irradiation without any photocatalyst, demonstrating the synthetic versatility of areneazo‐2‐(2‐nitro)propanes. The <em>in situ</em> generation of aryl azide intermediates was executed under mild visible light photolysis conditions, showcasing the synthetic versatility of areneazo‐2‐(2‐nitro)propanes, a safe alternative of diazonium salts.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401333"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A series of 3,5‐diaryl‐4‐selanylisoxazoles were synthesized in 56–97% yields (most cases>80% yield), which was first accomplished via bromide‐catalyzed selenylation of 2‐alkyn‐1‐one O‐methyloximes using element Se and boronic acids as the selenyl source. Compared to traditional strategies, this method proceeded under simple catalytic system. Broad substrate scope, good functional group compatibility, metal‐free conditions, and easy operation was showed in this protocol. Additionally, this method was easily amendable to gram‐scale reaction and synthetic transformations. Furthermore, preliminary mechanistic experiments demonstrated that a radical pathway was possibly involved in this work.
{"title":"First Bromide‐Catalyzed Selenylation of 2‐Alkyn‐1‐One O‐Methyloximes Enabled the Synthesis of 4‐Selenylated Isoxazoles","authors":"Jinhui Cai , Zhouting Zeng","doi":"10.1002/adsc.202401477","DOIUrl":"10.1002/adsc.202401477","url":null,"abstract":"<div><div>A series of 3,5‐diaryl‐4‐selanylisoxazoles were synthesized in 56–97% yields (most cases>80% yield), which was first accomplished via bromide‐catalyzed selenylation of 2‐alkyn‐1‐one <em>O</em>‐methyloximes using element Se and boronic acids as the selenyl source. Compared to traditional strategies, this method proceeded under simple catalytic system. Broad substrate scope, good functional group compatibility, metal‐free conditions, and easy operation was showed in this protocol. Additionally, this method was easily amendable to gram‐scale reaction and synthetic transformations. Furthermore, preliminary mechanistic experiments demonstrated that a radical pathway was possibly involved in this work.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401477"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramachandra Reddy Putta , Junhwa Hong , Seung Hyun Choi , Jinwoo Lee , Honghui Lee , Seok Beom Lee , Suckchang Hong
Herein, we describe a two‐component methodology developed for the synthesis of pyrimidine derivatives using tertiary alkylamines and amidines. Tertiary alkylamines serve as dual C2 synthons through copper‐catalyzed aerobic difunctionalization of the α,β−C(sp3)−H bonds. The process operates under mild conditions and uses atmospheric oxygen as the oxidant. Notably, by this methodology yields up to 85% yields are obtained and a broad substrate scope is shown. Mechanistic studies indicate that the annulation proceeds via a radical‐mediated oxidation and C−N bond coupling process. This approach provides a pathway for synthesizing various heterocycles by employing tertiary alkylamines as dual C2 synthons.
{"title":"Dual C2 Synthon Strategy for the Synthesis of Pyrimidines: Copper‐Catalyzed Aerobic α,β‐C(sp3)−H Bond Difunctionalization of Tertiary Alkylamines","authors":"Ramachandra Reddy Putta , Junhwa Hong , Seung Hyun Choi , Jinwoo Lee , Honghui Lee , Seok Beom Lee , Suckchang Hong","doi":"10.1002/adsc.202400907","DOIUrl":"10.1002/adsc.202400907","url":null,"abstract":"<div><div>Herein, we describe a two‐component methodology developed for the synthesis of pyrimidine derivatives using tertiary alkylamines and amidines. Tertiary alkylamines serve as dual C2 synthons through copper‐catalyzed aerobic difunctionalization of the α,β−C(<em>sp</em><sup>3</sup>)−H bonds. The process operates under mild conditions and uses atmospheric oxygen as the oxidant. Notably, by this methodology yields up to 85% yields are obtained and a broad substrate scope is shown. Mechanistic studies indicate that the annulation proceeds <em>via</em> a radical‐mediated oxidation and C−N bond coupling process. This approach provides a pathway for synthesizing various heterocycles by employing tertiary alkylamines as dual C2 synthons.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202400907"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号