This study investigates the visible‐light‐initiated uranyl(VI)‐catalyzed activation of Si−H bonds through direct hydrogen atom transfer, which facilitates the formation of silyl radicals from silanes. The silyl radical can abstract a chlorine atom from the sulfonyl chloride, leading to the generation of sulfonyl radicals. These silyl radicals and sulfonyl radicals could react with alkenes and alkynes, achieving the first example of uranyl‐catalyzed hydrosilylation and hydrosulfonylation of unsaturated C−C bonds. This method features mild reaction conditions and a broad substrate scope, and exhibits exceptional functional‐group tolerance. Consequently, it is suitable for the late‐stage functionalization of drug derivatives.
{"title":"Visible‐Light‐Initiated Uranyl‐Catalyzed Hydrosilylation and Hydrosulfonylation of Alkenes and Alkynes","authors":"Xingxing Gong , Qianyi Zhao , Congqing Zhu","doi":"10.1002/adsc.202400745","DOIUrl":"10.1002/adsc.202400745","url":null,"abstract":"<div><div>This study investigates the visible‐light‐initiated uranyl(VI)‐catalyzed activation of Si−H bonds through direct hydrogen atom transfer, which facilitates the formation of silyl radicals from silanes. The silyl radical can abstract a chlorine atom from the sulfonyl chloride, leading to the generation of sulfonyl radicals. These silyl radicals and sulfonyl radicals could react with alkenes and alkynes, achieving the first example of uranyl‐catalyzed hydrosilylation and hydrosulfonylation of unsaturated C−C bonds. This method features mild reaction conditions and a broad substrate scope, and exhibits exceptional functional‐group tolerance. Consequently, it is suitable for the late‐stage functionalization of drug derivatives.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202400745"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142085311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Trinidad Martín , Celia Maya , Agustín Galindo , M. Carmen Nicasio
We report the Ni‐catalyzed cyclotrimerization of terminal alkynes at very low loadings of catalysts (0.05 mol% for all substrates). The nickel catalyst containing a terphenyl phosphine ligand allows carrying out the reactions at room temperature in only 30 min, providing the arene products as a single regioisomer in most cases. The Ni complex is also competent for the synthesis of polysubstituted pyridines through the cycloadditions of diynes and nitriles at mild temperatures (25 ° or 50 °C) and low Ni loadings (1 mol%). Experimental data and computational studies support the involvement of monoligated PNi species in all fundamental steps of the catalytic cycle.
{"title":"Ni‐Catalyzed [2+2+2] Cycloaddition of Alkynes To Form Arenes and Pyridines at Low Catalyst Loadings","authors":"M. Trinidad Martín , Celia Maya , Agustín Galindo , M. Carmen Nicasio","doi":"10.1002/adsc.202400765","DOIUrl":"10.1002/adsc.202400765","url":null,"abstract":"<div><div>We report the Ni‐catalyzed cyclotrimerization of terminal alkynes at very low loadings of catalysts (0.05 mol% for all substrates). The nickel catalyst containing a terphenyl phosphine ligand allows carrying out the reactions at room temperature in only 30 min, providing the arene products as a single regioisomer in most cases. The Ni complex is also competent for the synthesis of polysubstituted pyridines through the cycloadditions of diynes and nitriles at mild temperatures (25 ° or 50 °C) and low Ni loadings (1 mol%). Experimental data and computational studies support the involvement of monoligated PNi species in all fundamental steps of the catalytic cycle.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202400765"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsc.202400765","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Celeste Nobbio , William R. Birmingham , Elisabetta Brenna , Nicholas J. Turner , Davide Tessaro , Fabio Parmeggiani
Phenylalanine ammonia lyase (PAL) enzymes have been extensively exploited to produce differently substituted arylalanine analogues, but their use in the stereoselective synthesis of aliphatic fatty amino acids has never been addressed. In this work, a two‐step hydroamination‐hydrodesulfurisation process has been investigated for the production of aliphatic L‐α‐amino acids from thienylacrylic acids, easily accessible by condensation from the corresponding arylaldehydes. Wild‐type PALs from Planctomyces brasiliensis and Streptomyces rimosus were selected as the most promising candidates and improved by site‐directed mutagenesis, thus unlocking the hydroamination of a broad panel of 10 different thienylacrylic acids bearing aliphatic and aromatic substituents. The subsequent hydrodesulfurisation step, accomplished by means of inexpensive Raney nickel in mild conditions and aqueous medium, afforded the corresponding aliphatic α‐amino acids in 10–63% overall isolated yield and perfect enantiopurity. This chemo‐enzymatic process represents the first example of aliphatic amino acid production using PALs, circumventing a major limitation of those biocatalysts.
{"title":"Stereoselective Synthesis of Aliphatic α‐Amino Acids by Chemo‐Enzymatic Hydroamination‐Hydrodesulfurisation","authors":"Celeste Nobbio , William R. Birmingham , Elisabetta Brenna , Nicholas J. Turner , Davide Tessaro , Fabio Parmeggiani","doi":"10.1002/adsc.202401223","DOIUrl":"10.1002/adsc.202401223","url":null,"abstract":"<div><div>Phenylalanine ammonia lyase (PAL) enzymes have been extensively exploited to produce differently substituted arylalanine analogues, but their use in the stereoselective synthesis of aliphatic fatty amino acids has never been addressed. In this work, a two‐step hydroamination‐hydrodesulfurisation process has been investigated for the production of aliphatic L‐α‐amino acids from thienylacrylic acids, easily accessible by condensation from the corresponding arylaldehydes. Wild‐type PALs from <em>Planctomyces brasiliensis</em> and <em>Streptomyces rimosus</em> were selected as the most promising candidates and improved by site‐directed mutagenesis, thus unlocking the hydroamination of a broad panel of 10 different thienylacrylic acids bearing aliphatic and aromatic substituents. The subsequent hydrodesulfurisation step, accomplished by means of inexpensive Raney nickel in mild conditions and aqueous medium, afforded the corresponding aliphatic α‐amino acids in 10–63% overall isolated yield and perfect enantiopurity. This chemo‐enzymatic process represents the first example of aliphatic amino acid production using PALs, circumventing a major limitation of those biocatalysts.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401223"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsc.202401223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ye Zhang , Zhoulu Wang , Min Ren , Xiaoxiang Zhang , Zhenqian Fu
A variety of structurally diverse spirocyclohexane oxindoles featuring a quaternary carbon centre have been successfully constructed through an N‐heterocyclic carbene‐catalyzed [4+2] annulation of isatin‐derived enals with α‐cyano‐β‐methylenones. This domino process exhibits a wide substrate tolerance, operates under mild conditions, and yields products with high enantioselectivities.
{"title":"N‐Heterocyclic Carbene‐Catalyzed Enantioselective Synthesis of Spirocyclohexane Oxindoles","authors":"Ye Zhang , Zhoulu Wang , Min Ren , Xiaoxiang Zhang , Zhenqian Fu","doi":"10.1002/adsc.202401205","DOIUrl":"10.1002/adsc.202401205","url":null,"abstract":"<div><div>A variety of structurally diverse spirocyclohexane oxindoles featuring a quaternary carbon centre have been successfully constructed through an N‐heterocyclic carbene‐catalyzed [4+2] annulation of isatin‐derived enals with <em>α</em>‐cyano‐<em>β</em>‐methylenones. This domino process exhibits a wide substrate tolerance, operates under mild conditions, and yields products with high enantioselectivities.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401205"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This is the report on the Lewis base catalysis of annulenones. Additionally, the synthesis of chiral annulenone catalysts and their application in asymmetric ring‐opening reactions of meso‐epoxides is shown. Annulenones, such as cyclopropenones and tropones, function as Lewis bases owing to their inherent polarity caused by aromaticity, resulting in the activation of silicon tetrachloride, which catalyzes the ring‐opening reaction of meso‐epoxides. Moreover, various chiral annulenone catalysts have been designed and synthesized, and microwave irradiation has been shown to improve the synthetic efficiency of chiral tropones. The chiral annulenones successfully catalyzed the asymmetric ring‐opening reaction of meso‐epoxides, resulting in the formation of 1,2‐chlorohydrins in a high yield and high enantioselectivity (up to 90% ee in 96% yield). These results represent the example of three‐ and seven‐membered annulenones as a chiral Lewis base catalyst.
{"title":"Three‐ and Seven‐membered Annulenones as a Lewis Base Catalyst for Enantioselective meso‐Epoxide Opening","authors":"Sachie Arae , Yasushi Shimoda , Mizuki Kuwajima , Shunsuke Kotani , Makoto Nakajima","doi":"10.1002/adsc.202401186","DOIUrl":"10.1002/adsc.202401186","url":null,"abstract":"<div><div>This is the report on the Lewis base catalysis of annulenones. Additionally, the synthesis of chiral annulenone catalysts and their application in asymmetric ring‐opening reactions of <em>meso</em>‐epoxides is shown. Annulenones, such as cyclopropenones and tropones, function as Lewis bases owing to their inherent polarity caused by aromaticity, resulting in the activation of silicon tetrachloride, which catalyzes the ring‐opening reaction of <em>meso</em>‐epoxides. Moreover, various chiral annulenone catalysts have been designed and synthesized, and microwave irradiation has been shown to improve the synthetic efficiency of chiral tropones. The chiral annulenones successfully catalyzed the asymmetric ring‐opening reaction of <em>meso</em>‐epoxides, resulting in the formation of 1,2‐chlorohydrins in a high yield and high enantioselectivity (up to 90% ee in 96% yield). These results represent the example of three‐ and seven‐membered annulenones as a chiral Lewis base catalyst.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401186"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Gómez‐Gil , Samuel Suárez‐Pantiga , María R. Pedrosa , Roberto Sanz
A molybdenum‐catalyzed synthesis of N‐(hetero)aryl pyrroles directly from inexpensive and commonly available (hetero)nitroarenes via reduction with pinacol and annulation with 1,4‐dicarbonyls or cyclobutane‐1,2‐diols has been described. The process does not require an inert atmosphere and tolerates the presence of air and water. This non‐noble catalytic system shows high chemoselectivity, allowing a diverse range of potentially reducible functional groups such as alkynes, alkenes, halogens, cyano, and carbonyls. Moreover, this strategy enables the reuse of a waste byproduct as reactant, facilitating the formation of challenging 1,4‐dicarbonyls from accessible cyclobutane‐1,2‐diols used as reducing agents.
{"title":"Molybdenum‐Catalyzed Direct Synthesis of Pyrroles from Nitroarenes with Glycols as Reductants","authors":"Sara Gómez‐Gil , Samuel Suárez‐Pantiga , María R. Pedrosa , Roberto Sanz","doi":"10.1002/adsc.202401170","DOIUrl":"10.1002/adsc.202401170","url":null,"abstract":"<div><div>A molybdenum‐catalyzed synthesis of <em>N</em>‐(hetero)aryl pyrroles directly from inexpensive and commonly available (hetero)nitroarenes via reduction with pinacol and annulation with 1,4‐dicarbonyls or cyclobutane‐1,2‐diols has been described. The process does not require an inert atmosphere and tolerates the presence of air and water. This non‐noble catalytic system shows high chemoselectivity, allowing a diverse range of potentially reducible functional groups such as alkynes, alkenes, halogens, cyano, and carbonyls. Moreover, this strategy enables the reuse of a waste byproduct as reactant, facilitating the formation of challenging 1,4‐dicarbonyls from accessible cyclobutane‐1,2‐diols used as reducing agents.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401170"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsc.202401170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Owing to multiple reactive sites, such as an acidic α‐carbon and an isocyano group, isocyanide esters can successfully participate in the synthesis of various five‐ and six‐membered N‐heterocycles through the cycloaddition reactions under metal‐catalyzed systems. Considering the unique and versatile functionality of this synthon, in this review, we have highlighted silver and copper‐catalyzed cycloadditions of isocyanide esters over the last decade.
{"title":"Silver and Copper‐Catalyzed Cycloaddition Reactions of Isocyanide Esters","authors":"Fatemeh Doraghi , Parsa Baghershahi , Farzad Gilaninezhad , Negar Mehdi Zadeh Darban , Navid Dastyafteh , Milad Noori , Mohammad Mahdavi","doi":"10.1002/adsc.202400994","DOIUrl":"10.1002/adsc.202400994","url":null,"abstract":"<div><div>Owing to multiple reactive sites, such as an acidic α‐carbon and an isocyano group, isocyanide esters can successfully participate in the synthesis of various five‐ and six‐membered <em>N</em>‐heterocycles through the cycloaddition reactions under metal‐catalyzed systems. Considering the unique and versatile functionality of this synthon, in this review, we have highlighted silver and copper‐catalyzed cycloadditions of isocyanide esters over the last decade.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202400994"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Herein, we develop the first one‐pot amide synthesis from aldehyde/ketone and amino acids via transaminative amidation reaction and the method requires no catalyst or promoters, by allowing a concise access to structurally diverse amides and lactams with good efficiency. This transformation could also proceed smoothly by direct use of ether solvent as the formylated reagent in stead of formylic acid, thus furnishing an unique synthesis of formamides. The underlying principles of this unique amide synthesis was rationalized by a series of mechanistic studies, which involved a concerted decarboxylatively structural isomerization/acylation process as the key for amidation and a transamination/imine formation/aerobic oxidation cascade for formamidation. The potential utility of this strategy has been demonstrated by the readily accessible late‐stage transformation of biologically active molecules by 15N incorporating. This protocol was also applied to the total synthesis of a kind of drug Butenafine with 15N‐enrichment.
{"title":"Amide synthesis via transaminative amidation of aromatic aldehydes/ketones: An entry to 15N isotopologs","authors":"Jiaping Wu, Yufang Wang, Chaoying Fang, Yuhao Wang, Caiyang Kong, Xinghui Tao, Meihua Xie, Jitan Zhang","doi":"10.1002/adsc.202401592","DOIUrl":"https://doi.org/10.1002/adsc.202401592","url":null,"abstract":"Herein, we develop the first one‐pot amide synthesis from aldehyde/ketone and amino acids via transaminative amidation reaction and the method requires no catalyst or promoters, by allowing a concise access to structurally diverse amides and lactams with good efficiency. This transformation could also proceed smoothly by direct use of ether solvent as the formylated reagent in stead of formylic acid, thus furnishing an unique synthesis of formamides. The underlying principles of this unique amide synthesis was rationalized by a series of mechanistic studies, which involved a concerted decarboxylatively structural isomerization/acylation process as the key for amidation and a transamination/imine formation/aerobic oxidation cascade for formamidation. The potential utility of this strategy has been demonstrated by the readily accessible late‐stage transformation of biologically active molecules by 15N incorporating. This protocol was also applied to the total synthesis of a kind of drug Butenafine with 15N‐enrichment.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"15 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
β‐pyridinyl ketones and β‐pyridinyl thiocyanates are commonly used as an essential organic synthesis intermediate and widely present in various drug molecules and bioactive molecules. Herein, a photoredox catalyzed acyl and thiocyano pyridylation of alkenes with aldehydes and NH4SCN via HAT and SET strategy respectively is described. This protocol employs more readily accessible aldehydes and NH4SCN as radical precursors under redox‐neutral conditions. Moreover, high atom economy, simple and accessible starting materials, late‐stage modification and wide substrate scope including primary, secondary alkyl aldehydes and aromatic aldehydes enable the potential application in the organic synthesis.
{"title":"Visible‐Light‐Induced Acyl and Thiocyano Pyridylation of Alkenes with Aldehyde and NH4SCN","authors":"Xu Wang , Qi‐Xuan Jiang , Bi‐Yin Xiao , Wei Huang , Feng‐Hua Zhang","doi":"10.1002/adsc.202401373","DOIUrl":"10.1002/adsc.202401373","url":null,"abstract":"<div><div>β‐pyridinyl ketones and β‐pyridinyl thiocyanates are commonly used as an essential organic synthesis intermediate and widely present in various drug molecules and bioactive molecules. Herein, a photoredox catalyzed acyl and thiocyano pyridylation of alkenes with aldehydes and NH<sub>4</sub>SCN via HAT and SET strategy respectively is described. This protocol employs more readily accessible aldehydes and NH<sub>4</sub>SCN as radical precursors under redox‐neutral conditions. Moreover, high atom economy, simple and accessible starting materials, late‐stage modification and wide substrate scope including primary, secondary alkyl aldehydes and aromatic aldehydes enable the potential application in the organic synthesis.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202401373"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A metal‐ and irradiation‐free approach for the direct arylation of secondary phosphines has been developed. The reaction employs diaryliodonium salts as electrophilic aryl‐transfer reagents, effecting the P−Ar bond‐formation in a single step, under mild conditions, using t‐BuOK as a base and DMSO as a solvent. The protocol furnishes expedient access to diverse unsymmetrical triarylphosphines and, upon a one‐pot oxidation, the corresponding triarylphosphine oxides. Experimental and computational studies support the inner sphere aryl‐transfer mechanism through a reductive coupling at the hypervalent iodine center. The calculations also point to a key role played by potassium ions, providing extra stabilization to the P−C bond‐forming transition state by binding the reactants via cation‐π interactions.
{"title":"Arylation of Secondary Phosphines with Diaryliodonium Salts under Metal‐Free and Non‐Photochemical Conditions","authors":"Ajit Kumar Jha , Sudeep Sarkar , Kacper Szczepanski , Marcin Kalek","doi":"10.1002/adsc.202400919","DOIUrl":"10.1002/adsc.202400919","url":null,"abstract":"<div><div>A metal‐ and irradiation‐free approach for the direct arylation of secondary phosphines has been developed. The reaction employs diaryliodonium salts as electrophilic aryl‐transfer reagents, effecting the P−Ar bond‐formation in a single step, under mild conditions, using <em>t</em>‐BuOK as a base and DMSO as a solvent. The protocol furnishes expedient access to diverse unsymmetrical triarylphosphines and, upon a one‐pot oxidation, the corresponding triarylphosphine oxides. Experimental and computational studies support the inner sphere aryl‐transfer mechanism through a reductive coupling at the hypervalent iodine center. The calculations also point to a key role played by potassium ions, providing extra stabilization to the P−C bond‐forming transition state by binding the reactants via cation‐π interactions.</div></div>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 4","pages":"Article e202400919"},"PeriodicalIF":4.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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